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Pharmacological Characterization of a Novel, Potent Adenosine A1 and A2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in Models of Parkinson's Disease and Cognition

Pharmacological Characterization of a Novel, Potent Adenosine A1 and A2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in Models of Parkinson's Disease and Cognition

by Mihara, Takuma, Mihara, Kayoko, Yarimizu, Junko, Mitani, Yasuyuki, Matsuda, Ritsuko, Yamamoto, Hiroko, Aoki, Satoshi, Akahane, Atsushi, Iwashita, Akinori, Matsuoka, Nobuya
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)

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Journal Article

Pharmacological Characterization of FR194921, a New Potent, Selective, and Orally Active Antagonist for Central Adenosine A1 Receptors

Pharmacological Characterization of FR194921, a New Potent, Selective, and Orally Active Antagonist for Central Adenosine A1 Receptors

by Maemoto, Takuya, Tada, Miho, Mihara, Takuma, Ueyama, Noriko, Matsuoka, Hideaki, Harada, Katsuya, Yamaji, Takayuki, Shirakawa, Kiyoharu, Kuroda, Satoru, Akahane, Atsushi, Iwashita, Akinori, Matsuoka, Nobuya, Mutoh, Seitaro
Published in Journal of Pharmacological Sciences (2004)

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Design, Synthesis and Biological Evaluation of a Novel Series of Potent, Orally Active Adenosine A1 Receptor Antagonists with High Blood-Brain Barrier Permeability

Design, Synthesis and Biological Evaluation of a Novel Series of Potent, Orally Active Adenosine A1 Receptor Antagonists with High Blood-Brain Barrier Permeability

by KURODA, Satoru, TAKAMURA, Fujiko, TENDA, Yoshiyuki, ITANI, Hiromichi, TOMISHIMA, Yasuyo, AKAHANE, Atsushi, SAKANE, Kazuo
Published in Chemical & pharmaceutical bulletin (01.08.2001)

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Species differences in brain adenosine A1 receptor pharmacology revealed by use of xanthine and pyrazolopyridine based antagonists

Species differences in brain adenosine A1 receptor pharmacology revealed by use of xanthine and pyrazolopyridine based antagonists

by Maemoto, Takuya, Finlayson, Keith, Olverman, Henry J., Akahane, Atsushi, Horton, Roger W., Butcher, Steven P.
Published in British journal of pharmacology (01.11.1997)

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Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist

Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist

by KURODA, S, AKAHANE, A, ITANI, H, NISHIMURA, S, DURKIN, K, KINOSHITA, T, TENDA, Y, SAKANE, K
Published in Bioorganic & medicinal chemistry letters (19.07.1999)

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Synthesis of the water-soluble adenosine A1 receptor antagonist FR166124 through a novel sequential Horner-Emmons / isomerization reaction

Synthesis of the water-soluble adenosine A1 receptor antagonist FR166124 through a novel sequential Horner-Emmons / isomerization reaction

by Kuroda, Satoru, Akahane, Atsushi, Itani, Hiromichi, Nishimura, Shintaro, Durkin, Kieran, Kinoshita, Takayoshi, Nakanishi, Isao, Sakane, Kazuo
Published in Tetrahedron (01.08.1999)

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Novel adenosine A 1 receptor antagonists. Synthesis and structure–activity relationships of a novel series of 3-(2-cyclohexenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5- a ]pyridines

Novel adenosine A 1 receptor antagonists. Synthesis and structure–activity relationships of a novel series of 3-(2-cyclohexenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5- a ]pyridines

by Kuroda, Satoru, Akahane, Atsushi, Itani, Hiromichi, Nishimura, Shintaro, Durkin, Kieran, Tenda, Yoshiyuki, Sakane, Kazuo
Published in Bioorganic & medicinal chemistry (01.01.2000)

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CHIRAL FORMAMIDINES - ASYMMETRIC-SYNTHESIS OF 1,1-DISUBSTITUTED TETRAHYDROISOQUINOLINES

CHIRAL FORMAMIDINES - ASYMMETRIC-SYNTHESIS OF 1,1-DISUBSTITUTED TETRAHYDROISOQUINOLINES

by MEYERS, AI, GONZALEZ, MA, STRUZKA, AKAHANE, A, GUILES, J, WARMUS, JS
Published in Tetrahedron letters (30.09.1991)

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Synthesis and Anticholinergic Activity of the Four Stereoisomers of 4-(Dimethylamino)-2-phenyl-2-(2-pyridyl)pentanamide

Synthesis and Anticholinergic Activity of the Four Stereoisomers of 4-(Dimethylamino)-2-phenyl-2-(2-pyridyl)pentanamide

by Oyasu, Hitoshi, Nagano, Masanobu, Akahane, Atsushi, Tomoi, Masaaki, Tada, Toshiji, Matsuo, Masaaki
Published in Journal of medicinal chemistry (01.04.1994)

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Species differences in brain adenosine A 1 receptor pharmacology revealed by use of xanthine and pyrazolopyridine based antagonists

Species differences in brain adenosine A 1 receptor pharmacology revealed by use of xanthine and pyrazolopyridine based antagonists

by Maemoto, Takuya, Finlayson, Keith, Olverman, Henry J., Akahane, Atsushi, Horton, Roger W., Butcher, Steven P.
Published in British journal of pharmacology (03.02.2009)

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Journal Article

Pharmacological Characterization of a Novel, Potent Adenosine A 1 and A 2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1 H )-one (ASP5854), in Models of Parkinson's Disease and Cognition

Pharmacological Characterization of a Novel, Potent Adenosine A 1 and A 2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1 H )-one (ASP5854), in Models of Parkinson's Disease and Cognition

by Mihara, Takuma, Mihara, Kayoko, Yarimizu, Junko, Mitani, Yasuyuki, Matsuda, Ritsuko, Yamamoto, Hiroko, Aoki, Satoshi, Akahane, Atsushi, Iwashita, Akinori, Matsuoka, Nobuya
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)

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Journal Article

Discovery of 6-Oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinebutanoic Acid (FK 838): A Novel Non-Xanthine Adenosine A1 Receptor Antagonist with Potent Diuretic Activity

Discovery of 6-Oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinebutanoic Acid (FK 838): A Novel Non-Xanthine Adenosine A1 Receptor Antagonist with Potent Diuretic Activity

by Akahane, Atsushi, Katayama, Hirohito, Mitsunaga, Takafumi, Kato, Takeshi, Kinoshita, Takayoshi, Kita, Yasuhiro, Kusunoki, Takahiro, Terai, Takao, Yoshida, Keizo, Shiokawa, Youichi
Published in Journal of medicinal chemistry (11.03.1999)

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Syntheses of arborescin, 1,10-epiarborescin, and (11S)-guaia-3,10(14)-dieno-13,6.alpha.-lactone, the key intermediate in Greene and Crabbe's estafiatin synthesis, and the stereochemical assignment of arborescin

Syntheses of arborescin, 1,10-epiarborescin, and (11S)-guaia-3,10(14)-dieno-13,6.alpha.-lactone, the key intermediate in Greene and Crabbe's estafiatin synthesis, and the stereochemical assignment of arborescin

by Ando, Masayoshi, Akahane, Atsushi, Yamaoka, Hiroaki, Takase, Kahei
Published in Journal of organic chemistry (01.09.1982)

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Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques

Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques

by Marston, H M, Finlayson, K, Maemoto, T, Olverman, H J, Akahane, A, Sharkey, J, Butcher, S P
Published in The Journal of pharmacology and experimental therapeutics (01.06.1998)

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Journal Article

PYRAZOLE COMPOUNDS AND MEDICINAL USE THEREOF

PYRAZOLE COMPOUNDS AND MEDICINAL USE THEREOF

by KURODA, SATORU, AKAHANE, ATSUSHI, ITANI, HIROMICHI
Year of Publication 20.05.1999

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Patent

Novel adenosine A1 receptor antagonists. Synthesis and structure-activity relationships of a novel series of 3-(2-cyclohexenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5 -a]pyridines

Novel adenosine A1 receptor antagonists. Synthesis and structure-activity relationships of a novel series of 3-(2-cyclohexenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5 -a]pyridines

by Kuroda, S, Akahane, A, Itani, H, Nishimura, S, Durkin, K, Tenda, Y, Sakane, K
Published in Bioorganic & medicinal chemistry (01.01.2000)

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Journal Article

PYRAZOLOPYRIDINE COMPOUND AND PROCESSES FOR PREPARATION THEREOF

PYRAZOLOPYRIDINE COMPOUND AND PROCESSES FOR PREPARATION THEREOF

by SHIOKAWA, YOUICHI, MITSUNAGA, TAKAFUMI, KATAYAMA, HIROHITO, AKAHANE, ATSUSHI
Year of Publication 01.08.2000

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Patent

NEW USE OF THE ADENOSINE ANTAGONIST

NEW USE OF THE ADENOSINE ANTAGONIST

by SHIOKAWA, YOUICHI, MITSUNAGA, TAKAFUMI, KATAYAMA, HIROHITO, AKAHANE, ATSUSHI
Year of Publication 01.02.2000

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Patent

PYRAZOLOPYRIDINE COMPOUNDS AND MEDICINAL USES THEREOF

PYRAZOLOPYRIDINE COMPOUNDS AND MEDICINAL USES THEREOF

by NISHIMURA, SHINTARO, KURODA, SATORU, AKAHANE, ATSUSHI, ITANI, HIROMICHI
Year of Publication 29.12.1999

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Patent

PYRAZOLOPYRIDINE COMPOUND AND PROCESSES FOR PREPARATION THEREOF

PYRAZOLOPYRIDINE COMPOUND AND PROCESSES FOR PREPARATION THEREOF

by SHIOKAWA, YOUICHI, MITSUNAGA, TAKAFUMI, KATAYAMA, HIROHITO, AKAHANE, ATSUSHI
Year of Publication 01.09.1999

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Patent

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