Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening
Elkamhawy, Ahmed, Ammar, Usama M., Paik, Sora, Abdellattif, Magda H., Elsherbeny, Mohamed H., Lee, Kyeong, Roh, Eun Joo
Published in Molecules (Basel, Switzerland) (01.09.2021)
Published in Molecules (Basel, Switzerland) (01.09.2021)
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Design, synthesis and anti-inflammatory activity of imidazol-5-yl pyridine derivatives as p38α/MAPK14 inhibitor
Ali, Eslam M.H., Abdel-Maksoud, Mohammed S., Hassan, Rasha Mohamed, Mersal, Karim I., Ammar, Usama M., Se-In, Choi, He-Soo, Han, Kim, Hee-Kwon, Lee, Anna, Lee, Kyung-Tae, Oh, Chang-Hyun
Published in Bioorganic & medicinal chemistry (01.02.2021)
Published in Bioorganic & medicinal chemistry (01.02.2021)
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Discovery of New Imidazo[2,1‑b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising In Vitro and In Vivo Anti-melanoma Activity
Abdel-Maksoud, Mohammed S, El-Gamal, Mohammed I, Lee, Bong S, Gamal El-Din, Mahmoud M, Jeon, Hong R, Kwon, Dow, Ammar, Usama M, Mersal, Karim I, Ali, Eslam M. H, Lee, Kyung-Tae, Yoo, Kyung Ho, Han, Dong Keun, Lee, Jae Kyun, Kim, Garam, Choi, Hong Seok, Kwon, Young Jik, Lee, Kwan Hyi, Oh, Chang Hyun
Published in Journal of medicinal chemistry (27.05.2021)
Published in Journal of medicinal chemistry (27.05.2021)
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Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3- b ]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling
Riley, Christopher, Ammar, Usama, Alsfouk, Aisha, Anthony, Nahoum G, Baiget, Jessica, Berretta, Giacomo, Breen, David, Huggan, Judith, Lawson, Christopher, McIntosh, Kathryn, Plevin, Robin, Suckling, Colin J, Young, Louise C, Paul, Andrew, Mackay, Simon P
Published in Molecules (Basel, Switzerland) (01.08.2024)
Published in Molecules (Basel, Switzerland) (01.08.2024)
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Modification of imidazothiazole derivatives gives promising activity in B-Raf kinase enzyme inhibition; synthesis, in vitro studies and molecular docking
Ammar, Usama M., Abdel-Maksoud, Mohammed S., Mersal, Karim I., Ali, Eslam M.H., Yoo, Kyung Ho, Choi, Hong Seok, Lee, Jae Kyun, Cha, Sun Young, Oh, Chang-Hyun
Published in Bioorganic & medicinal chemistry letters (15.10.2020)
Published in Bioorganic & medicinal chemistry letters (15.10.2020)
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Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells
Mersal, Karim I., Abdel-Maksoud, Mohammed S., Ali, Eslam M.H., Ammar, Usama M., Zaraei, Seyed-Omar, Haque, Md Mamunul, Das, Tanuza, Hassan, Noha F., Kim, Eunice EunKyeong, Lee, Jun-Seok, Park, HaJeung, Lee, Kwan Hyi, El-Gamal, Mohammed I., Kim, Hee-Kwon, Ibrahim, Tamer M., Oh, Chang-Hyun
Published in European journal of medicinal chemistry (05.12.2023)
Published in European journal of medicinal chemistry (05.12.2023)
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Structural optimization of 4-(imidazol-5-yl)pyridine derivatives affords broad-spectrum anticancer agents with selective B-RAFV600E/p38α kinase inhibitory activity: Synthesis, in vitro assays and in silico study
Ali, Eslam M.H., Mersal, Karim I., Ammar, Usama M., Zaraei, Seyed-Omar, Abdel-Maksoud, Mohammed S., El-Gamal, Mohammed I., Haque, Md Mamunul, Das, Tanuza, Kim, Eunice EunKyeong, Lee, Jun-Seok, Lee, Kwan Hyi, Kim, Hee-Kwon, Oh, Chang-Hyun
Published in European journal of pharmaceutical sciences (01.04.2022)
Published in European journal of pharmaceutical sciences (01.04.2022)
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Discovery of Benzopyrone-Based Candidates as Potential Antimicrobial and Photochemotherapeutic Agents through Inhibition of DNA Gyrase Enzyme B: Design, Synthesis, In Vitro and In Silico Evaluation
Abd El-Haleem, Akram, Ammar, Usama, Masci, Domiziana, El-Ansary, Sohair, Abdel Rahman, Doaa, Abou-Elazm, Fatma, El-Dydamony, Nehad
Published in Pharmaceuticals (Basel, Switzerland) (11.09.2024)
Published in Pharmaceuticals (Basel, Switzerland) (11.09.2024)
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Correction: Elsherbeny et al. 2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation. Life 2022, 12 , 876
Elsherbeny, Mohamed H, Ammar, Usama M, Abdellattif, Magda H, Abourehab, Mohammed A S, Abdeen, Ahmed, Ibrahim, Samah F, Abdelrahaman, Doaa, Mady, Wessam, Roh, Eun Joo, Elkamhawy, Ahmed
Published in Life (Basel, Switzerland) (22.03.2024)
Published in Life (Basel, Switzerland) (22.03.2024)
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Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors
Ali, Eslam M.H., El-Telbany, Rania Farag A., Abdel-Maksoud, Mohammed S., Ammar, Usama M., Mersal, Karim I., Zaraei, Seyed-Omar, El-Gamal, Mohammed I., Choi, Se-In, Lee, Kyung-Tae, Kim, Hee-Kwon, Lee, Kwan Hyi, Oh, Chang-Hyun
Published in European journal of medicinal chemistry (05.04.2021)
Published in European journal of medicinal chemistry (05.04.2021)
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Structural optimization of imidazothiazole derivatives affords a new promising series as B-Raf V600E inhibitors; synthesis, in vitro assay and in silico screening
Ammar, Usama M., Abdel-Maksoud, Mohammed S., Ali, Eslam M.H., Mersal, Karim I., Ho Yoo, Kyung, Oh, Chang-Hyun
Published in Bioorganic chemistry (01.07.2020)
Published in Bioorganic chemistry (01.07.2020)
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Journal Article
Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors
Abdel-Maksoud, Mohammed S., Ammar, Usama M., El-Gamal, Mohammed I., Gamal El-Din, Mahmoud M., Mersal, Karim I., Ali, Eslam M.H., Yoo, Kyung Ho, Lee, Kyung-Tae, Oh, Chang-Hyun
Published in Bioorganic chemistry (01.12.2019)
Published in Bioorganic chemistry (01.12.2019)
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Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties
Amin, Kamelia M, El-Badry, Ossama M, Abdel Rahman, Doaa E, Abdellattif, Magda H, Abourehab, Mohammed A. S, El-Maghrabey, Mahmoud H, Elsaid, Fahmy G, El Hamd, Mohamed A, Elkamhawy, Ahmed, Ammar, Usama M
Published in Pharmaceutics (01.09.2022)
Published in Pharmaceutics (01.09.2022)
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Journal Article
2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation
Elsherbeny, Mohamed H, Ammar, Usama M, Abdellattif, Magda H, Abourehab, Mohammed A S, Abdeen, Ahmed, Ibrahim, Samah F, Abdelrahaman, Doaa, Mady, Wessam, Roh, Eun Joo, Elkamhawy, Ahmed
Published in Life (Basel, Switzerland) (01.06.2022)
Published in Life (Basel, Switzerland) (01.06.2022)
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Design, synthesis, and biological evaluation of novel imidazole derivatives possessing terminal sulphonamides as potential BRAFV600Einhibitors
Ali, Eslam M.H., Abdel-Maksoud, Mohammed S., Ammar, Usama M., Mersal, Karim I., Ho Yoo, Kyung, Jooryeong, Park, Oh, Chang-Hyun
Published in Bioorganic chemistry (01.01.2021)
Published in Bioorganic chemistry (01.01.2021)
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Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells
Mersal, Karim I., Abdel-Maksoud, Mohammed S., Ali, Eslam M. H., Ammar, Usama M., Zaraei, Seyed-Omar, Kim, Jae-Min, Kim, Su-Yeon, Lee, Kyung-Tae, Lee, Kwan Hyi, Kim, Si-Won, Park, Hyun-Mee, Ji, Mi-Jung, Oh, Chang-Hyun
Published in Medicinal chemistry research (01.10.2021)
Published in Medicinal chemistry research (01.10.2021)
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