Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial
Srivastava, Shobhit, Saksena, Anil K., Khattri, Sanjay, Kumar, Santosh, Dagur, Raghubendra Singh
Published in Inflammopharmacology (01.12.2016)
Published in Inflammopharmacology (01.12.2016)
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Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection
Venkatraman, Srikanth, Bogen, Stéphane L, Arasappan, Ashok, Bennett, Frank, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond, Hendrata, Siska, Huang, Yuhua, Pan, Weidong, Parekh, Tejal, Pinto, Patrick, Popov, Veljko, Pike, Russel, Ruan, Sumei, Santhanam, Bama, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Kong, Jianshe, Liang, Xiang, Wong, Jesse, Liu, Rong, Butkiewicz, Nancy, Chase, Robert, Hart, Andrea, Agrawal, Sony, Ingravallo, Paul, Pichardo, John, Kong, Rong, Baroudy, Bahige, Malcolm, Bruce, Guo, Zhuyan, Prongay, Andrew, Madison, Vincent, Broske, Lisa, Cui, Xiaoming, Cheng, Kuo-Chi, Hsieh, Yunsheng, Brisson, Jean-Marc, Prelusky, Danial, Korfmacher, Walter, White, Ronald, Bogdanowich-Knipp, Susan, Pavlovsky, Anastasia, Bradley, Prudence, Saksena, Anil K, Ganguly, Ashit, Piwinski, John, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of medicinal chemistry (05.10.2006)
Published in Journal of medicinal chemistry (05.10.2006)
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Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor
Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Venkatraman, Srikanth, Blackman, Melissa, Chen, Kevin X, Hendrata, Siska, Huang, Yuhua, Huelgas, Regina M, Nair, Latha, Padilla, Angela I, Pan, Weidong, Pike, Russell, Pinto, Patrick, Ruan, Sumei, Sannigrahi, Mousumi, Velazquez, Francisco, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Saksena, Anil K, Girijavallabhan, Viyyoor, Shih, Neng-Yang, Kong, Jianshe, Meng, Tao, Jin, Yan, Wong, Jesse, McNamara, Paul, Prongay, Andrew, Madison, Vincent, Piwinski, John J, Cheng, Kuo-Chi, Morrison, Richard, Malcolm, Bruce, Tong, Xiao, Ralston, Robert, Njoroge, F. George
Published in ACS medicinal chemistry letters (13.05.2010)
Published in ACS medicinal chemistry letters (13.05.2010)
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Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization
Prongay, Andrew J, Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers, Joseph, Weber, Patricia C, Beyer, Brian M, Ingram, Richard, Hong, Zhi, Prosise, Winifred W, Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Saksena, Anil K, Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George, Madison, Vincent
Published in Journal of medicinal chemistry (17.05.2007)
Published in Journal of medicinal chemistry (17.05.2007)
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Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations
Yi, MinKyung, Tong, Xiao, Skelton, Angela, Chase, Robert, Chen, Tong, Prongay, Andrew, Bogen, Stephane L, Saksena, Anil K, Njoroge, F George, Veselenak, Ronald L, Pyles, Richard B, Bourne, Nigel, Malcolm, Bruce A, Lemon, Stanley M
Published in The Journal of biological chemistry (24.03.2006)
Published in The Journal of biological chemistry (24.03.2006)
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The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor
Bennett, Frank, Huang, Yuhua, Hendrata, Siska, Lovey, Raymond, Bogen, Stephane L., Pan, Weidong, Guo, Zhuyan, Prongay, Andrew, Chen, Kevin X., Arasappan, Ashok, Venkatraman, Srikanth, Velazquez, Francisco, Nair, Latha, Sannigrahi, Mousumi, Tong, Xiao, Pichardo, John, Cheng, Kuo-Chi, Girijavallabhan, Viyyoor M., Saksena, Anil K., Njoroge, F. George
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: Key intermediates towards synthesis of highly active azole antifungals SCH 51048 and SCH 56592
Saksena, Anil K, Girijavallabhan, Viyyoor M, Wang, Haiyan, Liu, Yi-Tsung, Pike, Russel E, Ganguly, Ashit K
Published in Tetrahedron letters (05.08.1996)
Published in Tetrahedron letters (05.08.1996)
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Toward the Back-Up of Boceprevir (SCH 503034): Discovery of New Extended P4-Capped Ketoamide Inhibitors of Hepatitis C Virus NS3 Serine Protease with Improved Potency and Pharmacokinetic Profiles
Bogen, Stéphane L, Pan, Weidong, Ruan, Sumei, Nair, Latha G, Arasappan, Ashok, Bennett, Frank, Chen, Kevin X, Jao, Edwin, Venkatraman, Srikanth, Vibulbhan, Bancha, Liu, Rong, Cheng, Kuo-Chi, Guo, Zhuyan, Tong, Xiao, Saksena, Anil K, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of medicinal chemistry (25.06.2009)
Published in Journal of medicinal chemistry (25.06.2009)
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Toward Second Generation Hepatitis C Virus NS3 Serine Protease Inhibitors: Discovery of Novel P4 Modified Analogues with Improved Potency and Pharmacokinetic Profile
Arasappan, Ashok, Padilla, Angela I, Jao, Edwin, Bennett, Frank, Bogen, Stephane L, Chen, Kevin X, Pike, Russell E, Sannigrahi, Mousumi, Soares, Joana, Venkatraman, Srikanth, Vibulbhan, Bancha, Saksena, Anil K, Girijavallabhan, Viyyoor, Tong, Xiao, Cheng, Kuo-Chi, Njoroge, F. George
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Discovery of SCH446211 (SCH6): A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication
Bogen, Stéphane L, Arasappan, Ashok, Bennett, Frank, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Venkatraman, Srikanth, Pan, Weidong, Parekh, Tajel, Pike, Russel E, Ruan, Sumei, Liu, Rong, Baroudy, Bahige, Agrawal, Sony, Chase, Robert, Ingravallo, Paul, Pichardo, John, Prongay, Andrew, Brisson, Jean-Marc, Hsieh, Tony Y, Cheng, Kuo-Chi, Kemp, Scott J, Levy, Odile E, Lim-Wilby, Marguerita, Tamura, Susan Y, Saksena, Anil K, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of medicinal chemistry (04.05.2006)
Published in Journal of medicinal chemistry (04.05.2006)
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Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5]
Bennett, Frank, Saksena, Anil K., Lovey, Raymond G., Liu, Yi-Tsung, Patel, Naginbhai M., Pinto, Patrick, Pike, Russel, Jao, Edwin, Girijavallabhan, Viyyoor M., Ganguly, Ashit K., Loebenberg, David, Wang, Haiyan, Cacciapuoti, Anthony, Moss, Eugene, Menzel, Fred, Hare, Roberta S., Nomeir, Amin
Published in Bioorganic & medicinal chemistry letters (2006)
Published in Bioorganic & medicinal chemistry letters (2006)
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Structure elucidation of everninomicin-6, a new oligosaccharide antibiotic, by chemical degradation and FAB-MS methods
Bartner, Peter, Pramanik, Birendra N., Saksena, Anil K., Liu, Yan-Hui, Das, Pradip R., Sarre, Olga, Ganguly, Ashit K.
Published in Journal of the American Society for Mass Spectrometry (01.11.1997)
Published in Journal of the American Society for Mass Spectrometry (01.11.1997)
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Conference Proceeding
Structural Characterization of the Oligosaccharide Antibiotics Everninomicins by Negative Ion FAB and ESI/MS
PRAMANIK, BIRENDRA N., SHIPKOVA, PETIA A., BARTNER, PETER L., HEIMARK, LARRY, LIU, YAN-HUI, DAS, PRADIP R., SAKSENA, ANIL K., SARRE, OLGA Z., GIRIJAVALLABHAN, VIYYOR M., GANGULY, ASHIT K.
Published in Journal of antibiotics (2000)
Published in Journal of antibiotics (2000)
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Depeptidization efforts on P3–P2′ α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity
Bogen, Stéphane L., Ruan, Sumei, Liu, Rong, Agrawal, Sony, Pichardo, John, Prongay, Andrew, Baroudy, Bahige, Saksena, Anil K., Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Journal Article
Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034
Madison, Vincent, Prongay, Andrew J., Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers Jr, Joseph, Weber, Patricia C., Beyer, Brian M., Ingram, Richard, Hong, Zhi, Prosise, Winifred W., Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L., Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G., Saksena, Anil K., Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of synchrotron radiation (01.05.2008)
Published in Journal of synchrotron radiation (01.05.2008)
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Mutations Conferring Resistance to SCH6, a Novel Hepatitis C Virus NS3/4A Protease Inhibitor
Yi, MinKyung, Tong, Xiao, Skelton, Angela, Chase, Robert, Chen, Tong, Prongay, Andrew, Bogen, Stephane L., Saksena, Anil K., Njoroge, F. George, Veselenak, Ronald L., Pyles, Richard B., Bourne, Nigel, Malcolm, Bruce A., Lemon, Stanley M.
Published in The Journal of biological chemistry (24.03.2006)
Published in The Journal of biological chemistry (24.03.2006)
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