Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily
Schroeder, Gretchen M, An, Yongmi, Cai, Zhen-Wei, Chen, Xiao-Tao, Clark, Cheryl, Cornelius, Lyndon A. M, Dai, Jun, Gullo-Brown, Johnni, Gupta, Ashok, Henley, Benjamin, Hunt, John T, Jeyaseelan, Robert, Kamath, Amrita, Kim, Kyoung, Lippy, Jonathan, Lombardo, Louis J, Manne, Veeraswamy, Oppenheimer, Simone, Sack, John S, Schmidt, Robert J, Shen, Guoxiang, Stefanski, Kevin, Tokarski, John S, Trainor, George L, Wautlet, Barri S, Wei, Donna, Williams, David K, Zhang, Yingru, Zhang, Yueping, Fargnoli, Joseph, Borzilleri, Robert M
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
Get full text
Journal Article
Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases
Xie, Jenny H, Yamniuk, Aaron P, Borowski, Virna, Kuhn, Robert, Susulic, Vojkan, Rex-Rabe, Sandra, Yang, Xiaoxia, Zhou, Xiadi, Zhang, Yifan, Gillooly, Kathleen, Brosius, Ruth, Ravishankar, Rathna, Waggie, Kimberly, Mink, Kathy, Price, Laura, Rehfuss, Robert, Tamura, James, An, Yongmi, Cheng, Lin, Abramczyk, Bozena, Ignatovich, Olga, Drew, Philip, Grant, Steven, Bryson, James W, Suchard, Suzanne, Salter-Cid, Luisa, Nadler, Steven, Suri, Anish
Published in The Journal of immunology (1950) (01.05.2014)
Published in The Journal of immunology (1950) (01.05.2014)
Get full text
Journal Article
Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope
Yamniuk, Aaron P., Suri, Anish, Krystek, Stanley R., Tamura, James, Ramamurthy, Vidhyashankar, Kuhn, Robert, Carroll, Karen, Fleener, Catherine, Ryseck, Rolf, Cheng, Lin, An, Yongmi, Drew, Philip, Grant, Steven, Suchard, Suzanne J., Nadler, Steven G., Bryson, James W., Sheriff, Steven
Published in Journal of molecular biology (17.07.2016)
Published in Journal of molecular biology (17.07.2016)
Get full text
Journal Article
Discovery of Pyrrolopyridine−Pyridone Based Inhibitors of Met Kinase: Synthesis, X-ray Crystallographic Analysis, and Biological Activities
Kim, Kyoung Soon, Zhang, Liping, Schmidt, Robert, Cai, Zhen-Wei, Wei, Donna, Williams, David K, Lombardo, Louis J, Trainor, George L, Xie, Dianlin, Zhang, Yaquan, An, Yongmi, Sack, John S, Tokarski, John S, Darienzo, Celia, Kamath, Amrita, Marathe, Punit, Zhang, Yueping, Lippy, Jonathan, Jeyaseelan, Robert, Wautlet, Barri, Henley, Benjamin, Gullo-Brown, Johnni, Manne, Veeraswamy, Hunt, John T, Fargnoli, Joseph, Borzilleri, Robert M
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
Get full text
Journal Article
Discovery of the CCR1 Antagonist, BMS-817399, for the Treatment of Rheumatoid Arthritis
Santella, Joseph B, Gardner, Daniel S, Duncia, John V, Wu, Hong, Dhar, Murali, Cavallaro, Cullen, Tebben, Andrew J, Carter, Percy H, Barrish, Joel C, Yarde, Melissa, Briceno, Stephanie W, Cvijic, Mary Ellen, Grafstrom, R. Robert, Liu, Richard, Patel, Sima R, Watson, Andrew J, Yang, Guchen, Rose, Anne V, Vickery, Rodney D, Caceres-Cortes, Janet, Caporuscio, Christian, Camac, Daniel M, Khan, Javed A, An, Yongmi, Foster, William R, Davies, Paul, Hynes, John
Published in Journal of medicinal chemistry (25.09.2014)
Published in Journal of medicinal chemistry (25.09.2014)
Get full text
Journal Article
Crystallographic Structures of the Ligand-Binding Domains of the Androgen Receptor and Its T877A Mutant Complexed with the Natural Agonist Dihydrotestosterone
Sack, John S., Kish, Kevin F., Wang, Chihuei, Attar, Ricardo M., Kiefer, Susan E., An, Yongmi, Wu, Ginger Y., Scheffler, Julie E., Salvati, Mark E., Krystek, Stanley R., Weinmann, Roberto, Einspahr, Howard M.
Published in Proceedings of the National Academy of Sciences - PNAS (24.04.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (24.04.2001)
Get full text
Journal Article
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors
Cai, Zhen-Wei, Wei, Donna, Schroeder, Gretchen M., Cornelius, Lyndon A.M., Kim, Kyoung, Chen, Xiao-Tao, Schmidt, Robert J., Williams, David K., Tokarski, John S., An, Yongmi, Sack, John S., Manne, Veeraswamy, Kamath, Amrita, Zhang, Yueping, Marathe, Punit, Hunt, John T., Lombardo, Louis J., Fargnoli, Joseph, Borzilleri, Robert M.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
Get full text
Journal Article
Identification of pyrrolo[2,1- f][1,2,4]triazine-based inhibitors of Met kinase
Schroeder, Gretchen M., Chen, Xiao-Tao, Williams, David K., Nirschl, David S., Cai, Zhen-Wei, Wei, Donna, Tokarski, John S., An, Yongmi, Sack, John, Chen, Zhong, Huynh, Tram, Vaccaro, Wayne, Poss, Michael, Wautlet, Barri, Gullo-Brown, Johnni, Kellar, Kristen, Manne, Veeraswamy, Hunt, John T., Wong, Tai W., Lombardo, Louis J., Fargnoli, Joseph, Borzilleri, Robert M.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
Get full text
Journal Article
Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold
Sun, Chongqing, Robl, Jeffrey A, Wang, Tammy C, Huang, Yanting, Kuhns, Joyce E, Lupisella, John A, Beehler, Blake C, Golla, Rajasree, Sleph, Paul G, Seethala, Ramakrishna, Fura, Aberra, Krystek, Stanley R, An, Yongmi, Malley, Mary F, Sack, John S, Salvati, Mark E, Grover, Gary J, Ostrowski, Jacek, Hamann, Lawrence G
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
Get full text
Journal Article
Design, synthesis and structure–activity relationships of novel biarylamine-based Met kinase inhibitors
Williams, David K., Chen, Xiao-Tao, Tarby, Christine, Kaltenbach, Robert, Cai, Zhen-Wei, Tokarski, John S., An, Yongmi, Sack, John S., Wautlet, Barri, Gullo-Brown, Johnni, Henley, Benjamin J., Jeyaseelan, Robert, Kellar, Kristen, Manne, Veeraswamy, Trainor, George L., Lombardo, Louis J., Fargnoli, Joseph, Borzilleri, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Get full text
Journal Article
N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation
Nirschl, Alexandra A, Zou, Yan, Krystek, Stanley R, Sutton, James C, Simpkins, Ligaya M, Lupisella, John A, Kuhns, Joyce E, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Beehler, Blake C, Grover, Gary J, Egan, Donald, Fura, Aberra, Vyas, Viral P, Li, Yi-Xin, Sack, John S, Kish, Kevin F, An, Yongmi, Bryson, James A, Gougoutas, Jack Z, DiMarco, John, Zahler, Robert, Ostrowski, Jacek, Hamann, Lawrence G
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
Get full text
Journal Article
Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists
SALVATI, Mark E, BALOG, Aaron, KRYSTEK, Stanley R, SACK, John, YONGMI AN, KISH, Kevin, WEIFANG SHAN, WEI, Donna D, PICKERING, Dacia, ATTAR, Ricardo M, JIEPING GENG, RIZZO, Cheryl A, GOTTARDIS, Marco M, WEINMANN, Roberto
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
Get full text
Journal Article
Synthesis and structure–activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARα selective activators- PPARα and PPARγ selectivity modulation
Ye, Xiang-Yang, Chen, Stephanie, Zhang, Hao, Locke, Kenneth T., O’Malley, Kevin, Zhang, Litao, Srivastava, Raijit, Miao, Bowman, Meyers, Daniel, Monshizadegan, Hossain, Search, Debra, Grimm, Denise, Zhang, Rongan, Lippy, Jonathan, Twamley, Celeste, Muckelbauer, Jodi K., Chang, Chiehying, An, Yongmi, Hosagrahara, Vinayak, Zhang, Lisa, Yang, T.-J., Mukherjee, Ranjan, Cheng, Peter T.W., Tino, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Get full text
Journal Article
Expression, purification, and characterization of human and rat acetyl cfenzyme A carboxylase (ACC) isozymes
Cheng, Dong, Chu, Ching-Hsuen, Chen, Luping, Feder, John N., Mintier, Gabe A., Wu, Yuli, Cook, Joseph W., Harpel, Mark R., Locke, Gregory A., An, Yongmi, Tamura, James K.
Published in Protein expression and purification (2007)
Published in Protein expression and purification (2007)
Get full text
Journal Article
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists
Lu, Zhonghui, Duan, James J.-W., Xiao, Haiyun, Neels, James, Wu, Dauh-Rurng, Weigelt, Carolyn A., Sack, John S., Khan, Javed, Ruzanov, Max, An, Yongmi, Yarde, Melissa, Karmakar, Ananta, Vishwakrishnan, Sureshbabu, Baratam, Venkata, Shankarappa, Harisha, Vanteru, Sridhar, Babu, Venkatesh, Basha, Mushkin, Kumar Gupta, Arun, Kumaravel, Selvakumar, Mathur, Arvind, Zhao, Qihong, Salter-Cid, Luisa M., Carter, Percy H., Murali Dhar, T.G.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Get full text
Journal Article
Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton’s tyrosine kinase (BTK) and Janus kinase 2 (JAK2)
Liu, Qingjie, Batt, Douglas G., Lippy, Jonathan S., Surti, Neha, Tebben, Andrew J., Muckelbauer, Jodi K., Chen, Lin, An, Yongmi, Chang, Chiehying, Pokross, Matt, Yang, Zheng, Wang, Haiqing, Burke, James R., Carter, Percy H., Tino, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
Get full text
Journal Article
Purine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors for autoimmune diseases
Shi, Qing, Tebben, Andrew, Dyckman, Alaric J., Li, Hedy, Liu, Chunjian, Lin, James, Spergel, Steve, Burke, James R., McIntyre, Kim W., Olini, Gilbert C., Strnad, Joann, Surti, Neha, Muckelbauer, Jodi K., Chang, Chiehying, An, Yongmi, Cheng, Lin, Ruan, Qian, Leftheris, Katerina, Carter, Percy H., Tino, Joseph, De Lucca, George V.
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
Get full text
Journal Article
Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR
Khan, Javed A., Camac, Daniel M., Low, Simon, Tebben, Andrew J., Wensel, David L., Wright, Martin C., Su, Julie, Jenny, Victoria, Gupta, Ruchira Das, Ruzanov, Max, Russo, Katie A., Bell, Aneka, An, Yongmi, Bryson, James W., Gao, Mian, Gambhire, Pallavi, Baldwin, Eric T., Gardner, Daniel, Cavallaro, Cullen L., Duncia, John V., Hynes, John
Published in Journal of molecular biology (27.02.2015)
Published in Journal of molecular biology (27.02.2015)
Get full text
Journal Article
Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats
Ostrowski, Jacek, Kuhns, Joyce E, Lupisella, John A, Manfredi, Mark C, Beehler, Blake C, Krystek, Stanley R, Bi, Yingzhi, Sun, Chongqing, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Fura, Aberra, An, Yongmi, Kish, Kevin F, Sack, John S, Mookhtiar, Kasim A, Grover, Gary J, Hamann, Lawrence G
Published in Endocrinology (Philadelphia) (01.01.2007)
Published in Endocrinology (Philadelphia) (01.01.2007)
Get full text
Journal Article