Search Results - "ALEXANDER L RUCHELMAN" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

by Ruchelman, Alexander L., Man, Hon-Wah, Zhang, Weihong, Chen, Roger, Capone, Lori, Kang, Jian, Parton, Anastasia, Corral, Laura, Schafer, Peter H., Babusis, Darius, Moghaddam, Mehran F., Tang, Yang, Shirley, Michael A., Muller, George W.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)

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A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

by Matyskiela, Mary E, Lu, Gang, Ito, Takumi, Pagarigan, Barbra, Lu, Chin-Chun, Miller, Karen, Fang, Wei, Wang, Nai-Yu, Nguyen, Derek, Houston, Jack, Carmel, Gilles, Tran, Tam, Riley, Mariko, Nosaka, Lyn'Al, Lander, Gabriel C, Gaidarova, Svetlana, Xu, Shuichan, Ruchelman, Alexander L, Handa, Hiroshi, Carmichael, James, Daniel, Thomas O, Cathers, Brian E, Lopez-Girona, Antonia, Chamberlain, Philip P
Published in Nature (London) (14.07.2016)

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1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

by Ruchelman, Alexander L., Man, Hon-Wah, Chen, Roger, Liu, Wei, Lu, Ling, Cedzik, Dorota, Zhang, Ling, Leisten, Jim, Collette, Alice, Narla, Rama Krishna, Raymon, Heather K., Muller, George W.
Published in Bioorganic & medicinal chemistry (01.11.2011)

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Special issue of Medicinal Chemistry Research in honor of Professor Edmond J. LaVoie

Special issue of Medicinal Chemistry Research in honor of Professor Edmond J. LaVoie

by Ruchelman, Alexander L., Hu, Longqin
Published in Medicinal chemistry research (01.10.2022)

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Journal Article

5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-Alkyl Substituents Modulates Sensitivity to Efflux Transporters Associated with Multidrug Resistance

5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-Alkyl Substituents Modulates Sensitivity to Efflux Transporters Associated with Multidrug Resistance

by Ruchelman, Alexander L, Houghton, Peter J, Zhou, Nai, Liu, Angela, Liu, Leroy F, LaVoie, Edmond J
Published in Journal of medicinal chemistry (10.02.2005)

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Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[ i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents

Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[ i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents

by Zhu, Shejin, Ruchelman, Alexander L., Zhou, Nai, Liu, Angela A., Liu, Leroy F., LaVoie, Edmond J.
Published in Bioorganic & medicinal chemistry (15.12.2005)

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Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug

Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug

by LI, Tsai-Kun, HOUGHTON, Peter J, DESAI, Shyamal D, DAROUI, Parima, LIU, Angela A, HARS, Eszter S, RUCHELMAN, Alexander L, LAVOIE, Edmond J, LIU, Leroy F
Published in Cancer research (Chicago, Ill.) (01.12.2003)

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5H-dibenzo[c, h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

5H-dibenzo[c, h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

by RUCHELMAN, Alexander L, SINGH, Sudhir K, RAY, Abhijit, XIAO HUA WU, YANG, Jin-Ming, LI, Tsai-Kun, LIU, Angela, LIU, Leroy F, LAVOIE, Edmond J
Published in Bioorganic & medicinal chemistry (01.05.2003)

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6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5 -ones : Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5 -ones : Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

by SHEJIN ZHU, RUCHELMAN, Alexander L, NAI ZHOU, LIU, Angela, LIU, Leroy F, LAVOIE, Edmond J
Published in Bioorganic & medicinal chemistry (01.05.2006)

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11H-isoquino[4,3-c]cinnolin-12-ones: novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

11H-isoquino[4,3-c]cinnolin-12-ones: novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

by RUCHELMAN, Alexander L, SINGH, Sudhir K, RAY, Abhijit, XIAOHUA WU, YANG, Jin-Ming, NAI ZHOU, LIU, Angela, LIU, Leroy F, LAVOIE, Edmond J
Published in Bioorganic & medicinal chemistry (15.02.2004)

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Journal Article

Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity

Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity

by Singh, Sudhir K, Ruchelman, Alexander L, Li, Tsai-Kun, Liu, Angela, Liu, Leroy F, LaVoie, Edmond J
Published in Journal of medicinal chemistry (22.05.2003)

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Journal Article

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

by Matyskiela, Mary E., Lu, Gang, Ito, Takumi, Pagarigan, Barbra, Lu, Chin-Chun, Miller, Karen, Fang, Wei, Wang, Nai-Yu, Nguyen, Derek, Houston, Jack, Carmel, Gilles, Tran, Tam, Riley, Mariko, Nosaka, Lyn’Al, Lander, Gabriel C., Gaidarova, Svetlana, Xu, Shuichan, Ruchelman, Alexander L., Handa, Hiroshi, Carmichael, James, Daniel, Thomas O., Cathers, Brian E., Lopez-Girona, Antonia, Chamberlain, Philip P.
Published in Nature (London) (22.06.2016)

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Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435

Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435

by Ruchelman, Alexander L., Singh, Sudhir K., Wu, Xiaohua, Ray, Abhijit, Yang, Jin-Ming, Li, Tsai-Kun, Liu, Angela, Liu, Leroy F., LaVoie, Edmond J.
Published in Bioorganic & medicinal chemistry letters (18.11.2002)

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Journal Article

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity

by Ruchelman, Alexander L, Kerrigan, John E, Li, Tsai-Kun, Zhou, Nai, Liu, Angela, Liu, Leroy F, LaVoie, Edmond J
Published in Bioorganic & medicinal chemistry (01.07.2004)

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Journal Article

4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME

4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME

by MULLER GEORG W, ALEXANDER L RUCHELMAN, MAN HON-WAH
Year of Publication 08.02.2018

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Patent

ISOINDOLINE COMPOUNDS FOR USE IN TREATMENT OF CANCER

ISOINDOLINE COMPOUNDS FOR USE IN TREATMENT OF CANCER

by GEORGE W MULLER, ALEXANDER L RUCHELMAN
Year of Publication 17.12.2015

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Patent

ISOINDOLINE COMPOUNDS FOR USE IN CANCER TREATMENT

ISOINDOLINE COMPOUNDS FOR USE IN CANCER TREATMENT

by GEORGE W MULLER, ALEXANDER L RUCHELMAN
Year of Publication 04.12.2014

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Patent

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c, h][2,6]naphthyridin-5-ones with potent topoisomerase i-targeting activity and cytotoxicity

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c, h][2,6]naphthyridin-5-ones with potent topoisomerase i-targeting activity and cytotoxicity

by RUCHELMAN, Alexander L, SHEJIN ZHU, NAI ZHOU, LIU, Angela, LIU, Leroy F, LAVOIE, Edmond J
Published in Bioorganic & medicinal chemistry letters (15.11.2004)

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Journal Article

4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME AND METHODS OF USING THE SAME

4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME AND METHODS OF USING THE SAME

by MULLER GEORG W, ALEXANDER L RUCHELMAN, MAN HON-WAH
Year of Publication 28.04.2016

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Patent

Enantioselective synthesis of the apremilast aminosulfone using catalytic asymmetric hydrogenation

Enantioselective synthesis of the apremilast aminosulfone using catalytic asymmetric hydrogenation

by Ruchelman, Alexander L., Connolly, Terrence J.
Published in Tetrahedron: asymmetry (31.05.2015)

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Journal Article

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