Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene
Beckers, Albert, Aaltonen, Lauri A, Daly, Adrian F, Karhu, Auli
Published in Endocrine reviews (01.04.2013)
Published in Endocrine reviews (01.04.2013)
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Colibactin DNA-damage signature indicates mutational impact in colorectal cancer
Dziubańska-Kusibab, Paulina J., Berger, Hilmar, Battistini, Federica, Bouwman, Britta A. M., Iftekhar, Amina, Katainen, Riku, Cajuso, Tatiana, Crosetto, Nicola, Orozco, Modesto, Aaltonen, Lauri A., Meyer, Thomas F.
Published in Nature medicine (01.07.2020)
Published in Nature medicine (01.07.2020)
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Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer
Rajamäki, Kristiina, Taira, Aurora, Katainen, Riku, Välimäki, Niko, Kuosmanen, Anna, Plaketti, Roosa-Maria, Seppälä, Toni T., Ahtiainen, Maarit, Wirta, Erkki-Ville, Vartiainen, Emilia, Sulo, Päivi, Ravantti, Janne, Lehtipuro, Suvi, Granberg, Kirsi J., Nykter, Matti, Tanskanen, Tomas, Ristimäki, Ari, Koskensalo, Selja, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Taipale, Jussi, Mecklin, Jukka-Pekka, Aavikko, Mervi, Palin, Kimmo, Aaltonen, Lauri A.
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2021)
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2021)
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Exome-wide somatic mutation characterization of small bowel adenocarcinoma
Hänninen, Ulrika A, Katainen, Riku, Tanskanen, Tomas, Plaketti, Roosa-Maria, Laine, Riku, Hamberg, Jiri, Ristimäki, Ari, Pukkala, Eero, Taipale, Minna, Mecklin, Jukka-Pekka, Forsström, Linda M, Pitkänen, Esa, Palin, Kimmo, Välimäki, Niko, Mäkinen, Netta, Aaltonen, Lauri A
Published in PLoS genetics (09.03.2018)
Published in PLoS genetics (09.03.2018)
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Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers
Mehine, Miika, Kaasinen, Eevi, Heinonen, Hanna-Riikka, Mäkinen, Netta, Kämpjärvi, Kati, Sarvilinna, Nanna, Aavikko, Mervi, Vähärautio, Anna, Pasanen, Annukka, Bützow, Ralf, Heikinheimo, Oskari, Sjöberg, Jari, Pitkänen, Esa, Vahteristo, Pia, Aaltonen, Lauri A.
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2016)
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Diagnostic Cancer Genome Sequencing and the Contribution of Germline Variants
Kilpivaara, O., Aaltonen, L. A.
Published in Science (American Association for the Advancement of Science) (29.03.2013)
Published in Science (American Association for the Advancement of Science) (29.03.2013)
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Characterization of Uterine Leiomyomas by Whole-Genome Sequencing
Mehine, Miika, Kaasinen, Eevi, Mäkinen, Netta, Katainen, Riku, Kämpjärvi, Kati, Pitkänen, Esa, Heinonen, Hanna-Riikka, Bützow, Ralf, Kilpivaara, Outi, Kuosmanen, Anna, Ristolainen, Heikki, Gentile, Massimiliano, Sjöberg, Jari, Vahteristo, Pia, Aaltonen, Lauri A
Published in The New England journal of medicine (04.07.2013)
Published in The New England journal of medicine (04.07.2013)
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Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival
Cajuso, Tatiana, Sulo, Päivi, Tanskanen, Tomas, Katainen, Riku, Taira, Aurora, Hänninen, Ulrika A., Kondelin, Johanna, Forsström, Linda, Välimäki, Niko, Aavikko, Mervi, Kaasinen, Eevi, Ristimäki, Ari, Koskensalo, Selja, Lepistö, Anna, Renkonen-Sinisalo, Laura, Seppälä, Toni, Kuopio, Teijo, Böhm, Jan, Mecklin, Jukka-Pekka, Kilpivaara, Outi, Pitkänen, Esa, Palin, Kimmo, Aaltonen, Lauri A.
Published in Nature communications (06.09.2019)
Published in Nature communications (06.09.2019)
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Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity
Turunen, Mikko, Spaeth, Jason M., Keskitalo, Salla, Park, Min Ju, Kivioja, Teemu, Clark, Alison D., Mäkinen, Netta, Gao, Fangjian, Palin, Kimmo, Nurkkala, Helka, Vähärautio, Anna, Aavikko, Mervi, Kämpjärvi, Kati, Vahteristo, Pia, Kim, Chongwoo A., Aaltonen, Lauri A., Varjosalo, Markku, Taipale, Jussi, Boyer, Thomas G.
Published in Cell reports (Cambridge) (08.05.2014)
Published in Cell reports (Cambridge) (08.05.2014)
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Mutations in BRIP1 confer high risk of ovarian cancer
Rafnar, Thorunn, Stefansson, Kari, Gudbjartsson, Daniel F, Sulem, Patrick, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Jonasdottir, Adalbjorg, Besenbacher, Soren, Lundin, Pär, Stacey, Simon N, Gudmundsson, Julius, Magnusson, Olafur T, le Roux, Louise, Orlygsdottir, Gudbjorg, Helgadottir, Hafdis T, Johannsdottir, Hrefna, Gylfason, Arnaldur, Tryggvadottir, Laufey, Jonasson, Jon G, de Juan, Ana, Ortega, Eugenia, Ramon-Cajal, Jose M, García-Prats, Maria D, Mayordomo, Carlos, Panadero, Angeles, Rivera, Fernando, Aben, Katja K H, van Altena, Anne M, Massuger, Leon F A G, Aavikko, Mervi, Kujala, Paula M, Staff, Synnöve, Aaltonen, Lauri A, Olafsdottir, Kristrun, Bjornsson, Johannes, Kong, Augustine, Salvarsdottir, Anna, Saemundsson, Hafsteinn, Olafsson, Karl, Benediktsdottir, Kristrun R, Gulcher, Jeffrey, Masson, Gisli, Kiemeney, Lambertus A, Mayordomo, Jose I, Thorsteinsdottir, Unnur
Published in Nature genetics (01.11.2011)
Published in Nature genetics (01.11.2011)
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Ten Years After Mutation Testing for Lynch Syndrome: Cancer Incidence and Outcome in Mutation-Positive and Mutation-Negative Family Members
Järvinen, Heikki J., Renkonen-Sinisalo, Laura, Aktán-Collán, Katja, Peltomäki, Päivi, Aaltonen, Lauri A., Mecklin, Jukka-Pekka
Published in Journal of clinical oncology (01.10.2009)
Published in Journal of clinical oncology (01.10.2009)
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Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer
JORISSEN, Robert N, GIBBS, Peter, ØRNTOFT, Torben F, LINDBJERG ANDERSEN, Claus, GRUIDL, Mike, KAMATH, Vidya P, ESCHRICH, Steven, YEATMAN, Timothy J, SIEBER, Oliver M, CHRISTIE, Michael, PRAKASH, Saurabh, LIPTON, Lara, DESAI, Jayesh, KERR, David, AALTONEN, Lauri A, ARANGO, Diego, KRUHØFFER, Mogens
Published in Clinical cancer research (15.12.2009)
Published in Clinical cancer research (15.12.2009)
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Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability
Välimäki, Niko, Kuisma, Heli, Pasanen, Annukka, Heikinheimo, Oskari, Sjöberg, Jari, Bützow, Ralf, Sarvilinna, Nanna, Heinonen, Hanna-Riikka, Tolvanen, Jaana, Bramante, Simona, Tanskanen, Tomas, Auvinen, Juha, Uimari, Outi, Alkodsi, Amjad, Lehtonen, Rainer, Kaasinen, Eevi, Palin, Kimmo, Aaltonen, Lauri A
Published in eLife (18.09.2018)
Published in eLife (18.09.2018)
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Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer
Fang, Hu, Barbour, Jayne A, Poulos, Rebecca C, Katainen, Riku, Aaltonen, Lauri A, Wong, Jason W H
Published in PLoS genetics (03.02.2020)
Published in PLoS genetics (03.02.2020)
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The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
Taipale, Jussi, Aaltonen, Lauri A, Tuupanen, Sari, Turunen, Mikko, Lehtonen, Rainer, Hallikas, Outi, Vanharanta, Sakari, Kivioja, Teemu, Björklund, Mikael, Wei, Gonghong, Yan, Jian, Niittymäki, Iina, Mecklin, Jukka-Pekka, Järvinen, Heikki, Ristimäki, Ari, Di-Bernardo, Mariachiara, East, Phil, Carvajal-Carmona, Luis, Houlston, Richard S, Tomlinson, Ian, Palin, Kimmo, Ukkonen, Esko, Karhu, Auli
Published in Nature genetics (01.08.2009)
Published in Nature genetics (01.08.2009)
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Cancer incidence following non-neoplastic medical conditions: a prospective population-based cohort study
Sipilä, Lauri J., Tanskanen, Tomas, Heikkinen, Sanna, Seppä, Karri, Aavikko, Mervi, Ravantti, Janne, Aaltonen, Lauri A., Pitkäniemi, Janne
Published in Acta oncologica (04.11.2024)
Published in Acta oncologica (04.11.2024)
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Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19
Park, Min Ju, Shen, Hailian, Spaeth, Jason M., Tolvanen, Jaana H., Failor, Courtney, Knudtson, Jennifer F., McLaughlin, Jessica, Halder, Sunil K., Yang, Qiwei, Bulun, Serdar E., Al-Hendy, Ayman, Schenken, Robert S., Aaltonen, Lauri A., Boyer, Thomas G.
Published in The Journal of biological chemistry (30.03.2018)
Published in The Journal of biological chemistry (30.03.2018)
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Loss of SUFU Function in Familial Multiple Meningioma
Aavikko, Mervi, Li, Song-Ping, Saarinen, Silva, Alhopuro, Pia, Kaasinen, Eevi, Morgunova, Ekaterina, Li, Yilong, Vesanen, Kari, Smith, Miriam J., Evans, D. Gareth R., Pöyhönen, Minna, Kiuru, Anne, Auvinen, Anssi, Aaltonen, Lauri A., Taipale, Jussi, Vahteristo, Pia
Published in American journal of human genetics (07.09.2012)
Published in American journal of human genetics (07.09.2012)
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