Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV‑2
Ghahremanpour, Mohammad M, Tirado-Rives, Julian, Deshmukh, Maya, Ippolito, Joseph A, Zhang, Chun-Hui, Cabeza de Vaca, Israel, Liosi, Maria-Elena, Anderson, Karen S, Jorgensen, William L
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Popovici-Muller, Janeta, Lemieux, René M, Artin, Erin, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy, Cianchetta, Giovanni, Cai, Zhenwei, Zhou, Ding, Cui, Dawei, Chen, Ping, Straley, Kimberly, Tobin, Erica, Wang, Fang, David, Muriel D, Penard-Lacronique, Virginie, Quivoron, Cyril, Saada, Véronique, de Botton, Stéphane, Gross, Stefan, Dang, Lenny, Yang, Hua, Utley, Luke, Chen, Yue, Kim, Hyeryun, Jin, Shengfang, Gu, Zhiwei, Yao, Gui, Luo, Zhiyong, Lv, Xiaobing, Fang, Cheng, Yan, Liping, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shin-San M, Yen, Katharine
Published in ACS medicinal chemistry letters (12.04.2018)
Published in ACS medicinal chemistry letters (12.04.2018)
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Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment
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Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp2)–C(sp3) Cross-Coupling Methods by Library Synthesis
Dombrowski, Amanda W, Gesmundo, Nathan J, Aguirre, Ana L, Sarris, Katerina A, Young, Jonathon M, Bogdan, Andrew R, Martin, M. Cynthia, Gedeon, Shasline, Wang, Ying
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
Yue, Eddy W, Sparks, Richard, Polam, Padmaja, Modi, Dilip, Douty, Brent, Wayland, Brian, Glass, Brian, Takvorian, Amy, Glenn, Joseph, Zhu, Wenyu, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J, Hansbury, Michael J, Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C, Koblish, Holly K, Fridman, Jordan S, Emm, Tom, Scherle, Peggy A, Metcalf, Brian, Combs, Andrew P
Published in ACS medicinal chemistry letters (11.05.2017)
Published in ACS medicinal chemistry letters (11.05.2017)
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Solution Conformations Shed Light on PROTAC Cell Permeability
Atilaw, Yoseph, Poongavanam, Vasanthanathan, Nilsson, Caroline Svensson, Duy Nguyen, Giese, Anja, Meibom, Daniel, Erdelyi, Mate, Kihlberg, Jan
Published in ACS medicinal chemistry letters (14.01.2021)
Published in ACS medicinal chemistry letters (14.01.2021)
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INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (ID01) Inhibitor for Immunooncology
Yue, Eddy W., Sparks, Richard, Polam, Padmaja, Modi, Dilip, Douty, Brent, Wayland, Brian, Glass, Brian, Takvorian, Amy, Glenn, Joseph, Zhu, Wenyu, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J., Hansbury, Michael J., Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C., Koblish, Holly K., Fridman, Jordan S., Emm, Tom, Scherle, Peggy A., Metcalf, Brian, Combs, Andrew P.
Published in ACS medicinal chemistry letters (01.05.2017)
Published in ACS medicinal chemistry letters (01.05.2017)
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Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
Konteatis, Zenon, Artin, Erin, Nicolay, Brandon, Straley, Kimberly, Padyana, Anil K, Jin, Lei, Chen, Yue, Narayaraswamy, Rohini, Tong, Shuilong, Wang, Feng, Zhou, Ding, Cui, Dawei, Cai, Zhenwei, Luo, Zhiyong, Fang, Cheng, Tang, Huachun, Lv, Xiaobing, Nagaraja, Raj, Yang, Hua, Su, Shin-San M, Sui, Zhihua, Dang, Lenny, Yen, Katharine, Popovici-Muller, Janeta, Codega, Paolo, Campos, Carl, Mellinghoff, Ingo K, Biller, Scott A
Published in ACS medicinal chemistry letters (13.02.2020)
Published in ACS medicinal chemistry letters (13.02.2020)
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LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity
Bonday, Zahid Q., Cortez, Guillermo S., Grogan, Michael J., Antonysamy, Stephen, Weichert, Ken, Bocchinfuso, Wayne P., Li, Fengling, Kennedy, Steven, Li, Binghui, Mader, Mary M., Arrowsmith, Cheryl H., Brown, Peter J., Eram, Mohammad S., Szewczyk, Magdalena M., Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Guccione, Ernesto, Campbell, Robert M.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry
Laudadio, Gabriele, Palkowitz, Maximilian D., El-Hayek Ewing, Tamara, Baran, Phil S.
Published in ACS medicinal chemistry letters (08.09.2022)
Published in ACS medicinal chemistry letters (08.09.2022)
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Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
Hendrick, Charles E., Jorgensen, Jeff R., Chaudhry, Charu, Strambeanu, Iulia I., Brazeau, Jean-Francois, Schiffer, Jamie, Shi, Zhicai, Venable, Jennifer D., Wolkenberg, Scott E.
Published in ACS medicinal chemistry letters (14.07.2022)
Published in ACS medicinal chemistry letters (14.07.2022)
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The Advent of Generative Chemistry
Vanhaelen, Quentin, Lin, Yen-Chu, Zhavoronkov, Alex
Published in ACS medicinal chemistry letters (13.08.2020)
Published in ACS medicinal chemistry letters (13.08.2020)
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Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA(2) Inhibitor
Measom, Nicholas D., Down, Kenneth D., Hirst, David J., Jamieson, Craig, Manas, Eric S., Patel, Vipulkumar K., Somers, Don O.
Published in ACS medicinal chemistry letters (01.01.2017)
Published in ACS medicinal chemistry letters (01.01.2017)
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Understanding and Improving the Membrane Permeability of VH032-Based PROTACs
Klein, Victoria G, Townsend, Chad E, Testa, Andrea, Zengerle, Michael, Maniaci, Chiara, Hughes, Scott J, Chan, Kwok-Ho, Ciulli, Alessio, Lokey, R. Scott
Published in ACS medicinal chemistry letters (10.09.2020)
Published in ACS medicinal chemistry letters (10.09.2020)
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Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase
Yang, Ka, Wu, Hao, Zhang, Zhongrui, Leisten, Eric D, Nie, Xueqing, Liu, Binkai, Wen, Zhi, Zhang, Jing, Cunningham, Michael D, Tang, Weiping
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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