The landscape of somatic mutation in normal colorectal epithelial cells
Lee-Six, Henry, Olafsson, Sigurgeir, Ellis, Peter, Osborne, Robert J., Sanders, Mathijs A., Moore, Luiza, Georgakopoulos, Nikitas, Torrente, Franco, Noorani, Ayesha, Goddard, Martin, Robinson, Philip, Coorens, Tim H. H., O’Neill, Laura, Alder, Christopher, Wang, Jingwei, Fitzgerald, Rebecca C., Zilbauer, Matthias, Coleman, Nicholas, Saeb-Parsy, Kourosh, Martincorena, Inigo, Campbell, Peter J., Stratton, Michael R.
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
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Somatic Evolution in Non-neoplastic IBD-Affected Colon
Olafsson, Sigurgeir, McIntyre, Rebecca E., Coorens, Tim, Butler, Timothy, Jung, Hyunchul, Robinson, Philip S., Lee-Six, Henry, Sanders, Mathijs A., Arestang, Kenneth, Dawson, Claire, Tripathi, Monika, Strongili, Konstantina, Hooks, Yvette, Stratton, Michael R., Parkes, Miles, Martincorena, Inigo, Raine, Tim, Campbell, Peter J., Anderson, Carl A.
Published in Cell (06.08.2020)
Published in Cell (06.08.2020)
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Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Robinson, Philip S., Coorens, Tim H. H., Palles, Claire, Mitchell, Emily, Abascal, Federico, Olafsson, Sigurgeir, Lee, Bernard C. H., Lawson, Andrew R. J., Lee-Six, Henry, Moore, Luiza, Sanders, Mathijs A., Hewinson, James, Martin, Lynn, Pinna, Claudia M. A., Galavotti, Sara, Rahbari, Raheleh, Campbell, Peter J., Martincorena, Iñigo, Tomlinson, Ian, Stratton, Michael R.
Published in Nature genetics (01.10.2021)
Published in Nature genetics (01.10.2021)
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Mutational landscape of normal epithelial cells in Lynch Syndrome patients
Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.
Published in Nature communications (17.05.2022)
Published in Nature communications (17.05.2022)
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Reproductive fitness and genetic risk of psychiatric disorders in the general population
Mullins, Niamh, Ingason, Andrés, Porter, Heather, Euesden, Jack, Gillett, Alexandra, Ólafsson, Sigurgeir, Gudbjartsson, Daniel F., Lewis, Cathryn M., Sigurdsson, Engilbert, Saemundsen, Evald, Gudmundsson, Ólafur Ó, Frigge, Michael L., Kong, Augustine, Helgason, Agnar, Walters, G. Bragi, Gustafsson, Omar, Stefansson, Hreinn, Stefansson, Kari
Published in Nature communications (13.06.2017)
Published in Nature communications (13.06.2017)
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Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Robinson, Philip S., Thomas, Laura E., Abascal, Federico, Jung, Hyunchul, Harvey, Luke M. R., West, Hannah D., Olafsson, Sigurgeir, Lee, Bernard C. H., Coorens, Tim H. H., Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A., Lensing, Stefanie V., Buczacki, Simon J. A., ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J., Martincorena, Iñigo, Sampson, Julian R., Stratton, Michael R.
Published in Nature communications (08.07.2022)
Published in Nature communications (08.07.2022)
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Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis
Sigurdsson, Snaevar, Alexandersson, Kristjan F., Sulem, Patrick, Feenstra, Bjarke, Gudmundsdottir, Steinunn, Halldorsson, Gisli H., Olafsson, Sigurgeir, Sigurdsson, Asgeir, Rafnar, Thorunn, Thorgeirsson, Thorgeir, Sørensen, Erik, Nordholm-Carstensen, Andreas, Burcharth, Jakob, Andersen, Jens, Jørgensen, Henrik Stig, Possfelt-Møller, Emma, Ullum, Henrik, Thorleifsson, Gudmar, Masson, Gisli, Thorsteinsdottir, Unnur, Melbye, Mads, Gudbjartsson, Daniel F., Stefansson, Tryggvi, Jonsdottir, Ingileif, Stefansson, Kari
Published in Nature communications (06.06.2017)
Published in Nature communications (06.06.2017)
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Sequence variants affecting the genome-wide rate of germline microsatellite mutations
Kristmundsdottir, Snaedis, Jonsson, Hakon, Hardarson, Marteinn T., Palsson, Gunnar, Beyter, Doruk, Eggertsson, Hannes P., Gylfason, Arnaldur, Sveinbjornsson, Gardar, Holley, Guillaume, Stefansson, Olafur A., Halldorsson, Gisli H., Olafsson, Sigurgeir, Arnadottir, Gudny. A., Olason, Pall I., Eiriksson, Ogmundur, Masson, Gisli, Thorsteinsdottir, Unnur, Rafnar, Thorunn, Sulem, Patrick, Helgason, Agnar, Gudbjartsson, Daniel F., Halldorsson, Bjarni V., Stefansson, Kari
Published in Nature communications (29.06.2023)
Published in Nature communications (29.06.2023)
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A sequence variant associating with educational attainment also affects childhood cognition
Gunnarsson, Bjarni, Jónsdóttir, Guðrún A., Björnsdóttir, Gyða, Konte, Bettina, Sulem, Patrick, Kristmundsdóttir, Snædís, Kehr, Birte, Gústafsson, Ómar, Helgason, Hannes, Iordache, Paul D., Ólafsson, Sigurgeir, Frigge, Michael L., Þorleifsson, Guðmar, Arnarsdóttir, Sunna, Stefánsdóttir, Berglind, Giegling, Ina, Djurovic, Srdjan, Sundet, Kjetil S., Espeseth, Thomas, Melle, Ingrid, Hartmann, Annette M., Thorsteinsdottir, Unnur, Kong, Augustine, Guðbjartsson, Daníel F., Ettinger, Ulrich, Andreassen, Ole A., Dan Rujescu, Halldórsson, Jónas G., Stefánsson, Hreinn, Halldórsson, Bjarni V., Stefánsson, Kári
Published in Scientific reports (04.11.2016)
Published in Scientific reports (04.11.2016)
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Somatic mutation landscapes at single-molecule resolution
Abascal, Federico, Harvey, Luke M. R., Mitchell, Emily, Lawson, Andrew R. J., Lensing, Stefanie V., Ellis, Peter, Russell, Andrew J. C., Alcantara, Raul E., Baez-Ortega, Adrian, Wang, Yichen, Kwa, Eugene Jing, Lee-Six, Henry, Cagan, Alex, Coorens, Tim H. H., Chapman, Michael Spencer, Olafsson, Sigurgeir, Leonard, Steven, Jones, David, Machado, Heather E., Davies, Megan, Øbro, Nina F., Mahubani, Krishnaa T., Allinson, Kieren, Gerstung, Moritz, Saeb-Parsy, Kourosh, Kent, David G., Laurenti, Elisa, Stratton, Michael R., Rahbari, Raheleh, Campbell, Peter J., Osborne, Robert J., Martincorena, Iñigo
Published in Nature (London) (20.05.2021)
Published in Nature (London) (20.05.2021)
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Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk
Tengvall, Katarina, Huang, Jesse, Hellström, Cecilia, Kammer, Patrick, Biström, Martin, Ayoglu, Burcu, Bomfim, Izaura Lima, Stridh, Pernilla, Butt, Julia, Brenner, Nicole, Michel, Angelika, Lundberg, Karin, Padyukov, Leonid, Lundberg, Ingrid E., Svenungsson, Elisabet, Ernberg, Ingemar, Olafsson, Sigurgeir, Dilthey, Alexander T., Hillert, Jan, Alfredsson, Lars, Sundström, Peter, Nilsson, Peter, Waterboer, Tim, Olsson, Tomas, Kockum, Ingrid
Published in Proceedings of the National Academy of Sciences - PNAS (20.08.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (20.08.2019)
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DNA methylation as a mediator of HLA-DRB1 15:01 and a protective variant in multiple sclerosis
Kular, Lara, Liu, Yun, Ruhrmann, Sabrina, Zheleznyakova, Galina, Marabita, Francesco, Gomez-Cabrero, David, James, Tojo, Ewing, Ewoud, Lindén, Magdalena, Górnikiewicz, Bartosz, Aeinehband, Shahin, Stridh, Pernilla, Link, Jenny, Andlauer, Till F.M, Gasperi, Christiane, Wiendl, Heinz, Zipp, Frauke, Gold, Ralf, Tackenberg, Björn, Weber, Frank, Hemmer, Bernhard, Strauch, Konstantin, Heilmann-Heimbach, Stefanie, Rawal, Rajesh, Schminke, Ulf, Schmidt, Carsten O, Kacprowski, Tim, Franke, Andre, Laudes, Matthias, Dilthey, Alexander T, Celius, Elisabeth Gulowsen, Søndergaard, Helle Bach, Tegnér, Jesper, Harbo, Hanne Flinstad, Oturai, Annette B, Olafsson, Sigurgeir, Eggertsson, Hannes P, Halldorsson, Bjarni V, Hjaltason, Haukur, Olafsson, Elias, Jonsdottir, Ingileif, Stefansson, Kari, Olsson, Tomas, Piehl, Fredrik, Ekström, Tomas J, Kockum, Ingrid, Feinberg, Andrew P, Jagodic, Maja
Published in Nature communications (2018)
Published in Nature communications (2018)
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Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin
Olafsson, Sigurgeir, Rodriguez, Elke, Lawson, Andrew R. J., Abascal, Federico, Huber, Axel Rosendahl, Suembuel, Melike, Jones, Philip H., Gerdes, Sascha, Martincorena, Iñigo, Weidinger, Stephan, Campbell, Peter J., Anderson, Carl A.
Published in Nature genetics (01.11.2023)
Published in Nature genetics (01.11.2023)
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Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction
Reginsson, Gunnar W., Ingason, Andres, Euesden, Jack, Bjornsdottir, Gyda, Olafsson, Sigurgeir, Sigurdsson, Engilbert, Oskarsson, Hogni, Tyrfingsson, Thorarinn, Runarsdottir, Valgerdur, Hansdottir, Ingunn, Steinberg, Stacy, Stefansson, Hreinn, Gudbjartsson, Daniel F., Thorgeirsson, Thorgeir E., Stefansson, Kari
Published in Addiction biology (01.01.2018)
Published in Addiction biology (01.01.2018)
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Identification of sequence variants influencing immunoglobulin levels
Jonsson, Stefan, Sveinbjornsson, Gardar, de Lapuente Portilla, Aitzkoa Lopez, Swaminathan, Bhairavi, Plomp, Rosina, Dekkers, Gillian, Ajore, Ram, Ali, Mina, Bentlage, Arthur E H, Elmér, Evelina, Eyjolfsson, Gudmundur I, Gudjonsson, Sigurjon A, Gullberg, Urban, Gylfason, Arnaldur, Halldorsson, Bjarni V, Hansson, Markus, Holm, Hilma, Johansson, Åsa, Johnsson, Ellinor, Jonasdottir, Aslaug, Ludviksson, Bjorn R, Oddsson, Asmundur, Olafsson, Isleifur, Olafsson, Sigurgeir, Sigurdardottir, Olof, Sigurdsson, Asgeir, Stefansdottir, Lilja, Masson, Gisli, Sulem, Patrick, Wuhrer, Manfred, Wihlborg, Anna-Karin, Thorleifsson, Gudmar, Gudbjartsson, Daniel F, Thorsteinsdottir, Unnur, Vidarsson, Gestur, Jonsdottir, Ingileif, Nilsson, Björn, Stefansson, Kari
Published in Nature genetics (01.08.2017)
Published in Nature genetics (01.08.2017)
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Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
Stacey, Simon N., Zink, Florian, Halldorsson, Gisli H., Stefansdottir, Lilja, Gudjonsson, Sigurjon A., Einarsson, Gudmundur, Hjörleifsson, Grimur, Eiriksdottir, Thjodbjorg, Helgadottir, Anna, Björnsdottir, Gyda, Thorgeirsson, Thorgeir E., Olafsdottir, Thorunn A., Jonsdottir, Ingileif, Gretarsdottir, Solveig, Tragante, Vinicius, Magnusson, Magnus K., Jonsson, Hakon, Gudmundsson, Julius, Olafsson, Sigurgeir, Holm, Hilma, Gudbjartsson, Daniel F., Sulem, Patrick, Helgason, Agnar, Thorsteinsdottir, Unnur, Tryggvadottir, Laufey, Rafnar, Thorunn, Melsted, Pall, Ulfarsson, Magnus Ö., Vidarsson, Brynjar, Thorleifsson, Gudmar, Stefansson, Kari
Published in Nature genetics (01.12.2023)
Published in Nature genetics (01.12.2023)
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Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis
Magnusson, Magnus I., Agnarsson, Bjarni A., Jonasson, Jon G., Tryggvason, Thordur, Aeffner, Famke, le Roux, Louise, Magnusdottir, Droplaug N., Gunnarsdottir, Helga S., Alexíusdóttir, Kristín K., Gunnarsdottir, Kristbjorg, Söebech, Emilia, Runarsdottir, Hjaltey, Jonsdottir, Erna M., Kristinsdottir, Bjarney S., Olafsson, Sigurgeir, Knutsdottir, Hildur, Thorsteinsdottir, Unnur, Ulfarsson, Magnus O., Gudbjartsson, Daniel F., Saemundsdottir, Jona, Magnusson, Olafur T., Norddahl, Gudmundur L., Watson, J. E. Vivienne, Rafnar, Thorunn, Lund, Sigrun H., Stefansson, Kari
Published in British journal of cancer (19.10.2023)
Published in British journal of cancer (19.10.2023)
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