The novel GIP, GLP‐1 and glucagon receptor agonist retatrutide delays gastric emptying
Urva, Shweta, O'Farrell, Libbey, Du, Yu, Loh, Mei Teng, Hemmingway, Andrea, Qu, Hongchang, Alsina‐Fernandez, Jorge, Haupt, Axel, Milicevic, Zvonko, Coskun, Tamer
Published in Diabetes, obesity & metabolism (01.09.2023)
Published in Diabetes, obesity & metabolism (01.09.2023)
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Journal Article
Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity‐induced insulin resistance
Borg, Melissa L., Massart, Julie, De Castro Barbosa, Thais, Archilla‐Ortega, Adrià, Smith, Jonathon A.B., Lanner, Johanna T., Alsina‐Fernandez, Jorge, Yaden, Benjamin, Culver, Alexander E., Karlsson, Håkan K.R., Brozinick, Joseph T., Zierath, Juleen R.
Published in Journal of cachexia, sarcopenia and muscle (01.10.2021)
Published in Journal of cachexia, sarcopenia and muscle (01.10.2021)
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Journal Article
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
Emmerson, Paul J, Wang, Feng, Du, Yong, Liu, Qian, Pickard, Richard T, Gonciarz, Malgorzata D, Coskun, Tamer, Hamang, Matthew J, Sindelar, Dana K, Ballman, Kimberly K, Foltz, Lisa A, Muppidi, Avinash, Alsina-Fernandez, Jorge, Barnard, Gavin C, Tang, Jason X, Liu, Xilin, Mao, Xudong, Siegel, Robert, Sloan, John H, Mitchell, Pamela J, Zhang, Bei B, Gimeno, Ruth E, Shan, Bei, Wu, Xinle
Published in Nature medicine (01.10.2017)
Published in Nature medicine (01.10.2017)
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Journal Article
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
Li, Yongguo, Schnabl, Katharina, Gabler, Sarah-Madeleine, Willershäuser, Monja, Reber, Josefine, Karlas, Angelos, Laurila, Sanna, Lahesmaa, Minna, u Din, Mueez, Bast-Habersbrunner, Andrea, Virtanen, Kirsi A., Fromme, Tobias, Bolze, Florian, O’Farrell, Libbey S., Alsina-Fernandez, Jorge, Coskun, Tamer, Ntziachristos, Vasilis, Nuutila, Pirjo, Klingenspor, Martin
Published in Cell (29.11.2018)
Published in Cell (29.11.2018)
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Journal Article
LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
Coskun, Tamer, Sloop, Kyle W., Loghin, Corina, Alsina-Fernandez, Jorge, Urva, Shweta, Bokvist, Krister B., Cui, Xuewei, Briere, Daniel A., Cabrera, Over, Roell, William C., Kuchibhotla, Uma, Moyers, Julie S., Benson, Charles T., Gimeno, Ruth E., D'Alessio, David A., Haupt, Axel
Published in Molecular metabolism (Germany) (01.12.2018)
Published in Molecular metabolism (Germany) (01.12.2018)
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Journal Article
GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models
Borner, Tito, Geisler, Caroline E, Fortin, Samantha M, Cosgrove, Richard, Alsina-Fernandez, Jorge, Dogra, Mridula, Doebley, Sarah, Sanchez-Navarro, Marcos J, Leon, Rosa M, Gaisinsky, Jane, White, Arianna, Bamezai, Ankur, Ghidewon, Misgana Y, Grill, Harvey J, Crist, Richard C, Reiner, Benjamin C, Ai, Minrong, Samms, Ricardo J, De Jonghe, Bart C, Hayes, Matthew R
Published in Diabetes (New York, N.Y.) (01.11.2021)
Published in Diabetes (New York, N.Y.) (01.11.2021)
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Journal Article
Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male Mice
Snider, Brandy, Geiser, Andrea, Yu, Xiao-Peng, Beebe, Emily Cathleen, Willency, Jill Amanda, Qing, Keyun, Guo, Lili, Lu, Jianliang, Wang, Xiaojun, Yang, Qian, Efanov, Alexander, Adams, Andrew Charles, Coskun, Tamer, Emmerson, Paul Joseph, Alsina-Fernandez, Jorge, Ai, Minrong
Published in Journal of the Endocrine Society (01.07.2019)
Published in Journal of the Endocrine Society (01.07.2019)
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Journal Article
1 GIP AND GLP-1 CO-AGONIST COMPOUNDS
CUMMINS ROBERT CHADWICK, ALSINA FERNANDEZ JORGE, BOKVIST BENGT KRISTER, COSKUN TAMER
Year of Publication 10.09.2024
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Year of Publication 10.09.2024
Patent
1 GIP AND GLP-1 CO-AGONIST COMPOUNDS
CUMMINS ROBERT CHADWICK, ALSINA FERNANDEZ JORGE, BOKVIST BENGT KRISTER, COSKUN TAMER
Year of Publication 17.02.2023
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Year of Publication 17.02.2023
Patent
인크레틴 유사체 및 그의 용도
QU HONGCHANG, ALSINA FERNANDEZ JORGE, COSKUN TAMER, WALLIS JAMES LINCOLN, ABRAHAM MILATA MARY
Year of Publication 15.07.2022
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Year of Publication 15.07.2022
Patent
1 GIP AND GLP-1 CO-AGONIST COMPOUNDS
CUMMINS ROBERT CHADWICK, ALSINA FERNANDEZ JORGE, BOKVIST BENGT KRISTER, COSKUN TAMER
Year of Publication 01.12.2021
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Year of Publication 01.12.2021
Patent
GIP/GLP1 공동-효능제 화합물
QU HONGCHANG, CUMMINS ROBERT CHADWICK, ELSAYED MOHAMED ELSAYED HAMED, WATSON BRIAN MORGAN, ALSINA FERNANDEZ JORGE, BROWN ROBERT ANDREW, GEISER ANDREA RENEE, LAI XIANYIN
Year of Publication 27.09.2022
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Year of Publication 27.09.2022
Patent
GIP/GLP1 GIP/GLP1 CO-AGONIST COMPOUNDS
QU HONGCHANG, CUMMINS ROBERT CHADWICK, ELSAYED MOHAMED ELSAYED HAMED, TRAN THI THANH HUYEN, ALSINA FERNANDEZ JORGE, ABURUB AKTHAM, COSKUN TAMER, WALLIS JAMES LINCOLN, ABRAHAM MILATA MARY, CABRERA OVER, BROWN ROBERT ANDREW, SLOOP KYLE WYNN, WILLARD FRANCIS STAFFORD, DATTA MANNAN AMITA, PATEL PHENIL JAYANTILAL, LAI XIANYIN
Year of Publication 19.04.2024
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Year of Publication 19.04.2024
Patent