Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models
Okamoto, Kiyoshi, Kodama, Kotaro, Takase, Kazuma, Sugi, Naoko Hata, Yamamoto, Yuji, Iwata, Masao, Tsuruoka, Akihiko
Published in Cancer letters (28.10.2013)
Published in Cancer letters (28.10.2013)
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Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase
MATSUI, Junji, FUNAHASHI, Yasuhiro, UENAKA, Toshimitsu, WATANABE, Tatsuo, TSURUOKA, Akihiko, ASADA, Makoto
Published in Clinical cancer research (01.09.2008)
Published in Clinical cancer research (01.09.2008)
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Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization
Okamoto, Kiyoshi, Ikemori-Kawada, Megumi, Jestel, Anja, von König, Konstanze, Funahashi, Yasuhiro, Matsushima, Tomohiro, Tsuruoka, Akihiko, Inoue, Atsushi, Matsui, Junji
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models
Watanabe Miyano, Saori, Yamamoto, Yuji, Kodama, Kotaro, Miyajima, Yukiko, Mikamoto, Masaki, Nakagawa, Takayuki, Kuramochi, Hiroko, Funasaka, Setsuo, Nagao, Satoshi, Sugi, Naoko Hata, Okamoto, Kiyoshi, Minoshima, Yukinori, Nakatani, Yusuke, Karoji, Yuki, Ohashi, Isao, Yamane, Yoshinobu, Okada, Toshimi, Matsushima, Tomohiro, Matsui, Junji, Iwata, Masao, Uenaka, Toshimitsu, Tsuruoka, Akihiko
Published in Molecular cancer therapeutics (01.11.2016)
Published in Molecular cancer therapeutics (01.11.2016)
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Lenvatinib in combination with golvatinib overcomes hepatocyte growth factor pathway‐induced resistance to vascular endothelial growth factor receptor inhibitor
Nakagawa, Takayuki, Matsushima, Tomohiro, Kawano, Satoshi, Nakazawa, Youya, Kato, Yu, Adachi, Yusuke, Abe, Takanori, Semba, Taro, Yokoi, Akira, Matsui, Junji, Tsuruoka, Akihiko, Funahashi, Yasuhiro
Published in Cancer science (01.06.2014)
Published in Cancer science (01.06.2014)
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Antitumour activity of oral E7080, a novel inhibitor of multiple tyrosine kinases, in human sarcoma xenografts
Bruheim, Skjalg, Kristian, Alexandr, Uenaka, Toshimitsu, Suo, Zhenhe, Tsuruoka, Akihiko, Nesland, Jahn M., Fodstad, Øystein
Published in International journal of cancer (01.08.2011)
Published in International journal of cancer (01.08.2011)
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E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition
Matsui, Junji, Yamamoto, Yuji, Funahashi, Yasuhiro, Tsuruoka, Akihiko, Watanabe, Tatsuo, Wakabayashi, Toshiaki, Uenaka, Toshimitsu, Asada, Makoto
Published in International journal of cancer (01.02.2008)
Published in International journal of cancer (01.02.2008)
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Journal Article
E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling
Yamada, Kazuhiko, Hori, Yusaku, Inoue, Satoshi, Yamamoto, Yuji, Iso, Kentaro, Kamiyama, Hiroshi, Yamaguchi, Atsumi, Kimura, Takayuki, Uesugi, Mai, Ito, Junichi, Matsuki, Masahiro, Nakamoto, Kazutaka, Harada, Hitoshi, Yoneda, Naoki, Takemura, Atsushi, Kushida, Ikuo, Wakayama, Naomi, Kubara, Kenji, Kato, Yu, Semba, Taro, Yokoi, Akira, Matsukura, Masayuki, Odagami, Takenao, Iwata, Masao, Tsuruoka, Akihiko, Uenaka, Toshimitsu, Matsui, Junji, Matsushima, Tomohiro, Nomoto, Kenichi, Kouji, Hiroyuki, Owa, Takashi, Funahashi, Yasuhiro, Ozawa, Yoichi
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage
Yamamoto, Yuji, Matsui, Junji, Matsushima, Tomohiro, Obaishi, Hiroshi, Miyazaki, Kazuki, Nakamura, Katsuji, Tohyama, Osamu, Semba, Taro, Yamaguchi, Atsumi, Hoshi, Sachi Suzuki, Mimura, Fusayo, Haneda, Toru, Fukuda, Yoshio, Kamata, Jun-Ichi, Takahashi, Keiko, Matsukura, Masayuki, Wakabayashi, Toshiaki, Asada, Makoto, Nomoto, Ken-Ichi, Watanabe, Tatsuo, Dezso, Zoltan, Yoshimatsu, Kentaro, Funahashi, Yasuhiro, Tsuruoka, Akihiko
Published in Vascular cell (06.09.2014)
Published in Vascular cell (06.09.2014)
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Synthesis and Antifungal Activity of Novel Thiazole-Containing Triazole Antifungals. II. Optically Active ER-30346 and Its Derivatives
TSURUOKA, Akihiko, KAKU, Yumiko, KAKINUMA, Hiroyuki, TSUKADA, Itaru, YANAGISAWA, Manabu, NARA, Kazumasa, NAITO, Toshihiko
Published in Chemical & pharmaceutical bulletin (01.04.1998)
Published in Chemical & pharmaceutical bulletin (01.04.1998)
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Abstract 1362: Distinct binding mode of lenvatinib to VEGFR2 revealed by biochemical characterization
Okamoto, Kiyoshi, Kawada, Megumi Ikemori, Jestel, Anja, von König, Konstanze, Funahashi, Yasuhiro, Matsushima, Tomohiro, Tsuruoka, Akihiko, Inoue, Atsushi, Matsui, Junji
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 5177: E7386 : First-in-class orally active CBP/beta-catenin modulator as an anticancer agent
Yamada, Kazuhiko, Hori, Yusaku, Yamaguchi, Atsumi, Matsuki, Masahiro, Tsukamoto, Shuntaro, Yokoi, Akira, Semba, Taro, Ozawa, Yoichi, Inoue, Satoshi, Yamamoto, Yuji, Iso, Kentaro, Nakamoto, Kazutaka, Harada, Hitoshi, Yoneda, Naoki, Takemura, Atsushi, Matsukura, Masayuki, Kubara, Kenji, Odagami, Takenao, Iwata, Masao, Tsuruoka, Akihiko, Uenaka, Toshimitsu, Matsui, Junji, Matsushima, Tomohiro, Nomoto, Kenich, Kouji, Hiroyuki, Owa, Takashi
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 3614: Multi-targeted kinase inhibitor E7080 showed anti-tumor activity against medullary thyroid carcinoma and squamous thyroid carcinoma cell line based on RET and VEGFR2 tyrosine kinase inhibition
Matsui, Junji, Minoshima, Yukinori, Tsuruoka, Akihiko, Funahashi, Yasuhiro
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Abstract 770: E7090: A potent and selective FGFR inhibitor with activity in multiple FGFR-driven cancer models with distinct mechanisms of activation
Miyano, Saori Watanabe, Yamamoto, Yuji, Kodama, Kotaro, Funasaka, Setsuo, Nagao, Satoshi, Sugi, Naoko Hata, Kuramochi, Hiroko, Ishikawa, Katsuyuki, Okamoto, Kiyoshi, Minoshima, Yukinori, Nakagawa, Takayuki, Nakatani, Yusuke, Karoji, Yuki, Ohashi, Isao, Yamane, Yoshinobu, Tanaka, Keigo, Okada, Toshimi, Matsushima, Tomohiro, Matsui, Junji, Iwata, Masao, Tsuruoka, Akihiko, Uenaka, Toshimitsu
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Preclinical and clinical researches of lenvatinib mesylate (Lenvima capsule), a novel antitumor agent approved for thyroid cancer treatment
Tsuruoka, Akihiko, Matsui, Junji, Suzuki, Takuya, Koyama, Noriyuki, Watanabe, Tatsuo, Funahashi, Yasuhiro
Published in Nihon yakurigaku zasshi (01.11.2015)
Published in Nihon yakurigaku zasshi (01.11.2015)
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E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor
Ogino, Hirokazu, Hanibuchi, Masaki, Kakiuchi, Soji, Trung, Van The, Goto, Hisatsugu, Ikuta, Kenji, Yamada, Tadaaki, Uehara, Hisanori, Tsuruoka, Akihiko, Uenaka, Toshimitsu, Wang, Wei, Li, Qi, Takeuchi, Shinji, Yano, Seiji, Nishioka, Yasuhiko, Sone, Saburo
Published in Molecular cancer therapeutics (01.07.2011)
Published in Molecular cancer therapeutics (01.07.2011)
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STUDIES ON ORALLY ACTIVE CEPHALOSPORINS: I. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NEW 3-SUBSTITUTED CARBAMOYLOXYMETHYL CEPHALOSPORINS
NEGI, SHIGETO, YAMANAKA, MOTOSUKE, SUGIYAMA, ISAO, KOMATSU, YUKI, SASHO, MANABU, TSURUOKA, AKIHIKO, KAMADA, ATSUSHI, TSUKADA, ITARU, HIRUMA, RYOICHI, KATSU, KANEMASA, MACHIDA, YOSHIMASA
Published in Journal of antibiotics (1994)
Published in Journal of antibiotics (1994)
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Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin α2 subunit on endothelium
FUNAHASHI, Yasuhiro, SUGI, Naoko Hata, OKABE, Tadashi, KAMATA, Junichi, OWA, Takashi, UEDA, Norihiro, HANEDA, Toru, YONAGA, Masahiro, YOSHIMATSU, Kentaro, WAKABAYASHI, Toshiaki, SEMBA, Taro, YAMAMOTO, Yuji, HAMAOKA, Shinichi, TSUKAHARA-TAMAI, Naoko, OZAWA, Yoichi, TSURUOKA, Akihiko, NARA, Kazumasa, TAKAHASHI, Keiko
Published in Cancer research (Chicago, Ill.) (2002)
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Published in Cancer research (Chicago, Ill.) (2002)
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