Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity
Campagne, Olivia, Delmas, Audrey, Fouliard, Sylvain, Chenel, Marylore, Chichili, Gurunadh R, Li, Hua, Alderson, Ralph, Scherrmann, Jean-Michel, Mager, Donald E
Published in Clinical cancer research (01.06.2018)
Published in Clinical cancer research (01.06.2018)
Get full text
Journal Article
Development of an Fc-Enhanced Anti―B7-H3 Monoclonal Antibody with Potent Antitumor Activity
LOO, Deryk, ALDERSON, Ralph F, SON, Tom, YAN CHEN, EASTON, Ann N, LI, Jonathan C, RILLEMA, Jill R, LICEA, Monica, FIEGER, Claudia, LIANG, Tony W, MATHER, Jennie P, KOENIG, Scott, CHEN, Francine Z, STEWART, Stanford J, JOHNSON, Syd, BONVINI, Ezio, MOORE, Paul A, LING HUANG, WENJUN ZHANG, GORLATOV, Sergey, BURKE, Steve, CICCARONE, Valentina, HUA LI, YINHUA YANG
Published in Clinical cancer research (15.07.2012)
Published in Clinical cancer research (15.07.2012)
Get full text
Journal Article
MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies
Liu, Liqin, Lam, Chia-Ying K, Long, Vatana, Widjaja, Lusiana, Yang, Yinhua, Li, Hua, Jin, Linda, Burke, Steve, Gorlatov, Sergey, Brown, Jennifer, Alderson, Ralph, Lewis, Margaret D, Nordstrom, Jeffrey L, Koenig, Scott, Moore, Paul A, Johnson, Syd, Bonvini, Ezio
Published in Clinical cancer research (15.03.2017)
Published in Clinical cancer research (15.03.2017)
Get full text
Journal Article
CAT-8015: A Second-Generation Pseudomonas Exotoxin A–Based Immunotherapy Targeting CD22-Expressing Hematologic Malignancies
ALDERSON, Ralph F, KREITMAN, RobertJ, CHEN, Tianling, YEUNG, Peter, HERBST, Ronald, FOX, JudyA, PASTAN, Ira
Published in Clinical cancer research (01.02.2009)
Published in Clinical cancer research (01.02.2009)
Get full text
Journal Article
682 Antibody-mediated blockade of interleukin-10 receptor-alpha promotes the activation of immune cells from in vitro dissociated tumor samples
Berezhnoy, Alexey, Shah, Kalpana, Liu, Daorong, Lung, Peter, Long, Vatana, Stahl, Kurt, Smith, Douglas, Chen, Francine, Li, Hua, Li, Jonathan, Alderson, Ralph, Ciccarone, Valentina, Tamura, James, Bonvini, Ezio, Diedrich, Gundo, Moore, Paul
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
Get full text
Journal Article
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression
Maisonpierre, Peter C., Belluscio, Leonardo, Friedman, Beth, Alderson, Ralph F., Wiegand, Stanley J., Furth, Mark E., Lindsay, Ronald M., Yancopoulos, George D.
Published in Neuron (Cambridge, Mass.) (01.10.1990)
Published in Neuron (Cambridge, Mass.) (01.10.1990)
Get full text
Journal Article
Vascular Endothelial Cell Growth Factors Promote the In Vitro Development of Rat Photoreceptor Cells
Yourey, Pamela A, Gohari, Shiva, Su, Jeffery L, Alderson, Ralph F
Published in The Journal of neuroscience (15.09.2000)
Published in The Journal of neuroscience (15.09.2000)
Get full text
Journal Article
Characterization of a CC49-Based Single-Chain Fragment−β-Lactamase Fusion Protein for Antibody-Directed Enzyme Prodrug Therapy (ADEPT)
Alderson, Ralph F, Toki, Brian E, Roberge, Martin, Geng, Wei, Basler, Joshua, Chin, Regina, Liu, Amy, Ueda, Roanna, Hodges, Douglas, Escandon, Enrique, Chen, Tianling, Kanavarioti, Tessi, Babé, Lilia, Senter, Peter D, Fox, Judith A, Schellenberger, Volker
Published in Bioconjugate chemistry (01.03.2006)
Published in Bioconjugate chemistry (01.03.2006)
Get full text
Journal Article
Characterization of the Signal Transduction Pathway Activated in Human Monocytes and Dendritic Cells by MPIF-1, a Specific Ligand for CC Chemokine Receptor 1
Nardelli, Bernardetta, Tiffany, H. Lee, Bong, Gary W, Yourey, Pamela A, Morahan, Diana K, Li, Yuling, Murphy, Philip M, Alderson, Ralph F
Published in The Journal of immunology (1950) (01.01.1999)
Published in The Journal of immunology (1950) (01.01.1999)
Get full text
Journal Article
Expression of Ciliary Neurotrophic Factor and the Neurotrophins-Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin 3-in Cultured Rat Hippocampal Astrocytes
Rudge, John S., Alderson, Ralph F., Pasnikowski, Elizabeth, McClain, Joyce, Ip, Nancy Y., Lindsay, Ronald M.
Published in The European journal of neuroscience (01.06.1992)
Published in The European journal of neuroscience (01.06.1992)
Get more information
Journal Article
A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: preclinical activity and safety in nonhuman primates
Chichili, Gurunadh R, Huang, Ling, Li, Hua, Burke, Steve, He, Leilei, Tang, Qin, Jin, Linda, Gorlatov, Sergey, Ciccarone, Valentina, Chen, Francine, Koenig, Scott, Shannon, Michele, Alderson, Ralph, Moore, Paul A, Johnson, Syd, Bonvini, Ezio
Published in Science translational medicine (27.05.2015)
Published in Science translational medicine (27.05.2015)
Get more information
Journal Article
Combinatorial Anti-Tumor Activity in Animal Models of a Novel CD123 x CD3 Bispecific Dart® Molecule (MGD024) with Cytarabine, Venetoclax or Azacitidine Supports Combination Therapy in Acute Myeloid Leukemia
Alderson, Ralph F., Huang, Ling, Zhang, Xiaoyu, Li, Haiquan, Kaufman, Thomas, Diedrich, Gundo, Moore, Paul, Bonvini, Ezio
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
Get full text
Journal Article
In vitro and in vivo effects of repifermin (keratinocyte growth factor-2, KGF-2) on human carcinoma cells
ALDERSON, Ralph, GOHARI-FRITSCH, Shiva, OLSEN, Hendrik, ROSCHKE, Viktor, VANCE, Courtney, CONNOLLY, Kevin
Published in Cancer chemotherapy and pharmacology (01.09.2002)
Published in Cancer chemotherapy and pharmacology (01.09.2002)
Get full text
Journal Article
Modeling Flotetuzumab-Associated CRS in AML Using in Vitro and in Vivo Preclinical Models
Patel, Dilan Anil, Chendamarai, Ezhilarasi, Ritchey, Julie K., Rettig, Michael P., Gehrs, Leah, Moore, Paul, Alderson, Ralph F., Bonvini, Ezio, Christopher, Matthew, DiPersio, John F.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
Modeling Flotetuzumab-Associated CRS in AML Using inVitro and inVivo Preclinical Models
Patel, Dilan Anil, Chendamarai, Ezhilarasi, Ritchey, Julie K., Rettig, Michael P., Gehrs, Leah, Moore, Paul, Alderson, Ralph F., Bonvini, Ezio, Christopher, Matthew, DiPersio, John F.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
POSTER: AML-080 Modeling Flotetuzumab-Associated Cytokine Release Syndrome (CRS) in AML Using In Vitro and In Vivo Preclinical Models
Patel, Dilan, Chendamarai, Ezhil, Ritchey, Julie, Rettig, Michael, Gehrs, Leah, Moore, Paul, Alderson, Ralph, Bonvini, Ezio, Christopher, Matthew, DiPersio, John
Published in Clinical lymphoma, myeloma and leukemia (01.09.2023)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2023)
Get full text
Journal Article
AML-080 Modeling Flotetuzumab-Associated Cytokine Release Syndrome (CRS) in AML Using In Vitro and In Vivo Preclinical Models
Patel, Dilan, Chendamarai, Ezhil, Ritchey, Julie, Rettig, Michael, Gehrs, Leah, Moore, Paul, Alderson, Ralph, Bonvini, Ezio, Christopher, Matthew, DiPersio, John
Published in Clinical lymphoma, myeloma and leukemia (01.09.2023)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2023)
Get full text
Journal Article
Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer
Moore, Paul A, Shah, Kalpana, Yang, Yinhua, Alderson, Ralph, Roberts, Penny, Long, Vatana, Liu, Daorong, Li, Jonathan C, Burke, Steve, Ciccarone, Valentina, Li, Hua, Fieger, Claudia B, Hooley, Jeff, Easton, Ann, Licea, Monica, Gorlatov, Sergey, King, Kathy L, Young, Peter, Adami, Arash, Loo, Deryk, Chichili, Gurunadh R, Liu, Liqin, Smith, Douglas H, Brown, Jennifer G, Chen, Francine Z, Koenig, Scott, Mather, Jennie, Bonvini, Ezio, Johnson, Syd
Published in Molecular cancer therapeutics (01.08.2018)
Published in Molecular cancer therapeutics (01.08.2018)
Get full text
Journal Article