Insulin sensitivity is increased and fat oxidation after a high-fat meal is reduced in normal-weight healthy men with strong familial predisposition to overweight
Giacco, R, OBJECTIVE: To evaluate whether postprandial abnormalities of energy expenditure and/or lipid oxidation are present in healthy, normal-weight subjects with a strong family history of obesity and thus at high risk to become obese. DESIGN: Case-control study. SUBJECTS: A total of 16 young healthy men participated in the study. Eight subjects had both parents overweight (father's and mother's body mass index (BMI) >25 kg/m2) and eight had both parents with normal body weight (father's and mother's BMI<25 kg/m2, respectively). The group of subjects with overweight parents was similar to that with normal-weight parents (control group) in terms of BMI (23.7±1.7 vs 22.7±1.1 kg/m2) (M±s.d.) and fat-free body mass (FFM) (60.5±4.9 vs 58.4±2.0 kg), but was slightly older than the control group (25.4±3.3 vs 22.7±2.4 y; P<0.05). MEASUREMENTS: Energy expenditure (EE) was measured by indirect calorimetry, and blood samples were taken for the evaluation of metabolic variables in the fasting state and every hour for 8 h after a standard fat-rich meal (protein 15%, carbohydrate 34%, fat 51%, 4090 kJ). RESULTS: Fasting plasma glucose, cholesterol, HDL-cholesterol, triglyceride, free fatty acid (FFA) and leptin concentrations were similar in both groups of participants, but subjects with overweight parents has significantly lower plasma insulin concentrations (5.11±0.51 vs 7.07±1.56 U/ml; P<0.007) and HOMA index of insulin resistance (1.1±0.1 vs 1.6±0.4; P<0.01). Postprandial plasma glucose, triglyceride, FFA and leptin concentrations were similar in the two groups, whereas insulin levels were significantly lower in the group with both parents overweight at 3, 5, 6, 7 and 8 h. Fasting and postprandial EE, and fasting lipid and carbohydrate oxidation were similar in both groups. On the contrary, postprandial carbohydrate oxidation (incremental area under curve) was significantly higher (196.2594.75 vs 75.8874.72 mg/kg FFM 8 h; P<0.007) and that of lipid oxidation lower (90.9380.32 vs 163.68108.22 mg/kg FFM 8 h; P<0.05) in the group of subjects with overweight parents. CONCLUSION: Normal-weight subjects with a strong family history of obesity present a reduced lipid oxidation in the postprandial period and a metabolic profile characterized by low plasma insulin levels and the HOMA index, which is compatible with increased insulin sensitivity. These metabolic characteristics may be considered as early predictors of weight gain and are probably genetically determined, Clemente, G, Busiello, L, Lasorella, G, Rivieccio, A.M, Rivellese, A.A, Riccardi, G
Published in International Journal of Obesity (01.07.2003)
Published in International Journal of Obesity (01.07.2003)
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Debutant Lal bags five in big win for Bengal [Times Sport]
SCOREBOARDNagaland 1st innings 166 Bengal 1st innings overnight 3364 Manoj Tiwary not out 51 Shahbaz Ahmed not out 75 Extrasb 6 lb 3 nb 2 w 5 16 Total For 4 wickets decl in 96 overs 450 Fall of wickets 110 2234 3304 4329 Bowling Hopongkyu 2211132 K Kense 121460 I Lemtur 230940 N Chishi 1251630 S Mundhe 911460 R Jonathan 170792 Nagaland 2nd innings Y Singh lbw K Lal 19 J Ozukum c M Tiwary b P Pramanik 26 S Mundhe c M Tiwary b Shahbaz 28 R Jonathan b K Lal 2 C Bist lbw K Lal 4 H Zhimomi c P Pramanik b K Lal 12 S Rupero c Shahbaz b P Pramanik 14 I Lemtur c S Gharami b K Lal 5 N Chishi c K Ghosh b Shahbaz 8 K Kense not out 2 C Hopongkyu c A Easwaran b Shahbaz 0 Extrasnb 3 3 TotalAll out in 453 overs123 Fall of wickets 146 250 353 457 574 697 7112 8120 9123 BowlingI Porel 2120 A Deep 20120 Shahbaz 1131383 P Pramanik 133242 K Lal 173475 Result Bengal won by an inngs 161 runs
Published in The Times of India (Online) (30.12.2022)
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Published in The Times of India (Online) (30.12.2022)
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<, PARAGRAPH>, BYsourceline1<, TXTbodycopy<, New COVID-19 cases 21 Total cases 3,520 New deaths 1 Total deaths 112 Active cases 436 Hospitalizations 16 Total ICU beds 396 Available ICU beds 140 Total ventilators 318 Available ventilators 260 Alternatives 441
Published in Portland press herald (12.07.2020)
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Vital signs
<, PARAGRAPH>, BYsourceline1<, TXTbodycopy<, New COVID-19 cases 26 Total cases 3,486 New deaths 1 Total deaths 111 Active cases 474 Hospitalizations 16 Total ICU beds 396 Available ICU beds 136 Total ventilators 317 Available ventilators 257 Alternatives 440
Published in Portland press herald (10.07.2020)
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Nationals shut down Atlanta, helping Mets in playoff race
Irvin, Jake, three relievers held the visitors to six hits, CJ Abrams hit a home run as the Washington Nationals defeated Atlanta, 5-1 on Wednesday night Irvin 10-12 went six innings, giving up two hits, one earned run, struck out five, walked oneThe Mets are now a game ahead of Atlanta for the last National League wild-card spotBefore the game, in another blow to its playoff hopes, Atlanta placed All-Star pitcher Reynaldo Lpez on the 15-day injured list with right shoulder inflammationLpez lasted only one inning the previous night in a 12-0 victory over the Nationals He left after throwing 25 pitches, 16 for strikes His fastball velocity, usually 96 mph, was in the 89-94 mph range Lpez has been a breakout performer for Atlanta, going 8-5 with a 203 ERA in 24 startsD-backs 14, Rangers 4 Ketel Marte homered, had four RBIs, Eugenio Suarez hit two homers for host Arizona The Diamondbacks won the season series between last year's World Series' teams 6-0, jumped on Cody Bradford 5-3 early in the series finale Randal Grichuk hit a two-run homer off the righthander in a three-run first inning, Suarez added a solo shot in the second, Marte hit his three-run shot in the fourth Adrian Del Castillo added a three-run shot in the fifth inning, Suarez closed out a 4-for-4 day with a solo shot in the seventh Arizona had a season-high 13 extra-base hits, 16 total, to tie San Diego for the top NL wild-card spotTigers 7, Rockies 4 Kerry Carpenter matched a career-high with four hits, host Detroit kept its improbable wild-card hopes alive Carpenter came up in the seventh needing a homer for the cycle, the first for a Tiger since Carlos Guillen in 2006, but hit an infield singlePirates 3, Marlins 1 Lefthander Bailey Falter carried a no-hitter into the seventh inning, host Pittsburgh swept the season series 7-0 Falter 8-7 allowed three walks before Jonah Bride dropped a single into leftfield with one out in the seventh The 27-year-old Falter gave up a leadoff single to Cristian Pache in the eighth before being pulled on 93 pitches 57 strikes after getting the first out with Kyle Stowers flying to center Guardians 6, White Sox 4 Lane Thomas had four RBIs, visiting Cleveland held on behind its bullpen for a three-game series sweep Austin Hedges added a solo home run for the AL-Central leading Guardians, who moved four games ahead of second-place Kansas City in the division, a half-game ahead of the Yankees for the best record in the American League Chicago dropped a franchise-record 15th straight at home, lost its 17th in 19 overall, was swept for the 24th time At 33-114, the White Sox are closing in on the post-1900 record for losses, 120 the 1962 Mets- AP
Published in Newsday (12.09.2024)
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EDU BRIEFS [Times City]
49 clear head teacher testAhmedabad The Gujarat State Examination Board on Thursday announced the results of the Head Teacher Aptitude Test HTAT The board said that 5573 teachers had taken the exam of which 2732 or 4902 succeeded It is an aptitude test for those candidates who wish to be promoted to head teachers post in grantinaid secondary, higher secondary schools The exam was conducted on October 16 A total of 7815 teachers had registered for this test The test was held at 38 centres in four major cities TNNGTU applies for NAAC nodAhmedabad Gujarat Technological University GTU has applied to the National Assessment, Accreditation Council NAAC for recognition a decade after its establishment Sources said an application for NAAC recognition can be made only after the first batch of postgraduate students graduate from a universityGTU started its postgraduate courses in 2017, the first batch passed out this year TNN
Published in The Times of India (Online) (04.11.2022)
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Published in The Times of India (Online) (04.11.2022)
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THE 'FORTUNATE' AVERAGED $8.7 MILLION 2005 WASN'T THE BEST YEAR FOR THE HIGHEST-PAID LOCAL EXECUTIVES, AS THEIR TOTAL COMPENSATION DROPPED, BUT THEY STILL TOOK HOME AN AVERAGE OF $8.7 MILLION: REGION Edition
t was a tough year for the Fortunate 50. The 50 highest-paid executives in the region saw their total compensation slip 16 percent -- to an average of $8.7 million
Published in Pittsburgh post-gazette (Pittsburgh, Pa. 1978) (07.05.2006)
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Published in Pittsburgh post-gazette (Pittsburgh, Pa. 1978) (07.05.2006)
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VITAL SIGNS
<, PARAGRAPH>, BY.sourceline1<, /PARAGRAPH>, TXT.bodycopy<, New COVID-19 cases: 1,575 (over 3 days) Total cases: 168,474 New cases, 7-day average: 1,011.3 New deaths: 16 (over 3 days) Total deaths: 1,714 Hospitalizations: 416 Total critical care beds: 378 Available critical care beds: 49 Fully vaccinated: 972,715 Percentage of population: 72.36%
Published in Kennebec journal (Augusta, Me. : 1975) (26.01.2022)
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Published in Kennebec journal (Augusta, Me. : 1975) (26.01.2022)
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VITAL SIGNS
<, PARAGRAPH>, BY.sourceline1<, /PARAGRAPH>, TXT.bodycopy<, New COVID-19 cases: 1,575 (over 3 days) Total cases: 168,474 New cases, 7-day average: 1,011.3 New deaths: 16 (over 3 days) Total deaths: 1,714 Hospitalizations: 416 Total critical care beds: 378 Available critical care beds: 49 Fully vaccinated: 972,715 Percentage of population: 72.36%
Published in Morning sentinel (Waterville, Me. : 1996) (26.01.2022)
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City girl Priyanka reaches final of Colombo tourney [Times Sport]
Easy win for GCI AGujarat Cricket Institute GCI A handed a ninewicket defeat to Lions Cricket Academy LCA in their match at the SPCT U14 Cricket Tournament in Ahmedabad on Monday Batting first LCA were all out for 89 in 464 overs Fighting knocks by Dharav Patel 36, Joy Patel 16 saved LCA from total capitulation For GCI A Rudra Rajpurohit took three wickets for seven while Manyah Shah bagged two for 11 GCI A reached the target losing one wicket in 204 overs Dhairya Patel, Samarth Patel were unbeaten at 38, 18 respectively Manyah was named man of the match
Published in The Times of India (Online) (06.06.2023)
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Published in The Times of India (Online) (06.06.2023)
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