Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease–Like Pathology and Cognitive Decline in Aged 3xTgAD Mice
Medeiros, Rodrigo, Kitazawa, Masashi, Chabrier, Meredith A, Cheng, David, Baglietto-Vargas, David, Kling, Andreas, Moeller, Achim, Green, Kim N, LaFerla, Frank M
Published in The American journal of pathology (01.08.2012)
Published in The American journal of pathology (01.08.2012)
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Journal Article
The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo
Nikkel, Arthur L., Martino, Brenda, Markosyan, Stella, Brederson, Jill-Desiree, Medeiros, Rodrigo, Moeller, Achim, Bitner, Robert S.
Published in Neuropharmacology (01.09.2012)
Published in Neuropharmacology (01.09.2012)
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Journal Article
P2-449: Inhibition of calpain by A-705253 prevents NMDA-induced neurodegeneration in hippocampal slice cultures and in the N. basalis magnocellularis of rats
Moeller, Achim H, Nimmrich, Volker, Szabo, Robert, Nyakas, Csaba, Schoemaker, Hans, Gross, Gerhard, Luiten, Paul
Published in Alzheimer's & dementia (01.07.2008)
Published in Alzheimer's & dementia (01.07.2008)
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Journal Article
Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability
Jantos, Katja, Kling, Andreas, Mack, Helmut, Hornberger, Wilfried, Moeller, Achim, Nimmrich, Volker, Lao, Yanbin, Nijsen, Marjoleen
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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Journal Article
Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer’s Disease: 2‑(3-Phenyl‑1H‑pyrazol-1-yl)-nicotinamides
Kling, Andreas, Jantos, Katja, Mack, Helmut, Hornberger, Wilfried, Drescher, Karla, Nimmrich, Volker, Relo, Ana, Wicke, Karsten, Hutchins, Charles W, Lao, Yanbin, Marsh, Kennan, Moeller, Achim
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Journal Article
Anticonvulsant effects of structurally diverse GABAB positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model
Brown, Jordan W., Moeller, Achim, Schmidt, Martin, Turner, Sean C., Nimmrich, Volker, Ma, Junli, Rueter, Lynne E., van der Kam, Elizabeth, Zhang, Min
Published in Neuropharmacology (02.10.2016)
Published in Neuropharmacology (02.10.2016)
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Journal Article
The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile
Vengeliene, Valentina, Moeller, Achim, Meinhardt, Marcus W, Beardsley, Patrick M, Sommer, Wolfgang H, Spanagel, Rainer, Bespalov, Anton
Published in Neuropsychopharmacology (New York, N.Y.) (01.03.2016)
Published in Neuropsychopharmacology (New York, N.Y.) (01.03.2016)
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Journal Article
Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model
Brown, Jordan W, Moeller, Achim, Schmidt, Martin, Turner, Sean C, Nimmrich, Volker, Ma, Junli, Rueter, Lynne E, van der Kam, Elizabeth, Zhang, Min
Published in Neuropharmacology (01.02.2016)
Published in Neuropharmacology (01.02.2016)
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Journal Article
Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1′ Extension
Kling, Andreas, Jantos, Katja, Mack, Helmut, Hornberger, Wilfried, Backfisch, Gisela, Lao, Yanbin, Nijsen, Marjoleen, Rendenbach-Mueller, Beatrice, Moeller, Achim
Published in ACS medicinal chemistry letters (08.03.2018)
Published in ACS medicinal chemistry letters (08.03.2018)
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Journal Article
Anticonvulsant effects of structurally diverse GABA B positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model
Brown, Jordan W., Moeller, Achim, Schmidt, Martin, Turner, Sean C., Nimmrich, Volker, Ma, Junli, Rueter, Lynne E., van der Kam, Elizabeth, Zhang, Min
Published in Neuropharmacology (01.02.2016)
Published in Neuropharmacology (01.02.2016)
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Journal Article
The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons
Sinjoanu, Roxana C., Kleinschmidt, Sara, Bitner, Robert S., Brioni, Jorge D., Moeller, Achim, Ferreira, Adriana
Published in Neurochemistry international (01.09.2008)
Published in Neurochemistry international (01.09.2008)
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Journal Article
Calpain inhibition prevents amyloid-β-induced neurodegeneration and associated behavioral dysfunction in rats
Granic, Ivica, Nyakas, Csaba, Luiten, Paul G.M., Eisel, Ulrich L.M., Halmy, László G., Gross, Gerhard, Schoemaker, Hans, Möller, Achim, Nimmrich, Volker
Published in Neuropharmacology (01.09.2010)
Published in Neuropharmacology (01.09.2010)
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Journal Article
NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST NOGO-66 RECEPTOR (NGR) AND USES THEREOF
AXEL MEYER, REINHOLD MUELLER, NICOLE TEUSCH, EVE H BARLOW, SCHMIDT MARTIN, ACHIM MOELLER, MARIO MEZLER, MULLER BERNHARD K, GHAYUR TARIQ
Year of Publication 17.05.2018
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Year of Publication 17.05.2018
Patent
Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na+/H+ exchange inhibitor Cariporide® in isolated perfused rabbit hearts
Neuhof, Christiane, Fabiunke, Verena, Speth, Maria, Möller, Achim, Fritz, Hans, Tillmanns, Harald, Neuhof, Heinz, Erdogan, Ali
Published in Biological chemistry (01.12.2008)
Published in Biological chemistry (01.12.2008)
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Journal Article
CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV
MACK HELMUT, GISELA BACKFISCH, LAO YANBIN, KLING ANDREAS, ACHIM MOELLER, KATJA JANTOS, WILFRIED HORNBERGER, MARJOLEEN NIJSEN
Year of Publication 28.04.2016
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Year of Publication 28.04.2016
Patent
NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST NOGO-66 RECEPTOR (NGR) AND USES THEREOF
AXEL MEYER, REINHOLD MUELLER, NICOLE TEUSCH, EVE H BARLOW, SCHMIDT MARTIN, ACHIM MOELLER, MARIO MEZLER, MULLER BERNHARD K, GHAYUR TARIQ
Year of Publication 26.01.2017
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Year of Publication 26.01.2017
Patent
Calpain inhibition prevents amyloid-b-induced neurodegeneration and associated behavioral dysfunction in rats
Granic, Ivica, Nyakas, Csaba, Luiten, Paul GM, Eisel, Ulrich LM, Halmy, Laszlo G, Gross, Gerhard, Schoemaker, Hans, Moeller, Achim, Nimmrich, Volker
Published in Neuropharmacology (01.10.2010)
Published in Neuropharmacology (01.10.2010)
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Journal Article
Inhibition of Calpain Prevents N-Methyl-d-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction
Nimmrich, Volker, Szabo, Robert, Nyakas, Csaba, Granic, Ivica, Reymann, Klaus G, Schröder, Ulrich H, Gross, Gerhard, Schoemaker, Hans, Wicke, Karsten, Möller, Achim, Luiten, Paul
Published in The Journal of pharmacology and experimental therapeutics (01.11.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2008)
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Journal Article
NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST NOGO-66 RECEPTOR (NGR) AND USES THEREOF
AXEL MEYER, REINHOLD MUELLER, NICOLE TEUSCH, EVE H BARLOW, SCHMIDT MARTIN, ACHIM MOELLER, MARIO MEZLER, MULLER BERNHARD K, GHAYUR TARIQ
Year of Publication 13.11.2014
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Year of Publication 13.11.2014
Patent