Twenty-eight-day repeated oral doses of sodium valproic acid increases neural stem cells and suppresses differentiation of granule cell lineages in adult hippocampal neurogenesis of postpubertal rats
Watanabe, Yousuke, Nakajima, Kota, Ito, Yuko, Akahori, Yumi, Saito, Fumiyo, Woo, Gye-Hyeong, Yoshida, Toshinori, Shibutani, Makoto
Published in Toxicology letters (15.09.2019)
Published in Toxicology letters (15.09.2019)
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Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens
Ito, Yuko, Nakajima, Kota, Masubuchi, Yasunori, Kikuchi, Satomi, Saito, Fumiyo, Akahori, Yumi, Jin, Meilan, Yoshida, Toshinori, Shibutani, Makoto
Published in Toxicological sciences (01.05.2019)
Published in Toxicological sciences (01.05.2019)
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Differential effects between developmental and postpubertal exposure to N-methyl-N-nitrosourea on progenitor cell proliferation of rat hippocampal neurogenesis in relation to COX2 expression in granule cells
Watanabe, Yousuke, Nakajima, Kota, Mizukami, Sayaka, Akahori, Yumi, Imatanaka, Nobuya, Woo, Gye-Hyeong, Yoshida, Toshinori, Shibutani, Makoto
Published in Toxicology (Amsterdam) (15.08.2017)
Published in Toxicology (Amsterdam) (15.08.2017)
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Glycidol induces axonopathy by adult-stage exposure and aberration of hippocampal neurogenesis affecting late-stage differentiation by developmental exposure in rats
Akane, Hirotoshi, Shiraki, Ayako, Imatanaka, Nobuya, Akahori, Yumi, Itahashi, Megu, Ohishi, Takumi, Mitsumori, Kunitoshi, Shibutani, Makoto
Published in Toxicological sciences (01.07.2013)
Published in Toxicological sciences (01.07.2013)
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Immunohistochemistry of aberrant neuronal development induced by 6-propyl-2-thiouracil in rats
Shiraki, Ayako, Tanaka, Takeshi, Watanabe, Yousuke, Saito, Fumiyo, Akahori, Yumi, Imatanaka, Nobuya, Yoshida, Toshinori, Shibutani, Makoto
Published in Toxicology letters (02.11.2016)
Published in Toxicology letters (02.11.2016)
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Journal Article
Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in Rat Offspring
Watanabe, Yousuke, Murakami, Tomoaki, Kawashima, Masashi, Hasegawa-Baba, Yasuko, Mizukami, Sayaka, Imatanaka, Nobuya, Akahori, Yumi, Yoshida, Toshinori, Shibutani, Makoto
Published in Neurotoxicity research (01.01.2017)
Published in Neurotoxicity research (01.01.2017)
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Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells
Ito, Yuko, Nakajima, Kota, Masubuchi, Yasunori, Kikuchi, Satomi, Saito, Fumiyo, Akahori, Yumi, Jin, Meilan, Yoshida, Toshinori, Shibutani, Makoto
Published in Journal of Toxicologic Pathology (01.01.2019)
Published in Journal of Toxicologic Pathology (01.01.2019)
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Journal Article
Glycidol induces axonopathy and aberrations of hippocampal neurogenesis affecting late-stage differentiation by exposure to rats in a framework of 28-day toxicity study
Akane, Hirotoshi, Shiraki, Ayako, Imatanaka, Nobuya, Akahori, Yumi, Itahashi, Megu, Abe, Hajime, Shibutani, Makoto
Published in Toxicology letters (30.01.2014)
Published in Toxicology letters (30.01.2014)
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OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study
Hecker, Markus, Hollert, Henner, Cooper, Ralph, Vinggaard, Anne Marie, Akahori, Yumi, Murphy, Margaret, Nellemann, Christine, Higley, Eric, Newsted, John, Laskey, John, Buckalew, Angela, Grund, Stefanie, Maletz, Sibylle, Giesy, John, Timm, Gary
Published in Environmental science and pollution research international (01.03.2011)
Published in Environmental science and pollution research international (01.03.2011)
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Gene expression profiling of the hippocampal dentate gyrus in an adult toxicity study captures a variety of neurodevelopmental dysfunctions in rat models of hypothyroidism
Shiraki, Ayako, Saito, Fumiyo, Akane, Hirotoshi, Akahori, Yumi, Imatanaka, Nobuya, Itahashi, Megu, Yoshida, Toshinori, Shibutani, Makoto
Published in Journal of applied toxicology (01.01.2016)
Published in Journal of applied toxicology (01.01.2016)
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Methacarn as a whole brain fixative for gene and protein expression analyses of specific brain regions in rats
Akane, Hirotoshi, Saito, Fumiyo, Yamanaka, Hidenori, Shiraki, Ayako, Imatanaka, Nobuya, Akahori, Yumi, Morita, Reiko, Mitsumori, Kunitoshi, Shibutani, Makoto
Published in Journal of toxicological sciences (2013)
Published in Journal of toxicological sciences (2013)
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In silico toxicology protocols
Myatt, Glenn J, Ahlberg, Ernst, Akahori, Yumi, Allen, David, Amberg, Alexander, Anger, Lennart T, Aptula, Aynur, Auerbach, Scott, Beilke, Lisa, Bellion, Phillip, Benigni, Romualdo, Bercu, Joel, Booth, Ewan D, Bower, Dave, Brigo, Alessandro, Burden, Natalie, Cammerer, Zoryana, Cronin, Mark T D, Cross, Kevin P, Custer, Laura, Dettwiler, Magdalena, Dobo, Krista, Ford, Kevin A, Fortin, Marie C, Gad-McDonald, Samantha E, Gellatly, Nichola, Gervais, Véronique, Glover, Kyle P, Glowienke, Susanne, Van Gompel, Jacky, Gutsell, Steve, Hardy, Barry, Harvey, James S, Hillegass, Jedd, Honma, Masamitsu, Hsieh, Jui-Hua, Hsu, Chia-Wen, Hughes, Kathy, Johnson, Candice, Jolly, Robert, Jones, David, Kemper, Ray, Kenyon, Michelle O, Kim, Marlene T, Kruhlak, Naomi L, Kulkarni, Sunil A, Kümmerer, Klaus, Leavitt, Penny, Majer, Bernhard, Masten, Scott, Miller, Scott, Moser, Janet, Mumtaz, Moiz, Muster, Wolfgang, Neilson, Louise, Oprea, Tudor I, Patlewicz, Grace, Paulino, Alexandre, Lo Piparo, Elena, Powley, Mark, Quigley, Donald P, Reddy, M Vijayaraj, Richarz, Andrea-Nicole, Ruiz, Patricia, Schilter, Benoit, Serafimova, Rositsa, Simpson, Wendy, Stavitskaya, Lidiya, Stidl, Reinhard, Suarez-Rodriguez, Diana, Szabo, David T, Teasdale, Andrew, Trejo-Martin, Alejandra, Valentin, Jean-Pierre, Vuorinen, Anna, Wall, Brian A, Watts, Pete, White, Angela T, Wichard, Joerg, Witt, Kristine L, Woolley, Adam, Woolley, David, Zwickl, Craig, Hasselgren, Catrin
Published in Regulatory toxicology and pharmacology (01.07.2018)
Published in Regulatory toxicology and pharmacology (01.07.2018)
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Transcriptomics-driven Evaluation on Liver Toxicity Using Adverse Outcome Pathways (AOP)
Akahori, Yumi, Yamashita, Kyousuke, Ishida, Kazuya, Saito, Fumiyo, Nakai, Makoto
Published in YAKUGAKU ZASSHI (01.04.2020)
Published in YAKUGAKU ZASSHI (01.04.2020)
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Journal Article
Gene expression profiles of multiple brain regions in rats differ between developmental and postpubertal exposure to valproic acid
Ojiro, Ryota, Watanabe, Yousuke, Okano, Hiromu, Takahashi, Yasunori, Takashima, Kazumi, Tang, Qian, Ozawa, Shunsuke, Saito, Fumiyo, Akahori, Yumi, Jin, Meilan, Yoshida, Toshinori, Shibutani, Makoto
Published in Journal of applied toxicology (01.05.2022)
Published in Journal of applied toxicology (01.05.2022)
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Genetic toxicology in silico protocol
Hasselgren, Catrin, Ahlberg, Ernst, Akahori, Yumi, Amberg, Alexander, Anger, Lennart T, Atienzar, Franck, Auerbach, Scott, Beilke, Lisa, Bellion, Phillip, Benigni, Romualdo, Bercu, Joel, Booth, Ewan D, Bower, Dave, Brigo, Alessandro, Cammerer, Zoryana, Cronin, Mark T D, Crooks, Ian, Cross, Kevin P, Custer, Laura, Dobo, Krista, Doktorova, Tatyana, Faulkner, David, Ford, Kevin A, Fortin, Marie C, Frericks, Markus, Gad-McDonald, Samantha E, Gellatly, Nichola, Gerets, Helga, Gervais, Véronique, Glowienke, Susanne, Van Gompel, Jacky, Harvey, James S, Hillegass, Jedd, Honma, Masamitsu, Hsieh, Jui-Hua, Hsu, Chia-Wen, Barton-Maclaren, Tara S, Johnson, Candice, Jolly, Robert, Jones, David, Kemper, Ray, Kenyon, Michelle O, Kruhlak, Naomi L, Kulkarni, Sunil A, Kümmerer, Klaus, Leavitt, Penny, Masten, Scott, Miller, Scott, Moudgal, Chandrika, Muster, Wolfgang, Paulino, Alexandre, Lo Piparo, Elena, Powley, Mark, Quigley, Donald P, Reddy, M Vijayaray, Richarz, Andrea-Nicole, Schilter, Benoit, Snyder, Ronald D, Stavitskaya, Lidiya, Stidl, Reinhard, Szabo, David T, Teasdale, Andrew, Tice, Raymond R, Trejo-Martin, Alejandra, Vuorinen, Anna, Wall, Brian A, Watts, Pete, White, Angela T, Wichard, Joerg, Witt, Kristine L, Woolley, Adam, Woolley, David, Zwickl, Craig, Myatt, Glenn J
Published in Regulatory toxicology and pharmacology (01.10.2019)
Published in Regulatory toxicology and pharmacology (01.10.2019)
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Journal Article
Downregulation of low‐density lipoprotein receptor class A domain‐containing protein 4 (Ldlrad4) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor β signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis
Ito, Yuko, Nakajima, Kota, Masubuchi, Yasunori, Kikuchi, Satomi, Okano, Hiromu, Saito, Fumiyo, Akahori, Yumi, Jin, Meilan, Yoshida, Toshinori, Shibutani, Makoto
Published in Journal of applied toxicology (01.11.2020)
Published in Journal of applied toxicology (01.11.2020)
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Journal Article
Developmental exposure to cuprizone reduces intermediate-stage progenitor cells and cholinergic signals in the hippocampal neurogenesis in rat offspring
Abe, Hajime, Tanaka, Takeshi, Kimura, Masayuki, Mizukami, Sayaka, Imatanaka, Nobuya, Akahori, Yumi, Yoshida, Toshinori, Shibutani, Makoto
Published in Toxicology letters (05.05.2015)
Published in Toxicology letters (05.05.2015)
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