Potentiation of brain natriuretic peptides by SQ 28,603, an inhibitor of neutral endopeptidase 3.4.24.11, in monkeys and rats
SEYMOUR, A. A, ASAAD, M. M, ABBOA-OFFEI, B. E, ROVNYAK, P. L, FENNELL, S, ROGERS, W. L
Published in The Journal of pharmacology and experimental therapeutics (01.07.1992)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1992)
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Possible regulation of atrial natriuretic factor by neutral endopeptidase 24.11 and clearance receptors
SEYMOUR, A. A, NORMAN, J. A, ASAAD, M. M, FENNELL, S. A, ABBOA-OFFEI, B, LITTLE, D. K, KRATUNIS, V. J, DELANEY, N. G, HUNT, J. T, DI DONATO, G
Published in The Journal of pharmacology and experimental therapeutics (01.03.1991)
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Published in The Journal of pharmacology and experimental therapeutics (01.03.1991)
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Arylpropanolamines : Selective β3 agonists arising from strategies to mitigate phase I metabolic transformations
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Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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BMS-201620: a selective beta 3 agonist
Washburn, W.N., Sun, C.-Q., Bisacchi, G., Wu, G., Cheng, P.T., Sher, P.M., Ryono, D., Gavai, A.V., Poss, K., Girotra, R.N., McCann, P.J., Mikkilineni, A.B., Dejneka, T.C., Wang, T.C., Merchant, Z., Morella, M., Arbeeny, C.M., Harper, T.W., Slusarchyk, D.A., Skwish, S., Russell, A.D., Allen, G.T., Tesfamariam, B., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Young, D., Dickinson, K.E., Seymour, A.A.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Beta 3 agonists. Part 1: evolution from inception to BMS-194449
Washburn, W.N., Sher, P.M., Poss, K.M., Girotra, R.N., McCann, P.J., Gavai, A.V., Mikkilineni, A.B., Mathur, A., Cheng, P., Dejneka, T.C., Sun, C.Q., Wang, T.C., Harper, T.W., Russell, A.D., Slusarchyk, D.A., Skwish, S., Allen, G.T., Hillyer, D.E., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Tesfamariam, B., Ciosek, C.P., Ryono, D., Young, D.A., Dickinson, K.E., Seymour, A.A., Arbeeny, C.M., Gregg, R.E.
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
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BMS-196085 : A potent and selective full agonist of the human β3 adrenergic receptor
GAVAI, A. V, SHER, P. M, WANG, T. C, SUN, C. Q, SLUSARCHYK, D. A, SKWISH, S, ALLEN, G. T, HILLYER, D. E, FROHLICH, B. H, ABBOA-OFFEI, B. E, CAP, M, WALDRON, T. L, MIKKILINENI, A. B, GEORGE, R. J, TESFAMARIAM, B, HARPER, T. W, CIOSEK, C. P, YOUNG, D. A, DICKINSON, K. E, SEYMOUR, A. A, ARBEENY, C. M, WASHBURN, W. N, POSS, K. M, MCCANN, P. J, GIROTRA, R. N, FISHER, L. G, WU, G, BEDNARZ, M. S, MATHUR, A
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
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BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor
Gavai, A V, Sher, P M, Mikkilineni, A B, Poss, K M, McCann, P J, Girotra, R N, Fisher, L G, Wu, G, Bednarz, M S, Mathur, A, Wang, T C, Sun, C Q, Slusarchyk, D A, Skwish, S, Allen, G T, Hillyer, D E, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Harper, T W, Ciosek, Jr, C P, Young, D A, Dickinson, K E, Seymour, A A, Arbeeny, C M, Washburn, W N
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
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Antiallergic properties of SQ 13,847, an orally effective agent. I. Activity in vivo
Casey, F B, Abboa-Offei, B E, Marretta, J
Published in The Journal of pharmacology and experimental therapeutics (01.06.1980)
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Published in The Journal of pharmacology and experimental therapeutics (01.06.1980)
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Renal and depressor activities of inhibitors of neutral endopeptidase and angiotensin converting enzyme in monkeys infused with angiotensin II
Seymour, A A, Asaad, M M, Abboa-Offei, B E, Smith, P L, Mathers, P D, Rogers, W L, Dorso, C R
Published in Journal of cardiovascular pharmacology (01.11.1996)
Published in Journal of cardiovascular pharmacology (01.11.1996)
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Determinants of in vivo activity of neutral endopeptidase 3.4.24.11 and angiotensin converting enzyme inhibitors
Seymour, A A, Asaad, M M, Abboa-Offei, B E, Smith, P L, Rogers, W L, Dorso, C R
Published in The Journal of pharmacology and experimental therapeutics (01.02.1996)
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Published in The Journal of pharmacology and experimental therapeutics (01.02.1996)
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Evaluation of SQ 28,603, an inhibitor of neutral endopeptidase, in conscious monkeys
Seymour, A A, Abboa-Offei, B, Asaad, M M, Rogers, W L
Published in Canadian journal of physiology and pharmacology (01.10.1991)
Published in Canadian journal of physiology and pharmacology (01.10.1991)
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Dual Metalloprotease Inhibitors: Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase
Robl, Jeffrey A, Sun, Chong-Qing, Stevenson, Jay, Ryono, Denis E, Simpkins, Ligaya M, Cimarusti, Maria P, Dejneka, Tamara, Slusarchyk, William A, Chao, Sam, Stratton, Leslie, Misra, Raj N, Bednarz, Mark S, Asaad, Magdi M, Cheung, Hong Son, Abboa-Offei, Benoni E, Smith, Patricia L, Mathers, Parker D, Fox, Maxine, Schaeffer, Thomas R, Seymour, Andrea A, Trippodo, Nick C
Published in Journal of medicinal chemistry (23.05.1997)
Published in Journal of medicinal chemistry (23.05.1997)
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Arylpropanolamines: Selective beta sub(3) agonists arising from strategies to mitigate phase I metabolic transformations
Washburn, W N, Harper, T W, Wu, G, Godfrey, J D, McCann, P, Girotra, R, Shao, C, Zhang, H, Gavai, A, Mikkilineni, A, Dejneka, T, Ahmed, S, Caringal, Y, Hangeland, J, Zhang, M, Cheng, PTW, Russell, AD, Skwish, S, Slusarchyk, DA, Allen, G T, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Dickinson, KE, Seymour, A A, Sher, P M
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article
Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations
Washburn, W N, Harper, T W, Wu, G, Godfrey, J D, McCann, P, Girotra, R, Shao, C, Zhang, H, Gavai, A, Mikkilineni, A, Dejneka, T, Ahmed, S, Caringal, Y, Hangeland, J, Zhang, M, Cheng, P T W, Russell, A D, Skwish, S, Slusarchyk, D A, Allen, G T, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Dickinson, K E, Seymour, A A, Sher, P M
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors
Magnin, David R, Robl, Jeffrey A, Sulsky, Richard B, Augeri, David J, Huang, Yanting, Simpkins, Ligaya M, Taunk, Prakash C, Betebenner, David A, Robertson, James G, Abboa-Offei, Benoni E, Wang, Aiying, Cap, Michael, Xin, Li, Tao, Li, Sitkoff, Doree F, Malley, Mary F, Gougoutas, Jack Z, Khanna, Ashish, Huang, Qi, Han, Song-Ping, Parker, Rex A, Hamann, Lawrence G
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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