Is Structure-Based Drug Design Ready for Selectivity Optimization?
Albanese, Steven K, Chodera, John D, Volkamer, Andrea, Keng, Simon, Abel, Robert, Wang, Lingle
Published in Journal of chemical information and modeling (28.12.2020)
Published in Journal of chemical information and modeling (28.12.2020)
Get full text
Journal Article
Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin
Xu, Jianing, Pham, Can G, Albanese, Steven K, Dong, Yiyu, Oyama, Toshinao, Lee, Chung-Han, Rodrik-Outmezguine, Vanessa, Yao, Zhan, Han, Song, Chen, David, Parton, Daniel L, Chodera, John D, Rosen, Neal, Cheng, Emily H, Hsieh, James J
Published in The Journal of clinical investigation (01.09.2016)
Published in The Journal of clinical investigation (01.09.2016)
Get full text
Journal Article
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance
Lyczek, Agatha, Berger, Benedict-Tilman, Rangwala, Aziz M, Paung, YiTing, Tom, Jessica, Philipose, Hannah, Guo, Jiaye, Albanese, Steven K, Robers, Matthew B, Knapp, Stefan, Chodera, John D, Seeliger, Markus A
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2021)
Get full text
Journal Article
An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression
Albanese, Steven K, Parton, Daniel L, Işık, Mehtap, Rodríguez-Laureano, Lucelenie, Hanson, Sonya M, Behr, Julie M, Gradia, Scott, Jeans, Chris, Levinson, Nicholas M, Seeliger, Markus A, Chodera, John D
Published in Biochemistry (Easton) (07.08.2018)
Published in Biochemistry (Easton) (07.08.2018)
Get full text
Journal Article
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation
Ruff, Emily F, Muretta, Joseph M, Thompson, Andrew R, Lake, Eric W, Cyphers, Soreen, Albanese, Steven K, Hanson, Sonya M, Behr, Julie M, Thomas, David D, Chodera, John D, Levinson, Nicholas M
Published in eLife (21.02.2018)
Published in eLife (21.02.2018)
Get full text
Journal Article
The maximal and current accuracy of rigorous protein-ligand binding free energy calculations
Ross, Gregory A, Lu, Chao, Scarabelli, Guido, Albanese, Steven K, Houang, Evelyne, Abel, Robert, Harder, Edward D, Wang, Lingle
Published in Communications chemistry (14.10.2023)
Published in Communications chemistry (14.10.2023)
Get full text
Journal Article
Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations
Hauser, Kevin, Negron, Christopher, Albanese, Steven K, Ray, Soumya, Steinbrecher, Thomas, Abel, Robert, Chodera, John D, Wang, Lingle
Published in Communications biology (01.01.2018)
Published in Communications biology (01.01.2018)
Get full text
Journal Article
Discovery and characterization of novel inhibitors of CTP synthase 1 (CTPS1) for the treatment of autoimmune and inflammatory disease
McElwee, Joshua J, Kaila, Neelu, Carreiro, Samantha, Kumar, Sheetal, Toms, Angela V, Phadke, Avinash, Jacques, Suzanne, Caravella, Justin A, Kreutter, Kevin, Campos, Sebastien, Verras, Andreas, Albanese, Steven K, Demarco, Kevin R, DiMattia, Michael A, Lynch, Eric, Kollman, Justin, Tummino, Peter
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
Get full text
Journal Article
Structural basis for isoform-specific inhibition of human CTPS1
Lynch, Eric M, DiMattia, Michael A, Albanese, Steven, van Zundert, Gydo C P, Hansen, Jesse M, Quispe, Joel D, Kennedy, Madison A, Verras, Andreas, Borrelli, Kenneth, Toms, Angela V, Kaila, Neelu, Kreutter, Kevin D, McElwee, Joshua J, Kollman, Justin M
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2021)
Get full text
Journal Article
Simulating mTOR Hyperactivating Mutations to Understand Functionally Significant Structural Rearrangements
Albanese, Steven, Xu, Jianing, Hsieh, James, Chodera, John D.
Published in Biophysical journal (16.02.2016)
Published in Biophysical journal (16.02.2016)
Get full text
Journal Article
Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia
Minuesa Dinares, Gerard, Albanese, Steven K., Chow, Arthur, Schurer, Alexandra, Park, Sun Mi, Rotsides, Christina Z., Taggart, James, Rizzi, Andrea, Naden, Levi N., Chou, Timothy, Gourkanti, Saroj, Cappel, Daniel, Passarelli, Maria C., Fairchild, Lauren, Adura, Carolina, Glickman, Joseph Fraser, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Eibl, Joseph K., Ross, Gregory M., Tan, Derek, Leslie, Christina, Beuming, Thijs, Goldgur, Yehuda, Chodera, John D., Kharas, Michael G.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
Get full text
Journal Article
헤테로시클릭 화합물 및 사용 방법
LEFFLER ABBA ELIAS, KIM BYUNGCHAN, LEVINSON ADAM MARC, HOUANG EVELYNE, THERRIEN ERIC, PALOMERO VAZQUEZ MARIA ANGEL, GORDON JAMES ALEXANDER, HUANG XIANHAI, ALBANESE STEVEN, HIRST KIM LOUISE, IGAWA HIDEYUKI, PLACZEK ANDREW, WATTS KARL SHAWN
Year of Publication 30.01.2024
Get full text
Year of Publication 30.01.2024
Patent
Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations
Hauser, Kevin, Negron, Christopher, Albanese, Steven K, Ray, Soumya, Steinbrecher, Thomas, Abel, Robert, Chodera, John D, Lingle Wang
Published in bioRxiv (02.04.2018)
Published in bioRxiv (02.04.2018)
Get full text
Paper
HPK1 길항제 및 이의 용도
GREENWOOD JEREMY ROBERT, WARD STUART, WHITTAKER BEN, ALBANESE STEVEN K, KAILA NEELU, LINNEY IAN, LEFFLER ABBA, WISHART GRANT, COTE ALEXANDRE, SEVERANCE DANIEL L
Year of Publication 27.07.2022
Get full text
Year of Publication 27.07.2022
Patent
Abstract 4975: A small molecule pan Id protein antagonist shows strong antitumor activity
Wojnarowicz, Paulina M., Desai, Bina, Chin, Yvette, Lee, Sang Bae, Garcia-Cao, Marta, Ouerfelli, Ouathek, Yang, Guangli, Xu, Sijia, Goldgur, Yehuda, Miller, Meredith A., Chaudhary, Jaideep, Garland, William A., Albanese, Steven K., Soni, Rajesh, Philip, John, Norton, Larry, Rosen, Neal, Hendrickson, Ronald C., Zhou, Xi Kathy, Iavarone, Antonio, Dannenberg, Andrew J., Chodera, John D., Pavletich, Nikola, Lasorella, Anna, Benezra, Robert
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation
Ruff, Emily F, Muretta, Joseph M, Thompson, Andrew, Lake, Eric W, Cyphers, Soreen, Albanese, Steven K, Hanson, Sonya M, Behr, Julie M, Thomas, David D, Chodera, John D, Levinson, Nicholas M
Published in bioRxiv (18.10.2017)
Published in bioRxiv (18.10.2017)
Get full text
Paper
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
Intlekofer, Andrew M, Shih, Alan H, Wang, Bo, Nazir, Abbas, Rustenburg, Ariën S, Albanese, Steven K, Patel, Minal, Famulare, Christopher, Correa, Fabian M, Takemoto, Naofumi, Durani, Vidushi, Liu, Hui, Taylor, Justin, Farnoud, Noushin, Papaemmanuil, Elli, Cross, Justin R, Tallman, Martin S, Arcila, Maria E, Roshal, Mikhail, Petsko, Gregory A, Wu, Bin, Choe, Sung, Konteatis, Zenon D, Biller, Scott A, Chodera, John D, Thompson, Craig B, Levine, Ross L, Stein, Eytan M
Published in Nature (London) (01.07.2018)
Published in Nature (London) (01.07.2018)
Get full text
Journal Article
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
Minuesa, Gerard, Albanese, Steven K, Xie, Wei, Kazansky, Yaniv, Worroll, Daniel, Chow, Arthur, Schurer, Alexandra, Park, Sun-Mi, Rotsides, Christina Z, Taggart, James, Rizzi, Andrea, Naden, Levi N, Chou, Timothy, Gourkanti, Saroj, Cappel, Daniel, Passarelli, Maria C, Fairchild, Lauren, Adura, Carolina, Glickman, J Fraser, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Eibl, Joseph K, Ross, Gregory M, Bhattacharya, Shibani, Tan, Derek S, Leslie, Christina S, Beuming, Thijs, Patel, Dinshaw J, Goldgur, Yehuda, Chodera, John D, Kharas, Michael G
Published in Nature communications (19.06.2019)
Published in Nature communications (19.06.2019)
Get full text
Journal Article
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
Wojnarowicz, Paulina M., Lima e Silva, Raquel, Ohnaka, Masayuki, Lee, Sang Bae, Chin, Yvette, Kulukian, Anita, Chang, Sung-Hee, Desai, Bina, Garcia Escolano, Marta, Shah, Riddhi, Garcia-Cao, Marta, Xu, Sijia, Kadam, Rashmi, Goldgur, Yehuda, Miller, Meredith A., Ouerfelli, Ouathek, Yang, Guangli, Arakawa, Tsutomu, Albanese, Steven K., Garland, William A., Stoller, Glenn, Chaudhary, Jaideep, Norton, Larry, Soni, Rajesh Kumar, Philip, John, Hendrickson, Ronald C., Iavarone, Antonio, Dannenberg, Andrew J., Chodera, John D., Pavletich, Nikola, Lasorella, Anna, Campochiaro, Peter A., Benezra, Robert
Published in Cell reports (Cambridge) (01.10.2019)
Published in Cell reports (Cambridge) (01.10.2019)
Get full text
Journal Article
IRE1A MODULATORS AND USES THEREOF
VERRAS, Andreas, ROMERO, Donna L, KREUTTER, Kevin, KOLDSOE, Heidi, WHITEHEAD, Lewis, ALBANESE, Steven K
Year of Publication 08.08.2024
Get full text
Year of Publication 08.08.2024
Patent