Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection
Raju, Ravikiran M, Unnikrishnan, Meera, Rubin, Daniel H F, Krishnamoorthy, Vidhya, Kandror, Olga, Akopian, Tatos N, Goldberg, Alfred L, Rubin, Eric J
Published in PLoS pathogens (01.02.2012)
Published in PLoS pathogens (01.02.2012)
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Pyrazinamide triggers degradation of its target aspartate decarboxylase
Gopal, Pooja, Sarathy, Jickky Palmae, Yee, Michelle, Ragunathan, Priya, Shin, Joon, Bhushan, Shashi, Zhu, Junhao, Akopian, Tatos, Kandror, Olga, Lim, Teck Kwang, Gengenbacher, Martin, Lin, Qingsong, Rubin, Eric J., Grüber, Gerhard, Dick, Thomas
Published in Nature communications (03.04.2020)
Published in Nature communications (03.04.2020)
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The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo
Gao, Wei, Kim, Jin-Yong, Anderson, Jeffrey R, Akopian, Tatos, Hong, Seungpyo, Jin, Ying-Yu, Kandror, Olga, Kim, Jong-Woo, Lee, In-Ae, Lee, Sun-Young, McAlpine, James B, Mulugeta, Surafel, Sunoqrot, Suhair, Wang, Yuehong, Yang, Seung-Hwan, Yoon, Tae-Mi, Goldberg, Alfred L, Pauli, Guido F, Suh, Joo-Won, Franzblau, Scott G, Cho, Sanghyun
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Published in Antimicrobial agents and chemotherapy (01.02.2015)
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Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis
Fraga, Hugo, Rodriguez, Beatriz, Bardera, Ana, Cid, Concha, Akopian, Tatos, Kandror, Olga, Park, Annie, Colmenarejo, Gonzalo, Lelievre, Joel, Goldberg, Alfred
Published in Analytical biochemistry (15.02.2019)
Published in Analytical biochemistry (15.02.2019)
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Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy
Won, Harim I., Zinga, Samuel, Kandror, Olga, Akopian, Tatos, Wolf, Ian D., Schweber, Jessica T. P., Schmid, Ernst W., Chao, Michael C., Waldor, Maya, Rubin, Eric J., Zhu, Junhao
Published in Nature communications (14.05.2024)
Published in Nature communications (14.05.2024)
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Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2
Gavrish, Ekaterina, Sit, Clarissa S, Cao, Shugeng, Kandror, Olga, Spoering, Amy, Peoples, Aaron, Ling, Losee, Fetterman, Ashley, Hughes, Dallas, Bissell, Anthony, Torrey, Heather, Akopian, Tatos, Mueller, Andreas, Epstein, Slava, Goldberg, Alfred, Clardy, Jon, Lewis, Kim
Published in Chemistry & biology (24.04.2014)
Published in Chemistry & biology (24.04.2014)
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Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase
Saric, Tomo, Beninga, Jochen, Graef, Claudia I., Akopian, Tatos N., Rock, Kenneth L., Goldberg, Alfred L.
Published in The Journal of biological chemistry (28.09.2001)
Published in The Journal of biological chemistry (28.09.2001)
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A novel approach to identifying β-secretase inhibitors: Bis-statine peptide mimetics discovered using structure and spot synthesis
Bridges, Kristie Grove, Chopra, Rajiv, Lin, Laura, Svenson, Kristine, Tam, Amy, Jin, Guixian, Cowling, Rebecca, Lovering, Frank, Akopian, Tatos N., DiBlasio-Smith, Elizabeth, Annis-Freeman, Bethany, Marvell, Tod H., LaVallie, Edward R., Zollner, Richard S., Bard, Jonathan, Somers, William S., Stahl, Mark L., Kriz, Ronald W.
Published in Peptides (New York, N.Y. : 1980) (01.07.2006)
Published in Peptides (New York, N.Y. : 1980) (01.07.2006)
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Correction: Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action
Weinhäupl, Katharina, Gragera, Marcos, Bueno-Carrasco, M. Teresa, Arranz, Rocío, Krandor, Olga, Akopian, Tatos, Soares, Raquel, Rubin, Eric, Felix, Jan, Fraga, Hugo
Published in The Journal of biological chemistry (01.07.2023)
Published in The Journal of biological chemistry (01.07.2023)
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Journal Article
Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action
Weinhäupl, Katharina, Gragera, Marcos, Bueno-Carrasco, M. Teresa, Arranz, Rocío, Krandor, Olga, Akopian, Tatos, Soares, Raquel, Rubin, Eric, Felix, Jan, Fraga, Hugo
Published in The Journal of biological chemistry (01.11.2022)
Published in The Journal of biological chemistry (01.11.2022)
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Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease
Famulla, Kirsten, Sass, Peter, Malik, Imran, Akopian, Tatos, Kandror, Olga, Alber, Marina, Hinzen, Berthold, Ruebsamen‐Schaeff, Helga, Kalscheuer, Rainer, Goldberg, Alfred L., Brötz‐Oesterhelt, Heike
Published in Molecular microbiology (01.07.2016)
Published in Molecular microbiology (01.07.2016)
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Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis
Li, Mi, Kandror, Olga, Akopian, Tatos, Dharkar, Poorva, Wlodawer, Alexander, Maurizi, Michael R., Goldberg, Alfred L.
Published in The Journal of biological chemistry (01.04.2016)
Published in The Journal of biological chemistry (01.04.2016)
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An Antibacterial β‐Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis
Lehmann, Johannes, Cheng, Tan‐Yun, Aggarwal, Anup, Park, Annie S., Zeiler, Evelyn, Raju, Ravikiran M., Akopian, Tatos, Kandror, Olga, Sacchettini, James C., Moody, D. Branch, Rubin, Eric J., Sieber, Stephan A.
Published in Angewandte Chemie International Edition (02.01.2018)
Published in Angewandte Chemie International Edition (02.01.2018)
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Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity
Akopian, Tatos, Kandror, Olga, Tsu, Christopher, Lai, Jack H., Wu, Wengen, Liu, Yuxin, Zhao, Peng, Park, Annie, Wolf, Lisa, Dick, Lawrence R., Rubin, Eric J., Bachovchin, William, Goldberg, Alfred L.
Published in The Journal of biological chemistry (24.04.2015)
Published in The Journal of biological chemistry (24.04.2015)
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