Development of an Efficient Large-Scale Synthesis for a 4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide Derivative for Depression and Anxiety
Giubellina, Nicola, Stabile, Paolo, Laval, Gilles, Perboni, Alcide D, Cimarosti, Zadeo, Westerduin, Pieter, Cooke, Jason W. B
Published in Organic process research & development (16.07.2010)
Published in Organic process research & development (16.07.2010)
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Journal Article
Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy End
Guercio, Giuseppe, Bacchi, Sergio, Perboni, Alcide, Leroi, Corinne, Tinazzi, Francesco, Bientinesi, Ilaria, Hourdin, Marie, Goodyear, Michael, Curti, Stefano, Provera, Stefano, Cimarosti, Zadeo
Published in Organic process research & development (20.11.2009)
Published in Organic process research & development (20.11.2009)
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Journal Article
2,3-Disubstituted Indoles via Palladium-Catalyzed Reaction of 2-Alkynyltrifluoroacetanilides with Arenediazonium Tetrafluoroborates
Cacchi, Sandro, Fabrizi, Giancarlo, Goggiamani, Antonella, Perboni, Alcide, Sferrazza, Alessio, Stabile, Paolo
Published in Organic letters (16.07.2010)
Published in Organic letters (16.07.2010)
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Application of the QbD Principles in the Development of the Casopitant Mesylate Manufacturing Process. Process Research Studies for the Definition of the Control Strategy of some Drug Substance-CQAs for Stages 2a, 2b, and 2c
Cimarosti, Zadeo, Bravo, Fernando, Castoldi, Damiano, Tinazzi, Francesco, Provera, Stefano, Perboni, Alcide, Papini, Damiano, Westerduin, Pieter
Published in Organic process research & development (16.07.2010)
Published in Organic process research & development (16.07.2010)
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An Alternative Synthesis of 2-Alkylidene-3,4-dihydro-2H-1,4-benzoxazines by Intramolecular Gold-Catalyzed Hydroalkoxylation of 2-(Prop-2-yn-1-ylamino)phenols
Manzo, Angelo M., Perboni, Alcide, Broggini, Gianluigi, Rigamonti, Micol
Published in Synthesis (Stuttgart) (01.01.2011)
Published in Synthesis (Stuttgart) (01.01.2011)
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The Synthesis of GV143253A: A Case Study for the Use of Analytical and Statistical Tools to Elucidate the Reaction Mechanism and to Optimize the Process
Guercio, Giuseppe, Perboni, Alcide, Tinazzi, Francesco, Rovatti, Luca, Provera, Stefano
Published in Organic process research & development (16.07.2010)
Published in Organic process research & development (16.07.2010)
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Discovery of 1-[4-(3-Chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a Brain Penetrant 5-Azaindole CB2 Agonist for the Treatment of Chronic Pain
Giblin, Gerard M. P, Billinton, Andrew, Briggs, Michael, Brown, Andrew J, Chessell, Iain P, Clayton, Nick M, Eatherton, Andrew J, Goldsmith, Paul, Haslam, Carl, Johnson, Matthew R, Mitchell, William L, Naylor, Alan, Perboni, Alcide, Slingsby, Brian P, Wilson, Alex W
Published in Journal of medicinal chemistry (08.10.2009)
Published in Journal of medicinal chemistry (08.10.2009)
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Journal Article
Development of an Efficient Large-Scale Synthesis for a 4 H -imidazo[5,1- c ][1,4]benzoxazine-3-carboxamide Derivative for Depression and Anxiety
Giubellina, Nicola, Stabile, Paolo, Laval, Gilles, Perboni, Alcide D., Cimarosti, Zadeo, Westerduin, Pieter, Cooke, Jason W. B.
Published in Organic process research & development (16.07.2010)
Published in Organic process research & development (16.07.2010)
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Journal Article
Identification of a Manufacturing Route of Novel CRF-1 Antagonists Containing a 2,3-Dihydro-1 H -pyrrolo[2,3- b ]pyridine Moiety
Ribecai, Arianna, Bacchi, Sergio, Delpogetto, Monica, Guelfi, Simone, Manzo, Angelo Maria, Perboni, Alcide, Stabile, Paolo, Westerduin, Pieter, Hourdin, Marie, Rossi, Sara, Provera, Stefano, Turco, Lucilla
Published in Organic process research & development (16.07.2010)
Published in Organic process research & development (16.07.2010)
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Journal Article
Identification of a Manufacturing Route of Novel CRF-1 Antagonists Containing a 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine Moiety
Ribecai, Arianna, Bacchi, Sergio, Delpogetto, Monica, Guelfi, Simone, Manzo, Angelo Maria, Perboni, Alcide, Stabile, Paolo, Westerduin, Pieter, Hourdin, Marie, Rossi, Sara, Provera, Stefano, Turco, Lucilla
Published in Organic process research & development (16.07.2010)
Published in Organic process research & development (16.07.2010)
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Journal Article
Process Development and Scale Up of a Glycine Antagonist
Banks, Adam, Breen, Gary F, Caine, Darren, Carey, John S, Drake, Christopher, Forth, Michael A, Gladwin, Asa, Guelfi, Simone, Hayes, Jerome F, Maragni, Paolo, Morgan, David O, Oxley, Paul, Perboni, Alcide, Popkin, Matthew E, Rawlinson, Fiona, Roux, Guillaume
Published in Organic process research & development (20.11.2009)
Published in Organic process research & development (20.11.2009)
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Journal Article
Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate
Demont, Emmanuel H, Andrews, Benjamin I, Bit, Rino A, Campbell, Colin A, Cooke, Jason W. B, Deeks, Nigel, Desai, Sapna, Dowell, Simon J, Gaskin, Pam, Gray, James R. J, Haynes, Andrea, Holmes, Duncan S, Kumar, Umesh, Morse, Mary A, Osborne, Greg J, Panchal, Terry, Patel, Bela, Perboni, Alcide, Taylor, Simon, Watson, Robert, Witherington, Jason, Willis, Robert
Published in ACS medicinal chemistry letters (09.06.2011)
Published in ACS medicinal chemistry letters (09.06.2011)
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Journal Article
Discovery of 1-[4-(3-Chlorophenylamino)-1-methyl-1 H -pyrrolo[3,2- c ]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a Brain Penetrant 5-Azaindole CB 2 Agonist for the Treatment of Chronic Pain
Giblin, Gerard M. P., Billinton, Andrew, Briggs, Michael, Brown, Andrew J., Chessell, Iain P., Clayton, Nick M., Eatherton, Andrew J., Goldsmith, Paul, Haslam, Carl, Johnson, Matthew R., Mitchell, William L., Naylor, Alan, Perboni, Alcide, Slingsby, Brian P., Wilson, Alex W.
Published in Journal of medicinal chemistry (08.10.2009)
Published in Journal of medicinal chemistry (08.10.2009)
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Journal Article
An Efficient Scalable Route for the Synthesis of Enantiomerically Pure tert-Butyl-(1R,4S,6R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate
Maton, William M, Stazi, Federica, Manzo, Angelo Maria, Pachera, Roberta, Ribecai, Arianna, Stabile, Paolo, Perboni, Alcide, Giubellina, Nicola, Bravo, Fernando, Castoldi, Damiano, Provera, Stefano, Turco, Lucilla, Bryant, Simon, Westerduin, Pieter, Profeta, Roberto, Nalin, Arnaldo, Miserazzi, Emanuele, Spada, Simone, Mingardi, Anna, Mattioli, Mario, Andreotti, Daniele
Published in Organic process research & development (17.09.2010)
Published in Organic process research & development (17.09.2010)
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Journal Article
Discovery of a Selective S1P 1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate
Demont, Emmanuel H., Andrews, Benjamin I., Bit, Rino A., Campbell, Colin A., Cooke, Jason W. B., Deeks, Nigel, Desai, Sapna, Dowell, Simon J., Gaskin, Pam, Gray, James R. J., Haynes, Andrea, Holmes, Duncan S., Kumar, Umesh, Morse, Mary A., Osborne, Greg J., Panchal, Terry, Patel, Bela, Perboni, Alcide, Taylor, Simon, Watson, Robert, Witherington, Jason, Willis, Robert
Published in ACS medicinal chemistry letters (09.06.2011)
Published in ACS medicinal chemistry letters (09.06.2011)
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Journal Article