A Bayesian machine learning approach for drug target identification using diverse data types
Madhukar, Neel S, Khade, Prashant K, Huang, Linda, Gayvert, Kaitlyn, Galletti, Giuseppe, Stogniew, Martin, Allen, Joshua E, Giannakakou, Paraskevi, Elemento, Olivier
Published in Nature communications (19.11.2019)
Published in Nature communications (19.11.2019)
Get full text
Journal Article
ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
Prabhu, Varun Vijay, Morrow, Sara, Rahman Kawakibi, Abed, Zhou, Lanlan, Ralff, Marie, Ray, Jocelyn, Jhaveri, Aakash, Ferrarini, Isacco, Lee, Young, Parker, Cassandra, Zhang, Yiqun, Borsuk, Robyn, Chang, Wen-I, Honeyman, Joshua N., Tavora, Fabio, Carneiro, Benedito, Raufi, Alexander, Huntington, Kelsey, Carlsen, Lindsey, Louie, Anna, Safran, Howard, Seyhan, Attila A., Tarapore, Rohinton S., Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, El-Deiry, Wafik S.
Published in Neoplasia (New York, N.Y.) (01.12.2020)
Published in Neoplasia (New York, N.Y.) (01.12.2020)
Get full text
Journal Article
A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma
Arrillaga-Romany, Isabel, Chi, Andrew S, Allen, Joshua E, Oster, Wolfgang, Wen, Patrick Y, Batchelor, Tracy T
Published in Oncotarget (03.10.2017)
Published in Oncotarget (03.10.2017)
Get full text
Journal Article
Role of Dopamine Receptors in the Anticancer Activity of ONC201
Kline, Christina Leah B., Ralff, Marie D., Lulla, Amriti R., Wagner, Jessica M., Abbosh, Phillip H., Dicker, David T., Allen, Joshua E., El-Deiry, Wafik S.
Published in Neoplasia (New York, N.Y.) (01.01.2018)
Published in Neoplasia (New York, N.Y.) (01.01.2018)
Get full text
Journal Article
Leveraging external data in the design and analysis of clinical trials in neuro-oncology
Rahman, Rifaquat, Ventz, Steffen, McDunn, Jon, Louv, Bill, Reyes-Rivera, Irmarie, Polley, Mei-Yin C, Merchant, Fahar, Abrey, Lauren E, Allen, Joshua E, Aguilar, Laura K, Aguilar-Cordova, Estuardo, Arons, David, Tanner, Kirk, Bagley, Stephen, Khasraw, Mustafa, Cloughesy, Timothy, Wen, Patrick Y, Alexander, Brian M, Trippa, Lorenzo
Published in The lancet oncology (01.10.2021)
Published in The lancet oncology (01.10.2021)
Get full text
Journal Article
Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects
Allen, Joshua E, Krigsfeld, Gabriel, Mayes, Patrick A, Patel, Luv, Dicker, David T, Patel, Akshal S, Dolloff, Nathan G, Messaris, Evangelos, Scata, Kimberly A, Wang, Wenge, Zhou, Jun-Ying, Wu, Gen Sheng, El-Deiry, Wafik S
Published in Science translational medicine (06.02.2013)
Published in Science translational medicine (06.02.2013)
Get more information
Journal Article
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
Ishizawa, Jo, Kojima, Kensuke, Chachad, Dhruv, Ruvolo, Peter, Ruvolo, Vivian, Jacamo, Rodrigo O, Borthakur, Gautam, Mu, Hong, Zeng, Zhihong, Tabe, Yoko, Allen, Joshua E, Wang, Zhiqiang, Ma, Wencai, Lee, Hans C, Orlowski, Robert, Sarbassov, Dos D, Lorenzi, Philip L, Huang, Xuelin, Neelapu, Sattva S, McDonnell, Timothy, Miranda, Roberto N, Wang, Michael, Kantarjian, Hagop, Konopleva, Marina, Davis, R Eric, Andreeff, Michael
Published in Science signaling (16.02.2016)
Published in Science signaling (16.02.2016)
Get more information
Journal Article
Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia
Nii, Takenobu, Prabhu, Varun V, Ruvolo, Vivian, Madhukar, Neel, Zhao, Ran, Mu, Hong, Heese, Lauren, Nishida, Yuki, Kojima, Kensuke, Garnett, Mathew J, McDermott, Ultan, Benes, Cyril H, Charter, Neil, Deacon, Sean, Elemento, Olivier, Allen, Joshua E, Oster, Wolfgang, Stogniew, Martin, Ishizawa, Jo, Andreeff, Michael
Published in Leukemia (01.12.2019)
Published in Leukemia (01.12.2019)
Get full text
Journal Article
A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer
Paraghamian, Sarah E., Qiu, Jianqing, Hawkins, Gabrielle M., Zhao, Ziyi, Sun, Wenchuan, Fan, Yali, Zhang, Xin, Suo, Hongyan, Hao, Tianran, Prabhu, Varun Vijay, Allen, Joshua E., Zhou, Chunxiao, Bae-Jump, Victoria
Published in Cancer biology & therapy (31.12.2023)
Published in Cancer biology & therapy (31.12.2023)
Get full text
Journal Article
Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212
Wagner, Jessica, Kline, Christina Leah, Ralff, Marie D, Lev, Avital, Lulla, Amriti, Zhou, Lanlan, Olson, Gary L, Nallaganchu, Bhaskara Rao, Benes, Cyril H, Allen, Joshua E, Prabhu, Varun V, Stogniew, Martin, Oster, Wolfgang, El-Deiry, Wafik S
Published in Cell cycle (Georgetown, Tex.) (02.10.2017)
Published in Cell cycle (Georgetown, Tex.) (02.10.2017)
Get full text
Journal Article
Discovery and clinical introduction of first-in-class imipridone ONC201
Allen, Joshua E, Kline, C Leah B, Prabhu, Varun V, Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L, Pottorf, Richard S, Nallaganchu, B Rao, Olson, Gary L, Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T, Talekar, Mala K, Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L, Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S
Published in Oncotarget (08.11.2016)
Published in Oncotarget (08.11.2016)
Get full text
Journal Article
Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer
Pierce, Stuart R, Fang, Ziwei, Yin, Yajie, West, Lindsay, Asher, Majdouline, Hao, Tianran, Zhang, Xin, Tucker, Katherine, Staley, Allison, Fan, Yali, Sun, Wenchuan, Moore, Dominic T, Xu, Chang, Tsai, Yi-Hsuan, Parker, Joel, Prabhu, Varun Vijay, Allen, Joshua E, Lee, Douglas, Zhou, Chunxiao, Bae-Jump, Victoria
Published in Journal of experimental & clinical cancer research (08.02.2021)
Published in Journal of experimental & clinical cancer research (08.02.2021)
Get full text
Journal Article
Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells
Amoroso, Francesca, Glass, Kimberley, Singh, Reema, Liberal, Francisco, Steele, Rebecca E, Maguire, Sarah, Tarapore, Rohinton, Allen, Joshua E, Van Schaeybroeck, Sandra, Butterworth, Karl T, Prise, Kevin, O'Sullivan, Joe M, Jain, Suneil, Waugh, David J, Mills, Ian G
Published in Scientific reports (19.02.2021)
Published in Scientific reports (19.02.2021)
Get full text
Journal Article
Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors
Prabhu, Varun V, Lulla, Amriti R, Madhukar, Neel S, Ralff, Marie D, Zhao, Dan, Kline, Christina Leah B, Van den Heuvel, A Pieter J, Lev, Avital, Garnett, Mathew J, McDermott, Ultan, Benes, Cyril H, Batchelor, Tracy T, Chi, Andrew S, Elemento, Olivier, Allen, Joshua E, El-Deiry, Wafik S
Published in PloS one (02.08.2017)
Published in PloS one (02.08.2017)
Get full text
Journal Article
Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10
Allen, Joshua E, Prabhu, Varun V, Talekar, Mala, van den Heuvel, A Pieter J, Lim, Bora, Dicker, David T, Fritz, Jennifer L, Beck, Adam, El-Deiry, Wafik S
Published in Cancer research (Chicago, Ill.) (15.04.2015)
Published in Cancer research (Chicago, Ill.) (15.04.2015)
Get full text
Journal Article
ONC206, an Imipridone Derivative, Induces Cell Death Through Activation of the Integrated Stress Response in Serous Endometrial Cancer In Vitro
Zhang, Yingao, Huang, Yu, Yin, Yajie, Fan, Yali, Sun, Wenchuan, Zhao, Xiaoling, Tucker, Katherine, Staley, Allison, Paraghamian, Sarah, Hawkins, Gabrielle, Prabhu, Varun, Allen, Joshua E., Zhou, Chunxiao, Bae-Jump, Victoria
Published in Frontiers in oncology (20.10.2020)
Published in Frontiers in oncology (20.10.2020)
Get full text
Journal Article
Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer
Fan, Yali, Wang, Jiandong, Fang, Ziwei, Pierce, Stuart R, West, Lindsay, Staley, Allison, Tucker, Katherine, Yin, Yajie, Sun, Wenchuan, Kong, Weimin, Prabhu, Varun, Allen, Joshua E, Zhou, Chunxiao, Bae-Jump, Victoria L
Published in Frontiers in oncology (17.03.2022)
Published in Frontiers in oncology (17.03.2022)
Get full text
Journal Article