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Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes

Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes

by Řezáčová, Pavlína, Pokorná, Jana, Brynda, Jiří, Kožíšek, Milan, Cígler, Petr, Lepšík, Martin, Fanfrlík, Jindřich, Řezáč, Jan, Grantz Šašková, Klára, Sieglová, Irena, Plešek, Jaromír, Šícha, Václav, Grüner, Bohumír, Oberwinkler, Heike, Sedláček’, Juraj, Kräusslich, Hans-Georg, Hobza, Pavel, Král, Vladimír, Konvalinka, Jan
Published in Journal of medicinal chemistry (26.11.2009)

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Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming Antiviral Resistance

Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming Antiviral Resistance

by Kožíšek, Milan, Cígler, Petr, Lepšík, Martin, Fanfrlík, Jindřich, Řezáčová, Pavlína, Brynda, Jiří, Pokorná, Jana, Plešek, Jaromír, Grüner, Bohumír, Grantz Šašková, Klára, Václavíková, Jana, Král, Vladimír, Konvalinka, Jan
Published in Journal of medicinal chemistry (14.08.2008)

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Specific Inhibitors of HIV Capsid Assembly Binding to the C‑Terminal Domain of the Capsid Protein: Evaluation of 2‑Arylquinazolines as Potential Antiviral Compounds

Specific Inhibitors of HIV Capsid Assembly Binding to the C‑Terminal Domain of the Capsid Protein: Evaluation of 2‑Arylquinazolines as Potential Antiviral Compounds

by Machara, Aleš, Lux, Vanda, Kožíšek, Milan, Grantz Šašková, Klára, Štěpánek, Ondřej, Kotora, Martin, Parkan, Kamil, Pávová, Marcela, Glass, Bärbel, Sehr, Peter, Lewis, Joe, Müller, Barbara, Kräusslich, Hans-Georg, Konvalinka, Jan
Published in Journal of medicinal chemistry (28.01.2016)

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Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease

Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease

by Kozísek, Milan, Henke, Sandra, Sasková, Klára Grantz, Jacobs, Graeme Brendon, Schuch, Anita, Buchholz, Bernd, Müller, Viktor, Kräusslich, Hans-Georg, Rezácová, Pavlína, Konvalinka, Jan, Bodem, Jochen
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)

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Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family

Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family

by Trempe, Jean-François, Šašková, Klára Grantz, Sivá, Monika, Ratcliffe, Colin D. H., Veverka, Václav, Hoegl, Annabelle, Ménade, Marie, Feng, Xin, Shenker, Solomon, Svoboda, Michal, Kožíšek, Milan, Konvalinka, Jan, Gehring, Kalle
Published in Scientific reports (20.09.2016)

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Structure-Aided Design of Novel Inhibitors of HIV Protease Based on a Benzodiazepine Scaffold

Structure-Aided Design of Novel Inhibitors of HIV Protease Based on a Benzodiazepine Scaffold

by Schimer, Jiří, Cígler, Petr, Veselý, Jan, Grantz Šašková, Klára, Lepšík, Martin, Brynda, Jiří, Řezáčová, Pavlína, Kožíšek, Milan, Císařová, Ivana, Oberwinkler, Heike, Kraeusslich, Hans-Georg, Konvalinka, Jan
Published in Journal of medicinal chemistry (26.11.2012)

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Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome

Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome

by Ramirez, Juanma, Lectez, Benoit, Osinalde, Nerea, Sivá, Monika, Elu, Nagore, Aloria, Kerman, Procházková, Michaela, Perez, Coralia, Martínez-Hernández, Jose, Barrio, Rosa, Šašková, Klára Grantz, Arizmendi, Jesus M, Mayor, Ugo
Published in Human molecular genetics (01.06.2018)

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Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir

Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir

by SASKOVA, Klara Grantz, KOZISEK, Milan, REZACOVA, Pavlina, BRYNDA, Jirí, YASHINA, Tatyana, KAGAN, Ron M, KONVALINKA, Jan
Published in Journal of Virology (01.09.2009)

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Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog

Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog

by Sivá, Monika, Svoboda, Michal, Veverka, Václav, Trempe, Jean-François, Hofmann, Kay, Kožíšek, Milan, Hexnerová, Rozálie, Sedlák, František, Belza, Jan, Brynda, Jiří, Šácha, Pavel, Hubálek, Martin, Starková, Jana, Flaisigová, Iva, Konvalinka, Jan, Šašková, Klára Grantz
Published in Scientific reports (27.07.2016)

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Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy

Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy

by Srb, Pavel, Svoboda, Michal, Benda, Ladislav, Lepšík, Martin, Tarábek, Ján, Šícha, Václav, Grüner, Bohumír, Grantz-Šašková, Klára, Brynda, Jiří, Řezáčová, Pavlína, Konvalinka, Jan, Veverka, Václav
Published in Physical chemistry chemical physics : PCCP (06.03.2019)

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Ninety-Nine Is Not Enough: Molecular Characterization of Inhibitor-Resistant Human Immunodeficiency Virus Type 1 Protease Mutants with Insertions in the Flap Region

Ninety-Nine Is Not Enough: Molecular Characterization of Inhibitor-Resistant Human Immunodeficiency Virus Type 1 Protease Mutants with Insertions in the Flap Region

by KOZISEK, Milan, GRANTZ SASKOVA, Klara, REZACOVA, Pavlina, BRYNDA, Jiri, VAN MAARSEVEEN, Noortje M, DE JONG, Dorien, BOUCHER, Charles A, KAGAN, Ron M, NIJHUIS, Monique, KONVALINKA, Jan
Published in Journal of Virology (01.06.2008)

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Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir

Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir

by Šašková, Klára Grantz, Kožíšek, Milan, Lepšík, Martin, Brynda, Jiří, Řezáčová, Pavlína, Václavíková, Jana, Kagan, Ron M., Machala, Ladislav, Konvalinka, Jan
Published in Protein science (01.09.2008)

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Thermodynamic and structural analysis of HIV protease resistance to darunavir – analysis of heavily mutated patient‐derived HIV‐1 proteases

Thermodynamic and structural analysis of HIV protease resistance to darunavir – analysis of heavily mutated patient‐derived HIV‐1 proteases

by Kožíšek, Milan, Lepšík, Martin, Grantz Šašková, Klára, Brynda, Jiří, Konvalinka, Jan, Řezáčová, Pavlína
Published in The FEBS journal (01.04.2014)

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Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies

Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies

by Bartoňová, Vanda, Král, Vlastimil, Sieglová, Irena, Brynda, Jiří, Fábry, Milan, Hořejší, Magdalena, Kožíšek, Milan, Šašková, Klára Grantz, Konvalinka, Jan, Sedláček, Juraj, Řezáčová, Pavlína
Published in Antiviral research (01.06.2008)

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Backbone (1)H, (13)C, and (15)N NMR assignment for the inactive form of the retroviral protease of the murine intracisternal A-type particle, inMIA-14 PR

Backbone (1)H, (13)C, and (15)N NMR assignment for the inactive form of the retroviral protease of the murine intracisternal A-type particle, inMIA-14 PR

by Motácková, Veronika, Kubícková, Monika, Kozísek, Milan, Sasková, Klára Grantz, Svec, Martin, Zídek, Lukás, Sklenár, Vladimír
Published in Biomolecular NMR assignments (01.12.2009)

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Backbone ¹H, ¹³C, and ¹⁵N NMR assignment for the inactive form of the retroviral protease of the murine intracisternal A-type particle, inMIA-14 PR

Backbone ¹H, ¹³C, and ¹⁵N NMR assignment for the inactive form of the retroviral protease of the murine intracisternal A-type particle, inMIA-14 PR

by Motáčková, Veronika, Kubíčková, Monika, Kožíšek, Milan, Šašková, Klára Grantz, Švec, Martin, Žídek, Lukáš, Sklenář, Vladimír
Published in Biomolecular NMR assignments (01.12.2009)

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Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopyElectronic supplementary information (ESI) available. See DOI: 10.1039/c9cp00416e

Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopyElectronic supplementary information (ESI) available. See DOI: 10.1039/c9cp00416e

by Srb, Pavel, Svoboda, Michal, Benda, Ladislav, Lepšík, Martin, Tarábek, Ján, Šícha, Václav, Grüner, Bohumír, Grantz-Šašková, Klára, Brynda, Ji í, ezá ová, Pavlína, Konvalinka, Jan, Veverka, Václav
Year of Publication 06.03.2019

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Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma

Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma

by Fassmannová, Dominika, Sedlák, František, Sedláček, Jindřich, Špička, Ivan, Grantz Šašková, Klára
Published in Cancers (25.04.2020)

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Molecular Analysis of the HIV-1 Resistance Development: Enzymatic Activities, Crystal Structures, and Thermodynamics of Nelfinavir-resistant HIV Protease Mutants

Molecular Analysis of the HIV-1 Resistance Development: Enzymatic Activities, Crystal Structures, and Thermodynamics of Nelfinavir-resistant HIV Protease Mutants

by Kožíšek, Milan, Bray, Jenelle, Řezáčová, Pavlína, Šašková, Klára, Brynda, Jiří, Pokorná, Jana, Mammano, Fabrizio, Rulíšek, Lubomír, Konvalinka, Jan
Published in Journal of molecular biology (07.12.2007)

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DDI2 protease controls embryonic development and inflammation via TCF11/NRF1

DDI2 protease controls embryonic development and inflammation via TCF11/NRF1

by Nedomova, Monika, Haberecht-Müller, Stefanie, Möller, Sophie, Venz, Simone, Prochazkova, Michaela, Prochazka, Jan, Sedlak, Frantisek, Chawengsaksophak, Kallayanee, Hammer, Elke, Kasparek, Petr, Adamek, Michael, Sedlacek, Radislav, Konvalinka, Jan, Krüger, Elke, Grantz Saskova, Klara
Published in iScience (18.10.2024)

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