Enantioselective Total Synthesis of Quadrigemine C and Psycholeine
Lebsack, Alec D, Link, J. T, Overman, Larry E, Stearns, Brian A
Published in Journal of the American Chemical Society (07.08.2002)
Published in Journal of the American Chemical Society (07.08.2002)
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Journal Article
Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist
Maher, Michael P., Bhattacharya, Anindya, Ao, Hong, Swanson, Nadia, Wu, Nyan-Tsz, Freedman, Jamie, Kansagara, Mena, Scott, Brian, Li, Dong H., Eckert, William A., Liu, Yi, Sepassi, Kia, Rizzolio, Michele, Fitzgerald, Anne, Liu, Jing, Branstetter, Bryan J., Rech, Jason C., Lebsack, Alec D., Breitenbucher, J. Guy, Wickenden, Alan D., Chaplan, Sandra R.
Published in European journal of pharmacology (01.08.2011)
Published in European journal of pharmacology (01.08.2011)
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Journal Article
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction
Blevitt, Jonathan M, Hack, Michael D, Herman, Krystal L, Jackson, Paul F, Krawczuk, Paul J, Lebsack, Alec D, Liu, Annie X, Mirzadegan, Taraneh, Nelen, Marina I, Patrick, Aaron N, Steinbacher, Stefan, Milla, Marcos E, Lumb, Kevin J
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
Enantioselective Total Synthesis of Shahamin K
Lebsack, Alec D, Overman, Larry E, Valentekovich, Robert J
Published in Journal of the American Chemical Society (23.05.2001)
Published in Journal of the American Chemical Society (23.05.2001)
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Journal Article
Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry
Damm-Ganamet, Kelly L, Arora, Nidhi, Becart, Stephane, Edwards, James P, Lebsack, Alec D, McAllister, Heather M, Nelen, Marina I, Rao, Navin L, Westover, Lori, Wiener, John J. M, Mirzadegan, Taraneh
Published in Journal of chemical information and modeling (28.05.2019)
Published in Journal of chemical information and modeling (28.05.2019)
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Journal Article
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors
Blevitt, Jonathan M., Hack, Michael D., Herman, Krystal, Chang, Leon, Keith, John M., Mirzadegan, Tara, Rao, Navin L., Lebsack, Alec D., Milla, Marcos E.
Published in The Journal of biological chemistry (10.06.2016)
Published in The Journal of biological chemistry (10.06.2016)
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Journal Article
Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity
Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists
Rech, Jason C., Bhattacharya, Anindya, Branstetter, Bryan J., Love, Christopher J., Leenaerts, Joseph E., Cooymans, Ludwig P., Eckert, William A., Ao, Hong, Wang, Qi, Chaplan, Sandra R., Wickenden, Alan D., Lebsack, Alec D., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Journal Article
Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform
Song, Jiao, Liu, Xuejun, Zhu, Jian, Tootoonchi, Mandana, Keith, John M, Meduna, Steven P, Dvorak, Curt A, Eccles, Wendy, Krawczuk, Paul J, Blevitt, Jonathan M, Wu, Jiejun, Rao, Navin L, Lebsack, Alec D, Milla, Marcos E
Published in Journal of biomolecular screening (01.02.2016)
Published in Journal of biomolecular screening (01.02.2016)
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Journal Article
Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the α2δ-1 subunit of voltage gated calcium channel
LEBSACK, Alec D, GUNZNER, Janet, VENKATRAMAN, Shankar, BOWEI WANG, PRACITTO, Richard, SCHAFFHAUSER, Hervé, SANTINI, Angelina, AIYAR, Jayashree, BEZVERKOV, Robert, MUNOZ, Benito, WENSHENG LIU
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
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Journal Article
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists
HAWRYLUK, Natalie A, MERIT, Jeffrey E, FREEDMAN, Jamie M, SCOTT, Brian P, WICKENDEN, Alan D, CHAPLAN, Sandra R, BREITENBUCHER, J. Guy, LEBSACK, Alec D, BRANSTETTER, Bryan J, HACK, Michael D, SWANSON, Nadia, HONG AO, MAHER, Michael P, BHATTACHARYA, Anindya, QI WANG
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Journal Article
Identification and synthesis of 2,7-diamino-thiazolo[5,4- d]pyrimidine derivatives as TRPV1 antagonists
Lebsack, Alec D., Branstetter, Bryan J., Hack, Michael D., Xiao, Wei, Peterson, Matthew L., Nasser, Nadia, Maher, Michael P., Ao, Hong, Bhattacharya, Anindya, Kansagara, Mena, Scott, Brian P., Luo, Lin, Rynberg, Raymond, Rizzolio, Michele, Chaplan, Sandra R., Wickenden, Alan D., Guy Breitenbucher, J.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
Discovery of N-{ N-[(3-cyanobenzene) sulfonyl]-4( R)-(3,3-difluoropiperidin-1-yl)-( l)-prolyl}-4-[(3′,5′-dichloro-isonicotinoyl) amino]-( l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist
Venkatraman, Shankar, Lebsack, Alec D., Alves, Kenneth, Gardner, Michael F., James, Joyce, Lingham, Russell B., Maniar, Salony, Mumford, Richard A., Si, Qian, Stock, Nicholas, Treonze, Kelly M., Wang, Bowei, Zunic, Jasmine, Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Journal Article
1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties
LEBSACK, Alec D, RECH, Jason C, HONG AO, MAHER, Michael P, HERRMANN, Michelle, FREEDMAN, Jamie, SCOTT, Brian P, LIN LUO, BHATTACHARYA, Anindya, QI WANG, CHAPLAN, Sandra R, WICKENDEN, Alan D, BRANSTETTER, Bryan J, BREITENBUCHER, J. Guy, HAWRYLUK, Natalie A, MERIT, Jeffrey E, ALLISON, Brett, RYNBERG, Raymond, BUMA, Johnathan, RIZZOLIO, Michele, SWANSON, Nadia
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Journal Article
The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)p y rimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists
Rech, Jason C, Bhattacharya, Anindya, Branstetter, Bryan J, Love, Christopher J, Leenaerts, Joseph E, Cooymans, Ludwig P, Eckert, William A, Ao, Hong, Wang, Qi, Chaplan, Sandra R, Wickenden, Alan D, Lebsack, Alec D, Breitenbucher, JGuy
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Journal Article
Discovery and synthesis of 6,7,8,9-tetrahydro-5 H-pyrimido-[4,5- d]azepines as novel TRPV1 antagonists
Hawryluk, Natalie A., Merit, Jeffrey E., Lebsack, Alec D., Branstetter, Bryan J., Hack, Michael D., Swanson, Nadia, Ao, Hong, Maher, Michael P., Bhattacharya, Anindya, Wang, Qi, Freedman, Jamie M., Scott, Brian P., Wickenden, Alan D., Chaplan, Sandra R., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5 H-pyrimido[4,5- d]azepines as TRPV1 antagonists with improved properties
Lebsack, Alec D., Rech, Jason C., Branstetter, Bryan J., Hawryluk, Natalie A., Merit, Jeffrey E., Allison, Brett, Rynberg, Raymond, Buma, Johnathan, Rizzolio, Michele, Swanson, Nadia, Ao, Hong, Maher, Michael P., Herrmann, Michelle, Freedman, Jamie, Scott, Brian P., Luo, Lin, Bhattacharya, Anindya, Wang, Qi, Chaplan, Sandra R., Wickenden, Alan D., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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