Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses
Cheng, Zhenxing, Abrams, Simon T, Alhamdi, Yasir, Toh, Julien, Yu, Weiping, Wang, Guozheng, Toh, Cheng-Hock
Published in Critical care medicine (01.08.2019)
Published in Critical care medicine (01.08.2019)
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Journal Article
COVID‐19 and immunothrombosis: emerging understanding and clinical management
Shaw, Rebecca J., Bradbury, Charlotte, Abrams, Simon T., Wang, Guozheng, Toh, Cheng‐Hock
Published in British journal of haematology (01.08.2021)
Published in British journal of haematology (01.08.2021)
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Journal Article
Circulating Histones Are Mediators of Trauma-associated Lung Injury
ABRAMS, Simon T, NAN ZHANG, GUOZHENG WANG, TON, Cheng-Hock, MANSON, Joanna, TINGTING LIU, DART, Caroline, BALUWA, Florence, SUSAN SIYU WANG, BROHI, Karim, KIPAR, Anja, WEIPING YU
Published in American journal of respiratory and critical care medicine (15.01.2013)
Published in American journal of respiratory and critical care medicine (15.01.2013)
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Journal Article
A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients
Abrams, Simon T, Morton, Ben, Alhamdi, Yasir, Alsabani, Mohmad, Lane, Steven, Welters, Ingeborg D, Wang, Guozheng, Toh, Cheng-Hock
Published in American journal of respiratory and critical care medicine (01.10.2019)
Published in American journal of respiratory and critical care medicine (01.10.2019)
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Journal Article
Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation
Abrams, Simon T., Su, Dunhao, Sahraoui, Yasmina, Lin, Ziqi, Cheng, Zhenxing, Nesbitt, Kate, Alhamdi, Yasir, Harrasser, Micaela, Du, Min, Foley, Jonathan H., Lillicrap, David, Wang, Guozheng, Toh, Cheng-Hock
Published in Blood (07.01.2021)
Published in Blood (07.01.2021)
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Journal Article
Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection
Alhamdi, Yasir, Neill, Daniel R, Abrams, Simon T, Malak, Hesham A, Yahya, Reham, Barrett-Jolley, Richard, Wang, Guozheng, Kadioglu, Aras, Toh, Cheng-Hock
Published in PLoS pathogens (01.05.2015)
Published in PLoS pathogens (01.05.2015)
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Journal Article
The Critical Roles and Mechanisms of Immune Cell Death in Sepsis
Cheng, Zhenxing, Abrams, Simon T, Toh, Julien, Wang, Susan Siyu, Wang, Zhi, Yu, Qian, Yu, Weiping, Toh, Cheng-Hock, Wang, Guozheng
Published in Frontiers in immunology (25.08.2020)
Published in Frontiers in immunology (25.08.2020)
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Journal Article
Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill
Alhamdi, Yasir, Abrams, Simon T, Lane, Steven, Wang, Guozheng, Toh, Cheng-Hock
Published in JAMA : the journal of the American Medical Association (23.02.2016)
Published in JAMA : the journal of the American Medical Association (23.02.2016)
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Journal Article
Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis
Abrams, Simon T, Alhamdi, Yasir, Zi, Min, Guo, Fengmei, Du, Min, Wang, Guozheng, Cartwright, Elizabeth J, Toh, Cheng-Hock
Published in International journal of molecular sciences (01.02.2023)
Published in International journal of molecular sciences (01.02.2023)
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Journal Article
Human CRP defends against the toxicity of circulating histones
Abrams, Simon T, Zhang, Nan, Dart, Caroline, Wang, Susan Siyu, Thachil, Jecko, Guan, Yunyan, Wang, Guozheng, Toh, Cheng-Hock
Published in The Journal of immunology (1950) (01.09.2013)
Published in The Journal of immunology (1950) (01.09.2013)
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Journal Article
Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Shaw, Rebecca J, Abrams, Simon T, Austin, James, Taylor, Joseph M, Lane, Steven, Dutt, Tina, Downey, Colin, Du, Min, Turtle, Lance, Baillie, J Kenneth, Openshaw, Peter J M, Wang, Guozheng, Semple, Malcolm G, Toh, Cheng-Hock
Published in Haematologica (Roma) (01.09.2021)
Published in Haematologica (Roma) (01.09.2021)
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Journal Article
The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction
Abrams, Simon T, Wang, Lijun, Yong, Jun, Yu, Qian, Du, Min, Alhamdi, Yasir, Cheng, Zhenxing, Dart, Caroline, Lane, Steven, Yu, Weiping, Toh, Cheng-Hock, Wang, Guozheng
Published in Biomedicines (01.12.2022)
Published in Biomedicines (01.12.2022)
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Journal Article
The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development
Wang, Guozheng, Toh, Cheng Hock, Yu, Qian, Wang, Zhi, Wang, Susan Siyu, Toh, Julien, Austin, James, Abrams, Simon T., Cheng, Zhenxing, Yu, Weiping
Published in Mediators of inflammation (2020)
Published in Mediators of inflammation (2020)
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Journal Article
The clinical utility of fibrin-related biomarkers in sepsis
Toh, Julien M H, Ken-Dror, Gie, Downey, Colin, Abrams, Simon T
Published in Blood coagulation & fibrinolysis (01.12.2013)
Published in Blood coagulation & fibrinolysis (01.12.2013)
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Journal Article
Cell-free histones and the cell-based model of coagulation
Yong, Jun, Abrams, Simon T., Wang, Guozheng, Toh, Cheng-Hock
Published in Journal of thrombosis and haemostasis (01.07.2023)
Published in Journal of thrombosis and haemostasis (01.07.2023)
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Journal Article
Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis
Alsabani, Mohmad, Abrams, Simon T., Cheng, Zhenxing, Morton, Ben, Lane, Steven, Alosaimi, Samar, Yu, Weiping, Wang, Guozheng, Toh, Cheng-Hock
Published in British journal of anaesthesia : BJA (01.02.2022)
Published in British journal of anaesthesia : BJA (01.02.2022)
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Journal Article
Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis
Alhamdi, Yasir, Abrams, Simon T, Cheng, Zhenxing, Jing, Shengjie, Su, Dunhao, Liu, Zhiyong, Lane, Steven, Welters, Ingeborg, Wang, Guozheng, Toh, Cheng-Hock
Published in Critical care medicine (01.10.2015)
Published in Critical care medicine (01.10.2015)
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Journal Article
Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia
Abrams, Simon T., Du, Min, Shaw, Rebecca J., Johnson, Carla, McGuinness, Dagmara, Schofield, Jeremy, Yong, Jun, Turtle, Lance, Nicolson, Phillip L.R., Moxon, Christopher, Wang, Guozheng, Toh, Cheng-Hock
Published in Journal of thrombosis and haemostasis (01.04.2024)
Published in Journal of thrombosis and haemostasis (01.04.2024)
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Journal Article