Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration
Krücken, Jürgen, Holden-Dye, Lindy, Keiser, Jennifer, Prichard, Roger K, Townson, Simon, Makepeace, Benjamin L, Hübner, Marc P, Hahnel, Steffen R, Scandale, Ivan, Harder, Achim, Kulke, Daniel
Published in PLoS pathogens (22.07.2021)
Published in PLoS pathogens (22.07.2021)
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Phylogenetic characterization of β-tubulins and development of pyrosequencing assays for benzimidazole resistance in cattle nematodes
Demeler, Janina, Krüger, Nina, Krücken, Jürgen, von der Heyden, Vera C, Ramünke, Sabrina, Küttler, Ursula, Miltsch, Sandra, López Cepeda, Michael, Knox, Malcolm, Vercruysse, Jozef, Geldhof, Peter, Harder, Achim, von Samson-Himmelstjerna, Georg
Published in PloS one (12.08.2013)
Published in PloS one (12.08.2013)
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Journal Article
Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside
Hübner, Marc P., Townson, Simon, Gokool, Suzanne, Tagboto, Senyo, Maclean, Mary J., Verocai, Guilherme G., Wolstenholme, Adrian J., Frohberger, Stefan J., Hoerauf, Achim, Specht, Sabine, Scandale, Ivan, Harder, Achim, Glenschek-Sieberth, Martin, Hahnel, Steffen R., Kulke, Daniel
Published in International journal for parasitology -- drugs and drug resistance (01.12.2021)
Published in International journal for parasitology -- drugs and drug resistance (01.12.2021)
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Journal Article
The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits
Crisford, Anna, Ebbinghaus-Kintscher, Ulrich, Schoenhense, Eva, Harder, Achim, Raming, Klaus, O'Kelly, Ita, Ndukwe, Kelechi, O'Connor, Vincent, Walker, Robert J, Holden-Dye, Lindy
Published in PLoS neglected tropical diseases (01.10.2015)
Published in PLoS neglected tropical diseases (01.10.2015)
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Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside
Kulke, Daniel, von Samson-Himmelstjerna, Georg, Miltsch, Sandra M, Wolstenholme, Adrian J, Jex, Aaron R, Gasser, Robin B, Ballesteros, Cristina, Geary, Timothy G, Keiser, Jennifer, Townson, Simon, Harder, Achim, Krücken, Jürgen
Published in PLoS neglected tropical diseases (01.12.2014)
Published in PLoS neglected tropical diseases (01.12.2014)
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SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants
Welz, Claudia, Krüger, Nina, Schniederjans, Monika, Miltsch, Sandra M, Krücken, Jürgen, Guest, Marcus, Holden-Dye, Lindy, Harder, Achim, von Samson-Himmelstjerna, Georg
Published in PLoS pathogens (01.04.2011)
Published in PLoS pathogens (01.04.2011)
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Journal Article
Efficacy of cyclooctadepsipeptides and aminophenylamidines against larval, immature and mature adult stages of a parasitologically characterized trichurosis model in mice
Kulke, Daniel, Krücken, Jürgen, Harder, Achim, von Samson-Himmelstjerna, Georg
Published in PLoS neglected tropical diseases (01.02.2014)
Published in PLoS neglected tropical diseases (01.02.2014)
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Journal Article
An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria
Ōmura, Satoshi, Miyadera, Hiroko, Ui, Hideaki, Shiomi, Kazuro, Yamaguchi, Yuuichi, Masuma, Rokuro, Nagamitsu, Tohru, Takano, Daisuke, Sunazuka, Toshiaki, Harder, Achim, Kölbl, Heinz, Namikoshi, Michio, Miyoshi, Hideto, Sakamoto, Kimitoshi, Kita, Kiyoshi
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2001)
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Journal Article
PF1022A and related cyclodepsipeptides - a novel class of anthelmintics
Scherkenbeck, Jurgen, Jeschke, Peter, Harder, Achim
Published in Current topics in medicinal chemistry (01.07.2002)
Published in Current topics in medicinal chemistry (01.07.2002)
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Journal Article
An Anthelmintic Compound, Nafuredin, Shows Selective Inhibition of Complex I in Helminth Mitochondria
Ōmura, Satoshi, Miyadera, Hiroko, Ui, Hideaki, Shiomi, Kazuro, Yamaguchi, Yuuichi, Masuma, Rokuro, Nagamitsu, Tohru, Takano, Daisuke, Sunazuka, Toshiaki, Harder, Achim, Kölbl, Heinz, Namikoshi, Michio, Miyoshi, Hideto, Sakamoto, Kimitoshi, Kita, Kiyoshi
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2001)
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Journal Article
A γ-Lactone Form Nafuredin, Nafuredin-γ, also Inhibits Helminth Complex I
Shiomi, Kazuro, Ui, Hideaki, Suzuki, Hideaki, Hatano, Hiroko, Nagamitsu, Tohru, Takano, Daisuke, Miyadera, Hiroko, Yamashita, Tetsuo, Kita, Kiyoshi, Miyoshi, Hideto, Harder, Achim, Tomoda, Hiroshi, Omura, Satoshi
Published in Journal of antibiotics (01.01.2005)
Published in Journal of antibiotics (01.01.2005)
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Journal Article
Praziquantel – 50 Years of Research
Waechtler, Andreas, Cezanne, Bertram, Maillard, David, Sun, Rui, Wang, Shaofang, Wang, Jihua, Harder, Achim
Published in ChemMedChem (15.06.2023)
Published in ChemMedChem (15.06.2023)
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Journal Article
Cyclooctadepsipeptides: a new class of anthelmintically active compounds
HARDER, Achim, VON SAMSON-HIMMELSTJERNA, Georg
Published in Parasitology research (1987) (01.06.2002)
Published in Parasitology research (1987) (01.06.2002)
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