Enhancing the Safety and Efficacy of PSMA-Based Small-Molecule Drug Conjugates by Linker Stabilization and Conjugation to Transthyretin Binding Ligand
Amin, Toufiq Ul, Emara, Rasha, Pal, Arindom, Aldawod, Hala, Jiang, Guanming, Liang, Dengpan, Haque Tuhin, Md Tariqul, Balgoname, Abdulmalek, Patel, Arjun D., Alhamadsheh, Mamoun M.
Published in Journal of medicinal chemistry (24.11.2022)
Published in Journal of medicinal chemistry (24.11.2022)
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Journal Article
A biomimetic approach for enhancing the in vivo half-life of peptides
Penchala, Sravan C, Miller, Mark R, Pal, Arindom, Dong, Jin, Madadi, Nikhil R, Xie, Jinghang, Joo, Hyun, Tsai, Jerry, Batoon, Patrick, Samoshin, Vyacheslav, Franz, Andreas, Cox, Trever, Miles, Jesse, Chan, William K, Park, Miki S, Alhamadsheh, Mamoun M
Published in Nature chemical biology (01.10.2015)
Published in Nature chemical biology (01.10.2015)
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Journal Article
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin
Penchala, Sravan C., Connelly, Stephen, Wang, Yu, Park, Miki S., Zhao, Lei, Baranczak, Aleksandra, Rappley, Irit, Vogel, Hannes, Liedtke, Michaela, Witteles, Ronald M., Powers, Evan T., Reixach, Natàlia, Chan, William K., Wilson, Ian A., Kelly, Jeffery W., Graef, Isabella A., Alhamadsheh, Mamoun M.
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
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Journal Article
Peripherally restricted transthyretin-based delivery system for probes and therapeutics avoiding opioid-related side effects
Tuhin, Md Tariqul Haque, Liang, Dengpan, Liu, Fang, Aldawod, Hala, Amin, Toufiq Ul, Ho, Joshua S., Emara, Rasha, Patel, Arjun D., Felmlee, Melanie A., Park, Miki S., Uchizono, James A., Alhamadsheh, Mamoun M.
Published in Nature communications (23.06.2022)
Published in Nature communications (23.06.2022)
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Journal Article
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine
Eustáquio, Alessandra S, McGlinchey, Ryan P, Liu, Yuan, Hazzard, Christopher, Beer, Laura L, Florova, Galina, Alhamadsheh, Mamoun M, Lechner, Anna, Kale, Andrew J, Kobayashi, Yoshihisa, Reynolds, Kevin A, Moore, Bradley S
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2009)
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Journal Article
Modular Polyketide Synthases and cis Double Bond Formation: Establishment of Activated cis-3-Cyclohexylpropenoic Acid as the Diketide Intermediate in Phoslactomycin Biosynthesis
Alhamadsheh, Mamoun M, Palaniappan, Nadaraj, DasChouduri, Suparna, Reynolds, Kevin A
Published in Journal of the American Chemical Society (21.02.2007)
Published in Journal of the American Chemical Society (21.02.2007)
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Journal Article
Enhancing the Pharmacokinetic Profile of Interleukin 2 through Site-Specific Conjugation to a Selective Small-Molecule Transthyretin Ligand
Liu, Fang, Ul Amin, Toufiq, Liang, Dengpan, Park, Miki S, Alhamadsheh, Mamoun M
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Journal Article
Hydrophilic Small Molecules That Harness Transthyretin To Enhance the Safety and Efficacy of Targeted Chemotherapeutic Agents
Pal, Arindom, Albusairi, Wabel, Liu, Fang, Tuhin, Md Tariqul Haque, Miller, Mark, Liang, Dengpan, Joo, Hyun, Amin, Toufiq Ul, Wilson, Elizabeth A, Faridi, Jesika S, Park, Miki, Alhamadsheh, Mamoun M
Published in Molecular pharmaceutics (01.07.2019)
Published in Molecular pharmaceutics (01.07.2019)
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Journal Article
Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity
Alhamadsheh, Mamoun M, Connelly, Stephen, Cho, Ahryon, Reixach, Natàlia, Powers, Evan T, Pan, Dorothy W, Wilson, Ian A, Kelly, Jeffery W, Graef, Isabella A
Published in Science translational medicine (24.08.2011)
Published in Science translational medicine (24.08.2011)
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Journal Article
Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli β-ketoacyl-ACP-synthase III (FabH)
Alhamadsheh, Mamoun M., Waters, Norman C., Huddler, Donald P., Kreishman-Deitrick, Mara, Florova, Galina, Reynolds, Kevin A.
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
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Journal Article
Application of a Newly Identified and Characterized 18-O-Acyltransferase in Chemoenzymatic Synthesis of Selected Natural and Nonnatural Bioactive Derivatives of Phoslactomycins
Ghatge, Mohini S, Palaniappan, Nadaraj, Alhamadsheh, Ma'moun M, DiBari, Jessica, Reynolds, Kevin A
Published in Applied and Environmental Microbiology (01.06.2009)
Published in Applied and Environmental Microbiology (01.06.2009)
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Journal Article
Elucidation of the Streptomyces coelicolor Pathway to 2-Undecylpyrrole, a Key Intermediate in Undecylprodiginine and Streptorubin B Biosynthesis
Mo, SangJoon, Sydor, Paulina K., Corre, Christophe, Alhamadsheh, Mamoun M., Stanley, Anna E., Haynes, Stuart W., Song, Lijiang, Reynolds, Kevin A., Challis, Gregory L.
Published in Chemistry & biology (01.02.2008)
Published in Chemistry & biology (01.02.2008)
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Journal Article
Breaking protein-protein interactions: A combined chemical and computational approach to develop a new class of protein aggregation inhibitors
Graef, Isabella, Alhamadsheh, Mamoun M, Esteras-Chopo, Alexandra, Branson, Kim, Bose, Mohua, Pande, Vijay
Published in Alzheimer's & dementia (01.07.2009)
Published in Alzheimer's & dementia (01.07.2009)
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Journal Article
Design, Total Synthesis, and Evaluation of Novel Open-Chain Epothilone Analogues
Alhamadsheh, Mamoun M, Hudson, Richard A, Viranga Tillekeratne, L. M
Published in Organic letters (16.02.2006)
Published in Organic letters (16.02.2006)
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Journal Article
Unsymmetric aryl–alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis
Turos, Edward, Revell, Kevin D., Ramaraju, Praveen, Gergeres, Danielle A., Greenhalgh, Kerriann, Young, Ashley, Sathyanarayan, Nalini, Dickey, Sonja, Lim, Daniel, Alhamadsheh, Mamoun M., Reynolds, Kevin
Published in Bioorganic & medicinal chemistry (01.07.2008)
Published in Bioorganic & medicinal chemistry (01.07.2008)
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Journal Article
Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates
Sachdeva, Sarbjot, Musayev, Faik, Alhamadsheh, Mamoun M., Neel Scarsdale, J., Tonie Wright, H., Reynolds, Kevin A.
Published in Bioorganic chemistry (01.04.2008)
Published in Bioorganic chemistry (01.04.2008)
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