Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2‑Substituted Benzamide Zinc Binding Group
Liu, Jian, Yu, Younong, Kelly, Joseph, Sha, Deyou, Alhassan, Abdul-Basit, Yu, Wensheng, Maletic, Milana M, Duffy, Joseph L, Klein, Daniel J, Holloway, M. Katharine, Carroll, Steve, Howell, Bonnie J, Barnard, Richard J. O, Wolkenberg, Scott, Kozlowski, Joseph A
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
Get full text
Journal Article
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes
Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Babu Boga, Sobhana, Alhassan, Abdul-Basit, Yu, Wensheng, Selyutin, Oleg, Yu, Younong, Anand, Rajan, Xu, Jiayi, Kelly, Joseph, Duffy, Joseph L., Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Bennett, Chad, Maloney, Kevin M., Tyagarajan, Sriram, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Get full text
Journal Article
Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology
Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Yao, Xin, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Hruza, Alan, Buevich, Alexei, Zhang, Li-Kang, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert
Published in Bioorganic & medicinal chemistry letters (15.06.2018)
Published in Bioorganic & medicinal chemistry letters (15.06.2018)
Get full text
Journal Article
Discovery of novel BTK inhibitors with carboxylic acids
Gao, Xiaolei, Wang, James, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Selyutin, Oleg, Yu, Wensheng, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Cooper, Alan, Zhu, Hugh, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joeseph A.
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Get full text
Journal Article
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis
Boga, Sobhana Babu, Alhassan, Abdul-Basit, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Zhu, Hugh, Desai, Jagdish, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Cooper, Alan, Kim, Ronald M., Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Get full text
Journal Article
Discovery of 8‑Amino-imidazo[1,5‑a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis
Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Yu, Younong, Vaccaro, Henry, Liu, Shilan, Yang, Chundao, Wu, Hao, Cooper, Alan, de Man, Jos, Kaptein, Allard, Maloney, Kevin, Hornak, Viktor, Gao, Ying-Duo, Fischmann, Thierry O, Raaijmakers, Hans, Vu-Pham, Diep, Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G, Bays, Nathan, Stivers, Peter, Brandish, Philip E, Hicks, Alexandra, Kim, Ronald, Kozlowski, Joseph A
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
Get full text
Journal Article
Azidonitration of Di-O-acetyl-L-fucal: X-Ray Crystal Structures of Intermediate Azidodeoxysugars and of the Bacterial Aminosugar N-Acetyl-L-fucosamine
Alhassan, Abdul-Basit, McCutcheon, David C., Zeller, Matthias, Norris, Peter
Published in Journal of carbohydrate chemistry (01.05.2012)
Published in Journal of carbohydrate chemistry (01.05.2012)
Get full text
Journal Article
4-Butyl-1-(2,3,4-tri-O-acetyl-β-l-fuco-pyranos-yl)-1H-1,2,3-triazole
Alhassan, Abdul-Basit, Norris, Peter, Zeller, Matthias
Published in Acta crystallographica. Section E, Structure reports online (25.07.2009)
Published in Acta crystallographica. Section E, Structure reports online (25.07.2009)
Get full text
Journal Article
1,2,3,4-Tetra- O -acetyl-α- L -fucopyranose
Alhassan, Abdul-Basit, Norris, Peter, Zeller, Matthias
Published in Acta crystallographica. Section E, Structure reports online (01.11.2005)
Published in Acta crystallographica. Section E, Structure reports online (01.11.2005)
Get full text
Journal Article
MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology
Boga, Sobhana Babu, Deng, Yongqi, Zhu, Liang, Nan, Yang, Cooper, Alan B., Shipps, Gerald W., Doll, Ronald, Shih, Neng-Yang, Zhu, Hugh, Sun, Robert, Wang, Tong, Paliwal, Sunil, Tsui, Hon-Chung, Gao, Xiaolei, Yao, Xin, Desai, Jagdish, Wang, James, Alhassan, Abdul Basit, Kelly, Joseph, Patel, Mehul, Muppalla, Kiran, Gudipati, Subrahmanyam, Zhang, Li-Kang, Buevich, Alexei, Hesk, David, Carr, Donna, Dayananth, Priya, Black, Stuart, Mei, Hong, Cox, Kathleen, Sherborne, Bradley, Hruza, Alan W., Xiao, Li, Jin, Weihong, Long, Brian, Liu, Gongjie, Taylor, Stacey A., Kirschmeier, Paul, Windsor, William T., Bishop, Robert, Samatar, Ahmed A.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
Get full text
Journal Article
BTK INHIBITORS
OUBRIE ARTHUR, ZHU HUGH Y, REWINKEL JOHANNES B.M, LIU SHILAN, YANG CHUNDAO, LIU JIAN, KAPTEIN ALLARD, BARF TJEERD A, JANS CHRISTIAAN G.J.M, ANAND RAJAN, WU HAO, STERRENBURG JAN GERARD, WIJKMANS JACOBUS C.H.M, WANG JAMES, YU YOUNONG, RAAIJMAKERS HANS C.A, KIM RONALD M, YAO XIN, COOPER ALAN B, VACCARO HENRY M, DE MAN ADRIANUS P.A, GAO XIAOLEI, ALHASSAN ABDUL BASIT, BOGA SOBHANA BABU
Year of Publication 05.06.2014
Get full text
Year of Publication 05.06.2014
Patent
Structure-based drug design of clinical compound MK-8353, a novel inhibitor of ERK
Hruza, Alan, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Buevich, Alexei, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2018)
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2018)
Get full text
Journal Article
COMPOUNDS THAT ARE ERK INHIBITORS
ZHU HUGH Y, TSUI HON CHUNG, PATEL MEHUL F, KELLY JOSEPH M, NAN YANG, DENG YONGQI, PALIWAL SUNIL, SHIH NENG YANG, DESAI JAGDISH A, DOLL RONALD J, YAO XIN, WANG JAMES J S, ZHU LIANG, COOPER ALAN B, ALHASSAN ABDUL BASIT, GAO XIAOLEI, SHIPPS GERALD W. JR, BOGA SOBHANA BABU, GUDIPATI SUBRAHMANYAM
Year of Publication 02.11.2010
Get full text
Year of Publication 02.11.2010
Patent
POLYCYCLIC INDAZOLE DERIVATIVES AND THEIR USE AS ERK INHIBITORS FOR THE TREATMENT OF CANCER
TSUI HON CHUNG, DESAI JAGDISH, DENG YONGQI, NAN YANG, PALIWAL SUNIL, SHIH NENG YANG, WANG JAMES, KELLY JOSEPH, DOLL RONALD, ZHU LIANG, ALHASSAN ABDUL BASIT, GAO XIAOLEI, SHIPPS GERALD W. JR, ZHU HUGH, COOPER ALAN, BOGA SOBHANA BABU, PATEL MEHUL
Year of Publication 09.03.2010
Get full text
Year of Publication 09.03.2010
Patent
BTK INHIBITORS
BOGA, Sobhana Babu, YU, Younong, WU, Hao, ALHASSAN, Abdul-Basit, YANG, Chundao, LIU, Shilan, ANAND, Rajan, KOZLOWSKI, Joseph, A, YU, Wensheng, GUIADEEN, Deodialsingh, LIU, Jian
Year of Publication 06.11.2024
Get full text
Year of Publication 06.11.2024
Patent
BENZAMIDE IMIDAZOPYRAZINE BTK INHIBITORS
WANG, Dahai, WU, Hao, LIU, Shilan, WANG, Jyhshing, KOZLOWSKI, Joseph, A, GUIADEEN, Deodialsingh, LIU, Jian, BOGA, Sobhana Babu, CAI, Jiaqiang, ALHASSAN, Abdul-Basit, YANG, Chundao, YU, Wensheng, GAO, Xiaolei
Year of Publication 01.11.2023
Get full text
Year of Publication 01.11.2023
Patent
BTK inhibitors
Yu, Younong, Liu, Jian, Anand, Rajan, Guiadeen, Deodial Guy, Yu, Wensheng, Wu, Hao, Liu, Shilan, Alhassan, Abdul-Basit, Yang, Chundao, Kozlowski, Joseph A, Boga, Sobhana Babu
Year of Publication 20.11.2018
Get full text
Year of Publication 20.11.2018
Patent
NOVEL COMPOUNDS THAT ARE ERK INHIBITORS
Gao;, Xiaolei, Lo;, Sie-Mun, Alhassan;, Abdul-Basit, Yao;, Xin, Zhu;, Liang, Boga;, Sobhana Babu, Wang;, James J-S, Zhu;, Hugh, Y, Gudipati;, Subrahmanyam, Shipps;, Gerald, W., Jr, Kelly;, Joseph, M, Deng;, Yongqi, Cooper;, Alan, B, Desai;, Jagdish, A
Year of Publication 11.09.2019
Get full text
Year of Publication 11.09.2019
Patent