Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
Brinkmann, Volker, Billich, Andreas, Baumruker, Thomas, Heining, Peter, Schmouder, Robert, Francis, Gordon, Aradhye, Shreeram, Burtin, Pascale
Published in Nature reviews. Drug discovery (01.11.2010)
Published in Nature reviews. Drug discovery (01.11.2010)
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Journal Article
Second generation S1P pathway modulators: Research strategies and clinical developments
Bigaud, Marc, Guerini, Danilo, Billich, Andreas, Bassilana, Frederic, Brinkmann, Volker
Published in Biochimica et biophysica acta (01.05.2014)
Published in Biochimica et biophysica acta (01.05.2014)
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Journal Article
Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo
Guendisch, Ulf, Weiss, Jessica, Ecoeur, Florence, Riker, Julia Christina, Kaupmann, Klemens, Kallen, Joerg, Hintermann, Samuel, Orain, David, Dawson, Janet, Billich, Andreas, Guntermann, Christine
Published in PloS one (20.11.2017)
Published in PloS one (20.11.2017)
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Journal Article
Orally Active 7‑Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1‑Phosphate Lyase for the Treatment of Multiple Sclerosis
Weiler, Sven, Braendlin, Nadine, Beerli, Christian, Bergsdorf, Christian, Schubart, Anna, Srinivas, Honnappa, Oberhauser, Berndt, Billich, Andreas
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
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Journal Article
Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis
Foster, Carolyn A, Howard, Laurence M, Schweitzer, Alain, Persohn, Elke, Hiestand, Peter C, Balatoni, Balázs, Reuschel, Roland, Beerli, Christian, Schwartz, Manuela, Billich, Andreas
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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Journal Article
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis
Zhang, Lin, Orban, Martin, Lorenz, Michael, Barocke, Verena, Braun, Daniel, Urtz, Nicole, Schulz, Christian, von Brühl, Marie-Luise, Tirniceriu, Anca, Gaertner, Florian, Proia, Richard L, Graf, Thomas, Bolz, Steffen-Sebastian, Montanez, Eloi, Prinz, Marco, Müller, Alexandra, von Baumgarten, Louisa, Billich, Andreas, Sixt, Michael, Fässler, Reinhard, von Andrian, Ulrich H, Junt, Tobias, Massberg, Steffen
Published in The Journal of experimental medicine (19.11.2012)
Published in The Journal of experimental medicine (19.11.2012)
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Journal Article
Interferon regulatory factor 5 and nuclear factor kappa‐B exhibit cooperating but also divergent roles in the regulation of pro‐inflammatory cytokines important for the development of TH1 and TH17 responses
Stein, Thomas, Wollschlegel, Audrey, Te, Helene, Weiss, Jessica, Joshi, Kushal, Kinzel, Bernd, Billich, Andreas, Guntermann, Christine, Lehmann, Joachim C. U.
Published in The FEBS journal (01.08.2018)
Published in The FEBS journal (01.08.2018)
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Journal Article
Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo
Urtz, Nicole, Gaertner, Florian, von Bruehl, Marie-Luise, Chandraratne, Sue, Rahimi, Faridun, Zhang, Lin, Orban, Mathias, Barocke, Verena, Beil, Johannes, Schubert, Irene, Lorenz, Michael, Legate, Kyle R, Huwiler, Andrea, Pfeilschifter, Josef M, Beerli, Christian, Ledieu, David, Persohn, Elke, Billich, Andreas, Baumruker, Thomas, Schnitzler, Michael Mederos y, Massberg, Steffen
Published in Circulation research (31.07.2015)
Published in Circulation research (31.07.2015)
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Journal Article
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720
Zemann, Barbara, Kinzel, Bernd, Müller, Matthias, Reuschel, Roland, Mechtcheriakova, Diana, Urtz, Nicole, Bornancin, Frédéric, Baumruker, Thomas, Billich, Andreas
Published in Blood (15.02.2006)
Published in Blood (15.02.2006)
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Journal Article
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis
Billich, Andreas, Baumruker, Thomas, Beerli, Christian, Bigaud, Marc, Bruns, Christian, Calzascia, Thomas, Isken, Andrea, Kinzel, Bernd, Loetscher, Erika, Metzler, Barbara, Mueller, Matthias, Nuesslein-Hildesheim, Barbara, Kleylein-Sohn, Bernadette
Published in PloS one (27.03.2013)
Published in PloS one (27.03.2013)
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Journal Article
Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor
Graf, Christine, Klumpp, Martin, Habig, Michael, Rovina, Philipp, Billich, Andreas, Baumruker, Thomas, Oberhauser, Berndt, Bornancin, Frédéric
Published in Molecular pharmacology (01.10.2008)
Published in Molecular pharmacology (01.10.2008)
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Journal Article
Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands
Meingassner, Josef G., Aschauer, Heinrich, Winiski, Anthony P., Dales, Natalie, Yowe, David, Winther, Michael D., Zhang, Zaihui, Stütz, Anton, Billich, Andreas
Published in Journal of investigative dermatology (01.08.2013)
Published in Journal of investigative dermatology (01.08.2013)
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Journal Article
2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase
Nussbaumer, Peter, Lehr, Philipp, Billich, Andreas
Published in Journal of medicinal chemistry (12.09.2002)
Published in Journal of medicinal chemistry (12.09.2002)
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Journal Article
Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses
Mechtcheriakova, Diana, Wlachos, Alexander, Sobanov, Jury, Kopp, Tamara, Reuschel, Roland, Bornancin, Frederic, Cai, Richard, Zemann, Barbara, Urtz, Nicole, Stingl, Georg, Zlabinger, Gerhard, Woisetschläger, Maximilian, Baumruker, Thomas, Billich, Andreas
Published in Cellular signalling (01.04.2007)
Published in Cellular signalling (01.04.2007)
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Journal Article
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations
Guntermann, Christine, Piaia, Alessandro, Hamel, Marie-Laure, Theil, Diethilde, Rubic-Schneider, Tina, Del Rio-Espinola, Alberto, Dong, Linda, Billich, Andreas, Kaupmann, Klemens, Dawson, Janet, Hoegenauer, Klemens, Orain, David, Hintermann, Samuel, Stringer, Rowan, Patel, Dhavalkumar D, Doelemeyer, Arno, Deurinck, Mark, Schümann, Jens
Published in JCI insight (09.03.2017)
Published in JCI insight (09.03.2017)
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Journal Article
The role of sphingosine and ceramide kinases in inflammatory responses
Baumruker, Thomas, Bornancin, Frédéric, Billich, Andreas
Published in Immunology letters (31.01.2005)
Published in Immunology letters (31.01.2005)
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Journal Article
Binding of Pimecrolimus and Tacrolimus to Skin and Plasma Proteins: Implications for Systemic Exposure after Topical Application
WEISS, H. Markus, FRESNEAU, Marcel, MOENIUS, Thomas, STUETZ, Anton, BILLICH, Andreas
Published in Drug metabolism and disposition (01.09.2008)
Published in Drug metabolism and disposition (01.09.2008)
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