Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension
Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter
Published in ChemMedChem (11.05.2009)
Published in ChemMedChem (11.05.2009)
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Journal Article
NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle
Stasch, Johannes‐Peter, Schmidt, Peter, Alonso‐Alija, Cristina, Apeler, Heiner, Dembowsky, Klaus, Haerter, Michael, Heil, Markus, Minuth, Torsten, Perzborn, Elisabeth, Pleiss, Ulrich, Schramm, Matthias, Schroeder, Werner, Schröder, Henning, Stahl, Elke, Steinke, Wolfram, Wunder, Frank
Published in British journal of pharmacology (01.07.2002)
Published in British journal of pharmacology (01.07.2002)
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Journal Article
Pharmacological actions of a novel NO‐independent guanylyl cyclase stimulator, BAY 41‐8543: in vitro studies
Stasch, Johannes‐Peter, Alonso‐Alija, Cristina, Apeler, Heiner, Dembowsky, Klaus, Feurer, Achim, Minuth, Torsten, Perzborn, Elisabeth, Schramm, Matthias, Straub, Alexander
Published in British journal of pharmacology (01.01.2002)
Published in British journal of pharmacology (01.01.2002)
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Journal Article
Efficient Regioselective Synthesis of 6-Amino-5-benzoyl-1-Substituted 2(1H)-Pyridinones
Schirok, Hartmut, Alonso-Alija, Cristina, Benet-Buchholz, Jordi, Göller, Andreas H, Grosser, Rolf, Michels, Martin, Paulsen, Holger
Published in Journal of organic chemistry (11.11.2005)
Published in Journal of organic chemistry (11.11.2005)
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Cover Picture: Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension (ChemMedChem 5/2009)
Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter
Published in ChemMedChem (11.05.2009)
Published in ChemMedChem (11.05.2009)
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Journal Article
Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis
Knorr, Andreas, Hirth-Dietrich, Claudia, Alonso-Alija, Cristina, Härter, Michael, Hahn, Michael, Keim, Yvonne, Wunder, Frank, Stasch, Johannes-Peter
Published in Arzneimittel-Forschung (01.01.2008)
Published in Arzneimittel-Forschung (01.01.2008)
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Journal Article
NO-independent regulatory site on soluble guanylate cyclase
Stasch, Johannes-Peter, Becker, Eva Maria, Alonso-Alija, Cristina, Apeler, Heiner, Dembowsky, Klaus, Feurer, Achim, Gerzer, Rupert, Minuth, Torsten, Perzborn, Elisabeth, Pleiß, Ulrich, Schröder, Henning, Schroeder, Werner, Stahl, Elke, Steinke, Wolfram, Straub, Alexander, Schramm, Matthias
Published in Nature (London) (08.03.2001)
Published in Nature (London) (08.03.2001)
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Journal Article
A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway
Wunder, Frank, Stasch, Johannes-Peter, Hütter, Joachim, Alonso-Alija, Cristina, Hüser, Jörg, Lohrmann, Emanuel
Published in Analytical biochemistry (01.04.2005)
Published in Analytical biochemistry (01.04.2005)
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Journal Article
A Convenient Synthesis of 4-Alkoxy- and 4-Hydroxy-2,6-difluoroanilines
Alonso-Alija, Cristina, Michels, Martin, Peilstoecker, Karen, Schirok, Hartmut
Published in ChemInform (13.04.2004)
Published in ChemInform (13.04.2004)
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A convenient synthesis of 4-alkoxy- and 4-hydroxy-2,6-difluoroanilines
Alonso-Alija, Cristina, Michels, Martin, Peilstöcker, Karen, Schirok, Hartmut
Published in Tetrahedron letters (2004)
Published in Tetrahedron letters (2004)
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Journal Article
A novel approach to amidines from esters
Gielen, Heike, Alonso-Alija, Cristina, Hendrix, Martin, Niewöhner, Ulrich, Schauss, Dagmar
Published in Tetrahedron letters (14.01.2002)
Published in Tetrahedron letters (14.01.2002)
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Journal Article
Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension
Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter
Published in BMC pharmacology (11.08.2009)
Published in BMC pharmacology (11.08.2009)
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Journal Article
Design and synthesis of the first NO- and haem-independent sGC activator BAY 58–2667 for the treatment of acute decompensated heart failure
Hahn, Michael G, Alonso-Alija, Cristina, Stoll, Friederike, Heil, Markus, Mittendorf, Joachim, Schlemmer, Karl-Heinz, Wunder, Frank, Stasch, Johannes-Peter
Published in BMC pharmacology (25.07.2007)
Published in BMC pharmacology (25.07.2007)
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