Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity
Guo, Yanxia, MacIsaac, Kenzie D., Chen, Yi, Miller, Richard J., Jain, Renu, Joyce-Shaikh, Barbara, Ferguson, Heidi, Wang, I-Ming, Cristescu, Razvan, Mudgett, John, Engstrom, Laura, Piers, Kyle J., Baltus, Gretchen A., Barr, Kenneth, Zhang, Hongjun, Mehmet, Huseyin, Hegde, Laxminarayan G., Hu, Xiao, Carter, Laura L., Aicher, Thomas D., Glick, Gary, Zaller, Dennis, Hawwari, Abbas, Correll, Craig C., Jones, Dallas C., Cua, Daniel J.
Published in Cell reports (Cambridge) (20.12.2016)
Published in Cell reports (Cambridge) (20.12.2016)
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Journal Article
Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator
Thomson, Christopher G., Aicher, Thomas D., Cheng, Weiwei, Du, Hongwen, Dudgeon, Crissy, Li, An-Hu, Li, Baozhong, Lightcap, Eric, Luo, Diheng, Mulvihill, Mark, Pan, Pengwei, Rahemtulla, Benjamin F., Rigby, Alan C., Sherborne, Bradley, Sood, Sanjeev, Surguladze, David, Talbot, Eric P. A., Tameire, Feven, Taylor, Simon, Wang, Yi, Wojnarowicz, Paulina, Xiao, Fenfen, Ramurthy, Savithri
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
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Journal Article
Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ) Agonist for Use in Treating Cancer
Aicher, Thomas D, Van Huis, Chad A, Hurd, Alexander R, Skalitzky, Donald J, Taylor, Clarke B, Beleh, Omar M, Glick, Gary, Toogood, Peter L, Yang, Bing, Zheng, Tao, Huo, Changxin, Gao, Jie, Qiao, Chenxi, Tian, Xiaolong, Zhang, Junping, Demock, Kellie, Hao, Ling-Yang, Lesch, Charles A, Morgan, Rodney W, Moisan, Jacques, Wang, Yahong, Scatina, JoAnn, Paulos, Chrystal M, Zou, Weiping, Carter, Laura L, Hu, Xiao
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Journal Article
Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity
Hu, Xiao, Liu, Xikui, Moisan, Jacques, Wang, Yahong, Lesch, Charles A., Spooner, Chauncey, Morgan, Rodney W., Zawidzka, Elizabeth M., Mertz, David, Bousley, Dick, Majchrzak, Kinga, Kryczek, Ilona, Taylor, Clarke, Van Huis, Chad, Skalitzky, Don, Hurd, Alexander, Aicher, Thomas D., Toogood, Peter L., Glick, Gary D., Paulos, Chrystal M., Zou, Weiping, Carter, Laura L.
Published in Oncoimmunology (01.12.2016)
Published in Oncoimmunology (01.12.2016)
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Journal Article
RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease
de Wit, Jelle, Al-Mossawi, M Hussein, Hühn, Michael H, Arancibia-Cárcamo, Carolina V, Doig, Karen, Kendrick, Benjamin, Gundle, Roger, Taylor, Peter, Mcclanahan, Terri, Murphy, Erin, Zhang, Hongjun, Barr, Ken, Miller, J Richard, Hu, Xiao, Aicher, Thomas D, Morgan, Rodney W, Glick, Gary D, Zaller, Dennis, Correll, Craig, Powrie, Fiona, Bowness, Paul
Published in Journal of allergy and clinical immunology (01.03.2016)
Published in Journal of allergy and clinical immunology (01.03.2016)
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Journal Article
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator
Hinklin, Ronald J., Baer, Brian R., Boyd, Steven A., Chicarelli, Mark D., Condroski, Kevin R., DeWolf, Walter E., Fischer, John, Frank, Michele, Hingorani, Gary P., Lee, Patrice A., Neitzel, Nickolas A., Pratt, Scott A., Singh, Ajay, Sullivan, Francis X., Turner, Timothy, Voegtli, Walter C., Wallace, Eli M., Williams, Lance, Aicher, Thomas D.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
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Journal Article
Total synthesis of halichondrin B and norhalichondrin B
Aicher, Thomas D, Buszek, Keith R, Fang, Francis G, Forsyth, Craig J, Jung, Sun Ho, Kishi, Yoshito, Matelich, Michael C, Scola, Paul M, Spero, Denice M, Yoon, Suk Kyoon
Published in Journal of the American Chemical Society (01.04.1992)
Published in Journal of the American Chemical Society (01.04.1992)
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Journal Article
Identification of a New Class of Glucokinase Activators through Structure-Based Design
Hinklin, Ronald J, Boyd, Steven A, Chicarelli, Mark J, Condroski, Kevin R, DeWolf, Walter E, Lee, Patrice A, Lee, Waiman, Singh, Ajay, Thomas, Laurie, Voegtli, Walter C, Williams, Lance, Aicher, Thomas D
Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
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Journal Article
Discovery of 2‑Pyridylureas as Glucokinase Activators
Hinklin, Ronald J, Aicher, Thomas D, Anderson, Deborah A, Baer, Brian R, Boyd, Steven A, Condroski, Kevin R, DeWolf, Walter E, Kraser, Christopher F, McVean, Maralee, Rhodes, Susan P, Sturgis, Hillary L, Voegtli, Walter C, Williams, Lance, Houze, Jonathan B
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
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Journal Article
Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache
Blanco, Maria-Jesus, Benesh, Dana R., Knobelsdorf, James A., Khilevich, Albert, Cortez, Guillermo S., Mokube, Fese, Aicher, Thomas D., Groendyke, Todd M., Marmsater, Fredrik P., Tang, Tony P., Johnson, Kirk W., Clemens-Smith, Amy, Muhlhauser, Mark A., Swanson, Steven, Catlow, John, Emkey, Renee, Johnson, Michael P., Schkeryantz, Jeffrey M.
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
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Journal Article
A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity
Yamamoto, Toshihiro, Yamaguchi, Hiroshi, Miki, Hiroshi, Kitamura, Shuji, Nakada, Yoshihisa, Aicher, Thomas D., Pratt, Scott A., Kato, Koki
Published in European journal of pharmacology (15.01.2011)
Published in European journal of pharmacology (15.01.2011)
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Journal Article
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394
Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
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Journal Article
Novel acyl coenzyme A (CoA): Diacylglycerol acyltransferase-1 inhibitors: Synthesis and biological activities of diacylethylenediamine derivatives
Nakada, Yoshihisa, Aicher, Thomas D., Huerou, Yvan Le, Turner, Timothy, Pratt, Scott A., Gonzales, Stephen S., Boyd, Steve A., Miki, Hiroshi, Yamamoto, Toshihiro, Yamaguchi, Hiroshi, Kato, Koki, Kitamura, Shuji
Published in Bioorganic & medicinal chemistry (01.04.2010)
Published in Bioorganic & medicinal chemistry (01.04.2010)
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Journal Article
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators
Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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Journal Article
Novel therapeutics and targets for the treatment of diabetes
Aicher, Thomas D, Boyd, Steven A, McVean, Maralee, Celeste, Anthony
Published in Expert review of clinical pharmacology (01.03.2010)
Published in Expert review of clinical pharmacology (01.03.2010)
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Journal Article
Non-charged thiamine analogs as inhibitors of enzyme transketolase
Thomas, Allen A., De Meese, J., Le Huerou, Y., Boyd, Steven A., Romoff, Todd T., Gonzales, Steven S., Gunawardana, Indrani, Kaplan, Tomas, Sullivan, Francis, Condroski, Kevin, Lyssikatos, Joseph P., Aicher, Thomas D., Ballard, Josh, Bernat, Bryan, DeWolf, Walter, Han, May, Lemieux, Christine, Smith, Darin, Weiler, Solly, Wright, S. Kirk, Vigers, Guy, Brandhuber, Barb
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Journal Article
Perhydroquinolylbenzamides as Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
Coppola, Gary M, Kukkola, Paivi J, Stanton, James L, Neubert, Alan D, Marcopulos, Nicholas, Bilci, Natalie A, Wang, Hua, Tomaselli, Hollis C, Tan, Jenny, Aicher, Thomas D, Knorr, Douglas C, Jeng, Arco Y, Dardik, Beatriz, Chatelain, Ricardo E
Published in Journal of medicinal chemistry (20.10.2005)
Published in Journal of medicinal chemistry (20.10.2005)
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Journal Article
Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase
Aicher, Thomas D, Anderson, Robert C, Gao, Jiaping, Shetty, Suraj S, Coppola, Gary M, Stanton, James L, Knorr, Douglas C, Sperbeck, Donald M, Brand, Leonard J, Vinluan, Christine C, Kaplan, Emma L, Dragland, Carol J, Tomaselli, Hollis C, Islam, Amin, Lozito, Robert J, Liu, Xilin, Maniara, Wieslawa M, Fillers, William S, DelGrande, Dominick, Walter, R. Eric, Mann, William R
Published in Journal of medicinal chemistry (27.01.2000)
Published in Journal of medicinal chemistry (27.01.2000)
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Journal Article
Anilides of (R)-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase
Bebernitz, Gregory R, Aicher, Thomas D, Stanton, James L, Gao, Jiaping, Shetty, Suraj S, Knorr, Douglas C, Strohschein, Robert J, Tan, Jennifer, Brand, Leonard J, Liu, Charles, Wang, Wei H, Vinluan, Christine C, Kaplan, Emma L, Dragland, Carol J, DelGrande, Dominick, Islam, Amin, Lozito, Robert J, Liu, Xilin, Maniara, Wieslawa M, Mann, William R
Published in Journal of medicinal chemistry (01.06.2000)
Published in Journal of medicinal chemistry (01.06.2000)
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Journal Article
Substituted Tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and Tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as Hypoglycemic Agents
Aicher, Thomas D, Balkan, Bork, Bell, Philip A, Brand, Leonard J, Cheon, S. H, Deems, Rhonda O, Fell, Jay B, Fillers, William S, Fraser, James D, Gao, Jiaping, Knorr, Douglas C, Kahle, Gerald G, Leone, Christina L, Nadelson, Jeffrey, Simpson, Ronald, Smith, Howard C
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
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