Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform
Cao, Liangxian, Weetall, Marla, Bombard, Jenelle, Qi, Hongyan, Arasu, Tamil, Lennox, William, Hedrick, Jean, Sheedy, Josephine, Risher, Nicole, Brooks, Peter C, Trifillis, Panayiota, Trotta, Christopher, Moon, Young-Choon, Babiak, John, Almstead, Neil G, Colacino, Joseph M, Davis, Thomas W, Peltz, Stuart W
Published in PloS one (16.12.2016)
Published in PloS one (16.12.2016)
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Safety, tolerability, and pharmacokinetics of PTC124, a nonaminoglycoside nonsense mutation suppressor, following single- and multiple-dose administration to healthy male and female adult volunteers
Hirawat, Samit, Welch, Ellen M, Elfring, Gary L, Northcutt, Valerie J, Paushkin, Sergey, Hwang, Seongwoo, Leonard, Eileen M, Almstead, Neil G, Ju, William, Peltz, Stuart W, Miller, Langdon L
Published in Journal of clinical pharmacology (01.04.2007)
Published in Journal of clinical pharmacology (01.04.2007)
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Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein
Gu, Zhengxian, Graci, Jason D, Lahser, Frederick C, Breslin, Jamie J, Jung, Stephen P, Crona, James H, McMonagle, Patricia, Xia, Ellen, Liu, Shaotang, Karp, Gary, Zhu, Jin, Huang, Song, Nomeir, Amin, Weetall, Marla, Almstead, Neil G, Peltz, Stuart W, Tong, Xiao, Ralston, Robert, Colacino, Joseph M
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
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SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
Naryshkin, Nikolai A., Weetall, Marla, Dakka, Amal, Narasimhan, Jana, Zhao, Xin, Feng, Zhihua, Ling, Karen K. Y., Karp, Gary M., Qi, Hongyan, Woll, Matthew G., Chen, Guangming, Zhang, Nanjing, Gabbeta, Vijayalakshmi, Vazirani, Priya, Bhattacharyya, Anuradha, Furia, Bansri, Risher, Nicole, Sheedy, Josephine, Kong, Ronald, Ma, Jiyuan, Turpoff, Anthony, Lee, Chang-Sun, Zhang, Xiaoyan, Moon, Young-Choon, Trifillis, Panayiota, Welch, Ellen M., Colacino, Joseph M., Babiak, John, Almstead, Neil G., Peltz, Stuart W., Eng, Loren A., Chen, Karen S., Mull, Jesse L., Lynes, Maureen S., Rubin, Lee L., Fontoura, Paulo, Santarelli, Luca, Haehnke, Daniel, McCarthy, Kathleen D., Schmucki, Roland, Ebeling, Martin, Sivaramakrishnan, Manaswini, Ko, Chien-Ping, Paushkin, Sergey V., Ratni, Hasane, Gerlach, Irene, Ghosh, Anirvan, Metzger, Friedrich
Published in Science (American Association for the Advancement of Science) (08.08.2014)
Published in Science (American Association for the Advancement of Science) (08.08.2014)
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Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
Cao, Liangxian, Weetall, Marla, Trotta, Christopher, Cintron, Katherine, Ma, Jiyuan, Kim, Min Jung, Furia, Bansri, Romfo, Charles, Graci, Jason D, Li, Wencheng, Du, Joshua, Sheedy, Josephine, Hedrick, Jean, Risher, Nicole, Yeh, Shirley, Qi, Hongyan, Arasu, Tamil, Hwang, Seongwoo, Lennox, William, Kong, Ronald, Petruska, Janet, Moon, Young-Choon, Babiak, John, Davis, Thomas W, Jacobson, Allan, Almstead, Neil G, Branstrom, Art, Colacino, Joseph M, Peltz, Stuart W
Published in Molecular cancer therapeutics (01.01.2019)
Published in Molecular cancer therapeutics (01.01.2019)
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PTC124 targets genetic disorders caused by nonsense mutations
Chen, Guangming, Jacobson, Allan, Spatrick, Phyllis, Peltz, Stuart W, Conn, M. Morgan, Friesen, Westley J, Almstead, Neil G, Hedrick, Jean, Campbell, Jeffrey A, Mollin, Anna, Kawana, Masataka, Wilde, Richard G, Yeh, Shirley, Sweeney, H. Lee, Trotta, Christopher R, Khan, Atiyya, Welch, Ellen M, Barton, Elisabeth R, Hirawat, Samit, Turpoff, Anthony A, Weetall, Marla, Ren, Hongyu, Risher, Nicole, Tomizawa, Yuki, Northcutt, Valerie J, Miller, Langdon L, He, Feng, Jones, Stephen, Colacino, Joseph M, Feng, Huisheng, Branstrom, Arthur A, Corson, Donald, Zhuo, Jin, Ju, William D, Patel, Meenal, Moon, Young-Choon, Hwang, Seongwoo, Paushkin, Sergey, Babiak, John, Trifillis, Panayiota, Karp, Gary, Takasugi, James
Published in Nature (03.05.2007)
Published in Nature (03.05.2007)
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Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy
Woll, Matthew G, Qi, Hongyan, Turpoff, Anthony, Zhang, Nanjing, Zhang, Xiaoyan, Chen, Guangming, Li, Chunshi, Huang, Song, Yang, Tianle, Moon, Young-Choon, Lee, Chang-Sun, Choi, Soongyu, Almstead, Neil G, Naryshkin, Nikolai A, Dakka, Amal, Narasimhan, Jana, Gabbeta, Vijayalakshmi, Welch, Ellen, Zhao, Xin, Risher, Nicole, Sheedy, Josephine, Weetall, Marla, Karp, Gary M
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Selective Synthesis of 1‑Substituted 4‑Chloropyrazolo[3,4‑d]pyrimidines
Babu, Suresh, Morrill, Christie, Almstead, Neil G, Moon, Young-Choon
Published in Organic letters (19.04.2013)
Published in Organic letters (19.04.2013)
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Journal Article
Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors
Cheng, Menyan, De, Biswanath, Pikul, Stanislaw, Almstead, Neil G, Natchus, Michael G, Anastasio, Melanie V, McPhail, Sara J, Snider, Catherine E, Taiwo, Yetunde O, Chen, Longyin, Dunaway, C. Michelle, Gu, Fei, Dowty, Martin E, Mieling, Glen E, Janusz, Michael J, Wang-Weigand, Sherry
Published in Journal of medicinal chemistry (10.02.2000)
Published in Journal of medicinal chemistry (10.02.2000)
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Discovery and Optimization of Indolyl-Containing 4‑Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria
Gerasyuto, Aleksey I, Arnold, Michael A, Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G, Baird, John, Zhang, Nanjing, Almstead, Neil G, Narasimhan, Jana, Peddi, Srinivasa, Dumble, Melissa, Sheedy, Josephine, Weetall, Marla, Branstrom, Arthur A, Prasad, J. V. N, Karp, Gary M
Published in Journal of medicinal chemistry (24.05.2018)
Published in Journal of medicinal chemistry (24.05.2018)
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Journal Article
Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors
Almstead, Neil G, Bradley, Rimma S, Pikul, Stanislaw, De, Biswanath, Natchus, Michael G, Taiwo, Yetunde O, Gu, Fei, Williams, Lisa E, Hynd, Barbara A, Janusz, Michael J, Dunaway, C. Michelle, Mieling, Glen E
Published in Journal of medicinal chemistry (04.11.1999)
Published in Journal of medicinal chemistry (04.11.1999)
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4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis
Arnold, Michael A., Gerasyuto, Aleksey I., Wang, Jiashi, Du, Wu, Gorske, Yi Jin Kim, Arasu, Tamil, Baird, John, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivasa, Ginzburg, Olya, Lue, Stanley W., Hedrick, Jean, Sheedy, Josephine, Lagaud, Guy, Branstrom, Arthur A., Weetall, Marla, Prasad, J.V.N. Vara, Karp, Gary M.
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
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Correction to Discovery and Optimization of Indolyl-Containing 4‑Hydroxy-2-pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-Negative Bacteria
Gerasyuto, Aleksey I, Arnold, Michael A, Wang, Jiashi, Chen, Guangming, Zhang, Xiaoyan, Smith, Sean, Woll, Matthew G, Baird, John, Zhang, Nanjing, Almstead, Neil G, Narasimhan, Jana, Peddi, Srinivasa, Dumble, Melissa, Sheedy, Josephine, Weetall, Marla, Branstrom, Arthur A, Prasad, J. V. N, Karp, Gary M
Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
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Studies on the mechanism and origin of stereoselective opening of chiral dioxane acetals
Denmark, Scott E, Almstead, Neil G
Published in Journal of the American Chemical Society (01.10.1991)
Published in Journal of the American Chemical Society (01.10.1991)
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Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors
Pikul, Stanislaw, McDow Dunham, Kelly L, Almstead, Neil G, De, Biswanath, Natchus, Michael G, Anastasio, Melanie V, McPhail, Sara J, Snider, Catherine E, Taiwo, Yetunde O, Rydel, Timothy, Dunaway, C. Michelle, Gu, Fei, Mieling, Glen E
Published in Journal of medicinal chemistry (10.09.1998)
Published in Journal of medicinal chemistry (10.09.1998)
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Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold
Cheng, Menyan, De, Biswanath, Almstead, Neil G, Pikul, Stanislaw, Dowty, Martin E, Dietsch, Charles R, Dunaway, C. Michelle, Gu, Fei, Hsieh, Lily C, Janusz, Michael J, Taiwo, Yetunde O, Natchus, Michael G, Hudlicky, Tomas, Mandel, Martin
Published in Journal of medicinal chemistry (30.12.1999)
Published in Journal of medicinal chemistry (30.12.1999)
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Spectroscopic studies on the structure and conformation of Lewis acid-aldehyde complexes
Denmark, Scott E, Almstead, Neil G
Published in Journal of the American Chemical Society (01.04.1993)
Published in Journal of the American Chemical Society (01.04.1993)
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On the stereochemical course of the addition of allylsilanes to aldehydes
Denmark, Scott E., Weber, Eric J., Almstead, Neil G., Wolf, Larry M.
Published in Tetrahedron (16.09.2012)
Published in Tetrahedron (16.09.2012)
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