Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8+ T cells to enhance antitumor immunity
Hernandez, Rosmely, Toomer, Kevin H., Põder, Janika, Santos Savio, Alicia, Hsiung, Sunnie, Malek, Thomas R.
Published in Cancer Immunology, Immunotherapy (01.04.2021)
Published in Cancer Immunology, Immunotherapy (01.04.2021)
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High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity
Hernandez, Rosmely, LaPorte, Kathryn M, Hsiung, Sunnie, Santos Savio, Alicia, Malek, Thomas R
Published in Journal for immunotherapy of cancer (01.09.2021)
Published in Journal for immunotherapy of cancer (01.09.2021)
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Journal Article
Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from rheumatoid arthritis patients
Santos Savio, Alicia, Machado Diaz, Ana Cecilia, Chico Capote, Araceli, Miranda Navarro, Jamilet, Rodríguez Alvarez, Yunier, Bringas Pérez, Ricardo, Estévez del Toro, Miguel, Guillen Nieto, Gerardo E
Published in BMC musculoskeletal disorders (12.03.2015)
Published in BMC musculoskeletal disorders (12.03.2015)
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Journal Article
Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms
Ward, Natasha C, Lui, Jen Bon, Hernandez, Rosmely, Yu, Liping, Struthers, Mary, Xie, Jenny, Santos Savio, Alicia, Dwyer, Connor J, Hsiung, Sunnie, Yu, Aixin, Malek, Thomas R
Published in Diabetes (New York, N.Y.) (01.11.2020)
Published in Diabetes (New York, N.Y.) (01.11.2020)
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Journal Article
Immunogenicity profile in African green monkeys of a vaccine candidate based on a mutated form of human Interleukin-15
Rodríguez-Álvarez, Yunier, Batista-Roche, Lino Gerardo, Llopiz-Arzuaga, Alexey, Puente-Pérez, Pedro, Martínez-Castillo, Rafael, Castro-Velazco, Jorge, Santos-Savio, Alicia
Published in BMC immunology (18.12.2021)
Published in BMC immunology (18.12.2021)
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In vitro and in vivo characterization of an interleukin-15 antagonist peptide by metabolic stability, 99m Tc-labeling, and biological activity assays
Rodríguez-Álvarez, Yunier, Cabrales-Rico, Ania, Perera-Pintado, Alejandro, Prats-Capote, Anais, Garay-Pérez, Hilda E, Reyes-Acosta, Osvaldo, Pérez-García, Erik, Chico-Capote, Araceli, Santos-Savio, Alicia
Published in Journal of peptide science (01.06.2018)
Published in Journal of peptide science (01.06.2018)
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Journal Article
In vitro and in vivo characterization of an interleukin‐15 antagonist peptide by metabolic stability, 99mTc‐labeling, and biological activity assays
Rodríguez‐Álvarez, Yunier, Cabrales‐Rico, Ania, Perera‐Pintado, Alejandro, Prats‐Capote, Anais, Garay‐Pérez, Hilda E., Reyes‐Acosta, Osvaldo, Pérez‐García, Erik, Chico‐Capote, Araceli, Santos‐Savio, Alicia
Published in Journal of peptide science (01.06.2018)
Published in Journal of peptide science (01.06.2018)
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Journal Article
Enhancement of the inhibitory effect of an IL-15 antagonist peptide by alanine scanning
Savio, Alicia Santos, Acosta, Osvaldo Reyes, Pérez, Haydee Gerónimo, Álvarez, Yunier Rodríguez, Chico, Araceli, Pérez, Hilda Garay, Ojeda, Miriam Ojeda, Aguero, Celia Aurora Arrieta, Estévez, Miguel, Nieto, Gerardo Guillen
Published in Journal of peptide science (01.01.2012)
Published in Journal of peptide science (01.01.2012)
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Journal Article
Proinflammatory Soluble Interleukin-15 Receptor Alpha Is Increased in Rheumatoid Arthritis
Machado Diaz, Ana Cecilia, Chico Capote, Araceli, Arrieta Aguero, Celia Aurora, Rodríguez Alvarez, Yunier, García del Barco Herrera, Diana, Estévez del Toro, Miguel, Guillen Nieto, Gerardo E., Santos Savio, Alicia
Published in Arthritis (01.01.2012)
Published in Arthritis (01.01.2012)
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Journal Article
Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells
Hsiung, Sunnie, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Savio, Alicia Santos, Hernandez, Rosmely, Malek, Thomas R
Published in ImmunoHorizons (17.12.2020)
Published in ImmunoHorizons (17.12.2020)
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Journal Article
Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates
Rodríguez-Álvarez, Yunier, Morera-Díaz, Yanelys, Gerónimo-Pérez, Haydee, Castro-Velazco, Jorge, Martínez-Castillo, Rafael, Puente-Pérez, Pedro, Besada-Pérez, Vladimir, Hardy-Rando, Eugenio, Chico-Capote, Araceli, Martínez-Cordovez, Klaudia, Santos-Savio, Alicia
Published in BMC immunology (26.09.2016)
Published in BMC immunology (26.09.2016)
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Journal Article
Obtention and characterization of the recombinant simian Interleukin-15 in Escherichia coli for the preclinical assessment of an IL-15-based therapeutic vaccine
Rodríguez-Álvarez, Yunier, Martínez-Cordovez, Klaudia, Llopiz-Arzuaga, Alexey, Ramos-Gómez, Yassel, Besada-Pérez, Vladimir, García-Lines, Dayana, Santos-Savio, Alicia
Published in Preparative biochemistry & biotechnology (21.10.2017)
Published in Preparative biochemistry & biotechnology (21.10.2017)
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Journal Article
PEPTIDES FOR TREATMENT OF THE HUMAN PAPILLOMAVIRUS(HPV)-ASSOCIATED CANCER AND OTHER EPITHELIAL TUMORS
SANTOS SAVIO, ALICIA, PUCHADES IZAGUIRRE, YAQUELIN, MORO SORIA, ALEJANDRO, PEREA RODRIGUEZ, SILVIO ERNESTO, SANTIAGO VISPO, NELSON FRANCISCO, GONZALEZ BARRIOS, BELKIS, SILVA RODRIGUEZ, RICARDO, REYES ACOSTA, OSVALDO, GONZALEZ LOPEZ, LUIS JAVIER
Year of Publication 31.01.2017
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Year of Publication 31.01.2017
Patent
peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, e, composição farmacêutica
Luis Javier González López, Silvio Ernesto Perea Rodríguez, Yaquelín Puchades Izaguirre, Osvaldo Reyes Acosta, Belkis González Barrios, Ricardo Silva Rodríguez, Alejandro Moro Soria, Alicia Santos Savio, Nelson Francisco Santiago Vispo
Year of Publication 25.05.2021
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Year of Publication 25.05.2021
Patent
Peptide antagonist of interleukin-15 activity
GERONIMO PEREZ HAYDEE, SANTOS SAVIO ALICIA, GARAY PEREZ HILDA ELISA, RODRIGUEZ ALVAREZ YUNIER, REYES ACOSTA OSVALDO, GUILLEN NIETO GERARDO ENRIQUE
Year of Publication 30.04.2013
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Year of Publication 30.04.2013
Patent
INTERLEUKIN-15 ANTAGONIST PEPTIDE
SANTOS SAVIO, ALICIA, ARRIETA AGUERO, CELIA AURORA, CABRALES RICO, ANIA, PEREA RODRIGUEZ, SILVIO ERNESTO, GERONIMO PEREZ, HAYDEE, REYES ACOSTA, OSVALDO
Year of Publication 21.08.2012
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Year of Publication 21.08.2012
Patent