Antibody–Drug Conjugate Payloads; Study of Auristatin Derivatives
Akaiwa, Michinori, Dugal-Tessier, Julien, Mendelsohn, Brian A.
Published in Chemical & pharmaceutical bulletin (01.03.2020)
Published in Chemical & pharmaceutical bulletin (01.03.2020)
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Journal Article
Design, Synthesis, and Structure–Activity Relationships Study of N-Pyrimidyl/Pyridyl-2-thiazolamine Analogues as Novel Positive Allosteric Modulators of M3 Muscarinic Acetylcholine Receptor
Tanaka, Hiroaki, Akaiwa, Michinori, Negoro, Kenji, Kawaminami, Eiji, Mihara, Hisashi, Fuji, Hideyoshi, Okimoto, Risa, Ino, Katsutoshi, Ishizu, Kenichiro, Takahashi, Taisuke
Published in Chemical & pharmaceutical bulletin (01.04.2021)
Published in Chemical & pharmaceutical bulletin (01.04.2021)
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Journal Article
Design, Synthesis, and Structure-Activity Relationships Study of N-Pyrimidyl/Pyridyl-2-thiazolamine Analogues as Novel Positive Allosteric Modulators of M3 Muscarinic Acetylcholine Receptor
Hiroaki Tanaka, Michinori Akaiwa, Kenji Negoro, Eiji Kawaminami, Hisashi Mihara, Hideyoshi Fuji, Risa Okimoto, Katsutoshi Ino, Kenichiro Ishizu, Taisuke Takahashi
Published in Chemical and Pharmaceutical Bulletin (01.04.2021)
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Published in Chemical and Pharmaceutical Bulletin (01.04.2021)
Journal Article
Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity
Imaizumi, Tomoyoshi, Akaiwa, Michinori, Abe, Tomoaki, Nigawara, Takahiro, Koike, Takanori, Satake, Yoshiki, Watanabe, Kazushi, Kaneko, Osamu, Amano, Yasushi, Mori, Kenichi, Yamanaka, Yosuke, Nagashima, Takeyuki, Shimazaki, Masashi, Kuramoto, Kazuyuki
Published in Bioorganic & medicinal chemistry (01.10.2022)
Published in Bioorganic & medicinal chemistry (01.10.2022)
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Journal Article
Design, Synthesis, and Structure-Activity Relationships Study of N-Pyrimidyl/Pyridyl-2-thiazolamine Analogues as Novel Positive Allosteric Modulators of M-3 Muscarinic Acetylcholine Receptor
Tanaka, Hiroaki, Akaiwa, Michinori, Negoro, Kenji, Kawaminami, Eiji, Mihara, Hisashi, Fuji, Hideyoshi, Okimoto, Risa, Ino, Katsutoshi, Ishizu, Kenichiro, Takahashi, Taisuke
Published in Chemical & pharmaceutical bulletin (01.04.2021)
Published in Chemical & pharmaceutical bulletin (01.04.2021)
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Journal Article
Total Synthesis of (−)-Lemonomycin
Yoshida, Atsushi, Akaiwa, Michinori, Asakawa, Tomohiro, Hamashima, Yoshitaka, Yokoshima, Satoshi, Fukuyama, Tohru, Kan, Toshiyuki
Published in Chemistry : a European journal (03.09.2012)
Published in Chemistry : a European journal (03.09.2012)
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Journal Article
ANTIBODY-DRUG COMPLEX CONTAINING TOLL-LIKE RECEPTOR 7/8 DUAL AGONIST COMPOUND
CHAEN, Takashi, OHNUKI, Kei, WANG, Yinghua, MIGUELEZ, Javier Ramos, AKAIWA, Michinori, KAMIKAWA, Akio, HOSHI, Rika, SEKI, Yohei, KWON, Chulwon, ASANO, Toru, SOGA, Shinji, KAMIKUBO, Takashi
Year of Publication 10.05.2024
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Year of Publication 10.05.2024
Patent
배위자, 스페이서, 펩티드 링커 및 생물 분자를 포함하는 복합체
AKAIWA MICHINORI, SUGANO YUKIHITO, SANO YORIKATA, YOSHIKAWA TOMOAKI, ASANO TORU, TOYA HIROKI, ISHIDA JUNYA
Year of Publication 15.09.2021
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Year of Publication 15.09.2021
Patent
항인간 MUC1 항체 Fab 프래그먼트, 펩티드 링커 및/또는 배위자를 포함하는 복합체
AKAIWA MICHINORI, MORINAKA AKIFUMI, YAMADA HIROYOSHI, SANO YORIKATA, SHIRAI HIROKI, HIRAYAMA KAZUNORI, SHIRAISHI NOBUYUKI, ASANO TORU
Year of Publication 02.02.2021
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Year of Publication 02.02.2021
Patent
배위자 및 CEACAM5 항체 Fab 프래그먼트를 포함하는 복합체
AKAIWA MICHINORI, SANO YORIKATA, SHIRAI HIROKI, SHIRAISHI NOBUYUKI, YOSHIKAWA TOMOAKI, HIRAYAMA KAZUNORI, DOIHARA HITOSHI, ASANO TORU, TOYA HIROKI, ISHIDA JUNYA
Year of Publication 15.09.2021
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Year of Publication 15.09.2021
Patent
COMPLEX COMPRISING LIGAND, SPACER, PEPTIDE LINKER, AND BIOMOLECULE
SANO, Yorikata, YOSHIKAWA, Tomoaki, AKAIWA, Michinori, ISHIDA, Junya, ASANO, Toru, SUGANO, Yukihito, TOYA, Hiroki
Year of Publication 16.07.2020
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Year of Publication 16.07.2020
Patent
COMPLEX COMPRISING LIGAND AND CEACAM5 ANTIBODY FAB FRAGMENT
SHIRAISHI, Nobuyuki, SANO, Yorikata, SHIRAI, Hiroki, AKAIWA, Michinori, YOSHIKAWA, TOMOAKI, DOIHARA, Hitoshi, ISHIDA, Junya, ASANO, Toru, TOYA, Hiroki, HIRAYAMA, Kazunori
Year of Publication 16.07.2020
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Year of Publication 16.07.2020
Patent
Luminescent palladium complexes containing thioamide-based SCS pincer ligands
Akaiwa, Michinori, Kanbara, Takaki, Fukumoto, Hiroki, Yamamoto, Takakazu
Published in Journal of organometallic chemistry (15.09.2005)
Published in Journal of organometallic chemistry (15.09.2005)
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Journal Article
퀴나졸린 화합물
ARAKAWA KEISUKE, KURAMOTO KAZUYUKI, NIGAWARA TAKAHIRO, SHIMADA ITSURO, ABE TOMOAKI, SATAKE YOSHIKI, AKAIWA MICHINORI, SHIMAZAKI MASASHI, WATANABE KAZUSHI, ARAKI TAKANOBU, YAMAKI SUSUMU, KUNIKAWA SHIGEKI, KOIKE TAKANORI, IMAIZUMI TOMOYOSHI
Year of Publication 08.10.2019
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Year of Publication 08.10.2019
Patent
2- 2-AMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
AKAIWA MICHINORI, MIHARA HISASHI, TANAKA HIROAKI, TAKAHASHI TAISUKE, TAKAMATSU HAJIME, NEGORO KENJI, FUJI HIDEYOSHI
Year of Publication 19.04.2017
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Year of Publication 19.04.2017
Patent
QUINAZOLINE COMPOUND
ABE, Tomoaki, KURAMOTO, Kazuyuki, AKAIWA, Michinori, YAMAKI, Susumu, KOIKE, Takanori, SATAKE, Yoshiki, NIGAWARA, Takahiro, SHIMADA, Itsuro, IMAIZUMI, Tomoyoshi, ARAKI, Takanobu, ARAKAWA, Keisuke, WATANABE, Kazushi, SHIMAZAKI, Masashi, KUNIKAWA, Shigeki
Year of Publication 09.08.2018
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Year of Publication 09.08.2018
Patent
2-AMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
TAKAMATSU, HAJIME, TAKAHASHI, TAISUKE, NEGORO, KENJI, FUJI, HIDEYOSHI, TANAKA, HIROAKI, MIHARA, HISASHI, AKAIWA, MICHINORI
Year of Publication 03.03.2016
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Year of Publication 03.03.2016
Patent
COMPLEX COMPRISING LIGAND, SPACER, PEPTIDE LINKER, AND BIOMOLECULE
SANO, Yorikata, YOSHIKAWA, Tomoaki, AKAIWA, Michinori, ISHIDA, Junya, ASANO, Toru, SUGANO, Yukihito, TOYA, Hiroki
Year of Publication 08.03.2023
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Year of Publication 08.03.2023
Patent