Search Results - "AKIHIRO TASAKA" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I

by Aikawa, Katsuji, Miyawaki, Toshio, Hitaka, Takenori, Imai, Yumi N., Hara, Takahito, Miyazaki, Junichi, Yamaoka, Masuo, Kusaka, Masami, Kanzaki, Naoyuki, Tasaka, Akihiro, Shiraishi, Mitsuru, Yamamoto, Satoshi
Published in Bioorganic & medicinal chemistry (15.05.2015)

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Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists

Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists

by Yamamoto, Satoshi, Matsunaga, Nobuyuki, Hitaka, Takenori, Yamada, Masami, Hara, Takahito, Miyazaki, Junichi, Santou, Takashi, Kusaka, Masami, Yamaoka, Masuo, Kanzaki, Naoyuki, Furuya, Shuichi, Tasaka, Akihiro, Hamamura, Kazumasa, Ito, Mitsuhiro
Published in Bioorganic & medicinal chemistry (01.01.2012)

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Highly Enantioselective Reformatsky Reaction of Ketones: Chelation-Assisted Enantioface Discrimination

Highly Enantioselective Reformatsky Reaction of Ketones: Chelation-Assisted Enantioface Discrimination

by Ojida, Akio, Yamano, Toru, Taya, Naohiro, Tasaka, Akihiro
Published in Organic letters (05.09.2002)

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C17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors

C17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors

by MATSUNAGA, Nobuyuki, KAKU, Tomohiro, TASAKA, Akihiro, ITOH, Fumio, TANAKA, Toshimasa, HARA, Takahito, MIKI, Hiroshi, IWASAKI, Masahiko, AONO, Tetsuya, YAMAOKA, Masuo, KUSAKA, Masami
Published in Bioorganic & medicinal chemistry (01.05.2004)

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Total Synthesis of (−)-Bafilomycin A1: Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions

Total Synthesis of (−)-Bafilomycin A1: Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions

by Scheidt, Karl A., Tasaka, Akihiro, Bannister, Thomas D., Wendt, Michael D., Roush, William R.
Published in Angewandte Chemie International Edition (01.06.1999)

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Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

by Kaku, Tomohiro, Hitaka, Takenori, Ojida, Akio, Matsunaga, Nobuyuki, Adachi, Mari, Tanaka, Toshimasa, Hara, Takahito, Yamaoka, Masuo, Kusaka, Masami, Okuda, Teruaki, Asahi, Satoru, Furuya, Shuichi, Tasaka, Akihiro
Published in Bioorganic & medicinal chemistry (01.11.2011)

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O2F-3-4 Inhibition of androgen synthesis by TAK-700, a 17, 20-lyase inhibitor

O2F-3-4 Inhibition of androgen synthesis by TAK-700, a 17, 20-lyase inhibitor

by Masuo Yamaoka, Takahito Hara, Hiromi Shinohara, Tsuneo Masaki, Hideo Araki, Yumiko Akinaga, Takenori Hitaka, Nobuyuki Matsunaga, Tomohiro Kaku, Akihiro Tasaka, Masami Kusaka, Shuichi Furuya
Published in Journal of Pharmacological Sciences (2009)

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Optically Active Antifungal Azoles. X. Synthesis and Antifungal Activity of N-[4-(Azolyl)phenyl]- and N-[4-(Azolylmethyl)phenyl]-N'-[(1R, 2R)-2-(2, 4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-azolones

Optically Active Antifungal Azoles. X. Synthesis and Antifungal Activity of N-[4-(Azolyl)phenyl]- and N-[4-(Azolylmethyl)phenyl]-N'-[(1R, 2R)-2-(2, 4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-azolones

by KITAZAKI, Tomoyuki, ICHIKAWA, Takashi, TASAKA, Akihiro, HOSONO, Hiroshi, MATSUSHITA, Yoshihiro, HAYASHI, Ryogo, OKONOGI, Kenji, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (2000)

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Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats

Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats

by Hara, Takahito, Kouno, Jin, Kaku, Tomohiro, Takeuchi, Toshiyuki, Kusaka, Masami, Tasaka, Akihiro, Yamaoka, Masuo
Published in The Journal of steroid biochemistry and molecular biology (01.03.2013)

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Optically Active Antifungal Azoles. IX. An Alternative Synthetic Route for 2-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone and Its Analogs

Optically Active Antifungal Azoles. IX. An Alternative Synthetic Route for 2-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone and Its Analogs

by KITAZAKI, Tomoyuki, TASAKA, Akihiro, HOSONO, Hiroshi, MATSUSHITA, Yoshihiro, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (1999)

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Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

by Yamaoka, Masuo, Hara, Takahito, Hitaka, Takenori, Kaku, Tomohiro, Takeuchi, Toshiyuki, Takahashi, Junzo, Asahi, Satoru, Miki, Hiroshi, Tasaka, Akihiro, Kusaka, Masami
Published in The Journal of steroid biochemistry and molecular biology (01.04.2012)

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Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys

Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys

by Yamaoka, Masuo, Hara, Takahito, Araki, Hideo, Kaku, Tomohiro, Hitaka, Takenori, Tasaka, Akihiro, Kusaka, Masami
Published in The Journal of steroid biochemistry and molecular biology (01.11.2013)

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17,20-Lyase inhibitors. Part 4: Design, synthesis and structure–activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors

17,20-Lyase inhibitors. Part 4: Design, synthesis and structure–activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors

by Kaku, Tomohiro, Matsunaga, Nobuyuki, Ojida, Akio, Tanaka, Toshimasa, Hara, Takahito, Yamaoka, Masuo, Kusaka, Masami, Tasaka, Akihiro
Published in Bioorganic & medicinal chemistry (01.03.2011)

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Optically Active Antifungal Azoles. VIII. Synthesis and Antifungal Activity of 1-((1R,2R)-2-(2,4-Difluoro- and 2-Fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-3-(4-substituted phenyl)-2(1H,3H)-imidazolones and 2-Imidazolidinones

Optically Active Antifungal Azoles. VIII. Synthesis and Antifungal Activity of 1-((1R,2R)-2-(2,4-Difluoro- and 2-Fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-3-(4-substituted phenyl)-2(1H,3H)-imidazolones and 2-Imidazolidinones

by KITAZAKI, Tomoyuki, TASAKA, Akihiro, TAMURA, Norikazu, MATSUSHITA, Yoshihiro, HOSONO, Hiroshi, HAYASHI, Ryogo, OKONOGI, Kenji, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (1999)

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17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure–activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors

17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure–activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors

by Kaku, Tomohiro, Tsujimoto, Saori, Matsunaga, Nobuyuki, Tanaka, Toshimasa, Hara, Takahito, Yamaoka, Masuo, Kusaka, Masami, Tasaka, Akihiro
Published in Bioorganic & medicinal chemistry (01.04.2011)

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Optically Active Antifungal Azoles. VII. Synthesis and Antifungal Activity of Stereoisomers of 2-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone (TAK-187)

Optically Active Antifungal Azoles. VII. Synthesis and Antifungal Activity of Stereoisomers of 2-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone (TAK-187)

by TASAKA, Akihiro, KITAZAKI, Tomoyuki, TSUCHIMORI, Noboru, MATSUSHITA, Yoshihiro, HAYASHI, Rryogo, OKONOGI, Kenji, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (1997)

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C17,20-lyase inhibitors. Part 2: Design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors

C17,20-lyase inhibitors. Part 2: Design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors

by MATSUNAGA, Nobuyuki, KAKU, Tomohiro, OJIDA, Akio, TANAKA, Toshimasa, HARA, Takahito, YAMAOKA, Masuo, KUSAKA, Masami, TASAKA, Akihiro
Published in Bioorganic & medicinal chemistry (15.08.2004)

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Optically Active Antifungal Azoles. VI. Synthesis and Antifungal Activity of N-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-N'-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones and 5(1H,4H)-tetrazolones

Optically Active Antifungal Azoles. VI. Synthesis and Antifungal Activity of N-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-N'-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones and 5(1H,4H)-tetrazolones

by KITAZAKI, Tomoyuki, TAMURA, Norikazu, TASAKA, Akihiro, MATSUSHITA, Yoshihiro, HAYASHI, Ryogo, OKONOGI, Kenji, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (1996)

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Optically Active Antifungal Azoles. V. Synthesis and Antifungal Activity of Stereoisomers of 3-Azolyl-2-(substituted phenyl)-1-(1H-1, 2, 4-triazol-1-yl)-2-butanols

Optically Active Antifungal Azoles. V. Synthesis and Antifungal Activity of Stereoisomers of 3-Azolyl-2-(substituted phenyl)-1-(1H-1, 2, 4-triazol-1-yl)-2-butanols

by TASAKA, Akihiro, TSUCHIMORI, Noboru, KITAZAKI, Tomoyuki, HIROE, Katsuhiko, HAYASHI, Ryogo, OKONOGI, Kenji, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (1995)

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Total Synthesis of (−)-Bafilomycin A1

Total Synthesis of (−)-Bafilomycin A1

by Scheidt, Karl A, Bannister, Thomas D, Tasaka, Akihiro, Wendt, Michael D, Savall, Brad M, Fegley, Glenn J, Roush, William R
Published in Journal of the American Chemical Society (19.06.2002)

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