Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3
Chadwick, Alexandra C, Evitt, Niklaus H, Lv, Wenjian, Musunuru, Kiran
Published in Circulation (New York, N.Y.) (27.02.2018)
Published in Circulation (New York, N.Y.) (27.02.2018)
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Journal Article
CRISPR-Cas9 Genome Editing for Treatment of Atherogenic Dyslipidemia
Chadwick, Alexandra C, Musunuru, Kiran
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2018)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2018)
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Journal Article
In utero CRISPR-mediated therapeutic editing of metabolic genes
Rossidis, Avery C., Stratigis, John D., Chadwick, Alexandra C., Hartman, Heather A., Ahn, Nicholas J., Li, Haiying, Singh, Kshitiz, Coons, Barbara E., Li, Li, Lv, Wenjian, Zoltick, Philip W., Alapati, Deepthi, Zacharias, William, Jain, Rajan, Morrisey, Edward E., Musunuru, Kiran, Peranteau, William H.
Published in Nature medicine (01.10.2018)
Published in Nature medicine (01.10.2018)
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In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
Musunuru, Kiran, Chadwick, Alexandra C., Mizoguchi, Taiji, Garcia, Sara P., DeNizio, Jamie E., Reiss, Caroline W., Wang, Kui, Iyer, Sowmya, Dutta, Chaitali, Clendaniel, Victoria, Amaonye, Michael, Beach, Aaron, Berth, Kathleen, Biswas, Souvik, Braun, Maurine C., Chen, Huei-Mei, Colace, Thomas V., Ganey, John D., Gangopadhyay, Soumyashree A., Garrity, Ryan, Kasiewicz, Lisa N., Lavoie, Jennifer, Madsen, James A., Matsumoto, Yuri, Mazzola, Anne Marie, Nasrullah, Yusuf S., Nneji, Joseph, Ren, Huilan, Sanjeev, Athul, Shay, Madeleine, Stahley, Mary R., Fan, Steven H. Y., Tam, Ying K., Gaudelli, Nicole M., Ciaramella, Giuseppe, Stolz, Leslie E., Malyala, Padma, Cheng, Christopher J., Rajeev, Kallanthottathil G., Rohde, Ellen, Bellinger, Andrew M., Kathiresan, Sekar
Published in Nature (London) (20.05.2021)
Published in Nature (London) (20.05.2021)
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In utero gene editing for monogenic lung disease
Alapati, Deepthi, Zacharias, William J, Hartman, Heather A, Rossidis, Avery C, Stratigis, John D, Ahn, Nicholas J, Coons, Barbara, Zhou, Su, Li, Hiaying, Singh, Kshitiz, Katzen, Jeremy, Tomer, Yaniv, Chadwick, Alexandra C, Musunuru, Kiran, Beers, Michael F, Morrisey, Edward E, Peranteau, William H
Published in Science translational medicine (17.04.2019)
Published in Science translational medicine (17.04.2019)
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GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy
Kasiewicz, Lisa N., Biswas, Souvik, Beach, Aaron, Ren, Huilan, Dutta, Chaitali, Mazzola, Anne Marie, Rohde, Ellen, Chadwick, Alexandra, Cheng, Christopher, Garcia, Sara P., Iyer, Sowmya, Matsumoto, Yuri, Khera, Amit V., Musunuru, Kiran, Kathiresan, Sekar, Malyala, Padma, Rajeev, Kallanthottathil G., Bellinger, Andrew M.
Published in Nature communications (15.05.2023)
Published in Nature communications (15.05.2023)
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Journal Article
Acrolein impairs the cholesterol transport functions of high density lipoproteins
Chadwick, Alexandra C, Holme, Rebecca L, Chen, Yiliang, Thomas, Michael J, Sorci-Thomas, Mary G, Silverstein, Roy L, Pritchard, Jr, Kirkwood A, Sahoo, Daisy
Published in PloS one (07.04.2015)
Published in PloS one (07.04.2015)
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Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis
Chen, Yiliang, Kennedy, David J, Ramakrishnan, Devi Prasadh, Yang, Moua, Huang, Wenxin, Li, Zhichuan, Xie, Zijian, Chadwick, Alexandra C, Sahoo, Daisy, Silverstein, Roy L
Published in Science signaling (08.09.2015)
Published in Science signaling (08.09.2015)
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Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress
Korytowski, Witold, Wawak, Katarzyna, Pabisz, Pawel, Schmitt, Jared C, Chadwick, Alexandra C, Sahoo, Daisy, Girotti, Albert W
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.2015)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.2015)
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Journal Article
CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity
Beres, Amy J, Haribhai, Dipica, Chadwick, Alexandra C, Gonyo, Patrick J, Williams, Calvin B, Drobyski, William R
Published in The Journal of immunology (1950) (01.07.2012)
Published in The Journal of immunology (1950) (01.07.2012)
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NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper Motif
Chadwick, Alexandra C., Jensen, Davin R., Hanson, Paul J., Lange, Philip T., Proudfoot, Sarah C., Peterson, Francis C., Volkman, Brian F., Sahoo, Daisy
Published in Structure (London) (07.03.2017)
Published in Structure (London) (07.03.2017)
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Journal Article
Where is the History of Political Thought Going?
John Dunn, Humeira Iqtidar, Iain Hampsher-Monk, Richard Bourke, Adrian Blau, Alexandra Chadwick, Duncan Kelly, David Leopold, Peter Burke, Richard Whatmore
Published in Scienza e politica (01.09.2023)
Published in Scienza e politica (01.09.2023)
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Expression, purification and reconstitution of the C-terminal transmembrane domain of scavenger receptor BI into detergent micelles for NMR analysis
Chadwick, Alexandra C., Jensen, Davin R., Peterson, Francis C., Volkman, Brian F., Sahoo, Daisy
Published in Protein expression and purification (01.03.2015)
Published in Protein expression and purification (01.03.2015)
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Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells
Kropp, Erin M., Oleson, Bryndon J., Broniowska, Katarzyna A., Bhattacharya, Subarna, Chadwick, Alexandra C., Diers, Anne R., Hu, Qinghui, Sahoo, Daisy, Hogg, Neil, Boheler, Kenneth R., Corbett, John A., Gundry, Rebekah L.
Published in Stem cells translational medicine (01.05.2015)
Published in Stem cells translational medicine (01.05.2015)
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