The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy
Sanderson, Michael P, Hofmann, Marco H, Garin-Chesa, Pilar, Schweifer, Norbert, Wernitznig, Andreas, Fischer, Stefan, Jeschko, Astrid, Meyer, Reiner, Moll, Jürgen, Pecina, Thomas, Arnhof, Heribert, Weyer-Czernilofsky, Ulrike, Zahn, Stephan K, Adolf, Günther R, Kraut, Norbert
Published in Molecular cancer therapeutics (01.10.2017)
Published in Molecular cancer therapeutics (01.10.2017)
Get full text
Journal Article
BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis
Sanderson, Michael P, Apgar, Joshua, Garin-Chesa, Pilar, Hofmann, Marco H, Kessler, Dirk, Quant, Jens, Savchenko, Alexander, Schaaf, Otmar, Treu, Matthias, Tye, Heather, Zahn, Stephan K, Zoephel, Andreas, Haaksma, Eric, Adolf, Günther R, Kraut, Norbert
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
Get full text
Journal Article
BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity
RUDOLPH, Dorothea, STEEGMAIER, Martin, HOFFMANN, Matthias, GRAUERT, Matthias, BAUM, Anke, QUANT, Jens, HASLINGER, Christian, GARIN-CHESA, Pilar, ADOLF, Gunther R
Published in Clinical cancer research (01.05.2009)
Published in Clinical cancer research (01.05.2009)
Get full text
Journal Article
BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo
Steegmaier, Martin, Hoffmann, Matthias, Baum, Anke, Lénárt, Péter, Petronczki, Mark, Krššák, Martin, Gürtler, Ulrich, Garin-Chesa, Pilar, Lieb, Simone, Quant, Jens, Grauert, Matthias, Adolf, Günther R., Kraut, Norbert, Peters, Jan-Michael, Rettig, Wolfgang J.
Published in Current biology (20.02.2007)
Published in Current biology (20.02.2007)
Get full text
Journal Article
Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia
Rudolph, Dorothea, Impagnatiello, Maria Antonietta, Blaukopf, Claudia, Sommer, Christoph, Gerlich, Daniel W, Roth, Mareike, Tontsch-Grunt, Ulrike, Wernitznig, Andreas, Savarese, Fabio, Hofmann, Marco H, Albrecht, Christoph, Geiselmann, Lena, Reschke, Markus, Garin-Chesa, Pilar, Zuber, Johannes, Moll, Jürgen, Adolf, Günther R, Kraut, Norbert
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
Get full text
Journal Article
Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
Hirt, Ulrich A., Waizenegger, Irene C., Schweifer, Norbert, Haslinger, Christian, Gerlach, Daniel, Braunger, Jürgen, Weyer-Czernilofsky, Ulrike, Stadtmüller, Heinz, Sapountzis, Ioannis, Bader, Gerd, Zoephel, Andreas, Bister, Bojan, Baum, Anke, Quant, Jens, Kraut, Norbert, Garin-Chesa, Pilar, Adolf, Günther R.
Published in Oncogenesis (New York, NY) (23.02.2018)
Published in Oncogenesis (New York, NY) (23.02.2018)
Get full text
Journal Article
Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression
WIELENGA, V. J. M, HEIDER, K.-H, OFFERHAUS, G. J. A, ADOLF, G. R, VAN DEN BERG, F. M, PONTA, H, HERRLICH, P, PALS, S. T
Published in Cancer research (Chicago, Ill.) (15.10.1993)
Get full text
Published in Cancer research (Chicago, Ill.) (15.10.1993)
Journal Article
A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation
Waizenegger, Irene C, Baum, Anke, Steurer, Steffen, Stadtmüller, Heinz, Bader, Gerd, Schaaf, Otmar, Garin-Chesa, Pilar, Schlattl, Andreas, Schweifer, Norbert, Haslinger, Christian, Colbatzky, Florian, Mousa, Sien, Kalkuhl, Arno, Kraut, Norbert, Adolf, Günther R
Published in Molecular cancer therapeutics (01.03.2016)
Published in Molecular cancer therapeutics (01.03.2016)
Get full text
Journal Article
A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies
Heider, Karl-Heinz, Kiefer, Kerstin, Zenz, Thorsten, Volden, Matthias, Stilgenbauer, Stephan, Ostermann, Elinborg, Baum, Anke, Lamche, Herbert, Küpcü, Zaruhi, Jacobi, Alexander, Müller, Steffen, Hirt, Ulrich, Adolf, Günther R., Borges, Eric
Published in Blood (13.10.2011)
Published in Blood (13.10.2011)
Get full text
Journal Article
Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases
Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K, Baumann, Christoph, Rudolph, Dorothea, Baumgartinger, Rosa, Strauss, Eva, Haslinger, Christian, Tontsch-Grunt, Ulrike, Waizenegger, Irene C, Solca, Flavio, Bader, Gerd, Zoephel, Andreas, Treu, Matthias, Reiser, Ulrich, Garin-Chesa, Pilar, Boehmelt, Guido, Kraut, Norbert, Quant, Jens, Adolf, Günther R
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
Get full text
Journal Article
HLA class II induction in human islet cells by interferon-gamma plus tumour necrosis factor or lymphotoxin
Pujol-Borrell, R, Todd, I, Doshi, M, Bottazzo, G F, Sutton, R, Gray, D, Adolf, G R, Feldmann, M
Published in Nature (London) (19.03.1987)
Published in Nature (London) (19.03.1987)
Get more information
Journal Article
Prognostic value of CD44 splice variant expression in ovarian cancer
Uhl-Steidl, M, Müller-Holzner, E, Zeimet, A G, Adolf, G R, Daxenbichler, G, Marth, C, Dapunt, O
Published in Oncology (01.09.1995)
Published in Oncology (01.09.1995)
Get more information
Journal Article
Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head‐and‐neck cancer xenografts
Verel, Iris, Heider, Karl‐Heinz, Siegmund, Miranda, Ostermann, Elínborg, Patzelt, Erik, Sproll, Marlies, Snow, Gordon B., Adolf, Günther R., van Dongen, Guus A.M.S.
Published in International journal of cancer (20.05.2002)
Published in International journal of cancer (20.05.2002)
Get full text
Journal Article
Identification and characterization of 9D7, a novel human protein overexpressed in renal cell carcinoma
Klade, Christoph S., Dohnal, Alexander, Fürst, Walter, Sommergruber, Wolfgang, Heider, Karl‐Heinz, Gharwan, Helen, Ratschek, Manfred, Adolf, Günther R.
Published in International journal of cancer (10.01.2002)
Published in International journal of cancer (10.01.2002)
Get full text
Journal Article
Abstract 1919: Pharmacological characterization of BI 847325, a dual inhibitor of MEK and Aurora kinases
Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K., Boehmelt, Guido, Garin-Chesa, Pilar, Kraut, Nobert, Rudolph, Dorothea, Solca, Flavio, Tontsch-Grunt, Ulrike, Waizenegger, Irene C., Adolf, Günther R.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Get full text
Journal Article
Abstract 2344: Modeling 1st- and 2nd-line therapy of BRAF mutant melanoma using a novel BRAF inhibitor with DFG-out binding mode
Waizenegger, Irene C., Baum, Anke, Stadtmüller, Heinz, Steurer, Steffen, Bader, Gerd, Garin-Chesa, Pilar, Schweifer, Norbert, Bernthaler, Andreas, Haslinger, Christian, Schaaf, Otmar, Mousa, Sien, Colbatzky, Florian, Adolf, Günther R.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article
Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae
Castañón, Maria J., Spevak, Walter, Adolf, Günther R., Chlebowicz-Śledziewska, Ewa, Śledziewski, Andrzej
Published in Gene (30.06.1988)
Published in Gene (30.06.1988)
Get full text
Journal Article
Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44
KOOPMAN, G, HEIDER, K.-H, HORST, E, ADOLF, G. R, VAN DEN BERG, F, PONTA, H, HERRLICH, P, PALS, S. T
Published in The Journal of experimental medicine (01.04.1993)
Published in The Journal of experimental medicine (01.04.1993)
Get full text
Journal Article