Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
Nanna, Alex R., Li, Xiuling, Walseng, Even, Pedzisa, Lee, Goydel, Rebecca S., Hymel, David, Burke Jr, Terrence R., Roush, William R., Rader, Christoph
Published in Nature communications (24.10.2017)
Published in Nature communications (24.10.2017)
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Journal Article
A new immunochemical strategy for triple-negative breast cancer therapy
Lin, Chih-Wei, Zheng, Tianqing, Grande, Geramie, Nanna, Alex R., Rader, Christoph, Lerner, Richard A.
Published in Scientific reports (21.07.2021)
Published in Scientific reports (21.07.2021)
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Journal Article
Chemically Programmed Bispecific Antibodies in Diabody Format
Walseng, Even, Nelson, Christopher G., Qi, Junpeng, Nanna, Alex R., Roush, William R., Goswami, Rajib K., Sinha, Subhash.C., Burke, Terrence R., Rader, Christoph
Published in The Journal of biological chemistry (09.09.2016)
Published in The Journal of biological chemistry (09.09.2016)
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Journal Article
Generation and validation of structurally defined antibody-siRNA conjugates
Nanna, Alex R, Kel'in, Alexander V, Theile, Christopher, Pierson, Justin M, Voo, Zhi Xiang, Garg, Ashish, Nair, Jayaprakash K, Maier, Martin A, Fitzgerald, Kevin, Rader, Christoph
Published in Nucleic acids research (04.06.2020)
Published in Nucleic acids research (04.06.2020)
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Journal Article
Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues
Hwang, Dobeen, Nilchan, Napon, Nanna, Alex R, Li, Xiaohai, Cameron, Michael D, Roush, William R, Park, HaJeung, Rader, Christoph
Published in Cell chemical biology (19.09.2019)
Published in Cell chemical biology (19.09.2019)
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Journal Article
Stable and Potent Selenomab-Drug Conjugates
Li, Xiuling, Nelson, Christopher G., Nair, Rajesh R., Hazlehurst, Lori, Moroni, Tina, Martinez-Acedo, Pablo, Nanna, Alex R., Hymel, David, Burke, Terrence R., Rader, Christoph
Published in Cell chemical biology (20.04.2017)
Published in Cell chemical biology (20.04.2017)
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Journal Article
Dual-mechanistic antibody-drug conjugate via site-specific selenocysteine/cysteine conjugation
Nilchan, Napon, Li, Xiuling, Pedzisa, Lee, Nanna, Alex R, Roush, William R, Rader, Christoph
Published in Antibody therapeutics (01.10.2019)
Published in Antibody therapeutics (01.10.2019)
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Journal Article
Abstract 5153: Tunable Drug Conjugates: a differentiated drug conjugate (DC) platform
Hickey, Sara C., Nanna, Alex R., Nguyen, Hanh N., Ofori, Leslie, Rader, Christoph, Rood, Michael K., Wanner, Jutta, Werner, Doug S.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Chemical Assembly of Antibody-Drug Conjugates
Nanna, Alex R., Roush, William R., Rader, Christoph
Published in Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins (01.01.2017)
Published in Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins (01.01.2017)
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Book Chapter
STRUCTURALLY DEFINED SIRNA-DUAL VARIABLE DOMAIN IMMUNOGLOBULIN CONJUGATES
THEILE, Christopher, RADER, Christoph, PIERSON, Justin, NANNA, Alex R, KEL'IN, Alexander V, VOO, Zhi Xiang, FITZGERALD, Kevin
Year of Publication 12.07.2023
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Year of Publication 12.07.2023
Patent
MODIFIED DOUBLE STRANDED OLIGONUCLEOTIDE
THEILE, Christopher, PIERSON, Justin, NANNA, Alex R, KEL'IN, Alexander V, VOO, Zhi Xiang, RADER, Christopher, FITZGERALD, Kevin
Year of Publication 16.02.2023
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Year of Publication 16.02.2023
Patent
STRUCTURALLY DEFINED SIRNA-DUAL VARIABLE DOMAIN IMMUNOGLOBULIN CONJUGATES
THEILE, Christopher, RADER, Christoph, PIERSON, Justin, NANNA, Alex R, KEL'IN, Alexander V, VOO, Zhi Xiang, FITZGERALD, Kevin
Year of Publication 27.04.2022
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Year of Publication 27.04.2022
Patent
Structurally defined siRNA-dual variable domain immunoglobulin conjugates
THEILE, Christopher, RADER, Christoph, PIERSON, Justin, NANNA, Alex R, KEL'IN, Alexander V, VOO, Zhi Xiang, FITZGERALD, Kevin
Year of Publication 23.12.2021
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Year of Publication 23.12.2021
Patent
STRUCTURALLY DEFINED SIRNA-DUAL VARIABLE DOMAIN IMMUNOGLOBULIN CONJUGATES
RADAR, Christoph, THEILE, Christopher, PIERSON, Justin, NANNA, Alex R, KEL'IN, Alexander V, VOO, Zhi Xiang, FITZGERALD, Kevin
Year of Publication 24.12.2020
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Year of Publication 24.12.2020
Patent
STRUCTURALLY DEFINED SIRNA-DUAL VARIABLE DOMAIN IMMUNOGLOBULIN CONJUGATES
RADER, CHRISTOPH, THEILE, CHRISTOPHER, VOO, ZHI XIANG, KEL'IN, ALEXANDER V, FITZGERALD, KEVIN, PIERSON, JUSTIN, NANNA, ALEX R
Year of Publication 24.12.2020
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Year of Publication 24.12.2020
Patent