Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
Solca, Flavio, Dahl, Goeran, Zoephel, Andreas, Bader, Gerd, Sanderson, Michael, Klein, Christian, Kraemer, Oliver, Himmelsbach, Frank, Haaksma, Eric, Adolf, Guenther R
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
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Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts
Ostermann, Elinborg, Garin-Chesa, Pilar, Heider, Karl Heinz, Kalat, Milena, Lamche, Herbert, Puri, Christina, Kerjaschki, Dontscho, Rettig, Wolfgang J., Adolf, Guenther R.
Published in Clinical cancer research (15.07.2008)
Published in Clinical cancer research (15.07.2008)
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A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation
Waizenegger, Irene C, Baum, Anke, Steurer, Steffen, Stadtmüller, Heinz, Bader, Gerd, Schaaf, Otmar, Garin-Chesa, Pilar, Schlattl, Andreas, Schweifer, Norbert, Haslinger, Christian, Colbatzky, Florian, Mousa, Sien, Kalkuhl, Arno, Kraut, Norbert, Adolf, Günther R
Published in Molecular cancer therapeutics (01.03.2016)
Published in Molecular cancer therapeutics (01.03.2016)
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Journal Article
BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo
Steegmaier, Martin, Hoffmann, Matthias, Baum, Anke, Lénárt, Péter, Petronczki, Mark, Krššák, Martin, Gürtler, Ulrich, Garin-Chesa, Pilar, Lieb, Simone, Quant, Jens, Grauert, Matthias, Adolf, Günther R., Kraut, Norbert, Peters, Jan-Michael, Rettig, Wolfgang J.
Published in Current biology (20.02.2007)
Published in Current biology (20.02.2007)
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A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies
Heider, Karl-Heinz, Kiefer, Kerstin, Zenz, Thorsten, Volden, Matthias, Stilgenbauer, Stephan, Ostermann, Elinborg, Baum, Anke, Lamche, Herbert, Küpcü, Zaruhi, Jacobi, Alexander, Müller, Steffen, Hirt, Ulrich, Adolf, Günther R., Borges, Eric
Published in Blood (13.10.2011)
Published in Blood (13.10.2011)
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Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia
Rudolph, Dorothea, Impagnatiello, Maria Antonietta, Blaukopf, Claudia, Sommer, Christoph, Gerlich, Daniel W, Roth, Mareike, Tontsch-Grunt, Ulrike, Wernitznig, Andreas, Savarese, Fabio, Hofmann, Marco H, Albrecht, Christoph, Geiselmann, Lena, Reschke, Markus, Garin-Chesa, Pilar, Zuber, Johannes, Moll, Jürgen, Adolf, Günther R, Kraut, Norbert
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
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Journal Article
Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases
Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K, Baumann, Christoph, Rudolph, Dorothea, Baumgartinger, Rosa, Strauss, Eva, Haslinger, Christian, Tontsch-Grunt, Ulrike, Waizenegger, Irene C, Solca, Flavio, Bader, Gerd, Zoephel, Andreas, Treu, Matthias, Reiser, Ulrich, Garin-Chesa, Pilar, Boehmelt, Guido, Kraut, Norbert, Quant, Jens, Adolf, Günther R
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
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Journal Article
Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
Hirt, Ulrich A., Waizenegger, Irene C., Schweifer, Norbert, Haslinger, Christian, Gerlach, Daniel, Braunger, Jürgen, Weyer-Czernilofsky, Ulrike, Stadtmüller, Heinz, Sapountzis, Ioannis, Bader, Gerd, Zoephel, Andreas, Bister, Bojan, Baum, Anke, Quant, Jens, Kraut, Norbert, Garin-Chesa, Pilar, Adolf, Günther R.
Published in Oncogenesis (New York, NY) (23.02.2018)
Published in Oncogenesis (New York, NY) (23.02.2018)
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BI 836845, a fully human IGF ligand neutralizing antibody, to improve the efficacy of rapamycin by blocking rapamycin-induced AKT activation
Adam, Paul J., Friedbichler, Katrin, Hofmann, Marco H., Bogenrieder, Thomas, Borges, Eric, Adolf, Guenther R.
Published in Journal of clinical oncology (20.05.2012)
Published in Journal of clinical oncology (20.05.2012)
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Abstract A208: Pharmacodynamic properties and antitumor efficacy of BI 836845, a fully human IGF ligand neutralizing antibody
Adam, Paul J., Ostermann, Elinborg, Lamche, Herbert R., Hofmann, Marco H., Kroez, Monika, Borges, Eric, Adolf, Guenther R.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Abstract 1082: BI 811283, a potent inhibitor of the mitotic kinase Aurora B, shows dose- and schedule-dependent efficacy in human cancer xenograft models
Gürtler, Ulrich, Tontsch-Grunt, Ulrike, Zahn, Stephan K., Quant, Jens, Adolf, Guenther R., Solca, Flavio
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Abstract A249: BI 853520, a potent and highly selective inhibitor of protein tyrosine kinase 2 (focal adhesion kinase), shows efficacy in multiple xenograft models of human cancer
Hirt, Ulrich A., Braunger, Juergen, Schleicher, Michael, Weyer-Czernilofsky, Ulrike, Garin-Chesa, Pilar, Bister, Bojan, Stadtmueller, Heinz, Sapountzis, Ioannis, Kraut, Norbert, Adolf, Guenther R.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Abstract 1080: Molecular and cellular pharmacology of BI 811283, a potent inhibitor of Aurora B kinase
Tontsch-Grunt, Ulrike, Gürtler, Ulrich, Zahn, Stephan K., Boehmelt, Guido, Jarvis, Marc, Adolf, Guenther R., Solca, Flavio
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Regulation of the expression of annexin VIII in acute promyelocytic leukemia
Sarkar, A, Yang, P, Fan, YH, Mu, ZM, Hauptmann, R, Adolf, GR, Stass, SA, Chang, KS
Published in Blood (01.07.1994)
Published in Blood (01.07.1994)
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