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Sheahan, Timothy P, Sims, Amy C, Graham, Rachel L, Menachery, Vineet D, Gralinski, Lisa E, Case, James B, Leist, Sarah R, Pyrc, Krzysztof, Feng, Joy Y, Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O, Mackman, Richard L, Spahn, Jamie E, Palmiotti, Christopher A, Siegel, Dustin, Ray, Adrian S, Cihlar, Tomas, Jordan, Robert, Denison, Mark R, Baric, Ralph S
Published in Science translational medicine (28.06.2017)
Published in Science translational medicine (28.06.2017)
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Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R
Published in mBio (06.03.2018)
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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.
Published in Scientific reports (06.03.2017)
Published in Scientific reports (06.03.2017)
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Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy
Murakami, Eisuke, Wang, Ting, Park, Yeojin, Hao, Jia, Lepist, Eve-Irene, Babusis, Darius, Ray, Adrian S
Published in Antimicrobial agents and chemotherapy (01.06.2015)
Published in Antimicrobial agents and chemotherapy (01.06.2015)
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Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents
Goedeke, Leigh, Bates, Jamie, Vatner, Daniel F., Perry, Rachel J., Wang, Ting, Ramirez, Ricardo, Li, Li, Ellis, Matthew W., Zhang, Dongyan, Wong, Kari E., Beysen, Carine, Cline, Gary W., Ray, Adrian S., Shulman, Gerald I.
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Published in Hepatology (Baltimore, Md.) (01.12.2018)
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Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance
Zamek-Gliszczynski, Maciej J, Taub, Mitchell E, Chothe, Paresh P, Chu, Xiaoyan, Giacomini, Kathleen M, Kim, Richard B, Ray, Adrian S, Stocker, Sophie L, Unadkat, Jashvant D, Wittwer, Matthias B, Xia, Cindy, Yee, Sook-Wah, Zhang, Lei, Zhang, Yan
Published in Clinical pharmacology and therapeutics (01.11.2018)
Published in Clinical pharmacology and therapeutics (01.11.2018)
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Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P., Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S.
Published in Kidney international (01.08.2014)
Published in Kidney international (01.08.2014)
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Structural basis for RNA replication by the hepatitis C virus polymerase
Appleby, Todd C., Perry, Jason K., Murakami, Eisuke, Barauskas, Ona, Feng, Joy, Cho, Aesop, Fox, David, Wetmore, Diana R., McGrath, Mary E., Ray, Adrian S., Sofia, Michael J., Swaminathan, S., Edwards, Thomas E.
Published in Science (American Association for the Advancement of Science) (13.02.2015)
Published in Science (American Association for the Advancement of Science) (13.02.2015)
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Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition
Liclican, Albert, Serafini, Loredana, Xing, Weimei, Czerwieniec, Gregg, Steiner, Bart, Wang, Ting, Brendza, Katherine M., Lutz, Justin D., Keegan, Kathleen S., Ray, Adrian S., Schultz, Brian E., Sakowicz, Roman, Feng, Joy Y.
Published in Biochimica et biophysica acta. General subjects (01.04.2020)
Published in Biochimica et biophysica acta. General subjects (01.04.2020)
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Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340, In Vitro
LEPIST, Eve-Irene, PHAN, Truc K, ROY, Anupma, TONG, Leah, MACLENNAN, Kelly, MURRAY, Bernard, RAY, Adrian S
Published in Antimicrobial Agents and Chemotherapy (01.10.2012)
Published in Antimicrobial Agents and Chemotherapy (01.10.2012)
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Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides
Arnold, Jamie J, Sharma, Suresh D, Feng, Joy Y, Ray, Adrian S, Smidansky, Eric D, Kireeva, Maria L, Cho, Aesop, Perry, Jason, Vela, Jennifer E, Park, Yeojin, Xu, Yili, Tian, Yang, Babusis, Darius, Barauskus, Ona, Peterson, Blake R, Gnatt, Averell, Kashlev, Mikhail, Zhong, Weidong, Cameron, Craig E
Published in PLoS pathogens (01.11.2012)
Published in PLoS pathogens (01.11.2012)
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Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus
Feng, Joy Y, Xu, Yili, Barauskas, Ona, Perry, Jason K, Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E, Sakowicz, Roman, Ray, Adrian S
Published in Antimicrobial agents and chemotherapy (01.02.2016)
Published in Antimicrobial agents and chemotherapy (01.02.2016)
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Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR‑2 (SLC19A3)
Liang, Xiaomin, Chien, Huan-Chieh, Yee, Sook Wah, Giacomini, Marilyn M, Chen, Eugene C, Piao, Meiling, Hao, Jia, Twelves, Jolyn, Lepist, Eve-Irene, Ray, Adrian S, Giacomini, Kathleen M
Published in Molecular pharmaceutics (07.12.2015)
Published in Molecular pharmaceutics (07.12.2015)
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Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes
Lepist, Eve-Irene, Gillies, Hunter, Smith, William, Hao, Jia, Hubert, Cassandra, St Claire, 3rd, Robert L, Brouwer, Kenneth R, Ray, Adrian S
Published in PloS one (30.01.2014)
Published in PloS one (30.01.2014)
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Renal drug-drug interactions: what we have learned and where we are going
Lepist, Eve-Irene, Ray, Adrian S
Published in Expert opinion on drug metabolism & toxicology (01.04.2012)
Published in Expert opinion on drug metabolism & toxicology (01.04.2012)
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Mechanism of Active Renal Tubular Efflux of Tenofovir
RAY, Adrian S, CIHLAR, Tomas, ROBINSON, Kelly L, TONG, Leah, VELA, Jennifer E, FULLER, Michael D, WIEMAN, Lani M, EISENBERG, Eugene J, RHODES, Gerry R
Published in Antimicrobial Agents and Chemotherapy (01.10.2006)
Published in Antimicrobial Agents and Chemotherapy (01.10.2006)
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Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir
STRAY, Kirsten M, BAM, Rujuta A, BIRKUS, Gabriel, JIA HAO, LEPIST, Eve-Irene, YANT, Stephen R, RAY, Adrian S, CIHLAR, Tomas
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
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Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir
Wang, Ting, Babusis, Darius, Park, Yeojin, Niu, Congrong, Kim, Cynthia, Zhao, Xiaofeng, Lu, Bing, Ma, Bin, Muench, Robert C., Sperger, Diana, Ray, Adrian S., Murakami, Eisuke
Published in Drug metabolism and pharmacokinetics (01.06.2020)
Published in Drug metabolism and pharmacokinetics (01.06.2020)
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