Lithioarene Cycliacylation and Pd-Catalyzed Aminoethylation/Cyclization to Access Electronically Diverse Saturated Isoquinoline Derivatives
Buchman, Marek, Farney, Elliot P, Greszler, Stephen N, Altenbach, Robert J, Gfesser, Gregory A, Voight, Eric A
Published in Journal of organic chemistry (07.01.2022)
Published in Journal of organic chemistry (07.01.2022)
Get full text
Journal Article
Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener
Altenbach, Robert J, Brune, Michael E, Buckner, Steven A, Coghlan, Michael J, Daza, Anthony V, Fabiyi, Adebola, Gopalakrishnan, Murali, Henry, Rodger F, Khilevich, Albert, Kort, Michael E, Milicic, Ivan, Scott, Victoria E, Smith, Jamie C, Whiteaker, Kristi L, Carroll, William A
Published in Journal of medicinal chemistry (16.11.2006)
Published in Journal of medicinal chemistry (16.11.2006)
Get full text
Journal Article
Discovery and SAR of 4-aminopyrrolidine-2-carboxylic acid correctors of CFTR for the treatment of cystic fibrosis
Scanio, Marc J.C., Searle, Xenia B., Liu, Bo, Koenig, John R., Altenbach, Robert J., Gfesser, Gregory A., Bogdan, Andrew, Greszler, Stephen, Zhao, Gang, Singh, Ashvani, Fan, Yihong, Swensen, Andrew M., Vortherms, Timothy, Manelli, Arlene, Balut, Corina, Gao, Wenqing, Yong, Hong, Schrimpf, Michael, Tse, Chris, Kym, Philip, Wang, Xueqing
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
Get full text
Journal Article
Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists
Gomtsyan, Arthur, Schmidt, Robert G, Bayburt, Erol K, Gfesser, Gregory A, Voight, Eric A, Daanen, Jerome F, Schmidt, Diana L, Cowart, Marlon D, Liu, Huaqing, Altenbach, Robert J, Kort, Michael E, Clapham, Bruce, Cox, Phil B, Shrestha, Anurupa, Henry, Rodger, Whittern, David N, Reilly, Regina M, Puttfarcken, Pamela S, Brederson, Jill-Desiree, Song, Ping, Li, Bin, Huang, Susan M, McDonald, Heath A, Neelands, Torben R, McGaraughty, Steve P, Gauvin, Donna M, Joshi, Shailen K, Banfor, Patricia N, Segreti, Jason A, Shebley, Mohamad, Faltynek, Connie R, Dart, Michael J, Kym, Philip R
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
Get full text
Journal Article
Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models
Cowart, Marlon D, Altenbach, Robert J, Liu, Huaqing, Hsieh, Gin C, Drizin, Irene, Milicic, Ivan, Miller, Thomas R, Witte, David G, Wishart, Neil, Fix-Stenzel, Shannon R, McPherson, Michael J, Adair, Ronald M, Wetter, Jill M, Bettencourt, Brian M, Marsh, Kennan C, Sullivan, James P, Honore, Prisca, Esbenshade, Timothy A, Brioni, Jorge D
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
Get full text
Journal Article
[125I]A-312110, a Novel High-Affinity 1,4-Dihydropyridine ATP-sensitive K+ Channel Opener: Characterization and Pharmacology of Binding
Davis-Taber, Rachel, Molinari, Eduardo J, Altenbach, Robert J, Whiteaker, Kristi L, Shieh, Char-Chang, Rotert, Gary, Buckner, Steven A, Malysz, John, Milicic, Ivan, McDermott, Jeffrey S, Gintant, Gary A, Coghlan, Michael J, Carroll, William A, Scott, Victoria E, Gopalakrishnan, Murali
Published in Molecular pharmacology (01.07.2003)
Published in Molecular pharmacology (01.07.2003)
Get full text
Journal Article
Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4 Receptor Ligands
Altenbach, Robert J, Adair, Ronald M, Bettencourt, Brian M, Black, Lawrence A, Fix-Stenzel, Shannon R, Gopalakrishnan, Sujatha M, Hsieh, Gin C, Liu, Huaqing, Marsh, Kennan C, McPherson, Michael J, Milicic, Ivan, Miller, Thomas R, Vortherms, Timothy A, Warrior, Usha, Wetter, Jill M, Wishart, Neil, Witte, David G, Honore, Prisca, Esbenshade, Timothy A, Hancock, Arthur A, Brioni, Jorge D, Cowart, Marlon D
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
Get full text
Journal Article
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia
Liu, Huaqing, Altenbach, Robert J, Carr, Tracy L, Chandran, Prasant, Hsieh, Gin C, Lewis, La Geisha R, Manelli, Arlene M, Milicic, Ivan, Marsh, Kennan C, Miller, Thomas R, Strakhova, Marina I, Vortherms, Timothy A, Wakefield, Brian D, Wetter, Jill M, Witte, David G, Honore, Prisca, Esbenshade, Timothy A, Brioni, Jorge D, Cowart, Marlon D
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
Get full text
Journal Article
Diaryldiamines with Dual Inhibition of the Histamine H3 Receptor and the Norepinephrine Transporter and the Efficacy of 4-(3-(Methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in Pain
Altenbach, Robert J, Black, Lawrence A, Strakhova, Marina I, Manelli, Arlene M, Carr, Tracy L, Marsh, Kennan C, Wetter, Jill M, Wensink, Erica J, Hsieh, Gin C, Honore, Prisca, Garrison, Tiffany Runyan, Brioni, Jorge D, Cowart, Marlon D
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
Get full text
Journal Article
In vitro studies on a class of quinoline containing histamine H3 antagonists
Liu, Huaqing, Altenbach, Robert J., Diaz, Gilbert J., Manelli, Arlene M., Martin, Ruth L., Miller, Thomas R., Esbenshade, Timothy A., Brioni, Jorge D., Cowart, Marlon D.
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Get full text
Journal Article
Synthesis, Potency, and In Vivo Profiles of Quinoline Containing Histamine H3 Receptor Inverse Agonists
Altenbach, Robert J, Liu, Huaqing, Banfor, Patricia N, Browman, Kaitlin E, Fox, Gerard B, Fryer, Ryan M, Komater, Victoria A, Krueger, Kathleen M, Marsh, Kennan, Miller, Thomas R, Pan, Jia Bao, Pan, Liping, Sun, Minghua, Thiffault, Christine, Wetter, Jill, Zhao, Chen, Zhou, Deliang, Esbenshade, Timothy A, Hancock, Arthur A, Cowart, Marlon D
Published in Journal of medicinal chemistry (01.11.2007)
Published in Journal of medicinal chemistry (01.11.2007)
Get full text
Journal Article
SUBSTITUTED CHROMANES AND METHOD OF USE
KYM PHILIP R, ALTENBACH ROBERT J, SEARLE XENIA B, LIU BO, WANG XUEQING, YEUNG MING C, KOENIG JOHN R, VOIGHT ERIC, GRESZLER STEPHEN N, BOGDAN ANDREW
Year of Publication 22.03.2023
Get full text
Year of Publication 22.03.2023
Patent
SUBSTITUTED CHROMANES AND METHOD OF USE
KYM PHILIP R, ALTENBACH ROBERT J, SEARLE XENIA B, LIU BO, WANG XUEQING, YEUNG MING C, KOENIG JOHN R, VOIGHT ERIC, GRESZLER STEPHEN N, BOGDAN ANDREW
Year of Publication 11.11.2022
Get full text
Year of Publication 11.11.2022
Patent
Structure−Activity Studies for a Novel Series of Tricyclic Substituted Hexahydrobenz[e]isoindole α1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH)
Meyer, Michael D, Altenbach, Robert J, Basha, Fatima Z, Carroll, William A, Condon, Stephen, Elmore, Steven W, Kerwin, James F, Sippy, Kevin B, Tietje, Karin, Wendt, Michael D, Hancock, Arthur A, Brune, Michael E, Buckner, Steven A, Drizin, Irene
Published in Journal of medicinal chemistry (20.04.2000)
Published in Journal of medicinal chemistry (20.04.2000)
Get full text
Journal Article
Synthesis and Structure−Activity Relationships of a Novel Series of Tricyclic Dihydropyridine-Based KATP Openers That Potently Inhibit Bladder Contractions in Vitro
Carroll, William A, Agrios, Konstantinos A, Altenbach, Robert J, Buckner, Steven A, Chen, Yiyuan, Coghlan, Michael J, Daza, Anthony V, Drizin, Irene, Gopalakrishnan, Murali, Henry, Rodger F, Kort, Michael E, Kym, Philip R, Milicic, Ivan, Smith, Jamie C, Tang, Rui, Turner, Sean C, Whiteaker, Kristi L, Zhang, Henry, Sullivan, James P
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
Get full text
Journal Article
Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers
DRIZIN, Irene, ALTENBACH, Robert J, CARROLL, William A, BUCKNER, Steven A, WHITEAKER, Kristi L, SCOTT, Victoria E, DARBYSHIRE, John F, JAYANTI, Venkata, HENRY, Rodger F, COGHLAN, Michael J, GOPALAKRISHNAN, Murali
Published in Bioorganic & medicinal chemistry (15.04.2004)
Published in Bioorganic & medicinal chemistry (15.04.2004)
Get full text
Journal Article
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE
MING C YEUNG, SYLVAIN COUTY, KARINE FABIENNE MALAGU, PIZZONERO MATHIEU RAFAEL, MERAYO NURIA MERAYO, NICOLAS DESROY, CHRISTOPHER GAETAN HOUSSEMAN, ALTENBACH ROBERT J, GREGORY A GFESSER, PHILIP R KYM, STEVEN EMIEL VAN DER PLAS, THI THU TRANG MAI, LIU BO, OLIVIER LAURENT PICOLET, ANDREW BOGDAN, WANG XUEQING, XENIA B SEARLE
Year of Publication 04.01.2022
Get full text
Year of Publication 04.01.2022
Patent
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE
MING C YEUNG, SYLVAIN COUTY, KARINE FABIENNE MALAGU, PIZZONERO MATHIEU RAFAEL, MERAYO NURIA MERAYO, NICOLAS DESROY, CHRISTOPHER GAETAN HOUSSEMAN, ALTENBACH ROBERT J, GREGORY A GFESSER, PHILIP R KYM, STEVEN EMIEL VAN DER PLAS, THI THU TRANG MAI, LIU BO, OLIVIER LAURENT PICOLET, ANDREW BOGDAN, WANG XUEQING, XENIA B SEARLE
Year of Publication 04.01.2022
Get full text
Year of Publication 04.01.2022
Patent