Potent, Orally Active Corticotropin-Releasing Factor Receptor-1 Antagonists Containing a Tricyclic Pyrrolopyridine or Pyrazolopyridine Core
Dyck, Brian, Grigoriadis, Dimitri E, Gross, Raymond S, Guo, Zhiqiang, Haddach, Mustapha, Marinkovic, Dragan, McCarthy, James R, Moorjani, Manisha, Regan, Collin F, Saunders, John, Schwaebe, Michael K, Szabo, Tomas, Williams, John P, Zhang, Xiaohu, Bozigian, Haig, Chen, Ta Kung
Published in Journal of medicinal chemistry (16.06.2005)
Published in Journal of medicinal chemistry (16.06.2005)
Get full text
Journal Article
Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF 1) receptor antagonist with improved pharmacokinetic properties
Tellew, John E., Lanier, Marion, Moorjani, Manisha, Lin, Emily, Luo, Zhiyong, Slee, Deborah H., Zhang, Xiaohu, Hoare, Sam R.J., Grigoriadis, Dimitri E., Denis, Yves St, Fabio, Romano Di, Modugno, Enza Di, Saunders, John, Williams, John P.
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Get full text
Journal Article
Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A(2A) Adenosine Receptor Antagonists for the Treatment of Parkinson's Disease
Zhang, Xiaohu, Tellew, John E., Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Williams, John P., Saunders, John, Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S., Wen, Jenny, Jalali, Kayvon, O'Brien, Zhihong, Stotz, Carol E., Crespo, Maria I., Diaz, Jose-Luis, Slee, Deborah H.
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
Get full text
Journal Article
2-amino-N-pyrimidin-4-ylacetamides as A(2A) receptor antagonists: 1. Structure-activity relationships and optimization of heterocyclic substituents
Slee, Deborah H., Chen, Yongsheng, Zhang, Xiaohu, Moorjani, Manisha, Lanier, Marion C., Lin, Emily, Rueter, Jaimie K., Williams, John P., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Santos, Mark, Gross, Raymond S., Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Castro-Palomino, Julio C., Crespo, Maria I., Prat, Maria, Gual, Silvia, Diaz, Jose-Luis, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
Get full text
Journal Article
Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A(2A) receptor antagonists with in vivo efficacy
Slee, Deborah H., Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Rueter, Jaimie K., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S., Williams, John P., Castro-Palomino, Julio C., Crespo, Maria I., Prat, Maria, Gual, Silvia, Diaz, Jose-Luis, Wen, Jenny, O'Brien, Zhihong, Saunders, John
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
Get full text
Journal Article
N -[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A 2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy
Lanier, Marion C., Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E., Zhang, Xiaohu, Williams, John P., Gross, Raymond S., Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, María I., Díaz, José-Luis, Saunders, John, Wen, Jenny, O’Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H.
Published in Journal of medicinal chemistry (12.02.2009)
Published in Journal of medicinal chemistry (12.02.2009)
Get full text
Journal Article
N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A(2A) Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy
Lanier, Marion C., Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E., Zhang, Xiaohu, Williams, John P., Gross, Raymond S., Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, Maria I., Diaz, Jose-Luis, Saunders, John, Wen, Jenny, O'Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H.
Published in Journal of medicinal chemistry (12.02.2009)
Published in Journal of medicinal chemistry (12.02.2009)
Get full text
Journal Article
Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease
Zhang, Xiaohu, Tellew, John E, Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Williams, John P, Saunders, John, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Wen, Jenny, Jalali, Kayvon, O’Brien, Zhihong, Stotz, Carol E, Crespo, María I, Díaz, José-Luis, Slee, Deborah H
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
Get full text
Journal Article
Sa1221 Rpc1063, a Potent, Selective S1P1 Receptor Modulator, Is Active in a Therapeutic IBD Model and Exhibits Favorable PK/PD Properties in Healthy Volunteers
Brooks, Jennifer, Peach, Robert J, Boehm, Marcus, Brahmachary, Enugurthi, Clemons, Bryan, Dedman, Harry, Desale, Hans, Gujrathi, Sheila, Huang, Liming, Hartung, Jeffrey P, Martinborough, Esther, Moorjani, Manisha, Powell, Rachel, Reinhart, Greg, Scott, Fiona L, Tamiya, Junko, Yeager, Adam, Rosen, Hugh, Timony, Gregg
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
Get full text
Journal Article
Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy
Slee, Deborah H, Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Wen, Jenny, O’Brien, Zhihong, Saunders, John
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
Get full text
Journal Article
2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 1. Structure−Activity Relationships and Optimization of Heterocyclic Substituents
Slee, Deborah H, Chen, Yongsheng, Zhang, Xiaohu, Moorjani, Manisha, Lanier, Marion C, Lin, Emily, Rueter, Jaimie K, Williams, John P, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
Get full text
Journal Article
GLP-1 GLP-1 RECEPTOR MODULATORS
TAMIYA JUNKO, MOORJANI MANISHA, YEAGER ADAM R, BRAHMACHARY ENUGURTHI, MILLS MARK, MEGHANI PREMJI, FOWLER THOMAS, KNAGGS MICHAEL, MARTINBOROUGH ESTHER, HUANG LIMING, NOVAK ANDREW, BOEHM MARCUS F, GLYNN DANIEL
Year of Publication 11.09.2017
Get full text
Year of Publication 11.09.2017
Patent
2-amino-N-pyrimidin-4-ylacetamides as A(2A) receptor antagonists: 2. Reduction of hERG activity, observed species selectivity, and structure-activity relationships
Slee, Deborah H., Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Rueter, Jaimie K., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Samos, Mark, Gross, Raymond S., Williams, John P., Castro-Palomino, Julio C., Crespo, Maria I., Prat, Maria, Gual, Silvia, Diaz, Jose-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O'Brien, Zhihong, Petroski, Robert, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
Get full text
Journal Article
GLP-1 NOVEL GLP-1 RECEPTOR MODULATORS
TAMIYA JUNKO, MOORJANI MANISHA, FOWLER THOMAS, KNAGGS MICHAEL, MARTINBOROUGH ESTHER, YEAGER ADAM R, HUANG LIMING, BRAHMACHARY ENUGURTHI, NOVAK ANDREW, BOEHM MARCUS F, MEGHANI PREMJI
Year of Publication 12.04.2017
Get full text
Year of Publication 12.04.2017
Patent
2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure−Activity Relationships
Slee, Deborah H, Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O’Brien, Zhihong, Petroski, Robert, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
Get full text
Journal Article
NOVEL GLP-1 RECEPTOR MODULATORS
TAMIYA JUNKO, MOORJANI MANISHA, FOWLER THOMAS, KNAGGS MICHAEL, MARTINBOROUGH ESTHER, YEAGER ADAM R, HUANG LIMING, BRAHMACHARY ENUGURTHI, NOVAK ANDREW, BOEHM MARCUS F, MEGHANI PREMJI
Year of Publication 20.04.2016
Get full text
Year of Publication 20.04.2016
Patent
1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYSTHESIS
TAMIYA JUNKO, BROOKS JENNIFER L, YEAGER ADAM RICHARD, MOORJANI MANISHA, MARTINBOROUGH ESTHER, PEACH ROBERT, HUANG LIMING, SCOTT FIONA LORRAINE, BRAHMACHARY ENUGURTHI, BOEHM MARCUS F, TIMONY GREGG ALAN, HANSON MICHAEL ALLEN
Year of Publication 27.12.2016
Get full text
Year of Publication 27.12.2016
Patent
Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists
XIAOHU ZHANG, RUETER, Jaimie K, MARKISON, Stacy, JOSWIG, Tanya, MALANY, Siobhan, SANTOS, Mark, CASTRO-PALOMINO, Julio C, CRESPO, Maria I, PRAT, Maria, GUAL, Silvia, DIAZ, José-Luis, SAUNDERS, John, YONGSHENG CHEN, SLEE, Deborah H, MOORJANI, Manisha, LANIER, Marion C, LIN, Emily, GROSS, Raymond S, TELLEW, John E, WILLIAMS, John P, LECHNER, Sandra M
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Get full text
Journal Article
Design and Synthesis of Tricyclic Corticotropin-Releasing Factor-1 Antagonists
Gross, Raymond S, Guo, Zhiqiang, Dyck, Brian, Coon, Tim, Huang, Charles Q, Lowe, Richard F, Marinkovic, Dragan, Moorjani, Manisha, Nelson, Jodene, Zamani-Kord, Said, Grigoriadis, Dimitri E, Hoare, Sam R. J, Crowe, Paul D, Bu, Jane Han, Haddach, Mustapha, McCarthy, James, Saunders, John, Sullivan, Robert, Chen, Williams, John P
Published in Journal of medicinal chemistry (08.09.2005)
Published in Journal of medicinal chemistry (08.09.2005)
Get full text
Journal Article