Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase
Modenutti, Carlos P., Blanco Capurro, Juan I., Ibba, Roberta, Alonzi, Dominic S., Song, Mauro N., Vasiljević, Snežana, Kumar, Abhinav, Chandran, Anu V., Tax, Gabor, Marti, Lucia, Hill, Johan C., Lia, Andrea, Hensen, Mario, Waksman, Thomas, Rushton, Jonathan, Rubichi, Simone, Santino, Angelo, Martí, Marcelo A., Zitzmann, Nicole, Roversi, Pietro
Published in Structure (London) (01.04.2021)
Published in Structure (London) (01.04.2021)
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Iminosugar antivirals: the therapeutic sweet spot
Alonzi, Dominic S, Scott, Kathryn A, Dwek, Raymond A, Zitzmann, Nicole
Published in Biochemical Society transactions (15.04.2017)
Published in Biochemical Society transactions (15.04.2017)
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Targeting Endoplasmic Reticulum α‑Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections
Warfield, Kelly L, Alonzi, Dominic S, Hill, Johan C, Caputo, Alessandro T, Roversi, Pietro, Kiappes, J. L, Sheets, Nicholas, Duchars, Matthew, Dwek, Raymond A, Biggins, Julia, Barnard, Dale, Shresta, Sujan, Treston, Anthony M, Zitzmann, Nicole
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes
Sayce, Andrew C, Alonzi, Dominic S, Killingbeck, Sarah S, Tyrrell, Beatrice E, Hill, Michelle L, Caputo, Alessandro T, Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, J L, Beatty, P Robert, Kato, Atsushi, Harris, Eva, Dwek, Raymond A, Miller, Joanna L, Zitzmann, Nicole
Published in PLoS neglected tropical diseases (14.03.2016)
Published in PLoS neglected tropical diseases (14.03.2016)
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Assessing Antigen Structural Integrity through Glycosylation Analysis of the SARS-CoV-2 Viral Spike
Brun, Juliane, Vasiljevic, Snežana, Gangadharan, Bevin, Hensen, Mario, V. Chandran, Anu, Hill, Michelle L., Kiappes, J.L., Dwek, Raymond A., Alonzi, Dominic S., Struwe, Weston B., Zitzmann, Nicole
Published in ACS central science (28.04.2021)
Published in ACS central science (28.04.2021)
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Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint
Roversi, Pietro, Marti, Lucia, Caputo, Alessandro T., Alonzi, Dominic S., Hill, Johan C., Dent, Kyle C., Kumar, Abhinav, Levasseur, Mikail D., Lia, Andrea, Waksman, Thomas, Basu, Souradeep, Albrecht, Yentli Soto, Qian, Kristin, McIvor, James Patrick, Lipp, Colette B., Siliqi, Dritan, Vasiljević, Snežana, Mohammed, Shabaz, Lukacik, Petra, Walsh, Martin A., Santino, Angelo, Zitzmann, Nicole
Published in Proceedings of the National Academy of Sciences - PNAS (08.08.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (08.08.2017)
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Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals
Caputo, Alessandro T., Alonzi, Dominic S., Marti, Lucia, Reca, Ida-Barbara, Kiappes, J. L., Struwe, Weston B., Cross, Alice, Basu, Souradeep, Lowe, Edward D., Darlot, Benoit, Santino, Angelo, Roversi, Pietro, Zitzmann, Nicole
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2016)
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Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model
Miller, Joanna L, Spiro, Simon G, Dowall, Stuart D, Taylor, Irene, Rule, Antony, Alonzi, Dominic S, Sayce, Andrew C, Wright, Edward, Bentley, Emma M, Thom, Ruth, Hall, Graham, Dwek, Raymond A, Hewson, Roger, Zitzmann, Nicole
Published in PloS one (23.11.2016)
Published in PloS one (23.11.2016)
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Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target
Sobala, Łukasz F., Fernandes, Pearl Z., Hakki, Zalihe, Thompson, Andrew J., Howe, Jonathon D., Hill, Michelle, Zitzmann, Nicole, Davies, Scott, Stamataki, Zania, Butters, Terry D., Alonzi, Dominic S., Williams, Spencer J., Davies, Gideon J.
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2020)
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Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies
Yu, Xiaojie, Baruah, Kavitha, Harvey, David J, Vasiljevic, Snezana, Alonzi, Dominic S, Song, Byeong-Doo, Higgins, Matthew K, Bowden, Thomas A, Scanlan, Christopher N, Crispin, Max
Published in Journal of the American Chemical Society (03.07.2013)
Published in Journal of the American Chemical Society (03.07.2013)
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Journal Article
Iminosugar C‐Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease
Zhu, Sha, Jagadeesh, Yerri, Tran, Anh Tuan, Imaeda, Shuki, Boraston, Alisdair, Alonzi, Dominic S., Poveda, Ana, Zhang, Yongmin, Désiré, Jérôme, Charollais‐Thoenig, Julie, Demotz, Stéphane, Kato, Atsushi, Butters, Terry D., Jiménez‐Barbero, Jesús, Sollogoub, Matthieu, Blériot, Yves
Published in Chemistry : a European journal (05.08.2021)
Published in Chemistry : a European journal (05.08.2021)
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Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease
Ersek, Adel, Xu, Ke, Antonopoulos, Aristotelis, Butters, Terry D, Santo, Ana Espirito, Vattakuzhi, Youridies, Williams, Lynn M, Goudevenou, Katerina, Danks, Lynett, Freidin, Andrew, Spanoudakis, Emmanouil, Parry, Simon, Papaioannou, Maria, Hatjiharissi, Evdoxia, Chaidos, Aristeidis, Alonzi, Dominic S, Twigg, Gabriele, Hu, Ming, Dwek, Raymond A, Haslam, Stuart M, Roberts, Irene, Dell, Anne, Rahemtulla, Amin, Horwood, Nicole J, Karadimitris, Anastasios
Published in The Journal of clinical investigation (01.06.2015)
Published in The Journal of clinical investigation (01.06.2015)
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Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
Warfield, Kelly L., Plummer, Emily M., Sayce, Andrew C., Alonzi, Dominic S., Tang, William, Tyrrell, Beatrice E., Hill, Michelle L., Caputo, Alessandro T., Killingbeck, Sarah S., Beatty, P. Robert, Harris, Eva, Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, J.L., Kato, Atsushi, Buck, Michael D., King, Kevin, Eddy, William, Khaliq, Mansoora, Sampath, Aruna, Treston, Anthony M., Dwek, Raymond A., Enterlein, Sven G., Miller, Joanna L., Zitzmann, Nicole, Ramstedt, Urban, Shresta, Sujan
Published in Antiviral research (01.05.2016)
Published in Antiviral research (01.05.2016)
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Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase
Thompson, Andrew J, Williams, Rohan J, Hakki, Zalihe, Alonzi, Dominic S, Wennekes, Tom, Gloster, Tracey M, Songsrirote, Kriangsak, Thomas-Oates, Jane E, Wrodnigg, Tanja M, Spreitz, Josef, Stütz, Arnold E, Butters, Terry D, Williams, Spencer J, Davies, Gideon J
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2012)
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Journal Article
ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α‑Glucosidase II Exhibiting Antiflaviviral Activity
Kiappes, J. L, Hill, Michelle L, Alonzi, Dominic S, Miller, Joanna L, Iwaki, Ren, Sayce, Andrew C, Caputo, Alessandro T, Kato, Atsushi, Zitzmann, Nicole
Published in ACS chemical biology (19.01.2018)
Published in ACS chemical biology (19.01.2018)
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Journal Article
An iminosugar with potent inhibition of dengue virus infection in vivo
Perry, Stuart T., Buck, Michael D., Plummer, Emily M., Penmasta, Raju A., Batra, Hitesh, Stavale, Eric J., Warfield, Kelly L., Dwek, Raymond A., Butters, Terry D., Alonzi, Dominic S., Lada, Steven M., King, Kevin, Klose, Brennan, Ramstedt, Urban, Shresta, Sujan
Published in Antiviral research (01.04.2013)
Published in Antiviral research (01.04.2013)
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Structural Insights into the Broad-Spectrum Antiviral Target Endoplasmic Reticulum Alpha-Glucosidase II
Caputo, Alessandro T, Alonzi, Dominic S, Kiappes, John L, Struwe, Weston B, Cross, Alice, Basu, Souradeep, Darlot, Benoit, Roversi, Pietro, Zitzmann, Nicole
Published in Advances in experimental medicine and biology (01.01.2018)
Published in Advances in experimental medicine and biology (01.01.2018)
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Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses
Chang, Jinhong, Warren, Travis K., Zhao, Xuesen, Gill, Tina, Guo, Fang, Wang, Lijuan, Comunale, Mary Ann, Du, Yanming, Alonzi, Dominic S., Yu, Wenquan, Ye, Hong, Liu, Fei, Guo, Ju-Tao, Mehta, Anand, Cuconati, Andrea, Butters, Terry D., Bavari, Sina, Xu, Xiaodong, Block, Timothy M.
Published in Antiviral research (01.06.2013)
Published in Antiviral research (01.06.2013)
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