ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models
Li, Yingchun, Hickson, Jonathan A, Ambrosi, Dominic J, Haasch, Deanna L, Foster-Duke, Kelly D, Eaton, Lucia J, DiGiammarino, Enrico L, Panchal, Sanjay C, Jiang, Fang, Mudd, Sarah R, Zhang, Catherine, Akella, Surekha S, Gao, Wenqing, Ralston, Sherry L, Naumovski, Louie, Gu, Jijie, Morgan-Lappe, Susan E
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Published in Molecular cancer therapeutics (01.05.2018)
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Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β
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ES Cell Cycle Progression and Differentiation Require the Action of the Histone Methyltransferase Dot1L
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Published in Stem cells (Dayton, Ohio) (01.07.2009)
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Reprogramming mediated by stem cell fusion
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Published in Journal of cellular and molecular medicine (01.04.2005)
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Abstract 867: ABT-165 is a first-in-class therapeutic Dual Variable Domain Immunoglobulin (DVD-IgTM) that targets DLL4 and VEGF for the treatment of cancer
Li, Yingchun, Hickson, Jonathan, Ambrosi, Dominic, Haasch, Deanna, Foster-Duke, Kelly, Eaton, Lucia, Jiang, Fang, Akella, Surekha, Gao, Wenqing, Ralston, Sherry, Gu, Jijie, Morgan-Lappe, Susan
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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4 ANTI-VEGF/DLL4 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
HAASCH DEANNA L, LAPPE SUSAN E, CHARI RAVI, LI YINGCHUN, AMBROSI DOMINIC J, GU JIJIE, NAUMOVSKI LOUIE, GUPTA SUPRIYA, CAO XIANHUA, HICKSON JONATHAN A, ZAMIRI CAMELLIA
Year of Publication 10.09.2021
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Year of Publication 10.09.2021
Patent
4 ANTI-VEGF/DLL4 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
HAASCH DEANNA L, LAPPE SUSAN E, CHARI RAVI, LI YINGCHUN, AMBROSI DOMINIC J, GU JIJIE, NAUMOVSKI LOUIE, GUPTA SUPRIYA, CAO XIANHUA, HICKSON JONATHAN A, ZAMIRI CAMELLIA
Year of Publication 18.09.2019
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Year of Publication 18.09.2019
Patent
4 ANTI-VEGF/DLL4 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
HAASCH DEANNA L, LAPPE SUSAN E, CHARI RAVI, LI YINGCHUN, AMBROSI DOMINIC J, GU JIJIE, NAUMOVSKI LOUIE, GUPTA SUPRIYA, CAO XIANHUA, HICKSON JONATHAN A, ZAMIRI CAMELLIA
Year of Publication 19.08.2019
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Year of Publication 19.08.2019
Patent
4 ANTI-VEGF/DLL4 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
HAASCH DEANNA L, LAPPE SUSAN E, CHARI RAVI, LI YINGCHUN, AMBROSI DOMINIC J, GU JIJIE, NAUMOVSKI LOUIE, GUPTA SUPRIYA, CAO XIANHUA, HICKSON JONATHAN A, ZAMIRI CAMELLIA
Year of Publication 24.01.2018
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Year of Publication 24.01.2018
Patent
ANTI-VEGF/DLL4 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
HAASCH DEANNA L, LAPPE SUSAN E, CHARI RAVI, LI YINGCHUN, AMBROSI DOMINIC J, GU JIJIE, NAUMOVSKI LOUIE, GUPTA SUPRIYA, CAO XIANHUA, HICKSON JONATHAN A, ZAMIRI CAMELLIA
Year of Publication 13.07.2015
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Year of Publication 13.07.2015
Patent
ANTI-DLL4/VEGF DUAL VARIABLE DOMAIN IMMMUNOGLOBULIN AND USES THEREOF
Haasch, Deanna L, Cao, Xianhua, Ambrosi, Dominic J, Gu, Jijie, Zamiri, Camellia, Lappe, Susan E, Chari, Ravi, Li, Yingchun, Hickson, Jonathan A, Gupta, Supriya, Naumovski, Louie
Year of Publication 22.12.2022
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Year of Publication 22.12.2022
Patent