Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation
Mendiola, Andrew S., Ryu, Jae Kyu, Bardehle, Sophia, Meyer-Franke, Anke, Ang, Kenny Kean-Hooi, Wilson, Chris, Baeten, Kim M., Hanspers, Kristina, Merlini, Mario, Thomas, Sean, Petersen, Mark A., Williams, Alexander, Thomas, Reuben, Rafalski, Victoria A., Meza-Acevedo, Rosa, Tognatta, Reshmi, Yan, Zhaoqi, Pfaff, Samuel J., Machado, Michael R., Bedard, Catherine, Rios Coronado, Pamela E., Jiang, Xiqian, Wang, Jin, Pleiss, Michael A., Green, Ari J., Zamvil, Scott S., Pico, Alexander R., Bruneau, Benoit G., Arkin, Michelle R., Akassoglou, Katerina
Published in Nature immunology (01.05.2020)
Published in Nature immunology (01.05.2020)
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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter
Published in eLife (20.07.2016)
Published in eLife (20.07.2016)
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A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels
Bagriantsev, Sviatoslav N, Ang, Kean-Hooi, Gallardo-Godoy, Alejandra, Clark, Kimberly A, Arkin, Michelle R, Renslo, Adam R, Minor, Daniel L
Published in ACS chemical biology (16.08.2013)
Published in ACS chemical biology (16.08.2013)
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Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis
Bulman, Christina A, Bidlow, Chelsea M, Lustigman, Sara, Cho-Ngwa, Fidelis, Williams, David, Rascón, Jr, Alberto A, Tricoche, Nancy, Samje, Moses, Bell, Aaron, Suzuki, Brian, Lim, K C, Supakorndej, Nonglak, Supakorndej, Prasit, Wolfe, Alan R, Knudsen, Giselle M, Chen, Steven, Wilson, Chris, Ang, Kean-Hooi, Arkin, Michelle, Gut, Jiri, Franklin, Chris, Marcellino, Chris, McKerrow, James H, Debnath, Anjan, Sakanari, Judy A
Published in PLoS neglected tropical diseases (01.02.2015)
Published in PLoS neglected tropical diseases (01.02.2015)
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Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH
Chin, Marcus Y, Patwardhan, Anand R, Ang, Kean-Hooi, Wang, Austin L, Alquezar, Carolina, Welch, Mackenzie, Nguyen, Phi T, Grabe, Michael, Molofsky, Anna V, Arkin, Michelle R, Kao, Aimee W
Published in ACS sensors (25.06.2021)
Published in ACS sensors (25.06.2021)
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Natural Product Libraries to Accelerate the High-Throughput Discovery of Therapeutic Leads
Johnson, Tyler A, Sohn, Johann, Inman, Wayne D, Estee, Samarkand A, Loveridge, Steven T, Vervoort, Helene C, Tenney, Karen, Liu, Junke, Ang, Kenny Kean-Hooi, Ratnam, Joseline, Bray, Walter M, Gassner, Nadine C, Shen, Young Y, Lokey, R. Scott, McKerrow, James H, Boundy-Mills, Kyria, Nukanto, Arif, Kanti, Atit, Julistiono, Heddy, Kardono, Leonardus B. S, Bjeldanes, Leonard F, Crews, Phillip
Published in Journal of natural products (Washington, D.C.) (27.12.2011)
Published in Journal of natural products (Washington, D.C.) (27.12.2011)
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Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells
Sun, Yaping, Dong, Zhiqiang, Jin, Taihao, Ang, Kean-Hooi, Huang, Miller, Haston, Kelly M, Peng, Jisong, Zhong, Tao P, Finkbeiner, Steven, Weiss, William A, Arkin, Michelle R, Jan, Lily Y, Guo, Su
Published in eLife (10.09.2013)
Published in eLife (10.09.2013)
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Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans ' Lifespan
Zhang, Peichuan, Zhai, Yuying, Cregg, James, Ang, Kenny Kean-Hooi, Arkin, Michelle, Kenyon, Cynthia
Published in G3 : genes - genomes - genetics (01.02.2020)
Published in G3 : genes - genomes - genetics (01.02.2020)
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The Marine Sponge Diacarnus bismarckensis as a Source of Peroxiterpene Inhibitors of Trypanosoma brucei, the Causative Agent of Sleeping Sickness
Rubio, Brent K, Tenney, Karen, Ang, Kean-Hooi, Abdulla, Maha, Arkin, Michelle, McKerrow, James H, Crews, Phillip
Published in Journal of natural products (Washington, D.C.) (27.02.2009)
Published in Journal of natural products (Washington, D.C.) (27.02.2009)
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Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB
Mott, Bryan T, Ferreira, Rafaela S, Simeonov, Anton, Jadhav, Ajit, Ang, Kenny Kean-Hooi, Leister, William, Shen, Min, Silveira, Julia T, Doyle, Patricia S, Arkin, Michelle R, McKerrow, James H, Inglese, James, Austin, Christopher P, Thomas, Craig J, Shoichet, Brian K, Maloney, David J
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model
Chin, Marcus Y., Ang, Kean-Hooi, Davies, Julia, Alquezar, Carolina, Garda, Virginia G., Rooney, Brendan, Leng, Kun, Kampmann, Martin, Arkin, Michelle R., Kao, Aimee W.
Published in ACS chemical neuroscience (18.05.2022)
Published in ACS chemical neuroscience (18.05.2022)
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Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi
Watts, Katharine R., Ratnam, Joseline, Ang, Kean-Hooi, Tenney, Karen, Compton, Jennifer E., McKerrow, James, Crews, Phillip
Published in Bioorganic & medicinal chemistry (01.04.2010)
Published in Bioorganic & medicinal chemistry (01.04.2010)
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A Cell-Based Renilla Luminescence Reporter Plasmid Assay for High-Throughput Screening to Identify Novel FDA-Approved Drug Inhibitors of HPV-16 Infection
Walhart, Tara, Isaacson-Wechsler, Erin, Ang, Kean-Hooi, Arkin, Michelle, Tugizov, Sharof, Palefsky, Joel M.
Published in SLAS discovery (01.01.2020)
Published in SLAS discovery (01.01.2020)
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Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents
Ding, Dazhong, Zhao, Yaxue, Meng, Qingqing, Xie, Dongsheng, Nare, Bakela, Chen, Daitao, Bacchi, Cyrus J, Yarlett, Nigel, Zhang, Yong-Kang, Hernandez, Vincent, Xia, Yi, Freund, Yvonne, Abdulla, Maha, Ang, Kean-Hooi, Ratnam, Joseline, McKerrow, James H, Jacobs, Robert T, Zhou, Huchen, Plattner, Jacob J
Published in ACS medicinal chemistry letters (08.07.2010)
Published in ACS medicinal chemistry letters (08.07.2010)
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Journal Article
Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation
Mendiola, Andrew S., Ryu, Jae Kyu, Bardehle, Sophia, Meyer-Franke, Anke, Ang, Kenny Kean-Hooi, Wilson, Chris, Baeten, Kim M., Hanspers, Kristina, Merlini, Mario, Thomas, Sean, Petersen, Mark A., Williams, Alexander, Thomas, Reuben, Rafalski, Victoria A., Meza-Acevedo, Rosa, Tognatta, Reshmi, Yan, Zhaoqi, Pfaff, Samuel J., Machado, Michael R., Bedard, Catherine, Coronado, Pamela E. Rios, Jiang, Xiqian, Wang, Jin, Pleiss, Michael A., Green, Ari J., Zamvil, Scott S., Pico, Alexander R., Bruneau, Benoit G., Arkin, Michelle R., Akassoglou, Katerina
Published in Nature immunology (01.09.2020)
Published in Nature immunology (01.09.2020)
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A high-throughput turbidometric assay for screening inhibitors of Leishmania major protein disulfide isomerase
Ben Khalaf, Noureddine, De Muylder, Géraldine, Ratnam, Joseline, Kean-Hooi Ang, Kenny, Arkin, Michelle, McKerrow, James, Chenik, Mehdi
Published in Journal of biomolecular screening (01.06.2011)
Published in Journal of biomolecular screening (01.06.2011)
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The Aignopsanes, a New Class of Sesquiterpenes from Selected Chemotypes of the Sponge Cacospongia mycofijiensis
Johnson, Tyler A, Amagata, Taro, Sashidhara, Koneni V, Oliver, Allen G, Tenney, Karen, Matainaho, Teatulohi, Ang, Kenny Kean-Hooi, McKerrow, James H, Crews, Phillip
Published in Organic letters (07.05.2009)
Published in Organic letters (07.05.2009)
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Abstract B004: ATR-CHK1-WEE1 pathway is a critical dependency in the context of DNA damage and replicative stress in osteosarcoma
Sayles, Leanne C., Martell, Henry, Koehne, Amanda, Ang, Kean-Hooi, Wilson, Chris, Arkin, Michelle, Sweet-Cordero, E. Alejandro
Published in Clinical cancer research (15.09.2022)
Published in Clinical cancer research (15.09.2022)
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An in vivo screening platform identifies senolytic compounds that target [p16.sup.INK4a+] fibroblasts in lung fibrosis
Lee, Jin Young, Reyes, Nabora S, Ravishankar, Supriya, Zhou, Minqi, Krasilnikov, Maria, Ringler, Christian, Pohan, Grace, Wilson, Chris, Ang, Kenny Kean-Hooi, Wolters, Paul J, Tsukui, Tatsuya, Sheppard, Dean, Arkin, Michelle R, Peng, Tien
Published in The Journal of clinical investigation (01.05.2024)
Published in The Journal of clinical investigation (01.05.2024)
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Journal Article
An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis
Lee, Jin Young, Reyes, Nabora S, Ravishankar, Supriya, Zhou, Minqi, Krasilnikov, Maria, Ringler, Christian, Pohan, Grace, Wilson, Chris, Ang, Kenny Kean-Hooi, Wolters, Paul J, Tsukui, Tatsuya, Sheppard, Dean, Arkin, Michelle R, Peng, Tien
Published in The Journal of clinical investigation (07.03.2024)
Published in The Journal of clinical investigation (07.03.2024)
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