Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin
Xu, Jianing, Pham, Can G, Albanese, Steven K, Dong, Yiyu, Oyama, Toshinao, Lee, Chung-Han, Rodrik-Outmezguine, Vanessa, Yao, Zhan, Han, Song, Chen, David, Parton, Daniel L, Chodera, John D, Rosen, Neal, Cheng, Emily H, Hsieh, James J
Published in The Journal of clinical investigation (01.09.2016)
Published in The Journal of clinical investigation (01.09.2016)
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Journal Article
The maximal and current accuracy of rigorous protein-ligand binding free energy calculations
Ross, Gregory A., Lu, Chao, Scarabelli, Guido, Albanese, Steven K., Houang, Evelyne, Abel, Robert, Harder, Edward D., Wang, Lingle
Published in Communications chemistry (14.10.2023)
Published in Communications chemistry (14.10.2023)
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Journal Article
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation
Ruff, Emily F, Muretta, Joseph M, Thompson, Andrew R, Lake, Eric W, Cyphers, Soreen, Albanese, Steven K, Hanson, Sonya M, Behr, Julie M, Thomas, David D, Chodera, John D, Levinson, Nicholas M
Published in eLife (21.02.2018)
Published in eLife (21.02.2018)
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Journal Article
Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations
Hauser, Kevin, Negron, Christopher, Albanese, Steven K., Ray, Soumya, Steinbrecher, Thomas, Abel, Robert, Chodera, John D., Wang, Lingle
Published in Communications biology (13.06.2018)
Published in Communications biology (13.06.2018)
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Journal Article
Is Structure-Based Drug Design Ready for Selectivity Optimization?
Albanese, Steven K, Chodera, John D, Volkamer, Andrea, Keng, Simon, Abel, Robert, Wang, Lingle
Published in Journal of chemical information and modeling (28.12.2020)
Published in Journal of chemical information and modeling (28.12.2020)
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Journal Article
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance
Lyczek, Agatha, Berger, Benedict-Tilman, Rangwala, Aziz M., Paung, YiTing, Tom, Jessica, Philipose, Hannah, Guo, Jiaye, Albanese, Steven K., Robers, Matthew B., Knapp, Stefan, Chodera, John D., Seeliger, Markus A.
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2021)
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Journal Article
An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression
Albanese, Steven K, Parton, Daniel L, Işık, Mehtap, Rodríguez-Laureano, Lucelenie, Hanson, Sonya M, Behr, Julie M, Gradia, Scott, Jeans, Chris, Levinson, Nicholas M, Seeliger, Markus A, Chodera, John D
Published in Biochemistry (Easton) (07.08.2018)
Published in Biochemistry (Easton) (07.08.2018)
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Journal Article
HPK1 길항제 및 이의 용도
GREENWOOD JEREMY ROBERT, WARD STUART, WHITTAKER BEN, ALBANESE STEVEN K, KAILA NEELU, LINNEY IAN, LEFFLER ABBA, WISHART GRANT, COTE ALEXANDRE, SEVERANCE DANIEL L
Year of Publication 27.07.2022
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Year of Publication 27.07.2022
Patent
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
Intlekofer, Andrew M., Shih, Alan H., Wang, Bo, Nazir, Abbas, Rustenburg, Ariën S., Albanese, Steven K., Patel, Minal, Famulare, Christopher, Correa, Fabian M., Takemoto, Naofumi, Durani, Vidushi, Liu, Hui, Taylor, Justin, Farnoud, Noushin, Papaemmanuil, Elli, Cross, Justin R., Tallman, Martin S., Arcila, Maria E., Roshal, Mikhail, Petsko, Gregory A., Wu, Bin, Choe, Sung, Konteatis, Zenon D., Biller, Scott A., Chodera, John D., Thompson, Craig B., Levine, Ross L., Stein, Eytan M.
Published in Nature (London) (01.07.2018)
Published in Nature (London) (01.07.2018)
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Journal Article
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
Minuesa, Gerard, Albanese, Steven K., Xie, Wei, Kazansky, Yaniv, Worroll, Daniel, Chow, Arthur, Schurer, Alexandra, Park, Sun-Mi, Rotsides, Christina Z., Taggart, James, Rizzi, Andrea, Naden, Levi N., Chou, Timothy, Gourkanti, Saroj, Cappel, Daniel, Passarelli, Maria C., Fairchild, Lauren, Adura, Carolina, Glickman, J. Fraser, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Eibl, Joseph K., Ross, Gregory M., Bhattacharya, Shibani, Tan, Derek S., Leslie, Christina S., Beuming, Thijs, Patel, Dinshaw J., Goldgur, Yehuda, Chodera, John D., Kharas, Michael G.
Published in Nature communications (19.06.2019)
Published in Nature communications (19.06.2019)
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Journal Article
Discovery and characterization of novel inhibitors of CTP synthase 1 (CTPS1) for the treatment of autoimmune and inflammatory disease
McElwee, Joshua J, Kaila, Neelu, Carreiro, Samantha, Kumar, Sheetal, Toms, Angela V, Phadke, Avinash, Jacques, Suzanne, Caravella, Justin A, Kreutter, Kevin, Campos, Sebastien, Verras, Andreas, Albanese, Steven K, Demarco, Kevin R, DiMattia, Michael A, Lynch, Eric, Kollman, Justin, Tummino, Peter
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
Wojnarowicz, Paulina M., Lima e Silva, Raquel, Ohnaka, Masayuki, Lee, Sang Bae, Chin, Yvette, Kulukian, Anita, Chang, Sung-Hee, Desai, Bina, Garcia Escolano, Marta, Shah, Riddhi, Garcia-Cao, Marta, Xu, Sijia, Kadam, Rashmi, Goldgur, Yehuda, Miller, Meredith A., Ouerfelli, Ouathek, Yang, Guangli, Arakawa, Tsutomu, Albanese, Steven K., Garland, William A., Stoller, Glenn, Chaudhary, Jaideep, Norton, Larry, Soni, Rajesh Kumar, Philip, John, Hendrickson, Ronald C., Iavarone, Antonio, Dannenberg, Andrew J., Chodera, John D., Pavletich, Nikola, Lasorella, Anna, Campochiaro, Peter A., Benezra, Robert
Published in Cell reports (Cambridge) (01.10.2019)
Published in Cell reports (Cambridge) (01.10.2019)
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Journal Article
Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia
Minuesa Dinares, Gerard, Albanese, Steven K., Chow, Arthur, Schurer, Alexandra, Park, Sun Mi, Rotsides, Christina Z., Taggart, James, Rizzi, Andrea, Naden, Levi N., Chou, Timothy, Gourkanti, Saroj, Cappel, Daniel, Passarelli, Maria C., Fairchild, Lauren, Adura, Carolina, Glickman, Joseph Fraser, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Eibl, Joseph K., Ross, Gregory M., Tan, Derek, Leslie, Christina, Beuming, Thijs, Goldgur, Yehuda, Chodera, John D., Kharas, Michael G.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations
Hauser, Kevin, Negron, Christopher, Albanese, Steven K, Ray, Soumya, Steinbrecher, Thomas, Abel, Robert, Chodera, John D, Lingle Wang
Published in bioRxiv (02.04.2018)
Published in bioRxiv (02.04.2018)
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Paper
Abstract 4975: A small molecule pan Id protein antagonist shows strong antitumor activity
Wojnarowicz, Paulina M., Desai, Bina, Chin, Yvette, Lee, Sang Bae, Garcia-Cao, Marta, Ouerfelli, Ouathek, Yang, Guangli, Xu, Sijia, Goldgur, Yehuda, Miller, Meredith A., Chaudhary, Jaideep, Garland, William A., Albanese, Steven K., Soni, Rajesh, Philip, John, Norton, Larry, Rosen, Neal, Hendrickson, Ronald C., Zhou, Xi Kathy, Iavarone, Antonio, Dannenberg, Andrew J., Chodera, John D., Pavletich, Nikola, Lasorella, Anna, Benezra, Robert
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation
Ruff, Emily F, Muretta, Joseph M, Thompson, Andrew, Lake, Eric W, Cyphers, Soreen, Albanese, Steven K, Hanson, Sonya M, Behr, Julie M, Thomas, David D, Chodera, John D, Levinson, Nicholas M
Published in bioRxiv (18.10.2017)
Published in bioRxiv (18.10.2017)
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Paper
IRE1A MODULATORS AND USES THEREOF
VERRAS, Andreas, ROMERO, Donna L, KREUTTER, Kevin, KOLDSOE, Heidi, WHITEHEAD, Lewis, ALBANESE, Steven K
Year of Publication 08.08.2024
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Year of Publication 08.08.2024
Patent
CTPS1 INHIBITORS AND USES THEREOF
VERRAS, Andreas, WEST, Angela V, CAMPOS, Sebastien, KAILA, Neelu, ALBANESE, Steven K, WHITEHEAD, Lewis, DEMARCO, Kevin, KREUTTER, Kevin D
Year of Publication 26.10.2023
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Year of Publication 26.10.2023
Patent
CTPS1 INHIBITORS AND USES THEREOF
VERRAS, Andreas, WEST, Angela V, CAMPOS, Sebastien, WHITEHEAD, Lewis, ALBANESE, Steven K, KAILA, Neelu, KREUTTER, Kevin D, DEMARCO, Kevin, ROBINSON, Shaughnessy
Year of Publication 24.07.2024
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Year of Publication 24.07.2024
Patent
HPK1 ANTAGONISTS AND USES THEREOF
WARD, Stuart, KAILA, Neelu, ALBANESE, Steven K, LINNEY, Ian, WHITTAKER, Ben, COTE, Alexandre, GREENWOOD, Jeremy Robert, WISHART, Grant, SEVERANCE, Daniel L, LEFFLER, Abba
Year of Publication 12.06.2024
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Year of Publication 12.06.2024
Patent