Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume
Acton, John J, Akiyama, Taro E, Chang, Ching H, Colwell, Lawrence, Debenham, Sheryl, Doebber, Thomas, Einstein, Monica, Liu, Kun, McCann, Margaret E, Moller, David E, Muise, Eric S, Tan, Yugen, Thompson, John R, Wong, Kenny K, Wu, Margaret, Xu, Libo, Meinke, Peter T, Berger, Joel P, Wood, Harold B
Published in Journal of medicinal chemistry (09.07.2009)
Published in Journal of medicinal chemistry (09.07.2009)
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Published in Bioorganic & medicinal chemistry letters (17.01.2005)
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease
Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael
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Published in Journal of medicinal chemistry (22.12.2022)
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Selective PPARgamma modulators with improved pharmacological profiles
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Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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Selective Protection and Relative Importance of the Carboxylic Acid Groups of Zaragozic Acid A for Squalene Synthase Inhibition
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Correction to Discovery of (2 R )-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1 H -indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume
Acton, John J., Akiyama, Taro E., Chang, Ching H., Colwell, Lawrence, Debenham, Sheryl, Doebber, Thomas, Einstein, Monica, Liu, Kun, McCann, Margaret E., Moller, David E., Muise, Eric S., Tan, Yejun, Thompson, John R., Wong, Kenny K., Wu, Margaret, Xu, Libo, Meinke, Peter T., Berger, Joel P., Wood, Harold B.
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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Journal Article
Discovery of (2 R )-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1 H -indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume
Acton, John J., Akiyama, Taro E., Chang, Ching H., Colwell, Lawrence, Debenham, Sheryl, Doebber, Thomas, Einstein, Monica, Liu, Kun, McCann, Margaret E., Moller, David E., Muise, Eric S., Tan, Yugen, Thompson, John R., Wong, Kenny K., Wu, Margaret, Xu, Libo, Meinke, Peter T., Berger, Joel P., Wood, Harold B.
Published in Journal of medicinal chemistry (09.07.2009)
Published in Journal of medicinal chemistry (09.07.2009)
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Journal Article
Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor y Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume
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