Discovery of the Selective Androgen Receptor Modulator MK-0773 Using a Rational Development Strategy Based on Differential Transcriptional Requirements for Androgenic Anabolism Versus Reproductive Physiology
Schmidt, Azriel, Kimmel, Donald B., Bai, Chang, Scafonas, Angela, Rutledge, SuJane, Vogel, Robert L., McElwee-Witmer, Sheila, Chen, Fang, Nantermet, Pascale V., Kasparcova, Viera, Leu, Chih-tai, Zhang, Hai-Zhuan, Duggan, Mark E., Gentile, Michael A., Hodor, Paul, Pennypacker, Brenda, Masarachia, Patricia, Opas, Evan E., Adamski, Sharon A., Cusick, Tara E., Wang, Jiabing, Mitchell, Helen J., Kim, Yuntae, Prueksaritanont, Thomayant, Perkins, James J., Meissner, Robert S., Hartman, George D., Freedman, Leonard P., Harada, Shun-ichi, Ray, William J.
Published in The Journal of biological chemistry (28.05.2010)
Published in The Journal of biological chemistry (28.05.2010)
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Photoredox Catalysis for Silyl‐Mediated C–H Alkylation of Heterocycles with Non‐Activated Alkyl Bromides
Perkins, James J., Schubert, Jeffrey W., Streckfuss, Eric C., Balsells, Jaume, ElMarrouni, Abdellatif
Published in European journal of organic chemistry (15.03.2020)
Published in European journal of organic chemistry (15.03.2020)
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Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic
Shurtleff, Valerie W., Layton, Mark E., Parish, Craig A., Perkins, James J., Schreier, John D., Wang, Yunyi, Adam, Gregory C., Alvarez, Nadine, Bahmanjah, Soheila, Bahnck-Teets, Carolyn M., Boyce, Christopher W., Burlein, Christine, Cabalu, Tamara D., Campbell, Brian T., Carroll, Steven S., Chang, Wonsuk, de Lera Ruiz, Manuel, Dolgov, Enriko, Fay, John F., Fox, Nicholas G., Goh, Shih Lin, Hartingh, Timothy J., Hurzy, Danielle M., Kelly, Michael J., Klein, Daniel J., Klingler, Franca-Maria, Krishnamurthy, Harini, Kudalkar, Shalley, Mayhood, Todd W., McKenna, Philip M., Murray, Edward M., Nahas, Debbie, Nawrat, Christopher C., Park, Steven, Qian, Dongming, Roecker, Anthony J., Sharma, Vijeta, Shipe, William D., Su, Jing, Taggart, Robert V., Truong, Quang, Wu, Yin, Zhou, Xiaoyan, Zhuang, Ningning, Perlin, David S., Olsen, David B., Howe, John A., McCauley, John A.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Discovery of [ 11 C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR 2 Negative Allosteric Modulators
Perkins, James J, McQuade, Paul, Bungard, Christopher J, Diamond, Tracy L, Gantert, Liza T, Gotter, Anthony L, Hanney, Barbara, Hills, Ivory D, Hurzy, Danielle M, Joshi, Aniket, Kern, Jonathan T, Schlegel, Kelly-Ann S, Manikowski, Jesse J, Meng, Zhaoyang, O'Brien, Julie A, Roecker, Anthony J, Smith, Sean M, Uslaner, Jason M, Hostetler, Eric, Meissner, Robert S
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator
Rudd, Michael T., Manley, Peter J., Hanney, Barbara, Meng, Zhaoyang, Shu, Youheng, de Leon, Pablo, Frie, Jessica L., Han, Yongxin, Wai, Jenny Miu-Chun, Yang, Zhi-Qiang, Perkins, James J., Hurzy, Danielle M., Manikowski, Jesse J., Zhu, Hong, Bungard, Christopher J., Converso, Antonella, Meissner, Robert S., Cosden, Mali L., Hayashi, Ikuo, Ma, Lei, O’Brien, Julie, Uebele, Victor N., Schachter, Joel B., Bhandari, Neetesh, Ward, Gwendolyn J., Fillgrove, Kerry L., Lu, Bing, Liang, Yuexia, Dubost, David C., Puri, Vanita, Eddins, Donnie M., Vardigan, Joshua D., Drolet, Robert E., Kern, Jonathan T., Uslaner, Jason M.
Published in ACS medicinal chemistry letters (10.08.2023)
Published in ACS medicinal chemistry letters (10.08.2023)
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Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells
Schmidt, Azriel, Meissner, Robert S, Gentile, Michael A, Chisamore, Michael J, Opas, Evan E, Scafonas, Angela, Cusick, Tara E, Gambone, Carlo, Pennypacker, Brenda, Hodor, Paul, Perkins, James J, Bai, Chang, Ferraro, Damien, Bettoun, David J, Wilkinson, Hilary A, Alves, Stephen E, Flores, Osvaldo, Ray, William J
Published in The Journal of steroid biochemistry and molecular biology (01.09.2014)
Published in The Journal of steroid biochemistry and molecular biology (01.09.2014)
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Discovery of selective glucocorticoid receptor modulator MK-5932
Bungard, Christopher J., Hartman, George D., Manikowski, Jesse J., Perkins, James J., Bai, Chang, Brandish, Philip E., Euler, Danielle H., Hershey, James C., Schmidt, Azriel, Fang, Yulin, Norcross, Ryan T., Rushmore, Tom H., Thompson, Charles D., Meissner, Robert S.
Published in Bioorganic & medicinal chemistry (15.12.2011)
Published in Bioorganic & medicinal chemistry (15.12.2011)
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Nonpeptide αvβ3 Antagonists. 8. In Vitro and in Vivo Evaluation of a Potent αvβ3 Antagonist for the Prevention and Treatment of Osteoporosis
Hutchinson, John H, Halczenko, Wasyl, Brashear, Karen M, Breslin, Michael J, Coleman, Paul J, Duong, Le T, Fernandez-Metzler, Carmen, Gentile, Michael A, Fisher, John E, Hartman, George D, Huff, Joel R, Kimmel, Donald B, Leu, Chih-Tai, Meissner, Robert S, Merkle, Kara, Nagy, Rose, Pennypacker, Brenda, Perkins, James J, Prueksaritanont, Thomayant, Rodan, Gideon A, Varga, Sandor L, Wesolowski, Greg A, Zartman, Amy E, Rodan, Sevgi B, Duggan, Mark E
Published in Journal of medicinal chemistry (23.10.2003)
Published in Journal of medicinal chemistry (23.10.2003)
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NAV1.8 억제제로서의 2-옥소이미다졸리딘-4-카르복스아미드
SHAH AKSHAY A, BUNGARD CHRISTOPHER JAMES, ARASAPPAN ASHOK, BURGEY CHRISTOPHER S, LIU JIAN, COX JASON M, PERKINS JAMES J, VANHEYST MICHAEL DAVID, BELL IAN M, LIU HONG, KELLY MICHAEL J. III, WU ZHE, LAYTON MARK E
Year of Publication 21.02.2023
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Year of Publication 21.02.2023
Patent
Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist
Duggan, Mark E, Naylor-Olsen, Adel M, Perkins, James J, Anderson, Paul S, Chang, Charles T.-C, Cook, Jacquelynn J, Gould, Robert J, Ihle, Nathan C, Hartman, George D
Published in Journal of medicinal chemistry (01.08.1995)
Published in Journal of medicinal chemistry (01.08.1995)
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NAV1.8 억제제로서의 2-옥소-옥사졸리딘-5-카르복스아미드
SHAH AKSHAY A, BUNGARD CHRISTOPHER JAMES, ARASAPPAN ASHOK, BURGEY CHRISTOPHER S, LIU JIAN, COX JASON M, PERKINS JAMES J, VANHEYST MICHAEL D, SCHUBERT JEFFREY W, BELL IAN M, LIU HONG, KELLY MICHAEL J. III, OLSEN JAMES T, GUIADEEN DEODIAL GUY, STACHEL SHAWN J, WU ZHE, LAYTON MARK E
Year of Publication 24.02.2023
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Year of Publication 24.02.2023
Patent
Nonpeptide αvβ3 antagonists. Part 2: Constrained glycyl amides derived from the RGD tripeptide
MEISSNER, Robert S, PERKINS, James J, RODAN, Gideon A, RODAN, Sevgi B, WHITMAN, David B, WESOLOWSKI, Gregg A, DUGGAN, Mark E, DUONG, Le T, HARTMAN, George D, HOFFMAN, William F, HUFF, Joel R, IHLE, Nathan C, LEU, Chih-Tai, NAGY, Rose M, NAYLOR-OLSEN, Adel
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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NAV1.8 억제제로서의 2-아미노-N-헤테로아릴-니코틴아미드
CHOBANIAN HARRY R, BUNGARD CHRISTOPHER JAMES, ARASAPPAN ASHOK, BURGEY CHRISTOPHER S, LIU JIAN, SUEN LAI LINDA M, COX JASON M, PERKINS JAMES J, BELL IAN M, BRESLIN MICHAEL J, LIU HONG, GUIADEEN DEODIAL GUY, JONES KRISTEN L. G, GINNETTI ANTHONY T, STACHEL SHAWN J, WU ZHE, LAYTON MARK E
Year of Publication 08.07.2021
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Year of Publication 08.07.2021
Patent
Non-peptide αvβ3 antagonists: Identification of potent, chain-shortened RGD mimetics that incorporate a central pyrrolidinone constraint
PERKINS, James J, DUONG, Le T, DUGGAN, Mark E, MEISSNER, Robert S, FERNANDEZ-METZLER, Carmen, HARTMAN, George D, KIMMEL, Donald B, LEU, Chih-Tai, LYNCH, Joseph J, PRUEKSARITANONT, Thomayant, RODAN, Gideon A, RODAN, Sevgi B
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Development of a sp2–sp3 Stille Cross-Coupling for Rapid Synthesis of HIV NNRTI Doravirine Analogues
ElMarrouni, Abdellatif, Campbell, Mark, Perkins, James J, Converso, Antonella
Published in Organic letters (16.06.2017)
Published in Organic letters (16.06.2017)
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Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators
Perkins, James J., McQuade, Paul, Bungard, Christopher J., Diamond, Tracy L., Gantert, Liza T., Gotter, Anthony L., Hanney, Barbara, Hills, Ivory D., Hurzy, Danielle M., Joshi, Aniket, Kern, Jonathan T., Schlegel, Kelly-Ann S., Manikowski, Jesse J., Meng, Zhaoyang, O’Brien, Julie A., Roecker, Anthony J., Smith, Sean M., Uslaner, Jason M., Hostetler, Eric, Meissner, Robert S.
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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