Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design
Alleyne, Candice, Amin, Rupesh P, Bhatt, Bhavana, Bianchi, Elisabetta, Blain, J. Craig, Boyer, Nicolas, Branca, Danila, Embrey, Mark W, Ha, Sookhee N, Jette, Kelli, Johns, Douglas G, Kerekes, Angela D, Koeplinger, Kenneth A, LaPlaca, Derek, Li, Nianyu, Murphy, Beth, Orth, Peter, Ricardo, Alonso, Salowe, Scott, Seyb, Kathleen, Shahripour, Aurash, Stringer, Joseph R, Sun, Yili, Tracy, Rodger, Wu, Chengwei, Xiong, Yusheng, Youm, Hyewon, Zokian, Hratch J, Tucker, Thomas J
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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Journal Article
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors
Tucker, Thomas J, Embrey, Mark W, Alleyne, Candice, Amin, Rupesh P, Bass, Alan, Bhatt, Bhavana, Bianchi, Elisabetta, Branca, Danila, Bueters, Tjerk, Buist, Nicole, Ha, Sookhee N, Hafey, Mike, He, Huaibing, Higgins, John, Johns, Douglas G, Kerekes, Angela D, Koeplinger, Kenneth A, Kuethe, Jeffrey T, Li, Nianyu, Murphy, BethAnn, Orth, Peter, Salowe, Scott, Shahripour, Aurash, Tracy, Rodger, Wang, Weixun, Wu, Chengwei, Xiong, Yusheng, Zokian, Hratch J, Wood, Harold B, Walji, Abbas
Published in Journal of medicinal chemistry (25.11.2021)
Published in Journal of medicinal chemistry (25.11.2021)
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Journal Article
Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
Himmel, Herbert, Lagrutta, Armando, Vömel, Matthias, Amin, Rupesh P, Imredy, John P, Johnson, Timothy, Vinzing, Maya, Prescott, Judith, Blaustein, Robert O
Published in The Journal of pharmacology and experimental therapeutics (01.07.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2023)
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Journal Article
Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties
Vachal, Petr, Duffy, Joseph L, Campeau, Louis-Charles, Amin, Rupesh P, Mitra, Kaushik, Murphy, Beth Ann, Shao, Pengcheng P, Sinclair, Peter J, Ye, Feng, Katipally, Revathi, Lu, Zhijian, Ondeyka, Debra, Chen, Yi-Heng, Zhao, Kake, Sun, Wanying, Tyagarajan, Sriram, Bao, Jianming, Wang, Sheng-Ping, Cote, Josee, Lipardi, Concetta, Metzger, Daniel, Leung, Dennis, Hartmann, Georgy, Wollenberg, Gordon K, Liu, Jian, Tan, Lushi, Xu, Yingju, Chen, Qinghao, Liu, Guiquan, Blaustein, Robert O, Johns, Douglas G
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Journal Article
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats
Gu, Yi-Zhong, Vlasakova, Katerina, Miller, Glen, Gatto, Nicholas T, Ciaccio, Paul J, Kuruvilla, Sabu, Besteman, Elizabeth G, Smith, Roger, Reynolds, Spencer J, Amin, Rupesh P, Glaab, Warren E, Wollenberg, Gordon, Lebron, Jose, Sistare, Frank D
Published in Toxicologic pathology (01.01.2023)
Published in Toxicologic pathology (01.01.2023)
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Journal Article
Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration
Dong, Shuzhi, Zhao, Zhiqiang, Tang, Haiqun, Li, Guoqing, Pan, Jianping, Gu, Xin, Jiang, Jinlong, Xiao, Li, Scapin, Giovanna, Hunter, David N., Yang, Dexi, Huang, Yuhua, Bennett, Frank, Yang, Shu-Wei, Mandal, Mihirbaran, Tang, Haifeng, Su, Jing, Tudge, Clare, deJesus, Reynalda Keh, Ding, Fa-Xiang, Lombardo, Matthew, Hicks, Jacqueline D., Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Bhatt, Bhavana, Chen, Feifei, Regan, Christopher P., Regan, Hillary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Pollack, Scott R., Scott, Jack D., Nargund, Ravi P., Therien, Alex G., Black, Todd, Young, Katherine, Pasternak, Alexander
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Journal Article
Lead Optimization to Advance Protease-Activated Receptor‑1 Antagonists in Early Discovery
Mandal, Mihirbaran, Madeira, Maria, Amin, Rupesh P, Buevich, Alexei V, Cheng, Alan, Labroli, Marc, Liu, Xiaoxiang, Acton, John, Pio, Barbara, Basso, Andrea, Chobanian, Harry, Dong, Grace, Dropinski, Jamie, Guo, Yan, Guo, Zhuyan, Kurowski, Stan, Korfmacher, Walter, Lee, Sandra, Meng, Dongfang, Ondeyka, Debra, Yang, Zhiqiang, Zhang, Rumin, Wei, Huijun, Wu, Zhicai, Zhang, Fengqi, Wollenberg, Gordon, Biftu, Tesfaye, Greenlee, William J, Chintala, Madhu, Maletic, Milana, Zhu, Zhaoning
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Journal Article
Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor
Morissette, Pierre, Li, Nianyu, Ballard, Jeanine E, Vavrek, Marissa, Adams, Gregory L, Regan, Chris, Regan, Hillary, Lee, K J, Wang, Weixun, Burton, Aimee, Chen, Feifei, Gerenser, Pamela, Li, Yuxing, Kraus, Richard L, Tellers, David, Palani, Anand, Zhu, Yuping, Sun, Chengzao, Bianchi, Elisabetta, Colarusso, Stefania, De Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo’ Maria, Amin, Rupesh P
Published in Toxicological sciences (24.01.2022)
Published in Toxicological sciences (24.01.2022)
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Journal Article
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain
Adams, Gregory L, Pall, Parul S, Grauer, Steven M, Zhou, Xiaoping, Ballard, Jeanine E, Vavrek, Marissa, Kraus, Richard L, Morissette, Pierre, Li, Nianyu, Colarusso, Stefania, Bianchi, Elisabetta, Palani, Anandan, Klein, Rebecca, John, Christopher T, Wang, Deping, Tudor, Matthew, Nolting, Andrew F, Biba, Mirlinda, Nowak, Timothy, Makarov, Alexey A, Reibarkh, Mikhail, Buevich, Alexei V, Zhong, Wendy, Regalado, Erik L, Wang, Xiao, Gao, Qi, Shahripour, Aurash, Zhu, Yuping, de Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo’ Maria, Magotti, Paola, Iaccarino, Roberto, Li, Yuxing, Solly, Kelli, Lee, Keun-Joong, Wang, Weixun, Chen, Feifei, Zeng, Haoyu, Wang, Jixin, Regan, Hilary, Amin, Rupesh P, Regan, Christopher P, Burgey, Christopher S, Henze, Darrell A, Sun, Chengzao, Tellers, David M
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Journal Article
Translational Safety Biomarkers of Kidney Injury
Troth, Sean P, Vlasakova, Katerina, Amur, Shashi, Amin, Rupesh P, Glaab, Warren E
Published in Seminars in nephrology (01.03.2019)
Published in Seminars in nephrology (01.03.2019)
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Journal Article
RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation
Bednarski, Jeffrey J, Nickless, Andrew, Bhattacharya, Deepta, Amin, Rupesh H, Schlissel, Mark S, Sleckman, Barry P
Published in The Journal of experimental medicine (16.01.2012)
Published in The Journal of experimental medicine (16.01.2012)
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Journal Article
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na v 1.7 for the Treatment of Pain
Adams, Gregory L, Pall, Parul S, Grauer, Steven M, Zhou, Xiaoping, Ballard, Jeanine E, Vavrek, Marissa, Kraus, Richard L, Morissette, Pierre, Li, Nianyu, Colarusso, Stefania, Bianchi, Elisabetta, Palani, Anandan, Klein, Rebecca, John, Christopher T, Wang, Deping, Tudor, Matthew, Nolting, Andrew F, Biba, Mirlinda, Nowak, Timothy, Makarov, Alexey A, Reibarkh, Mikhail, Buevich, Alexei V, Zhong, Wendy, Regalado, Erik L, Wang, Xiao, Gao, Qi, Shahripour, Aurash, Zhu, Yuping, de Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo' Maria, Magotti, Paola, Iaccarino, Roberto, Li, Yuxing, Solly, Kelli, Lee, Keun-Joong, Wang, Weixun, Chen, Feifei, Zeng, Haoyu, Wang, Jixin, Regan, Hilary, Amin, Rupesh P, Regan, Christopher P, Burgey, Christopher S, Henze, Darrell A, Sun, Chengzao, Tellers, David M
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Journal Article
A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model
Plitnick, Lisa M., Hutchins, Beth, Dubey, Sheri, Li, Nianyu, Amin, Rupesh P., Born, Stephanie, Mangadu, Ruban, Phillips, Joseph H., Sriram, Venkataraman, Herzyk, Danuta J.
Published in Journal of immunotoxicology (01.01.2020)
Published in Journal of immunotoxicology (01.01.2020)
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Journal Article
Oxidative stress and its role in skin disease
Trouba, Kevin J, Hamadeh, Hisham K, Amin, Rupesh P, Germolec, Dori R
Published in Antioxidants & redox signaling (01.08.2002)
Published in Antioxidants & redox signaling (01.08.2002)
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Journal Article
Identification of Putative Gene-Based Markers of Renal Toxicity
Amin, Rupesh P., Vickers, Alison E., Sistare, Frank, Thompson, Karol L., Roman, Richard J., Lawton, Michael, Kramer, Jeffrey, Hamadeh, Hisham K., Collins, Jennifer, Grissom, Sherry, Bennett, Lee, Tucker, C. Jeffrey, Wild, Stacie, Kind, Clive, Oreffo, Victor, Davis, John W., Curtiss, Sandra, Naciff, Jorge M., Cunningham, Michael, Tennant, Raymond, Stevens, James, Car, Bruce, Bertram, Timothy A., Afshari, Cynthia A.
Published in Environmental health perspectives (01.03.2004)
Published in Environmental health perspectives (01.03.2004)
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Journal Article
Biallelic, ubiquitous transcription from the distal germline Igκ locus promoter during B cell development
Amin, Rupesh H, Cado, Dragana, Nolla, Hector, Huang, Dan, Shinton, Susan A, Zhou, Yan, Hardy, Richard R, Schlissel, Mark S
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2009)
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Journal Article
Coordination of Altered DNA Repair and Damage Pathways in Arsenite-Exposed Keratinocytes
Hamadeh, Hisham K., Trouba, Kevin J., Amin, Rupesh P., Afshari, Cynthia A., Germolec, Dori
Published in Toxicological sciences (01.10.2002)
Published in Toxicological sciences (01.10.2002)
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Journal Article
Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations
Hamadeh, Hisham K, Knight, Brian L, Haugen, Astrid C, Sieber, Stella, Amin, Rupesh P, Bushel, Pierre R, Stoll, Raymond, Blanchard, Kerry, Jayadev, Supriya, Tennant, Raymond W, Cunningham, Michael L, Afshari, Cynthia A, Paules, Richard S
Published in Toxicologic pathology (01.07.2002)
Published in Toxicologic pathology (01.07.2002)
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