Risk of adverse coronavirus disease 2019 outcomes for people living with HIV
Mellor, Maya M, Bast, Anne C, Jones, Nicholas R, Roberts, Nia W, Ordóñez-Mena, José M, Reith, Alastair J M, Butler, Christopher C, Matthews, Philippa C, Dorward, Jienchi
Published in AIDS (London) (15.03.2021)
Published in AIDS (London) (15.03.2021)
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Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
Ito, Genta, Katsemonova, Kristina, Tonelli, Francesca, Lis, Pawel, Baptista, Marco A S, Shpiro, Natalia, Duddy, Graham, Wilson, Steve, Ho, Philip Wing-Lok, Ho, Shu-Leong, Reith, Alastair D, Alessi, Dario R
Published in Biochemical journal (01.09.2016)
Published in Biochemical journal (01.09.2016)
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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Steger, Martin, Tonelli, Francesca, Ito, Genta, Davies, Paul, Trost, Matthias, Vetter, Melanie, Wachter, Stefanie, Lorentzen, Esben, Duddy, Graham, Wilson, Stephen, Baptista, Marco As, Fiske, Brian K, Fell, Matthew J, Morrow, John A, Reith, Alastair D, Alessi, Dario R, Mann, Matthias
Published in eLife (29.01.2016)
Published in eLife (29.01.2016)
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Impact of Type II LRRK2 inhibitors on signaling and mitophagy
Tasegian, Anna, Singh, Francois, Ganley, Ian G, Reith, Alastair D, Alessi, Dario R
Published in Biochemical journal (15.10.2021)
Published in Biochemical journal (15.10.2021)
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Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice
Singh, Francois, Prescott, Alan R, Rosewell, Philippa, Ball, Graeme, Reith, Alastair D, Ganley, Ian G
Published in eLife (03.08.2021)
Published in eLife (03.08.2021)
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LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages
Härtlova, Anetta, Herbst, Susanne, Peltier, Julien, Rodgers, Angela, Bilkei‐Gorzo, Orsolya, Fearns, Antony, Dill, Brian D, Lee, Heyne, Flynn, Rowan, Cowley, Sally A, Davies, Paul, Lewis, Patrick A, Ganley, Ian G, Martinez, Jennifer, Alessi, Dario R, Reith, Alastair D, Trost, Matthias, Gutierrez, Maximiliano G
Published in The EMBO journal (15.06.2018)
Published in The EMBO journal (15.06.2018)
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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization
Dzamko, Nicolas, Deak, Maria, Hentati, Faycal, Reith, Alastair D, Prescott, Alan R, Alessi, Dario R, Nichols, R Jeremy
Published in Biochemical journal (15.09.2010)
Published in Biochemical journal (15.09.2010)
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Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease
Nichols, R Jeremy, Dzamko, Nicolas, Hutti, Jessica E, Cantley, Lewis C, Deak, Maria, Moran, Jennifer, Bamborough, Paul, Reith, Alastair D, Alessi, Dario R
Published in Biochemical journal (23.10.2009)
Published in Biochemical journal (23.10.2009)
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GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor
Reith, Alastair D., Bamborough, Paul, Jandu, Karamjit, Andreotti, Daniele, Mensah, Lucy, Dossang, Pamela, Choi, Hwan Geun, Deng, Xianming, Zhang, Jinwei, Alessi, Dario R., Gray, Nathanael S.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Characterization of the cellular action of the MSK inhibitor SB-747651A
Naqvi, Shaista, Macdonald, Andrew, McCoy, Claire E, Darragh, Joanne, Reith, Alastair D, Arthur, J Simon C
Published in Biochemical journal (01.01.2012)
Published in Biochemical journal (01.01.2012)
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A Protocol for Dual Calcium-Voltage Optical Mapping in Murine Sinoatrial Preparation With Optogenetic Pacing
Dong, Ruirui, Mu-U-Min, Razik, Reith, Alastair J M, O'Shea, Christopher, He, Shicheng, Duan, Kaizhong, Kou, Kun, Grassam-Rowe, Alexander, Tan, Xiaoqiu, Pavlovic, Davor, Ou, Xianhong, Lei, Ming
Published in Frontiers in physiology (06.08.2019)
Published in Frontiers in physiology (06.08.2019)
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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
Inman, Gareth J, Nicolás, Francisco J, Callahan, James F, Harling, John D, Gaster, Laramie M, Reith, Alastair D, Laping, Nicholas J, Hill, Caroline S
Published in Molecular pharmacology (01.07.2002)
Published in Molecular pharmacology (01.07.2002)
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Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors
Ding, Xiao, Stasi, Luigi Piero, Ho, Ming-Hsun, Zhao, Baowei, Wang, Hailong, Long, Kai, Xu, Qiongfeng, Sang, Yingxia, Sun, Changhui, Hu, Huan, Yu, Haihua, Wan, Zehong, Wang, Lizhen, Edge, Colin, Liu, Qian, Li, Yi, Dong, Kelly, Guan, Xiaoming, Tattersall, F. David, Reith, Alastair D., Ren, Feng
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
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Journal Article
5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy
Ding, Xiao, Stasi, Luigi Piero, Dai, Xuedong, Long, Kai, Peng, Cheng, Zhao, Baowei, Wang, Hailong, Sun, Changhui, Hu, Huan, Wan, Zehong, Jandu, Karamjit S., Philps, Oliver J., Chen, Yan, Wang, Lizhen, Liu, Qian, Edge, Colin, Li, Yi, Dong, Kelly, Guan, Xiaoming, Tattersall, F. David, Reith, Alastair D., Ren, Feng
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
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Journal Article
Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors
Ding, Xiao, Dai, Xuedong, Long, Kai, Peng, Cheng, Andreotti, Daniele, Bamborough, Paul, Eatherton, Andrew J., Edge, Colin, Jandu, Karamjit S., Nichols, Paula L., Philps, Oliver J., Stasi, Luigi Piero, Wan, Zehong, Xiang, Jia-Ning, Dong, Kelly, Dossang, Pamela, Ho, Ming-Hsun, Li, Yi, Mensah, Lucy, Guan, Xiaoming, Reith, Alastair D., Ren, Feng
Published in Bioorganic & medicinal chemistry letters (01.09.2017)
Published in Bioorganic & medicinal chemistry letters (01.09.2017)
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Journal Article
A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry
Leveridge, Melanie, Collier, Lee, Edge, Colin, Hardwicke, Phil, Leavens, Bill, Ratcliffe, Steve, Rees, Mike, Stasi, Luigi Piero, Nadin, Alan, Reith, Alastair D
Published in Journal of biomolecular screening (01.02.2016)
Published in Journal of biomolecular screening (01.02.2016)
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MSK1 and MSK2 Inhibit Lipopolysaccharide-Induced Prostaglandin Production via an Interleukin-10 Feedback Loop
MacKenzie, Kirsty F., Van Den Bosch, Mirjam W. M., Naqvi, Shaista, Elcombe, Suzanne E., McGuire, Victoria A., Reith, Alastair D., Blackshear, Perry J., Dean, Jonathan L. E., Arthur, J. Simon C.
Published in Molecular and Cellular Biology (01.04.2013)
Published in Molecular and Cellular Biology (01.04.2013)
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Journal Article
Selective small‐molecule inhibitors of glycogen synthase kinase‐3 activity protect primary neurones from death
Cross, Darren A. E., Culbert, Ainsley A., Chalmers, Katy A., Facci, Laura, Skaper, Stephen D., Reith, Alastair D.
Published in Journal of neurochemistry (01.04.2001)
Published in Journal of neurochemistry (01.04.2001)
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Journal Article
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase
Takle, Andrew K., Brown, Murray J.B., Davies, Susannah, Dean, David K., Francis, Gerraint, Gaiba, Alessandra, Hird, Alex W., King, Frank D., Lovell, Peter J., Naylor, Antoinette, Reith, Alastair D., Steadman, Jon G., Wilson, David M.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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