CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition
Quijada-Álamo, Miguel, Hernández-Sánchez, María, Alonso-Pérez, Verónica, Rodríguez-Vicente, Ana E., García-Tuñón, Ignacio, Martín-Izquierdo, Marta, Hernández-Sánchez, Jesús María, Herrero, Ana B., Bastida, José María, San Segundo, Laura, Gruber, Michaela, García, Juan Luis, Yin, Shanye, ten Hacken, Elisa, Benito, Rocío, Ordóñez, José Luis, Wu, Catherine J., Hernández-Rivas, Jesús María
Published in Leukemia (01.06.2020)
Published in Leukemia (01.06.2020)
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Journal Article
Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia
Forero-Castro, Maribel, Robledo, Cristina, Benito, Rocío, Bodega-Mayor, Irene, Rapado, Inmaculada, Hernández-Sánchez, María, Abáigar, María, Maria Hernández-Sánchez, Jesús, Quijada-Álamo, Miguel, María Sánchez-Pina, José, Sala-Valdés, Mónica, Araujo-Silva, Fernanda, Kohlmann, Alexander, Luis Fuster, José, Arefi, Maryam, de las Heras, Natalia, Riesco, Susana, Rodríguez, Juan N, Hermosín, Lourdes, Ribera, Jordi, Camos Guijosa, Mireia, Ramírez, Manuel, de Heredia Rubio, Cristina Díaz, Barragán, Eva, Martínez, Joaquín, Ribera, José M, Fernández-Ruiz, Elena, Hernández-Rivas, Jesús-María
Published in British journal of cancer (11.07.2017)
Published in British journal of cancer (11.07.2017)
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Journal Article
The Evolving Landscape of Chronic Lymphocytic Leukemia on Diagnosis, Prognosis and Treatment
Pérez-Carretero, Claudia, González-Gascón-y-Marín, Isabel, Rodríguez-Vicente, Ana E., Quijada-Álamo, Miguel, Hernández-Rivas, José-Ángel, Hernández-Sánchez, María, Hernández-Rivas, Jesús María
Published in Diagnostics (Basel) (10.05.2021)
Published in Diagnostics (Basel) (10.05.2021)
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Journal Article
Association of Cytogenetics Aberrations and IGHV Mutations with Outcome in Chronic Lymphocytic Leukemia Patients in a Real-World Clinical Setting
Muñoz-Novas, Carolina, González-Gascón-Y-Marín, Isabel, Figueroa, Iñigo, Sánchez-Paz, Laura, Pérez-Carretero, Claudia, Quijada-Álamo, Miguel, Rodríguez-Vicente, Ana-Eugenia, Infante, María-Stefania, Foncillas, María-Ángeles, Landete, Elena, Churruca, Juan, Marín, Karen, Ramos, Victoria, Sánchez Salto, Alejandro, Hernández-Rivas, José-Ángel
Published in Global medical genetics (01.01.2024)
Published in Global medical genetics (01.01.2024)
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Journal Article
LIPA-frogging blast phase chronic myeloid leukemia: hopping over resistance with lysosomal targeting
Quijada-Álamo, Miguel, Freed, Grace, Wagenblast, Elvin
Published in Haematologica (Roma) (22.08.2024)
Published in Haematologica (Roma) (22.08.2024)
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Journal Article
High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia
Ghia, Emanuela M., Rassenti, Laura Z., Choi, Michael Y., Quijada-Álamo, Miguel, Chu, Elvin, Widhopf, George F., Kipps, Thomas J.
Published in Leukemia (01.06.2022)
Published in Leukemia (01.06.2022)
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Journal Article
The Five "Ws" of Frailty Assessment and Chronic Lymphocytic Leukemia: Who, What, Where, Why, and When
González-Gascón-Y-Marín, Isabel, Ballesteros-Andrés, Mónica, Martínez-Flores, Sara, Rodríguez-Vicente, Ana-E, Pérez-Carretero, Claudia, Quijada-Álamo, Miguel, Rodríguez-Sánchez, Alberto, Hernández-Rivas, José-Ángel
Published in Cancers (02.09.2023)
Published in Cancers (02.09.2023)
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Journal Article
DNA damage response-related alterations define the genetic background of patients with chronic lymphocytic leukemia and chromosomal gains
Hernández-Sánchez, María, Rodríguez-Vicente, Ana Eugenia, González-Gascón y Marín, Isabel, Quijada-Álamo, Miguel, Hernández-Sánchez, Jesús María, Martín-Izquierdo, Marta, Hernández-Rivas, José Ángel, Benito, Rocío, Hernández-Rivas, Jesús María
Published in Experimental hematology (01.04.2019)
Published in Experimental hematology (01.04.2019)
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Journal Article
From Biomarkers to Models in the Changing Landscape of Chronic Lymphocytic Leukemia: Evolve or Become Extinct
González-Gascón-Y-Marín, Isabel, Muñoz-Novas, Carolina, Rodríguez-Vicente, Ana-Eugenia, Quijada-Álamo, Miguel, Hernández-Sánchez, María, Pérez-Carretero, Claudia, Ramos-Ascanio, Victoria, Hernández-Rivas, José-Ángel
Published in Cancers (08.04.2021)
Published in Cancers (08.04.2021)
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Journal Article
TRAF3 alterations are frequent in del‐3′IGH chronic lymphocytic leukemia patients and define a specific subgroup with adverse clinical features
Pérez‐Carretero, Claudia, Hernández‐Sánchez, María, González, Teresa, Quijada‐Álamo, Miguel, Martín‐Izquierdo, Marta, Santos‐Mínguez, Sandra, Miguel‐García, Cristina, Vidal, María‐Jesús, García‐De‐Coca, Alfonso, Galende, Josefina, Pardal, Emilia, Aguilar, Carlos, Vargas‐Pabón, Manuel, Dávila, Julio, Gascón‐Y‐Marín, Isabel, Hernández‐Rivas, José‐Ángel, Benito, Rocío, Hernández‐Rivas, Jesús‐María, Rodríguez‐Vicente, Ana‐Eugenia
Published in American journal of hematology (01.07.2022)
Published in American journal of hematology (01.07.2022)
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Journal Article
CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase
Hernández-Sánchez, María, Kotaskova, Jana, Rodríguez, Ana E, Radova, Lenka, Tamborero, David, Abáigar, María, Plevova, Karla, Benito, Rocío, Tom, Nikola, Quijada-Álamo, Miguel, Bikos, Vasileos, Martín, Ana África, Pal, Karol, García de Coca, Alfonso, Doubek, Michael, López-Bigas, Nuria, Hernández-Rivas, Jesús-María, Pospisilova, Sarka
Published in Leukemia (01.02.2019)
Published in Leukemia (01.02.2019)
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Journal Article
Chronic lymphocytic leukemia patients with chromosome 6q deletion as the sole cytogenetic abnormality display a high frequency of RPS15 mutations and have a poor prognosis
Pérez Carretero, Claudia, González, Teresa, Quijada Álamo, Miguel, Rigolin, Gian Matteo, Dubuc, Adrian, Villaverde Ramiro, Ángela, Rodríguez‐Sánchez, Alberto, Rubio, Araceli, Dávila, Julio, Vidal, Mª. Jesús, González Gascón y Marín, Isabel, Hernández‐Rivas, José‐Ángel, Benito, Rocío, Volpe, Virginia, Davids, Matthew S., Abramson, Jeremy S., Cuneo, Antonio, Dal Cin, Paola, Rodríguez‐Vicente, Ana‐Eugenia, Hernández‐Rivas, Jesús‐María
Published in American journal of hematology (01.09.2024)
Published in American journal of hematology (01.09.2024)
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Journal Article
Prognosis Assessment of Early-Stage Chronic Lymphocytic Leukemia: Are We Ready to Predict Clinical Evolution Without a Crystal Ball?
González-Gascón-y-Marín, Isabel, Muñoz-Novas, Carolina, Figueroa, Iñigo, Hernández-Sánchez, María, Rodríguez-Vicente, Ana-Eugenia, Quijada-Álamo, Miguel, Pérez-Carretero, Claudia, Moreno, Carol, Collado, Rosa, Espinet, Blanca, Puiggros, Anna, Heras, Natalia de las, Bosch, Francesc, Hernández, José-Ángel
Published in Clinical lymphoma, myeloma and leukemia (01.08.2020)
Published in Clinical lymphoma, myeloma and leukemia (01.08.2020)
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Journal Article
The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia
García-Tuñón, Ignacio, Hernández-Sánchez, María, Ordoñez, José Luis, Alonso-Pérez, Veronica, Álamo-Quijada, Miguel, Benito, Rocio, Guerrero, Carmen, Hernández-Rivas, Jesús María, Sánchez-Martín, Manuel
Published in Oncotarget (18.04.2017)
Published in Oncotarget (18.04.2017)
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Journal Article
TRAF3 -Inactivated Chronic Lymphocytic Leukemia Cells Show an Enhanced Metabolic Plasticity That Can be Attenuated By Glutaminolysis and Mitochondrial Pyruvate Import Inhibition
Perez Carretero, Claudia, Quijada Álamo, Miguel, Tannoury, Mariana, Dehgane, Léa, Rodríguez-Sánchez, Alberto, González, Teresa, Benito Sanchez, Maria Rocio, Chapiro, Elise, Rodriguez, Ana E., Nguyen-Khac, Florence, Susin, Santos A., Hernández-Rivas, Jesús María
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
NOTCH1 Signaling Is Dysregulated in CLL By the Deubiquitinase USP28 That Is Recurrently Affected By Del(11q) and Can be Therapeutically Targeted
Ehrmann, Alena Sophie, Quijada Álamo, Miguel, Close, Viola, Guo, Min, Pérez Carretero, Claudia, Corchete, Luis A, Tausch, Eugen, Schneider, Christof, Döhner, Hartmut, Stilgenbauer, Stephan, Oswald, Franz, Hernández-Rivas, Jesus Maria, Mertens, Daniel
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Chemotherapy-Based Regimes Increase Karyotype Complexity of Del(11q) CLL Cells and Impact the Response to Subsequent Ibrutinib Treatment
Quijada Álamo, Miguel, Rassenti, Laura Z., Ghia, Emanuela M., Tran, Tuan, Spydell, Monica, Molina, Elsa, Pérez Carretero, Claudia, Corchete, Luis A., González, Teresa, Hernández-Rivas, Jesús María, Kipps, Thomas J.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
TRAF3 Alterations Identify a Subgroup of Patients with Adverse Clinical Outcome and Induce Metabolic Reprogramming in Chronic Lymphocytic Leukemia
Pérez Carretero, Claudia, Quijada Álamo, Miguel, Tannoury, Mariana, Dehgane, Léa, Sanz, David J., González, Teresa, Benito, Rocio, Chapiro, Elise, Hernandez-Sanchez, Maria, Rodriguez, Ana E., Nguyen Khac, Florence, Susin, Santos A., Hernández-Rivas, Jesús María
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
ZMYM3 Mutations Cooperate with NOTCH1 Alterations, Reduce Histone H4 Acetylation and Promote Apoptosis Evasion in Chronic Lymphocytic Leukemia
Rodríguez-Sánchez, Alberto, Quijada Álamo, Miguel, Perez Carretero, Claudia, Corchete Sanchez, Luis Antonio, Villaverde Ramiro, Angela, Miguel-García, Cristina, Santos-Mínguez, Sandra, Valls, Julio Davila, Garcia de Coca, Alfonso, Olazabal, Julio, Benito Sanchez, Maria Rocio, Rodriguez, Ana E., Hernández-Rivas, Jesús María
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Chronic lymphocytic leukemia patients with IGH translocations are characterized by a distinct genetic landscape with prognostic implications
Pérez‐Carretero, Claudia, Hernández‐Sánchez, María, González, Teresa, Quijada‐Álamo, Miguel, Martín‐Izquierdo, Marta, Hernández‐Sánchez, Jesús‐María, Vidal, María‐Jesús, Coca, Alfonso García, Aguilar, Carlos, Vargas‐Pabón, Manuel, Alonso, Sara, Sierra, Magdalena, Rubio‐Martínez, Araceli, Dávila, Julio, Díaz‐Valdés, José R., Queizán, José‐Antonio, Hernández‐Rivas, José‐Ángel, Benito, Rocío, Rodríguez‐Vicente, Ana E., Hernández‐Rivas, Jesús‐María
Published in International journal of cancer (15.11.2020)
Published in International journal of cancer (15.11.2020)
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Journal Article