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Macpherson, Alex, Scott-Tucker, Anthony, Spiliotopoulos, Anastasios, Simpson, Catherine, Staniforth, Justin, Hold, Adam, Snowden, James, Manning, Leah, van den Elsen, Jean, Lawson, Alastair D. G.
Published in PLoS biology (04.09.2020)
Published in PLoS biology (04.09.2020)
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Rings in Clinical Trials and Drugs: Present and Future
Shearer, Jonathan, Castro, Jose L., Lawson, Alastair D. G., MacCoss, Malcolm, Taylor, Richard D.
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F
Adams, Ralph, Maroof, Asher, Baker, Terry, Lawson, Alastair D G, Oliver, Ruth, Paveley, Ross, Rapecki, Steve, Shaw, Stevan, Vajjah, Pavan, West, Shauna, Griffiths, Meryn
Published in Frontiers in immunology (21.08.2020)
Published in Frontiers in immunology (21.08.2020)
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A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF
Lightwood, Daniel J, Munro, Rebecca J, Porter, John, McMillan, David, Carrington, Bruce, Turner, Alison, Scott-Tucker, Anthony, Hickford, Elizabeth S, Schmidt, Antje, Fox, 3rd, David, Maloney, Alison, Ceska, Tom, Bourne, Tim, O'Connell, James, Lawson, Alastair D G
Published in Nature communications (25.01.2021)
Published in Nature communications (25.01.2021)
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Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism
Shaw, Daniel J, Waters, Lorna C, Strong, Sarah L, Schulze, Monika-Sarah E. D, Greetham, Gregory M, Towrie, Mike, Parker, Anthony W, Prosser, Christine E, Henry, Alistair J, Lawson, Alastair D. G, Carr, Mark. D, Taylor, Richard J, Hunt, Neil T, Muskett, Frederick W
Published in Chemical science (Cambridge) (12.07.2023)
Published in Chemical science (Cambridge) (12.07.2023)
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Modular design of bi- and multi-specific knob domain fusions
Kuravsky, Mikhail, Gibbons, Glyn F, Joyce, Callum, Scott-Tucker, Anthony, Macpherson, Alex, Lawson, Alastair D G
Published in Frontiers in immunology (27.03.2024)
Published in Frontiers in immunology (27.03.2024)
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The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method
Clargo, Alison M, Hudson, Ashley R, Ndlovu, Welcome, Wootton, Rebecca J, Cremin, Louise A, O'Dowd, Victoria L, Nowosad, Carla R, Starkie, Dale O, Shaw, Sophie P, Compson, Joanne E, White, Dominic P, MacKenzie, Brendon, Snowden, James R, Newnham, Laura E, Wright, Michael, Stephens, Paul E, Griffiths, Meryn R, Lawson, Alastair DG, Lightwood, Daniel J
Published in mAbs (01.01.2014)
Published in mAbs (01.01.2014)
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Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides
Adams, Ralph, Joyce, Callum, Kuravskiy, Mikhail, Harrison, Katriona, Ahdash, Zainab, Balmforth, Matthew, Chia, Kelda, Marceddu, Cinzia, Coates, Matthew, Snowden, James, Goursaud, Emmanuel, Ménochet, Karelle, Elsen, Jean van den, Payne, Richard J., Lawson, Alastair D. G., Scott-Tucker, Anthony, Macpherson, Alex
Published in Frontiers in immunology (12.05.2023)
Published in Frontiers in immunology (12.05.2023)
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Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics
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Book Review
The Chemical Synthesis of Knob Domain Antibody Fragments
Macpherson, Alex, Birtley, James R, Broadbridge, Robert J, Brady, Kevin, Schulze, Monika-Sarah E. D, Tang, Yalan, Joyce, Callum, Saunders, Kenneth, Bogle, Gregory, Horton, John, Kelm, Sebastian, Taylor, Richard D, Franklin, Richard J, Selby, Matthew D, Laabei, Maisem, Wonfor, Toska, Hold, Adam, Stanley, Phil, Vadysirisack, Douangsone, Shi, Jiye, van den Elsen, Jean, Lawson, Alastair D. G
Published in ACS chemical biology (17.09.2021)
Published in ACS chemical biology (17.09.2021)
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The Loss of Telomerase Activity in Highly Differentiated CD8+CD28-CD27- T Cells Is Associated with Decreased Akt (Ser473) Phosphorylation
Plunkett, Fiona J, Franzese, Ornella, Finney, Helene M, Fletcher, Jean M, Belaramani, Lavina L, Salmon, Mike, Dokal, Inderjeet, Webster, David, Lawson, Alastair D. G, Akbar, Arne N
Published in The Journal of immunology (1950) (15.06.2007)
Published in The Journal of immunology (1950) (15.06.2007)
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Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping
Liu, Xiaofeng, Taylor, Richard D, Griffin, Laura, Coker, Shu-Fen, Adams, Ralph, Ceska, Tom, Shi, Jiye, Lawson, Alastair D G, Baker, Terry
Published in Scientific reports (27.01.2017)
Published in Scientific reports (27.01.2017)
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Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discovery
Walker, Kayleigh, Baravalle, Roberta, Holyfield, Rachel, Kalms, Jacqueline, Wright, Helena, Seewooruthun, Chitra, Muskett, Frederick W, Scott-Tucker, Anthony, Merritt, Andy, Henry, Alistair, Lawson, Alastair D G, Hall, Gareth, Prosser, Christine, Carr, Mark D
Published in Frontiers in immunology (06.07.2023)
Published in Frontiers in immunology (06.07.2023)
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Rings in drugs
Taylor, Richard D, MacCoss, Malcolm, Lawson, Alastair D G
Published in Journal of medicinal chemistry (24.07.2014)
Published in Journal of medicinal chemistry (24.07.2014)
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Insights Into the Structure-Function Relationships of Dimeric C3d Fragments
Wahid, Ayla A, Dunphy, Rhys W, Macpherson, Alex, Gibson, Beth G, Kulik, Liudmila, Whale, Kevin, Back, Catherine, Hallam, Thomas M, Alkhawaja, Bayan, Martin, Rebecca L, Meschede, Ingrid, Laabei, Maisem, Lawson, Alastair D G, Holers, V Michael, Watts, Andrew G, Crennell, Susan J, Harris, Claire L, Marchbank, Kevin J, van den Elsen, Jean M H
Published in Frontiers in immunology (09.08.2021)
Published in Frontiers in immunology (09.08.2021)
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The allosteric modulation of complement C5 by knob domain peptides
Macpherson, Alex, Laabei, Maisem, Ahdash, Zainab, Graewert, Melissa A, Birtley, James R, Schulze, Monika-Sarah Ed, Crennell, Susan, Robinson, Sarah A, Holmes, Ben, Oleinikovas, Vladas, Nilsson, Per H, Snowden, James, Ellis, Victoria, Mollnes, Tom Eirik, Deane, Charlotte M, Svergun, Dmitri, Lawson, Alastair Dg, van den Elsen, Jean Mh
Published in eLife (11.02.2021)
Published in eLife (11.02.2021)
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