Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies
Taylor, Steven J, Padyana, Anil K, Abeywardane, Asitha, Liang, Shuang, Hao, Ming-Hong, De Lombaert, Stéphane, Proudfoot, John, Farmer, Bennett S, Li, Xiang, Collins, Brandon, Martin, Leslie, Albaugh, Daniel R, Hill-Drzewi, Melissa, Pullen, Steven S, Takahashi, Hidenori
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Journal Article
Indole Inhibitors of MMP-13 for Arthritic Disorders
Taylor, Steven J, Abeywardane, Asitha, Liang, Shuang, Xiong, Zhaoming, Proudfoot, John R, Farmer, Bennett Sandy, Gao, Donghong A, Heim-Riether, Alexander, Smith-Keenan, Lana Louise, Muegge, Ingo, Yu, Yang, Zhang, Qiang, Souza, Donald, Panzenbeck, Mark, Goldberg, Daniel, Hill-Drzewi, Melissa, Margarit, Mariana, Collins, Brandon, Li, John Xiang, Zuvela-Jelaska, Ljiljana, Li, Jun, Farrow, Neil A
Published in ACS omega (27.07.2021)
Published in ACS omega (27.07.2021)
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Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)
Takahashi, Hidenori, Riether, Doris, Bartolozzi, Alessandra, Bosanac, Todd, Berger, Valentina, Binetti, Ralph, Broadwater, John, Chen, Zhidong, Crux, Rebecca, De Lombaert, Stéphane, Dave, Rajvee, Dines, Jonathon A, Fadra-Khan, Tazmeen, Flegg, Adam, Garrigou, Michael, Hao, Ming-Hong, Huber, John, Hutzler, J. Matthew, Kerr, Steven, Kotey, Adrian, Liu, Weimin, Lo, Ho Yin, Loke, Pui Leng, Mahaney, Paige E, Morwick, Tina M, Napier, Spencer, Olague, Alan, Pack, Edward, Padyana, Anil K, Thomson, David S, Tye, Heather, Wu, Lifen, Zindell, Renee M, Abeywardane, Asitha, Simpson, Thomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Discovery and optimization of oxadiazole-based FLAP inhibitors
Bartolozzi, Alessandra, Abeywardane, Asitha, Bosanac, Todd, Broadwater, John A., Chen, Zhidong, Hutzler, J. Matthew, Huber, John D., Nemoto, Peter, Olague, Alan, Riether, Doris, Simpson, Tom, Takahashi, Hidenori, Wu, Lifen, Zhang, Yunlong, Zindell, Renee M.
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
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Journal Article
Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13
Taylor, Steven J, Abeywardane, Asitha, Liang, Shuang, Muegge, Ingo, Padyana, Anil K, Xiong, Zhaoming, Hill-Drzewi, Melissa, Farmer, Bennett, Li, Xiang, Collins, Brandon, Li, John Xiang, Heim-Riether, Alexander, Proudfoot, John, Zhang, Qiang, Goldberg, Daniel, Zuvela-Jelaska, Ljiljana, Zaher, Hani, Li, Jun, Farrow, Neil A
Published in Journal of medicinal chemistry (08.12.2011)
Published in Journal of medicinal chemistry (08.12.2011)
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Journal Article
Integrated Strategies for Identifying Leads That Target the NS3 Helicase of the Hepatitis C Virus
LaPlante, Steven R., Padyana, Anil K., Abeywardane, Asitha, Bonneau, Pierre, Cartier, Mireille, Coulombe, René, Jakalian, Araz, Wildeson-Jones, Jessi, Li, Xiang, Liang, Shuang, McKercher, Ginette, White, Peter, Zhang, Qiang, Taylor, Steven J.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity
Abeywardane, Asitha, Caviness, Gary, Choi, Younggi, Cogan, Derek, Gao, Amy, Goldberg, Daniel, Heim-Riether, Alexander, Jeanfavre, Debra, Klein, Elliott, Kowalski, Jennifer A., Mao, Wang, Miller, Craig, Moss, Neil, Ramsden, Philip, Raymond, Ernest, Skow, Donna, Smith-Keenan, Lana, Snow, Roger J., Wu, Frank, Wu, Jiang-Ping, Yu, Yang
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
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Journal Article
Correction to Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13
Taylor, Steven J, Abeywardane, Asitha, Liang, Shuang, Muegge, Ingo, Padyana, Anil K, Xiong, Zhaoming, Hill-Drzewi, Melissa, Farmer, Bennett, Li, Xiang, Collins, Brandon, Li, John Xiang, Heim-Riether, Alexander, Proudfoot, John, Zhang, Qiang, Goldberg, Daniel, Zuvela-Jelaska, Ljiljana, Zaher, Hani, Li, Jun, Farrow, Neil A
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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Journal Article
The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
Wu, Jiang-Ping, Wang, Ji, Abeywardane, Asitha, Andersen, Denise, Emmanuel, Michel, Gautschi, Elda, Goldberg, Daniel R., Kashem, Mohammed A., Lukas, Susan, Mao, Wang, Martin, Leslie, Morwick, Tina, Moss, Neil, Pargellis, Christopher, Patel, Usha R., Patnaude, Lori, Peet, Gregory W., Skow, Donna, Snow, Roger J., Ward, Yancey, Werneburg, Brian, White, Andre
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Journal Article
Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors
Snow, Roger J., Abeywardane, Asitha, Campbell, Scot, Lord, John, Kashem, Mohammed A., Khine, Hnin Hnin, King, Josephine, Kowalski, Jennifer A., Pullen, Steven S., Roma, Teresa, Roth, Gregory P., Sarko, Christopher R., Wilson, Noel S., Winters, Michael P., Wolak, John P., Cywin, Charles L.
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Journal Article
BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION
KIRRANE THOMAS MARTIN JR, NETHERTON MATTHEW RUSSELL, SMITH KEENAN LANA LOUISE, BURKE MICHAEL J, ZHANG QING, ABEYWARDANE ASITHA, TAKAHASHI HIDENORI, ZHANG QIANG, TURNER MICHAEL ROBERT, PADYANA ANIL KUMAR
Year of Publication 20.02.2014
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Year of Publication 20.02.2014
Patent
4+3 Cycloaddition reactions of halogen-substituted cyclohexenyl oxyallylic cations
Harmata, Michael, Shao, Lixin, Kürti, Laszlo, Abeywardane, Asitha
Published in Tetrahedron letters (05.02.1999)
Published in Tetrahedron letters (05.02.1999)
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